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Sesaminol Glucosides의 기억력 회복능 및 ${\beta}$, ${\gamma}$-Secretase
이선영,손동주,하태열,홍진태,Lee, Sun-Young,Son, Dong-Ju,Ha, Tae-Youl,Hong, Jin-Tae 대한약학회 2005 약학회지 Vol.49 No.2
Alzheimers disease (AD) is the most prevalent form of neurodegenerations associated with aging in the human population. This disease is characterized by the extracellular deposition of beta-amyloid (A ${\beta}$) peptide in cerebral plaques. The A ${\beta}$ peptide is derived from the ${\beta}$-amyloid precursor protein ( ${\beta}$APP). Photolytic processing of ${\beta}$APP by ${\beta}$-secretase(beta-site APP-cleaving enzyme, BASE) and ${\gamma}$-secretase generates the A ${\beta}$ peptide. Several lines of evidence support that A ${\beta}$-induced neuronal cell death is major mechanisms of development of AD. Accordingly, the ${\beta}$-and ${\gamma}$-secretase have been implicated to be excellent targets for the treatment of AD. We previously found that sesaminol glucosides have improving effect on memory functions through anti-oxidative mechanism. In this study, to elucidate possible other mechanism (inhibition of ${\beta}$-and ${\gamma}$-secretase) of sesaminol glucosides, we examined the improving effect of sesaminol glucosides in the scopolamine (1 mg/kg/mouse)-induced memory dysfunction using water maze test in the mice. Sesaminol glucosides (3.75, 7.5 mg/kg/6ml/day p.o., for 3 weeks) reversed the latency time, distance and velocity by scopolamine in dose dependent manner. Next, ${\beta}$-and ${\gamma}$-secretase activities were determined in different regions of brain. Sesaminol glucosides dose-dependently attenuated scopolamine-induced ${\beta}$-secretase activities in cortex and hippocampous and ${\gamma}$-secretase in cortex. This study therefore suggests that sesaminol glucosides may be a useful agent for prevention of the development or progression of AD, and its inhibitory effect on secretase may play a role in the improving action of sesaminol glucosides on memory function.
FGF-2와 덱사메타손이 지방기질세포의 증식 및 분화에 미치는 영향
이선영 ( Sun Young Lee ),손민정 ( Min Jung Shon ),김태호 ( Tae Ho Kim ),김석영 ( Suk Young Kim ),손영숙 ( Young Sook Son ),김신윤 ( Shin Yoon Kim ),박의균 ( Eui Kyun Park ) 한국조직공학과 재생의학회 2005 조직공학과 재생의학 Vol.2 No.4
Adipose tissue derived stromal cells (ATSCs) have been shown to be differentiated into several types of cells including osteoblasts. In the present study we have investigated the effects of fibroblast growth factor-2 (FGF- 2) and dexamethasone (Dex) on the proliferation and osteoblastic differentiation of ATSCs. A combination of FGF- 2 and Dex compared to untreated control stimulated proliferation of ATSCs up to 45% and 25% at day 5 and 7, respectively. Compared to FGF-2 alone, FGF-2 plus Dex further augmented proliferation of ATSCs by 15% (day 5) and 5% (day 7). In response to osteogenic stimulation, ATSCs expanded with FGF-2/Dex for 7 days were able to be differentiated into osteoblasts as revealed by increased calcium precipitation, and increased expression of osteocalcin, alkaline phosphatase and Runx2. Taken together, these results demonstrate that FGF-2 in combination with Dex stimulates proliferation of ATSCs and FGF-2/Dex-expanded ATSCs maintain a potential to be differentiated into osteoblasts.
한국인에서 헬리코박터 감염이 심혈관 질환에 미치는 영향
이선영 ( Sun Young Lee ),김덕경 ( Duk Kyung Kim ),손희정 ( Hee Jung Son ),이준행 ( Jun Haeng Lee ),김영호 ( Young Ho Kim ),김재준 ( Jae J. Kim ),백승운 ( Seung Woon Paik ),이종철 ( Jong Chul Rhee ) 대한소화기학회 2004 대한소화기학회지 Vol.44 No.4
Background/Aims: Although several studies have claimed that Helicobacter pylori (H. pylori) infection is related to cardiovascular disease, it is still uncertain whether it is related to the acute process or the chronic inflammatory atherosclerotic change
프레닐 페놀계 항생제인 4-O-methyl-ascochlorin에 의한 호중구 세포사멸의 유도
손동훈,이선영,이민정,박주인,홍영습,이용환,장영채,곽종영,Son Dong-Aoon,Lee Sun-Young,Lee Min-Jung,Park Joo-In,Hong Young-Seob,Lee Yong-Hwan,Chang Young-Chae,Kwak Jong-Young 한국생명과학회 2006 생명과학회지 Vol.16 No.1
호중구의 세포사멸은 자연적으로 일어나지만 여러 외부자극에 의한 신호의 전달에 의하여 증가하거나 지연된다. 본 연구에서는 항암, 항생제로 개발된 프레닐 페놀계인 ascochlorin의 유도체 중에서 백혈구 암의 세포사멸을 유도하는 4-O-methyl-ascochlorin (MAC)이 호중구의 자연 세포사멸 및 지연되는 세포사멸에 어떠한 영향을 미치는가와 그 작용기작을 연구하였다. 호중구의 세포사멸은 사람 말초 혈액으로부터 분리하여 세포 배양 시간에 따라 형태 변화, annexin-V/propidium iodide의 염색, 및 DNA 전기영동 등으로 조사하였다. MAC는 농도 및 시간 의존 형으로 호중구의 세포사멸을 증가시켰다. 그러나 granulocyte macrophage-colony stimulating factor나 lipopolysaccharide 등에 의한 세포사멸의 지연은 MAC에 의하여 부분적으로 억제되었다. MAC에 의한 세포사멸의 유도는 pancaspase, caspase-8 및 caspase-3 억제제인 zVAD-fmk. zIETD-fmk, 및 zDEVD-fmk에 의하여 억제되었으며 procaspase-8과 procaspase-3의 단백질 양도 MAC로 처리한 호중구에서 현저히 감소하였다. 미토콘드리아 막 투과성은 MAC에 의하여 현저히 감소하였으나 zVAD-fmk에 의하여 완전히 봉쇄되지 못하였다. 이들 결과 들은 MAC에 의한 호중구 세포사멸의 증가는 caspase-8 및 caspase-3의 활성을 통하여 일어나지만 미토콘드리아의 막성분에는 영향이 없다는 것을 제시하고 있다. Neutrophils are short-lived leukocytes that play a vital role in immune responses to bacteria, yeast, and fungi. This study was performed to investigate the effect of 4-O-methyl-ascochlorin (MAC), an anti-tumor, antibiotic, and anti-fungal prenyl-phenol compound on the spontaneous apoptosis of human neutrophils. MAC time- and dose-dependently accelerated the spontaneous apoptosis of human neutrophils. The effect of MAC on neutrophil apoptosis was blocked by pre-treatment of the neutrophils with specific inhibitors of pancaspase (zVAD-fmk), caspase-8 (zIETD-fmk), or caspase-3 (zDEVD-fmk). The cleavage of procaspase-8 and procaspase-3 was increased by MAC. Mitochondrial permeability, which was measured by the retention of $DiOC_6(3)$, was dose-de-pendently increased by MAC but the change of mitochondrial permeability was not blocked by pretreatment of neutrophils with zIETD-fmk. These results suggest that MAC induces neutrophil apoptosis by caspase-8-dependent but mitochondria-independent manner.
만성 특발성 변비증으로 수술을 시행한 환자의 임상적 고찰
이한철(Han Cheol Lee),홍성노(Sung No Hong),이준행(Jun Haeng Lee),이선영(Sun Young Lee),손희정(Hee Jung Son),김영호(Young Ho Kim),이풍렬(Poong Lyul Rhee),김재준(Jae J . Kim),이종철(Jong Chul Rhee),최규완(Kyoo Wan Choi),김정한(Jung Han 대한소화기기능성질환·운동학회 2001 Journal of Neurogastroenterology and Motility (JNM Vol.7 No.2
N/A Background: In patients with intractable constipation who are poorly responsive to medical treatments, surgical treatments may be considered. However, how preoperative physiologic evaluations contribute to some information in making surgical decision is not established. The aim of this study was to evaluate the outcome of surgical treatment in patients with severe constipation who underwent preoperative functional study. Methods: Preoperative functional evaluation included colon transit time test, defecography, scintigraphic gastric emptying time test, anorectal manometry and balloon expulsion test. Nine patients with a mean age of 48 years old were taken total colectomy with ileorectal anastomosis. Slow colonic transit was demonstrated in each case. All patients were available for follow-up, with median time of 35 (range; 10-55) months. Results: Seven patients (78%) were satisfied with outcome, improved the quality of life, and felt the operation was valuable despite of residual symptoms. Two patients did not experience symptom improvements. Six of seven colonic inertia or combined spastic pelvic floor syndrome patients had a satisfactory outcome. In contrast, one of two patients with generalized intestinal dysmotility did not show any improvement after surgery. Conclusions: Preoperative physiologic testing reliably identified patients with severe constipation who might have benefits from surgery. If cases are carefully diagnosed and selected, the surgical treatment may be highly effective in alleviating symptoms. (Korean Journal of Gastrointestinal Motility 2001;7:204-215)
Bisphenol A에 의한 신경계 세포의 칼슘 항상성 교란 및 세포독성에 미치는 영향
이윷모(Yoot Mo Lee),이상민(Sang Min Lee),손동주(Dong Ju Son),이선영(Sun Young Lee),박혜지(Hye Ji Park),남상윤(Sang Yun Nam),김대중(Dae Joong Kim),윤영원(Young Won Yun),유환수(Hwan Soo Yoo),오기완(Ki Wan Oh),김태성(Tae Seong Kim),한순영( 한국독성학회 2004 Toxicological Research Vol.20 No.3
We previously found that bisphenol A (BPA) caused neurotoxic behavioral alteration.<br/> Since disturbance of calcium homeostasis is an implicated contributor in the neurotoxic mechanism of<br/> environmental toxicants, we investigated whether BPA alters calcium homeostasis. Unlike other neurotoxic<br/> agents which cause increase of intracellular calcium level, BPA decreased [Ca2+]i dose-dependently<br/> in PC12 cells and cortical neuronal cells regardless of the calcium existence in buffer. BPA at<br/> greater concentrations than 100 μM reduced cell viability significantly in both types of cells. BPA also<br/> suppressed L-glutamate (L-type channel activator, 30 mM) and trifluoperazine (calmodulin antagonist,<br/> 30 μM)-induced increase of [Ca2+]i. BPA further lowered caffeine (RYR activator, 100 μM)-decreased<br/> [Ca2+]i, but did not alter dantrolene (RYR inhibitor, 100 μM), heparin (IP3 inhibitor, 200 units/ml) and<br/> xestospongin C (IP3 inhibitor, 5 μM)-decreased [Ca2+]i. Cell viability was not directly related to intracellular<br/> calcium change by bisphenol A that alternation of intracellular calcium may not be a direct causal<br/> factor of BPA-induced neuronal cell death.
일 대학병원 소아중환자실에서 Modified Glasgow Coma Scale 적용의 객관성 검증
송영주 ( Young Ju Song ),함귀선 ( Gui Sun Ham ),이선영 ( Sun Young Lee ),손인숙 ( Ihn Suk Son ),정유민 ( Yu Min Jung ),박보배 ( Bo Bae Park ),송민경 ( Min Kyung Song ) 서울대학교 간호과학연구소 2010 간호학의 지평 Vol.7 No.1
Purpose: Rapid and accurate assessment of impaired consciousness is very important, especially for critically ill patients. Therefore, the Glasgow coma scale (GCS) has been widely adopted in the assessment of adult and pediatric comas. But the GCS should not be used for small children who show various normal responses according to their developmental stage. Therefore, the objectivity of pediatric coma measurements was verified by applying the modified GCS to patients in a pediatric intensive care unit (PICU) at a university hospital in Korea. Methods: The level of consciousness was evaluated for 200 cases who were admitted to a PICU from July 4, 2009 to September 18, 2009 and could show a verbal response, with our modified GCS for children. In addition, and we confirmed the frequency analysis and Kappa statistics with SPSS/WIN 17.0. Results: Kappa statistics which show inter-observer reliability were very good for all components (eye opening, verbal, and motor score) and was good for total GCS scores. Conclusion: It is concluded that our modified GCS is reliable. Therefore, reliable assessment for the level of consciousness is clinically practicable if enough training is supported.
제강슬래그와 CaO를 이용한 폐광산 주변 중금속 오염 농경지 토양의 안정화 처리 연구
손정호,노훈,이선영,김성규,김길홍,박중규,양재규,장윤영,Son, Jung-Ho,Roh, Hoon,Lee, Sun-Young,Kim, Sung-Kyu,Kim, Gil-Hong,Park, Joong-Kyu,Yang, Jae-Kyu,Chang, Yoon-Young 한국지하수토양환경학회 2009 지하수토양환경 Vol.14 No.6
비소 및 여러 양이온 중금속으로 오염된 풍정광산 주변 밭토양 및 논토양의 안정화처리를 위해 CaO 및 제강슬래그를 여러 혼합비로 사용하였을 때의 적용성을 회분식 및 컬럼반응기를 이용하여 연구하였다. TCLP 용출시험법을 이용하여 안정화제 처리 전후의 중금속 고정화도 변화를 평가하였다. 안정화제로 제강슬래그만 사용한 경우에는 비소 및 양이온 중금속 모두에서 고정화도가 15% 이하로서 높지 않았다. 이러한 것은 제강슬래그 주요 성분인 $Fe_2O_3$와 $SiO_2$에 의한 중금속들의 안정화효과가 크지 않은 것과 제강슬래그 자체에 함유된 CaO에 의한 토양 pH 상승효과가 용출실험에 사용한 TCLP 용액의 산성도에 의해 상쇄된 것에 기인하여 나타난 것으로 여겨진다. CaO와 제강슬래그를 함께 사용한 경우에는 주입비율의 차이에 따른 양이온 중금속 제거율은 큰 변화가 없었으나 제강슬래그의 비를 높여 줄수록 비소의 제거율의 증가를 가져왔다. 컬럼실험에서도 CaO와 제강슬래그를 함께 주입한 경우 비소 및 양이온 중금속들의 용출농도는 처리기간 동안 수질배출허용 기준이하로 나왔다. 이것은 양이온 중금속의 경우 CaO 사용에 따른 pH 증가함에 따른 중금속의 고정화, 비소의 경우는 CaO에서 유리된 $Ca^{2+}$와 $AsO_4^{3-}$와의 반응에 의해서 생성되는 난용성의 $Ca_3(AsO_4)_2$가 생성되는 것에 기인한 결과로 판단된다. 비소 및 양이온 중금속이 함께 오염된 토양의 안정화에 CaO와 제강슬래그를 함께 주입할 경우 복합오염물질을 효과적으로 안정화처리가 가능함을 알 수 있었다. Applicability of CaO and steel slag as stabilizers in the treatment of field and paddy soils near Pungjeong mine contaminated with arsenic and cationic heavy metals was investigated from batch and column experiments. Immobilization of heavy metals was evaluated by TCLP dissolution test. Immobility of heavy metal ions was less than 15% when steel slag alone was used. This result suggests that $Fe_2O_3$ and $SiO_2$, known as the major component of steel slag, have little effect for the immobilization of heavy metal ions due to acidity of TCLP solution. Immobilization of cationic heavy metals was little affected by the ratio of CaO and steel slag while arsenic removal was increased as the ratio of steel slag to CaO increased. In the column test, concentrations of both arsenic and cationic heavy metals in effluents were below the water discharge guideline over the entire reaction period. This result can be explained by the immobilization of cationic heavy metals from the increased pH in soil solution as well as by the formation of insoluble $Ca_3(AsO_4)_2$. From this work, it is possible to suggest that arsenic and cationic heavy metals can be concurrently stabilized by application of both CaO and steel slag.
지문 인식과 전력 제어를 이용한 안전한 원격 부팅 시스템
장원영(Won-Young Jang),임홍택(Hong-Taek Lim),권설예(Seol-Ye Kwon),손주희(Ju-Hee Son),박인혁(In-Hyeok Park),이선영(Sun-Young Lee) 한국정보기술학회 2017 한국정보기술학회논문지 Vol.15 No.10
Currently, about 79% of computers types in domestic companies are desktop. Desktops used by most companies have the problem that unauthorized users can access the desktop by booting. To complement these vulnerabilities, BIOS password and user account login have been used. But they are vulnerable because of bypassing authentication. In this paper, we proposed a remote booting system that uses fingerprint recognition and power control to complement the physical access to the desktop. The proposed system uses fingerprint recognition technology for user authentication. And it overcomes vulnerability of physical access to the system by controlling power. Proposed system enables secure remote booting against physical vulnerabilities on desktop.