연성 인쇄 회로를 이용한 광대역 Marchand 발룬

이선호,주성호,이해영,Lee, Sun-Ho,Joo, Sung-Ho,Lee, Hai-Young 한국전자파학회 2007 한국전자파학회논문지 Vol.18 No.2

In this paper, a new marchand balun using broadside-coupled coplanar waveguide(CPW) on flexible printed circuit (FPC) is proposed. The proposed balun is designed based on the coupled line theory. The fabricated balun shows compact size and improved performance compared to the conventional microstrip line marchand balun. Measured amplitude and phase imbalance between the two balanced output ports are within 0.2 dB and $1^{\circ}$ respectively in a wide frequency range($1.63{\sim}3.44$ GHz). The proposed balun is expected to be used between various antennas and RF front-ends as a functional interconnection. 본 논문에서는 기능성 연결부에 대한 응용으로, 연성 인쇄 회로의 조건에서 광역 결합 CPW 구조를 이용한 광대역 Marchand 발룬을 제작 측정하였다. 제안된 발룬은 결합 선로 이론을 바탕으로 설계, 기존의 마이크로스트립 라인 구조의 발룬과 비교하여 작은 크기로 향상된 특성을 나타냈다. 측정 결과 72 %의 넓은 대역폭을 갖고, 가용 주파수 내($1.63{\sim}3.44$ GHz)에서 삽입 손실의 차이와 위상 차이는 각각 0.2 dB, $1^{\circ}$ 이내로 나타났다. 따라서 제안된 발룬은 안테나와 RF 전단부의 연결부로 사용되어 전체적인 성능 향상에 기여할 것으로 기대된다.

Clinical and Biochemical Diagnosis in Children with Leigh Syndrome

이선호,전미나,이현주,박대영,김세훈,이영목,Lee, Sun Ho,Jeon, Mina,Lee, Hyun Joo,Park, Dae Young,Kim, Se Hoon,Lee, Young-Mock The Korean Society of Inherited Metabolic Disease 2015 대한유전성대사질환학회지 Vol.15 No.2

Purpose: Deficits of the respiratory chain are reported to be the major cause of Leigh syndrome is said to be the underlying causes. The need for biochemical diagnosis to draw more accurate diagnosis or prognosis to support treatments is rapidly increasing. This study tried to analyze the aspects of clinical characteristics and biochemical diagnosis of mitochondrial respiratory chain complex (MRC) defect in Leigh syndrome, using methods of biochemical enzyme assay. Methods: We included total number of 47 patients who satisfied the clinical criteria of Leigh syndrome and confirmed by biochemical diagnosis. All those patients went through muscle biopsy to perform biochemical enzyme assay to analyze MRC enzyme in order to find the underlying cause of Leigh syndrome. Results: MRC I defect was seen in 23 (48.9%) cases taking the first place and MRC IV defect in 15 (31.9%) following it. There were 9 (19.2%) cases of combined MRC defect. Combined cases of type I and IV were detected in 7 (14.9%) patients while type I and V in 2 (4.3%). The onset age of symptom was less than 1 year old in 28 (59.6%). The most common early symptom, observed in 23 (48.9%), was delayed development, but there were other various neurological symptoms observed as well. In regard with the disease progression, 35 (74.5%) patients showed slowly progressive course, the one that progressed continuously but slowly over 2 years of period. As for Maximum motor development, 22 (46.8%) were bed-ridden state, most of them suffering serious delayed development. Patients showed various symptoms with different organs involved, though neuromuscular involvement was most prominent. Delayed development was seen in all cases. Multifocal lesion in brain MRI study was seen in 36 (76.6 %) cases, taking a greater percentage than 11 (23.4%) cases with single lesion. In MR spectroscopy study, the characteristic lactate peak of mitochondrial disease was identified in 20 (42.6%) patients. Conclusions: Further analysis of clinical and biochemical diagnosis on more extended group of patients with Leigh syndrome will enable us to improve diagnostic precision and to understand the natural course of mitochondrial disease.

마이크로어레이 자료분석에서 모수적 방법을 이용한 유전자군의 유의성 검정

이선호,이승규,이광현,Lee, Sun-Ho,Lee, Seung-Kyu,Lee, Kwang-Hyun 한국통계학회 2009 Communications for statistical applications and me Vol.16 No.3

마이크로어레이 기술은 수만 개 유전자의 발현 패턴을 동시에 관찰하는 것을 가능하게 하였고, 이들을 하나씩 검정하여 찾아낸 특이발현 현상을 보이는 유전자를 중심으로 질병의 진단, 치료법 정립과 신약 개발을 위한 기본 정보를 확립하였다. 그러나 개별 유전자분석의 여러 문제점이 발견되면서 유전자들을 생물학적 대사경로나 염색체 위치가 같은 것끼리 묶은 집단을 분석하여 질병의 발생이나 생존에 영향을 미치는 집단을 찾는 방법이 제시되었다. 이러한 유전자 집단의 유의성에 대한 연구는 2002년에 MIT에서 비롯되어 GSEA, SAM-GS와 중심극한 정리의 개념을 이용한 모수적 방법인 PAGE 등이 사용되고 있다. 본 논문에서는 이들 통계량의 구조적 한계를 극복하고 계산이 간단한 새로운 모수적 방법을 제안하고 자료 분석을 통하여 효율성을 보였다. The development of microarray technology makes possible to analyse many thousands of genes simultaneously. While it is important to test each gene whether it shows changes in expression associated with a phenotype, human diseases are thought to occur through the interactions of multiple genes within a same functional cafe-gory. Recent research interests aims to directly test the behavior of sets of functionally related genes, instead of focusing on single genes. Gene set enrichment analysis(GSEA), significance analysis of microarray to gene-set analysis(SAM-GS) and parametric analysis of gene set enrichment(PAGE) have been applied widely as a tool for gene-set analyses. We describe their problems and propose an alternative method using a parametric analysis by adopting normal score transformation of gene expression values. Performance of the newly derived method is compared with previous methods on three real microarray datasets.

마이크로어레이 자료에서 생존과 유의한 관련이 있는 유전자집단 검색

이선호,이광현,Lee, Sun-Ho,Lee, Kwang-Hyun 한국데이터정보과학회 2012 한국데이터정보과학회지 Vol.23 No.1

When the microarray experiment developed, main interest was limited to detect differentially expressed genes associated with a phenotype of interest. However, as human diseases are thought to occur through the interactions of multiple genes within a same functional category, the unit of analysis of the microarray experiment expanded to the set of genes. For the phenotype of censored survival time, Gene Set Enrichment Analysis(GSEA), Global test and Wald type test are widely used. In this paper, we modified the Wald type test by adopting normal score transformation of gene expression values and developed a parametric test which requires much less computation than others. The proposed method is compared with other methods using a real data set of ovarian cancer and a simulation data set. 환자의 생존시간과 함께 유전자 마이크로어레이 자료가 주어진 경우 생존에 유의한 영향을 미치는 대사경로를 찾는 방법을 연구하였다. 기존의 방법인 유전자 집합 농축도 분석, 글로벌 검정과 왈드 형태 검정을 비교 분석하였고, 치환을 통하여 p값을 구하는 단점을 개선한 수정된 왈드 형태 검정을 제안하였다. 모의실험과 실제자료 분석을 이용하여 새로운 방법의 적용 가능성을 보였다.

Ultrasensitive serum thyroglobulin의 유용성 평가

이선호,조은빛,신영균,이영지,유선희,김년옥,Lee, Sun Ho,Cho, Eun Bit,Shin, Young Kyun,Lee, Young Ji,Yoo, Seun Hee,Kim, Nyun Ok 대한핵의학기술학회 2015 핵의학 기술 Vol.19 No.2

Purpose Serum Thyroglobulin measurement is a major tool for the follow-up of differentiated thyroid cancer (DTC) patients. Thyroglobulin is Normal thyroid tissue, or thyroid cancer tissue produced only. Thyroid hormone to a halt without Tg differentiation of thyroid cancer recurrence just by measuring how to decide whether there was increasing expectations if I can do it instead. Therefore, in excellent sensitivity Tg new inspection of the functional sensitivity by measuring the looked to evaluate the usefulness of reagents. Thyroidectomy is measuring the numbers Tg (total thyroidectomy) remaining thyroid ablation and radioactive iodine (radioactive iodine remnant ablation, RRA) DTC in patients being diagnosed with or help predict the remaining early detection of thyroid cancer recurrence. Materials and Methods Agent that I'm currently using Tg of the measurements of low clinical specimen for a second drainage of the three (0.08 0.17, 0.98, ng/mL) within the scope of the dilute magnification (2, 4, 8, 16, 32 times) by dilute Intraassy (n=10) and Interassay (n=10) out in no time. Concentration value according to the coefficient of variation and the mean and standard deviation of each measurement (Coefficient of variation, CV) the absolute value of the measured values that corresponds to 20 percent target a coefficient of variation of CV Find the value of the concentration of the functional sensitivity measurement did. Also, analytical sensitivity with recovery rates, Dilution test inspections, and interrelationship, compared. Results Sensitivity is an excellent analytical sensitivity within the prosecutor kit Tg 0.006 ng/mL, and core analytical sensitivity, conducted by the 0.006 ng/mL to same conclusion. Be rather high to 142 percent recovery rate was 60 to measurement and functional sensitivity, 0.01766 ng/mL(Intraassay n=10) was measured at. CBC is relatively good correlation as ($R^2=0.949$) the correlation. Conclusion Recently ultrasensitive thyroglobulin this clinically important indicators of the previous kit and demands are lower than sensitivity to the measurement results. Therefore, ultrasensitive thyroglobulin test is correlated that there would be useful in value in nuclear medicine the thyroid gland.

무선 센서 네트워크에서 웜홀 공격 방어기법의 에너지 효율향상을 위한 TTL 결정 기법

이선호,조대호,Lee, Sun-Ho,Cho, Tae-Ho 한국시뮬레이션학회 2009 한국시뮬레이션학회 논문지 Vol.18 No.4

Attacks in wireless sensor networks (WSN), are similar to the attacks in ad-hoc networks because there are deployed on a wireless environment. However existing security mechanism cannot apply to WSN, because it has limited resource and hostile environment. One of the typical attack in WSN is setting up wrong route that using wormhole. To overcome this threat, Ji-Hoon Yun et al. proposed WODEM (WOrmhole attack DEfense Mechanism) which can detect and counter with wormhole. In this scheme, it can detect and counter with wormhole attacks by comparing hop count and initial TTL (Time To Live) which is pre-defined. The selection of a initial TTL is important since it can provide a tradeoff between detection ability ratio and energy consumption. In this paper, we proposed a fuzzy rule-based system for TTL determination that can conserve energy, while it provides sufficient detection ratio in wormhole attack.

원격 저장소 환경에서 다중 키워드를 이용한 효율적인 검색 가능한 대칭키 암호 시스템

이선호,이임영,Lee, Sun-Ho,Lee, Im-Yeong 한국정보처리학회 2011 정보처리학회논문지 C : 정보통신,정보보안 Vol.18 No.4

매우 가벼운 무게와 손안에 들어가는 작은 크기로 휴대성을 제공하는 휴대용 저장매체는 사용자들로부터 많은 호응을 받고 있다. 하지만 휴대용 저장매체의 휴대성으로 인하여 USB 메모리의 분실 및 도난이 잦아졌고 그로 인하여 저장매체 내부에 저장되어 있는 개인정보가 유출되는 사고가 발생하는 문제점이 발생되었다. 따라서 분실위험이 없고 네트워크를 통하여 언제든 자료를 저장하고 접근할 수 있는 원격 저장소 서비스가 등장하게 되었다. 정보통신산업이 발달함에 따라 여러 종류의 정보 기기를 통하여 언제 어디서든 빠른 네트워크에 접근할 수 있게 되었고, 이는 원격 저장소를 이용하는 사용자들을 더욱 증가하게 하였다. 하지만 여러 사용자의 주요 자료가 저장됨에 따라 비윤리적인 관리자 및 공격자로 인하여 서버에 저장된 여러 사용자의 주요자료가 동시에 유출될 수 있는 위험이 존재한다. 이를 해결하기 위해 서버에 저장되는 자료의 암호화가 필요해졌으며, 이와 동시에 암호화한 자료의 효율적인 검색 및 이용을 위하여 검색 가능 암호 시스템이 필요하다. 하지만, 기존의 대칭키 검색 가능 암호 시스템은 문서의 삽입/삭제 효율성 및 다중 키워드 검색 시 연산의 효율성이 떨어지는 문제점이 존재한다. 따라서 본 논문은 기존 대칭키 검색 가능 암호의 문제점을 해결할 수 있는 효율적인 대칭키 검색 가능 암호 시스템을 제안한다. Removable Storage provides the excellent portability with light weight and small size which fits in one's hand, many users have recently turned attention to the high-capacity products. However, due to the easy of portability for Removable Storage, Removable Storage are frequently lost and stolen and then many problems have been occurred such as the leaking of private information to the public. The advent of remote storage services where data is stored throughout the network, has allowed an increasing number of users to access data. The main data of many users is stored together on remote storage, but this has the problem of disclosure by an unethical administrator or attacker. To solve this problem, the encryption of data stored on the server has become necessary, and a searchable encryption system is needed for efficient retrieval of encrypted data. However, the existing searchable encryption system has the problem of low efficiency of document insert/delete operations and multi-keyword search. In this paper, an efficient searchable encryption system is proposed.

모바일 플랫폼에서 MTM을 이용한 보안영역 제공 및 인증에 관한 연구

이선호,이임영,Lee, Sun-Ho,Lee, Im-Yeong 한국정보처리학회 2011 정보처리학회논문지 C : 정보통신,정보보안 Vol.18 No.5

무선 통신 기술의 발달을 통해 스마트폰을 이용한 다양한 정보 서비스를 빠르게 받을 수 있게 되었다. 스마트 폰은 기존에 사용되고 있던 피처폰에 비하여 더 강력한 컴퓨팅 능력을 제공하며, 웹서핑, 문서 편집, 비디오 시청 그리고 게임과 같은 다양한 기능을 제공한다. 스마트폰의 높은 활용성에 따라 수많은 개인정보가 단말기에 저장되고 있으며, 이의 분실 및 도난에 따른 개인정보 유출은 큰 문제가 될 것으로 예상된다. 따라서 본 연구는 기존에 제공되는 스마트폰 모바일 플랫폼의 보안영역 제공 및 인증 방법에 대하여 분석하고 요구사항을 도출하였으며, 보안 요구사항을 만족하는 보안 기술을 제안한다. 제안방식은 인증 우회가 불가능한 보안영역을 제공하며, 보안영역에 접근하기 위해 필요한 정보의 손상으로부터 가용성을 제공한다. The various information services can be delivered by smartphone through advanced high-speed mobile communication. A smartphone is a mobile device that offers more powerful computing capacity than feature phone. Therefore this device can provide such as web surfing, editing documents, playing video, and playing games. A lot of personal information stored on smartphone. Because it has High usability. Personal information Leaks if the smart phone is lost or stolen may become a big problem. In this paper we have analyzed existing method for providing secure storage and user authentication on mobile platform and derived security requirement. Therefore we propose the following scheme that satisfy security requirement. Proposed scheme providing secure storage with preventing authentication bypass, and availability from damaged data to access secure area.

호소의 수질개선을 위한 원통형 여과장치의 평가

이선호(Sun Ho Lee),김승현(Seung Hyun Kim) 大韓環境工學會 2008 대한환경공학회지 Vol.30 No.10

癌毒 Toxohormone이 肝臟機能과 關聯있는 數種物質代謝에 미치는 影響

李善鎬(Sun Ho Lee) 대한외과학회 1961 Annals of Surgical Treatment and Research(ASRT) Vol.3 No.3