신생흰쥐의 알콜성 뇌손상 후 환경강화가 BDNF 발현 및 운동수행력에 미치는 영향

이선민,구현모,김진상,Lee Sun-Min,Koo Hyun-Mo,Kim Jin-Sang 대한물리치료학회 2003 대한물리치료학회지 Vol.15 No.3

Alcohol exposure during development leads to significant long-term neurobehavior dysfunction and central nervous system alteration. The purpose of this study was to determine the effects of enriched enviroment in developmental period through motor behavior test and expression of BDNF. Neonatal rat exposed to alcohol on postnatal days 4 through 10 were studied. Female Sprague-Dawley pups were assigned to two groups. Experimental group(EG) via 4.5 g kg-1day-1 of ethanol was housed in enriched enviornment for 9 weeks. The main result of this study were as follows: 1. There was significant difference in the mean of weight change between control and experimental group. 2. In motor behavior test, there was significant difference in the mean of weight change between control and experimental group. 3. Regarding the immunoreactivity of BDNF were higher appeared experimental group than control group. In conclusion, the present results reveals that enriched enviroment in developmental period is to be extremely useful in neuronal reprganization and motor behavior improvement after alcohol exposure.

흰쥐의 피부화상 후 저강도 레이저 조사가 표피성장인자의 발현에 미치는 영향

이선민,구현모,남기원,김석범,김진상,Lee Sun-Min,Koo Hyun-Mo,Nam Ki-Won,Kim Souk-Boum,Kim Jin-Sang 대한물리치료학회 2002 대한물리치료학회지 Vol.14 No.3

This study was performed to investigate the effect of low power laser irradiation on epidermal growth factor(EGF) expression in the burned skin of the rats. Burns of about 3cm in diameter were created with 75'c water on the back of the rats, and the lesion of experimental group were irradiated on days 1, 2, and 3 postwounding. Control tensions were not irradiated. After burns, low power laser irradiation was applied by using 1000Hz, 830nm GaAlAs (Gallium-aluminum- arsenide) semiconductor diode laser. The expression of epidermal growth factor evaluated immunohistochemistry on mouse anti-EGF. The results of this study were as follows 1. In expression of EGF, the lesion of experimental group made EGF to more induce significantly than control tensions. 2. EGF immunoreactivity in burned skin were increased markedly 3 days after burns, and increased gradually from 1 day to 2 days in burns which is laser irradiation These data suggest that low power laser have wound healing effect in the burned skin of the rats.

비소세포폐암의 림프절 병기 결정에서 Coincidence PET의 역할

이선민 ( Sun Min Lee ),최영화 ( Young Hwa Choi ),정성철 ( Seong Cheoll Cheong ),오윤정 ( Yoon Jung Oh ),박광주 ( Kwang Joo Park ),황성철 ( Sung Chul Hwang ),이이형 ( Yi Hyeong Lee ),박찬희 ( Chan H. Park ),한명호 ( Myung Ho Hah 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.47 No.5

콘크리트댐 누수량 관리기준치 산정

이선민(Lee, Sun Min) 한국콘크리트학회 2023 한국콘크리트학회 학술대회 논문집 Vol.35 No.2

Continuous distribution analysis 를 이용한 냉ㆍ해동과정 중 돈육의 NMR relaxation pattern의 변화

이선민(Sun-Min Lee),노정해(Jeong-Hae Rho),윤혜현(Hye-Hyun Yoon),이택수(Taek-Soo Lee) 한국식품과학회 2003 한국식품과학회지 Vol.35 No.1

성별영향분석평가에서의 젠더 거버넌스 활성화 방안

이선민(Sun-Min Lee) 이화여자대학교 젠더법학연구소 2016 이화젠더법학 Vol.8 No.2

이 연구는 성 주류화 추진 전략의 주요한 도구인 성별영향분석평가를 중심으로 구성, 운영되고 있는 젠더 거버넌스의 구성 주체를 대상으로 FGI를 실시하고, 이를 분석한 논문이다. 성별영향분석평가에 대한 경험이 풍부한 전문가, 공무원, NGO 활동가들을 중심으로 한 조사결과는 다음과 같다. 첫째, 성평등 추구라는 동일한 목적을 갖고 있다는 점이었다. 성평등이라는 동일한 이해와 목표는 정책수행에 있어 보다 빠른 합의를 가져올 수 있다는 측면에서 긍정적으로 기능한다는 것이었다. 둘째, 성별영향분석평가 제도를 중심으로 한 젠더 거버넌스의 운영은 제도를 중심으로 구성, 운영되었기 때문에 이른바 여성의 경험과 일상에서의 욕구를 분석평가를 통해 정책에 반영, 개선을 이루고자 한다는 것이었다. 셋째, 각 주체별 혹은 주체내에서의 다양한 역할 갈등이 내재되어 있으며 제도에 대한 이해에 있어서도 주체별로 약간씩 상이한 견해가 있었으나 아직까지 표면화되진 않고 있다는 점이었다. 넷째, 성 주류화 추진 전략의 일환으로 도입된 성별영향분석평가의 제도화 과정에서 제도에 대한 내실화를 위해 젠더거버넌스가 구축, 운영되다보니 활동영역에서의 자율성이나 네트워크의 확장에 있어 오히려 제약을 받는 한계점들이 제시되었다. 결과적으로 성평등 실현을 목적으로 추진되고 있는 성별영향분석평가의 내실 있는 운영을 위해선 성 주류화, 성평등이라는 큰 틀에서 젠더 거버넌스가 구축되고 운영될 수 있어야 하고, 각 주체들은 자신들의 역량을 강화, 향후 성별영향분석평가를 넘어선 영역의 확대 등이 필요하다는 정책적 함의를 도출할 수 있었다. This article was evaluated for gender governance of the gender impact assessment. Research with a focus on the gender impact assessment analysis of experienced professionals, government officials, NGO activists are as follows: First, it has the same purpose of pursuing gender equality. Secondly, the experiences and needs of women reflected in the policies that will achieve an improvement. Third, the fact that the various role conflicts within each specific subject or subjects are inherent. Even the understanding of the system, but this was a topic that is not yet expressed disagreement to. Fourth, since the progress in the gender impact assessment it was limited autonomy and network expansion. As a result, the gender governance of the gender impact assessment should be expanded must be operated for the purpose of pursuing gender equality and the scope of activities.

1980년대 이후 한국 단독주택 공간 형태 변화 연구

이선민(Lee, Sun-Min),허범팔(Hur, Bum-Pall) 한국실내디자인학회 2012 한국실내디자인학회논문집 Vol.21 No.5

This study found out the change of spacial form of detached house in Korea on a 10-year basis from 1980s though analysis on the architecture of each period. For the subject houses of this study, the detached houses introduced repeatedly as excellent cases in technical journals for architecture were collected among those completed by architects who designed numerous houses and a survey was conducted on 18 detached houses of 18 architects among the in urban style houses in Seoul and suburban style houses in the suburbs of Seoul. Through this study, it could be found that, as the morphological application of traditional architecture was settled with spatial concept, the external spatial form of the detached houses in Korea after 1980s was changed to westernized form but the internal spacial form had been continuously changing suitable to our emotion by reflecting the living habit and taste with the traditional attitude to perceive and accept the nature. As for the change in the forms of interior space, vertical space with more than two floors became common. Front porch and stair hall, which were located at the center of a house and became an important spacial element that overlapped family’s moving line, changed to open and bright space that used transparent glass and increased the space to contact the open air, reflecting our living habit and taste that preferred the feeling of internal openness. A Private space, main room, was more segmented and luxurious, and a public space, living room, secured the independency by getting close to symbolic yard. As for the change in the form of exterior space, the form of facade window has been changing in its location and size and brought free images due to the advancement of technology and material. The shape of roofs was borrowed from western style and a lot of geometrical forms that break away from the concept of angle rater and eaves are appearing.

Anti-proliferative Effects of β-ionone on Human Lung Cancer A-549 Cells

Sun Min Lee(이선민),Young Sook Kim(김영숙),Wook Jin Jang(장욱진),Abdur Md. Rakib(압두르 라키브),Tae Woo Oh(오태우),Boh Hyun Kim(김보현),So Young Kim(김소영),Jeong Ok Kim(김정옥),Yeong Lae Ha(하영래) 한국생명과학회 2013 생명과학회지 Vol.23 No.11

β-Ionone의 인체 비소폐암세포 A-549 cells (human non-small lung cancer A-549 cell)에 대한 anti-proliferative effect에 관한 연구를 수행하였다. A-549 cell에 다양한 농도의 β-ionone (1, 5, 10, and 15 μM)을 2, 4, 6일 간 처리 하고, 배양 2일에 A-549 cell의 생육억제와 관련되는 biochemical marker를 측정하였다. β-Ionone은 A-549 cell 생육을 dose와 time 의존적으로 저해하였다. β-Ionone 배양 2일의 IC50은 5.0 μg/ml이었다. β-Ionone은 농도 의존적으로 apoptosis를 유도하였다. β-Ionone은 p53, p21 및 Bax protein 수준을 증가시켰으나, Bcl-2 protein 발현은 억제시켰다. β-ionone은 cytosol cytochrome c 함량을 증가시켰고, caspase-9과 caspase-3 효소 활성증가를 유도하였다. 또한, β-ionone은 cPLA₂와 COX-2 protein level을 감소시켰다. 이와 같은 결과는 β-ionone의 A-549 cell에 대한 생육억제효과는 Bax와 Bcl-2 gene 발현을 reciprocal regulation하여 유도한 apoptosis와 cPLA₂ 및 COX-2 protein 발현 억제에 기인함을 의미한다. The anti-proliferative activity of β-ionone was investigated on human non-small lung cancer A-549 cells (designated A-549 cells). A-549 cells were treated with various concentrations of β-ionone (1, 5, 10, and 15 μM) for two, four, and six days. Biochemical markers related to the growth inhibition of A-549 cells by β-ionone were measured at the second day of incubation. β-Ionone inhibited the growth of A-549 cells by dose-and time-dependent manners, resulting in an IC50 of 5.0 μg/ml at the second day of incubation. β-Ionone induced apoptosis by a dose-dependent manner. β-Ionone increased levels of p53, p21, and Bax proteins, but suppressed expression of the Bcl-2 protein. Similarly, β-ionone enhanced cytochrome c release from the mitochondria to the cytosol, and induced activation of caspase-9 and -3. Additionally, β-ion-one reduced cPLA₂ and COX-2 protein levels. These results suggest that the β-ionone inhibits the proliferation of A-549 cells through reciprocal regulation of Bax and Bcl-2 gene expression and suppression of cPLA₂ and COX-2 protein expressions.

밀레니얼 세대의 뉴스 이용에 대한 탐색적 연구

이선민(Sun Min Lee),진민정(Min Jung Jin),이봉현(Bong Hyun Lee) 한국방송학회 2020 한국방송학보 Vol.34 No.4

고악성도 신경아교종의 수술 후 방사선 치료 성적과 예후인자 분석

이선민(Sun Min Lee),박영제(Young Je Park),윤원섭(Won Sup Yoon),이석(Suk Lee),양대식(Dae Sik Yang),정용구(Yong Gu Jeong),김철용(Chul Yong Kim) 대한방사선종양학회 1992 Radiation Oncology Journal Vol.10 No.1

Purpose: To analyze the postoperative radiotherapy results and prognostic factors in patients with WHO grade 3 and 4 gliomas. Materials and Methods: A total of 99 patients with malignant gliomas who underwent postoperative radiotherapy between 1988 and 2007 were enrolled in this study. Total resections, subtotal resections (≥50%), partial resections (<50%), and biopsies were performed in 16, 38, 22, and 23 patients, respectively. In total there were 32, 63 and 4 WHO grade 3, 4, and unspecified high grade gliomas, respectively. The biologically equivalent dose was in the range of 18.6 to 83.3 Gy10 (median dose, 72.2 Gy10). We retrospectively analyzed survival rate, patterns of failure, prognostic factors, and adverse effects. Results: The median follow-up time was 11 months and there were 54 patients (54.5%) with local failure. The one and 2-year survival rates were 56.6% and 29.3%, respectively, and the median survival duration was 13 months. The one and 2-year progression-free survival rates (PFS) were 31.3% and 18.2%, respectively, and the median PFS was 7 months. The prognostic factors for overall survival were age (p=0.0001), surgical extents (subtotal resection, p=0.023; partial resection, p=0.009; biopsy only, p=0.002), and enhancement of tumor in postoperative imaging study (p=0.049). The factors affecting PFS were age (p=0.036), tumor enhancement of the postoperative imaging study (p=0.006). There were 3 patients with grade 3 and 4 side effects during and after radiotherapy. Conclusion: In addition to age and surgical extents, tumor enhancement of the postoperative imaging study was included in the prognostic factors. The most common relapse patterns were local failures and hence, additional studies are needed to improve local control rates. 목 적: WHO 등급 3/4의 신경아교종 환자에서 수술 후 방사선 치료의 결과와 예후인자를 분석하였다. 대상 및 방법: 1988년부터 2007년까지 수술 후 고악성도 신경아교종으로 확진된 환자들 중 방사선 치료를 시행한 99명을 대상으로 하였다. 나이는 18∼77세(중앙값, 51세), 남, 여가 각각 55, 44명이었다. 수술은 완전절제, 아전절제(50% 이상 절제), 부분절제(50% 미만 절제), 조직검사만 시행한 예가 각각 16, 38, 22, 23명이었고, WHO 등급 3, 4, 기타(unspecified high grade glioma)가 각각 32, 63, 4명이었다. 방사선 치료는 1.8 또는 2 Gy 통상 분할치료 혹은 1.2 또는 1.5 Gy 하루 2회 치료 방법으로 하였고 중앙 생물학적 등가선량은 72.2 Gy10 (18.6∼83.3 Gy10)였다. 동시항암화학방사선치료나 연속화학방사선요법을 적용한 환자가 49명이었다. 환자들의 생존율 및 실패양상, 예후인자, 부작용에 대해 후향적으로 분석하였다. 결 과: 대상 환자의 중앙 추적 관찰기간은 11개월이었다. 국소치료 실패한 환자가 54명(54.5%)이었고, 이중 12명(22.2%)은 방사선치료부위 밖의 병변 진행을 동반하였다. 전체 생존율은 1년 56.6%, 2년 29.3%였고, 중앙생존기간은 13개월이었다. 무진행생존율은 1년, 2년이 각각 31.3%, 18.2%였으며, 중앙생존기간은 7개월이었다. 전체생존율에 영향을 미치는 인자로는 나이(p=0.0001), 수술 절제 정도(완전절제를 기준으로, 아전절제 p=0.023, 부분절제 p=0.009, 조직생검 p=0.002), 수술 후 영상검사에서 조영증가 여부(p=0.049)였다. 무진행생존율에 영향을 미치는 인자는 나이(p=0.036)와 수술 후 영상검사에서 조영증가 여부(p=0.006)였다. 방사선치료중과 후에 3등급 이상의 부작용이 각각 3명과 1명에서 발생하였다. 결 론: 나이, 수술절제 정도, 수술 후 영상검사에서 조영증가 여부가 생존율에 유의한 요인으로 분석되었다. 국소 치료실패가 대부분을 차지하여, 국소 제어율 향상을 위한 추가적인 연구가 필요할 것이다