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해조가 2,4,6-trinitrobenzene-sulfonic acid로 유발된 염증성 장질환 동물모델에 미치는 영향
이상욱,류봉하,박재우,Lee, Sang-Wook,Ryu, Bong-Ha,Park, Jae-Woo 대한한방내과학회 2010 大韓韓方內科學會誌 Vol.31 No.2
Objectives : The aim of the current study was to investigate the effects of Sargassum (Sargassum pallidum (TURN.) C. AG.; SP) on the experimental colitis induced by 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice. Methods : ICR mice were divided into 7 groups (NOR, CON, $SS50\times5$, $SP20\times3$, $SP50\times3$, $SP20\times5$, $SP50\times5$). TNBS processing was intrarectally applied to all experimental groups on the 3rd experiment day, except the normal group (NOR). For investigating the prophylactic effect, SP at doses of 20 mg/kg ($SP20\times5$) and 50 mg/kg ($SP50\times5$) were orally administered for 5 days. The SP at doses of 20 mg/kg ($SP20\times3$) and 50 mg/kg ($SP50\times3$) were orally administered for 3 days after the colitis induction in order to check the effect of treatment. As a positive control group, sulfasalazine 50 mg/kg ($SS50\times5$) was administrated. Macroscopic findings of epithelial tissue on mice were measured by colon length and macroscopic score. Histologic findings were also checked by crypt cell, epithelial cell, inflammatory cell and edema of submucosa. We measured the ability of SP to inhibit lipid peroxidation and myeloperoxidase activity. We also measured levels of the inflammatory markers, interleukin (IL)-$1\beta$ and cyclooxygenase-2 (COX-2), its transcription factor activation, phospho-NF-${\kappa}B$ (pp65), in the colon by enzyme-linked immunosorbent assay and immunoblot analysis. We measured activation of fecal bacterial enzyme, $\beta$-glucuronidase and degradation activation of fecal glycosaminoglycan (GAG), and hyaluronic acid. Results : Oral administration of SP on mice inhibited TNBS-induced colon shortening and myeloperoxidase activity in the colon of mice as well as IL-$1\beta$ and COX-2 expression. SP also inhibited TNBS-induced lipid peroxidation and pp65 activation in the colon of mice. SP inhibited $\beta$-glucuronidase activation and fecal hyaluronic acid degradation activation as well. Conclusions : SP could be a possible herbal candidate and preventive prebiotic agent for treating inflammatory bowel disease (IBD). Further experiments to differentiate effects of SP on IBD, such as other solutions and extracting times, might be promising.
肛門病 中 痔의 範疇와 原因 症狀 및 治療에 對한 文獻的 考察
이상욱,고우신,Lee, Sang-uk,Ko, Woo-shin 대한한방안이비인후피부과학회 1999 한방안이비인후피부과학회지 Vol.12 No.1
In oriental medicine, 'chi(痔)' is 'the prolapsed nodule' in 'Ku-gyu(九竅)', but in this paper, I will write about prolapsed nodule only in anus or around it, chi-jil(痔疾), it called hemorrhoid in western medicine. So in the literatual studies on chi(痔) in anus or around it, the results are as follows. 1. The etiology and pathogenesis of ch.i-jil(痔疾) is wind, wetness, dryness, and heat caused by inrregular diet habit, severe drinking and sexual action, deficiency of ki(氣) and hyeol(血). 2. Characteristic symptoms of chi-jil(痔疾) is the prolapsed nodule in the anus or around it, and general symptoms are hematochezia, pain, hernia, swelling, abcess, and mucosal secretion. 3. Chi-jil(痔疾) is classified eight types by characteristic symptom, shape, etiology and pathogenesis. They are mac-chi(脈痔), jang-chi(腸痔), ki-chi(氣痔), hyeol-chi(血痔), joo-chi(酒痔), mo-chi(牡痔), bin-chi(牡痔), and loo-chi(屢痔)(or young-chi(영痔), choong-chi(蟲痔)). Additionally, they are divided into two parts, internal and external chi-jil(痔疾), as likely as classification of internal and external hemorrhoid in western medicine. 4. Treatment of chi-jil(痔疾) is two methods, internal treatment and external treatment. Internal treatment is per os herb-pharmacotheraphy, external treatment is surgical or the other external pharmacotheraphy. There are several external treatment, these are fumigation-theraphy(熏痔法). irrigation-theraphy(洗痔法), paint-theraphy(塗痔法). withering-theraphy(枯痔法), bending-therphy(結紮法) and incisal -theraphy(切開法).
Sang-Wook Lee(이상욱),Myung-Rae Cho(조명래),Byoung-Kwan Lee(이병관),Sang-Bong Ko(고상봉),Dong-Kyu Shin(신동규),Koing-Woo Kwon(권굉우) 대한정형외과학회 2004 대한정형외과학회지 Vol.39 No.5
목적: 대퇴 경부 골절 환자에서 수술시 고정을 위해 사용하는 유관 나사를 이용하여 향후 대퇴 골두 골 괴사의 예측 방법에 대하여 조사하였다. 대상 및 방법: 1999년 3월부터 2001년 2월까지 44명을 대상으로 최소 25개월 이상 추시 관찰하였으며, 평균 나이는 51세(18-76세)였다. 근위부에 삽입된 유관 나사의 두부에 있는 관으로부터 출혈 유무를 관찰하였는데, 출혈군은 38예, 비 출혈군은 6예였다. 추시에서 대퇴 골두 골 괴사는 단순 방사선 사진으로 판독하였다. 두 군에서 유관나사 부위의 출혈 유무와 무혈성 괴사의 발생 관계에 있어 민감성, 정확성, 양성 예측도, 음성 예측도를 조사하였다. 결과: 대퇴 골두 골 괴사는 7예(16%)에서 발생하였다. 출혈군은 38예 중 1예(2.6%), 비 출혈군은 6예 모두에서 대퇴 골두골 괴사가 발생하였다. 비 출혈군과 골두 골 괴사의 관계에서는 민감도 86%, 정확도 100%, 양성 예측도 100%, 음성 예측도가 97%였다. 결론: 대퇴 경부 골절 환자에서 추후 발생할 수 있는 대퇴 골두 골 괴사에 대한 예측 방법으로 수술 중 유관 나사의 두부관 출혈 유무가 단순하면서 유용한 방법으로 판단된다. Purpose: The aim of this study was to examine the validity of using cannulated screws as a method for predicting avascular necrosis of the femoral head after a fixation of fractures in patients with femoral neck fractures. Materials and Methods: Between March 1999 and January 2001, 44 patients with a femoral neck fracture that had been fixed with cannulated screws were enrolled in this study. The follow up period was more than 25 months and the mean age of the patients was 51 years (range, 18 to 76 year). Blood drainage in the holes of the screw head was checked. There were 38 cases in the bleeding group, and 6 cases in the non-bleeding group. The development of head necrosis was evaluated using plain radiography. The validity of the relationship between the two groups and head necrosis was evaluated by the sensitivity, specificity, the positive predictive value, and the negative predictive value. Results: An avascular necrosis of the femoral head developed in 7 cases (16%). Only one of the 38 patients in the bleeding group developed head necrosis (2.6%). However, all those in the non-bleeding group developed head necrosis (100%). The sensitivity was 86%, the specificity was 100%, the positive predictive value was 100%, and the negative predictive value was 97%. Conclusion: Bleeding from holes in the cannulated screws is a simple and accurate perfusion assessment for predicting the development of an avascular necrosis of the femoral head after a femoral neck fracture.
이상욱 ( Sang Wook Yi ),손우석 ( Woo Seok Sohn ),박한뫼 ( Han Moie Park ),이상수 ( Sang Soo Lee ),임명철 ( Myoung Cheol Lim ),엄대운 ( Dae Woon Eom ),강길현 ( Gil Hyun Kang ) 대한산부인과학회 2008 Obstetrics & Gynecology Science Vol.51 No.7
Small cell carcinoma of ovary is extremely rare. This neoplasms compose predominantly or exclusively of small round cells with scant cytoplasm. There are two types of primary small cell carcinoma of ovary described in the literature : the hypercalcemic type and the pulmonary type. The first 11 patients with a primary ovarian small cell carcinoma of the pulmonary type were described by Eichorn et al. in 1992. The prognosis of this tumor is very poor and only limited data on the treatment of this tumor type are available. In the present case report, we describe a patient with the pulmonary type of small cell carcinoma associated with huge mucinous cystadenocarcinoma with a brief review of the concerned literatures.
이상욱(Sang-Wook Lee),박상욱(Sang-Wook Park),신정우(Jeong-Woo Shin) 대한기계학회 2017 大韓機械學會論文集A Vol.41 No.12
한국항공우주연구원에서는 태양광 에너지만을 이용해서 성층권에서 비행할 수 있는 고고도 태양광 무인기(EAV-3)를 개발하여, 2015년에는 고도 14.12㎞, 2016년에는 고도 18.5㎞의 성층권 비행에 성공하였다. EAV-3의 날개와 같은 양력면은 가로세로비가 큰 플랜폼 형상과 초경량 구조설계 개념을 적용하여 매우 유연한 구조로 개발되었다. 이에 따라 EAV-3는 비행 중 플러터와 같은 공탄성 불안정 현상에 취약할 수 있어, 개발 과정에서 이에 대한 면밀한 검토가 수행되었다. 본 논문에서는 EAV-3의 플러터 특성을 비행 전 확인하기 위해 수행한 플러터 해석 과정과 주요 결과를 기술하였다. The Korea Aerospace Research Institute (KARI) has developed a high-altitude solar powered UAV (EAV-3) which is capable of flying in the stratosphere using only solar energy. EAV-3 made a successful flight in the stratosphere at an altitude of 14.12㎞ in 2015 and 18.5㎞ in 2016. The lifting surfaces of the EAV-3, such as the wing, are inherently very flexible structures owing to the adoption of a high aspect ratio planform and a lightweight structural design concept. Hence, EAV-3 is vulnerable to aeroelastic instability problems such as flutter. Therefore, a thorough review of this phenomenon was carried out during the development process. In this study, the procedures and main results of EAV-3 flutter analysis are described.