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시동병(是動病).소생병(所生病)의 배속(配屬)에 관(關)한 고찰(考察)
이봉효,김성진,정창환,권수영,임성철,이경민,김재수,이윤경,정태영,고경모,이상남,Lee, Bong-Hyo,Kim, Seong-Jin,Jung, Chang-Hwan,Kwon, Su-Young,Lim, Sung-Chul,Lee, Kyung-Min,Kim, Jae-Su,Lee, Yoon-Kyoung,Jung, Tae-Young,Ko, Kyung-Mo,Lee, Sa 대한침구의학회 2008 대한침구의학회지 Vol.25 No.5
Objectives : The purpose of this study is to find the principal of the assignment of Sidong disease and Sosaeng disease(是動病 所生病) into 12 meridians and suggest the author's opinion. Methods : 1. The authors investigated the conception of Sidong disease and Sosaeng disease through several literatures. 2. The authors investigated the line course of 12 meridians(經脈流注) and their Sidong disease and Sosaeng disease. 3. The authors classified Sidong disease and Sosaeng disease following the study by Kim et al. 4. The authors suggested the opinions about the diseases that are difficult to be understood direct relation with the course of meridian. Results : 1. The result of classification of Sidong disease and Sosaeng disease into 5 shows that the percentages were 32.96% for meridian's own disease(本經病), 13.97% for organic own disease(本臟腑病), 12.85% for other organic own disease(他臟腑病), 20.67% for related organic disease(有關器官病), 19.55% for etc.(其他病). 2. Therefore, 19.55% of the whole Sidong disease and Sosaeng disease is that which occurred on the site that is not related directly with the meridian. Conclusions : 1. The exterior and interior relation(表裏關係) and mutual communication between organ and bowel(臟腑相通) are associated with the basic principal of the assignment of Sidong disease and Sosaeng disease that is not related with the course of meridian. 2. The cause of assignment of Sidong disease and Sosaeng disease can be explained according to the profound medical theories.
이봉효 ( Bong Hyo Lee ),임성철 ( Seong Chul Lim ),정태영 ( Tae Young Jung ),이경민 ( Kyung Min Lee ),김재수 ( Jae Su Kim ),이윤경 ( Yoon Kyoung Lee ) 대한경락경혈학회 2008 Korean Journal of Acupuncture Vol.25 No.2
Objectives: The aim of this study is to investigate the possibility of acupuncture to influence thyroglossal cyst. Methods: Acupuncture treatment was applied on several acupoints in the afternoon three to four times a week for 12 weeks. The effect of acupuncture treatment was evaluated with Visual Analogue Scale(VAS) and THYROID USG manipulated by a specialist in radiology. Results: VAS was decreased from 10 to 2, and this effect occurred in the first half of the treatment period. THYROID USG scan has shown that acupuncture treatment reduced the depth of the cyst approximately 6 ㎜in the first half of the period, but not in the Latter half. Conclusions : From this study, we suggest that acupuncture may take part in the treatment of thyroglossal cyst.
류마티스 관절염에 있어 종양괴사인자 다형성에 대한 연구
김경운,이경민,이봉효,임성철,정태영,서정철,Kim, Kyung-Un,Lee, Kyung-Min,Lee, Bong-Hyo,Lim, Seong-Chul,Jung, Tae-Young,Seo, Jung-Chul 대한약침학회 2007 Journal of pharmacopuncture Vol.10 No.2
Objectives : Tumor necrosis factor-${\alpha}{\cdot}$(TNF-${\alpha}{\cdot}$) is a proinflammatory cytokine involved in the pathogenesis of rheumatoid arthritis. This study was designed to investigate the relation between TNF-${\alpha}{\cdot}$ gene polymorphism and rheumatoid arthritis in Korean population. Methods : This study was carried out on 103 rheumatoid arthritis patients who fulfilled the American College of Rheumatology 1987 revised criteria for rheumatoid arthritis and 208 healthy control subjects. Blood samples from all subjects were obtained for DNA extraction. The extracted DNA was amplified by polymerse chain reaction(PCR). PCR products were visualized by 2% agarose gel electrophoresis. We investigated the genotyping of TNF-${\alpha}{\cdot}$ by using Pyrosequencing. Results : The genotypes of TNF-${\alpha}{\cdot}$ gene were GG, AG and AA. While the distribution of TNF-${\alpha}{\cdot}$ polymorphism in control subjects was 92.31%, 7.21%, 0.48% respectively, in rheumatoid arthritis patients was 93.20%, 6.80%, 0.00%(GG, AG. AA). There was no statistical significant allelic frequency difference between control and rheumatoid arthritis groups. Conclusion : We concluded that there was no significant association between TNF-${\alpha}{\cdot}$ gene polymorphism and rheumatoid arthritis. However, the findings of this study need to be confirmed in more patients and further studies.
구안와사(口眼渦斜) 환자(患者)의 Matrix Metalloprotease-l (MMP-l)의 유전자(遺傳子) 다형성(多形性)에 대한 연구(硏究)
최성훈,이경민,이봉효,임성철,정태영,서정철,Choi, Sung-Hun,Lee, Kyung-Min,Lee, Bong-Hyo,Lim, Seong-Chul,Jung, Tae-Young,Seo, Jung-Chul 대한침구의학회 2007 대한침구의학회지 Vol.24 No.2
Objectives : This study was designed to investigate the relation between the matrix metalloprotease-1 gene polymorphism and facial nerve palsy in Korean population. Methods : This study was carried out on 102 facial nerve palsy patients who were treated with oriental medicine therapy at the department of acupuncture & moxibustion, hospital of Oriental medical college, Daegu Hanny University and 104 healthy control subjects. Blood samples from all subjects were obtained for DNA extraction. We have investigated the genotyping of matrix metalloprotease-1 by using Pyrosequencing. Results : The genotypes of matrix metalloprotease-l gene were G/G homozygotes, A/G heterozygotes and A/A homozygotes. There was no significant difference between the control and facial nerve palsy groups. Conclusion: We concluded that there was no significant association between matrix metalloprotease-1 gene polymorphism and facial nerve palsy in Korean population. However, the findings of this study need to be confirmed in more patients and further studies.
구안와사(口眼渦斜) 환자(患者)의 Matrix Metalloprotease-l (MMP-l)의 유전자(遺傳子) 다형성(多形性)에 대한 연구(硏究)
최성훈,이경민,이봉효,임성철,정태영,서정철,Choi, Sung-Hun,Lee, Kyung-Min,Lee, Bong-Hyo,Lim, Seong-Chul,Jung, Tae-Young,Seo, Jung-Chul 대한침구의학회 2007 Korean Journal of Acupuncture Vol.24 No.2
Objectives : This study was designed to investigate the relation between the matrix metalloprotease-1 gene polymorphism and facial nerve palsy in Korean population. Methods : This study was carried out on 102 facial nerve palsy patients who were treated with oriental medicine therapy at the department of acupuncture & moxibustion, hospital of Oriental medical college, Daegu Hanny University and 104 healthy control subjects. Blood samples from all subjects were obtained for DNA extraction. We have investigated the genotyping of matrix metalloprotease-1 by using Pyrosequencing. Results : The genotypes of matrix metalloprotease-l gene were G/G homozygotes, A/G heterozygotes and A/A homozygotes. There was no significant difference between the control and facial nerve palsy groups. Conclusion: We concluded that there was no significant association between matrix metalloprotease-1 gene polymorphism and facial nerve palsy in Korean population. However, the findings of this study need to be confirmed in more patients and further studies.
녹용약침액(鹿茸藥鍼液)의 간암세포주(肝癌細胞柱)에 대한 DNA 및 단백질 발현(發顯)
류성현,이경민,이봉효,임성철,정태영,서정철,Ryu, Sung-Hyun,Lee, Kyung-Min,Lee, Bong-Hyo,Lim, Seong-Chul,Jung, Tae-Young,Seo, Jung-Chul 대한약침학회 2006 Journal of pharmacopuncture Vol.9 No.2
Objective : It has long been known about the osteogenic effect of CPC-HAS on bone tissues. However, it has not been determined the effect of CPC-HAS on cancer cells. The purpose of this study is to screen the CPC-HAS mediated differentially expressed genes in cancer cells such as HepG2 hepatoma cells. Oligonucleotide microarray and proteomics approaches were employed to screen the differential expression genes. Methods : CPC-HAS was prepared by boiling and stored at $-70^{\circ}C$ until use. Cells were treated with various concentrations of CPC-HAS (0.1, 0.5, 1.5, 10, 20mg/ml) for 24 h. Cell toxicity was tested by MTT assay. To screen the differentially expressed genes in cancer cells, cells were treated with 1.5mg/ml of CPC-HAS. For oligonucleotide microarray assay, total RNA was used for gene expression analysis using oligonucleotide Genechip(Human genome Ul33 Plus 2.0., Affimatrix Co.). For proteomic analysis, total protein was analyzed by 2D gel electrophoresis and Q-TOF mass spectrometer. Results : It has no cytotoxic effects on both HepG2 cell in all concentrations(0.l, 0.5, 1.5, 10, 20mg/ml). In oligonucleotide microarray assay, the number of more than twofold differentially regulated known genes was 23 with 5 up-regulated and 18 down-regulated genes in HepG2 cells. In proteomic analysis, three spots were identified by 2D-gel electrophoresis and Q-TOF analysis. Two down-regulated proteins were aldehyde dehydrogenase 1 and enolase 1, and up-regulated protein was fatty acid binding protein 1 by 1.5mg/ml of CPC-HAS. Discussion : This study showed the screening of CPC-HAS mediated differentially regulated genes using combined approaches of oligonucleotide microarray and proteomic analysis. The screened genes will be used for the better understanding of the therapeutic effects of CPC-HAS on cancer fields.
홍삼약침액(紅蔘藥鍼液)의 위암세포주(胃癌細胞柱) 유전자(遺傳子) 발현(發顯)에 미치는 영향(影響)
원은주,이경민,이봉효,임성철,정태영,서정철,Won, Eun-Ju,Lee, Kyung-Min,Lee, Bong-Hyo,Lim, Seong-Chul,Jung, Tae-Young,Seo, Jung-Chul 대한약침학회 2006 Journal of pharmacopuncture Vol.9 No.2
Objective : It has long been known about the anticancer effect of GRR-HAS, however, it has not been systemically determined the differentially regulated genes by GRR-HAS in cancer cells. The purpose of this study is to screen the GRR-HAS mediated differentially expressed genes in cancer cells such as SNU484 gastric cancer cell lines. Oligonucleotide microarray approache was employed to screen the differential expression genes. Methods : GRR-HAS was prepared by boiling and stored at $-70^{\circ}C$ until use. Cells were treated with various concentrations of GRR-HAS(0.1, 0.5, 1.5, 10, 20mg/ml) for 24 h. Cell toxicity was tested by MTT assay. To screen the differentially expressed genes in cancer cells, cells were treated with 1.5mg/ml of GRR-HAS. For oligonucleotide microarray assay, total RNA was used for gene expression analysis using oligonucleotide Genechip (Human genome Ul33 Plus 2.0., Affimatrix Co.). Results : It has no cytotoxic effects on both HepG2 and SNU484 cells in all concentrations(0.1, 0.5, 1.5, 10, 20mg/ml). In oligonucleotide microarray assay, in SNU484 cells, the number of more than twofold up-regulated genes was 346. The number of more than twofold down-regulated genes was 9. Discussion : This study showed the comprehensive gene expression analysis using oligonucleotide microarray for the screening of GRR-HAS mediated differentially regulated genes. These results will provide a better application of GRR-HAS in cancer field and drug target development.
우동수,이경민,이봉효,임성철,정태영,서정철,Woo, Dong-Su,Lee, Kyung-Min,Lee, Bong-Hyo,Lim, Seong-Chul,Jung, Tae-Young,Seo, Jung-Chul 대한약침학회 2007 Journal of pharmacopuncture Vol.10 No.2
Objectives : Free radical metabolism seems to occupy a remarkably common position in the mechanisms of aging and aging related disease. Oxidative damage to DNA, lipids. proteins and other molecules may contribute to the development of cancer, cardiovascular disease and possibly neurodegenerative disease. This study was designed to find out whether Carthami Flos Herbal-Acupuncture Solution can scavenge Nitric Oxide(NO) or not. SNAP is NO generator. NO concentration was estimated after 2,6, 12 and 24 hrs in no treatment group, after treatment with Vit. C or 1, 10, 100${\mu}$g/m1 of Carthami Flos Herbal-Acupuncture Solution. There was no significant scavenging effect of Carthami Flos Herbal-Acupuncture Solutionon NO after 2 hrs. But there was a significant scavenging effect of Cafhami Flos Herbal-Acupuncture Solution on NO in 10${\mu}$/m1 group after 6hrs. And there was a significant scavenging effect of carthami Flos Herbal-Acupuncture Solution on NO in 1, 10${\mu}$g/ml group after 12, 24 hrs. These results suggest that Carhami Flos Herbal-Acupuncture Solution has scavenging effect on NO. This study shows that Carthami Flos Herbal-Acupuncture Solution can be used for aging related disease and further studies are required to investigate the antioxidative effects of it.
정안침요법(整顔鍼療法)을 응용하여 호전된 후천성 사경환자 치험 2례
박서영,김재수,홍의재,이윤경,이봉효,임성철,정태영,이경민,Park, Seo-Young,Kim, Jae-Su,Hong, Eui-Jae,Lee, Yoon-Kyoung,Lee, Bong-Hyo,Lim, Seong-Chul,Jung, Tae-Young,Lee, Kyung-Min 대한침구의학회 2008 대한침구의학회지 Vol.25 No.4
Objectives : This report intended to estimate effects of Jung-an acupuncture on the acquired torticollis caused by muscle contraction. Methods : The patients were treated by Jung-an acupuncture, herb medication and Physical treatment daily. The improvement of the patients was judged by Toronto Western Spasmodic Torticollis Rating Scale(TWSTRS), Tsui's score and Visual Analogue Scale(VAS). Results : After 7 days of treatment, the 2 patients' neck pain and cervical movement were improved. Also, TWSTRS score, Tsui's score and VAS were all reduced. Conclusions : As the Jung-an acupuncture's theological base is organized with meridian theory and myofacial release therapy, We considered the Jung-an acupuncture is effective not only for the skin disease but also for the muscle problem such as torticollis.