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RISS 활용도 분석
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일본/중국/유럽자료
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RISS 인기검색어
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- 저자 : 이병석 ( Lee B) (검색결과 41 건)
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대간간학회지 제6차 춘계학술대회 초록집 : 포스터 발표 ; HBs Ag 양성인 간경변증 환자에서 일시적인 혈중 alpha fetoprotein 상승의 간암 발생에 대한 의의
이상우 ( Lee Sang U ), 문희석 ( Mun Hui Seog ), 박기오 ( Park Gi O ), 이엄석 ( Lee Eom Seog ), 김선문 ( Kim Seon Mun ), 서승원 ( Seo Seung Won ), 양현웅 ( Yang Hyeon Ung ), 성재규 ( Seong Jae Gyu ), 이승민 ( Lee Seung Min ), 이병석 ( Lee B) 대한간학회 2000 Clinical and Molecular Hepatology(대한간학회지) Vol.6 No.1(S)
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자궁근종시 LHRH agonist (D-Trp6-LHRH) 치료에 따른 근종세포내 미세구조의 변화
박기현,신명철,이보연,이병석,송찬호,Park,,K.H.,Shin,,M.C.,Lee,,B.Y.,Lee,,B.S.,Song,,C.H. 대한생식의학회 1991 Clinical and Experimental Reproductive Medicine Vol.18 No.2
Long-term administration of luteinizing hormone-releasing hormone(LHRH) agonists, through a process of pituitary desensitization and down-regulation of receptors, inhibits the secretion of gonadotropin and sex-steroids and induces a reversible suppression of gonadal activity. This approach can be used as an effective endocrine therapy for some hormone-dependent tumors. We have used D-Trp6-LHRH, a long acting LHRH agonist, for the treatment of eleven patients with uterine leiomyomas, thereafter myomectomy was performed in seven cases and observed the ultrastructural changes of leiomyoma with an electron microscope. The use of LHRH agonist may be effective in reducing the size of a myoma considerably by primarily inducing medical hypophysectomy and would allow easier surgical removal. Electron microscopic findings of myoma cells after the use of LHRH agonist included the following: loss of cristae and swelling nuclear chromatin, perinuclear vacuolation in cytoplasm. Bone mineral density was slightly decreased, however, the difference was not statistically significant.
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자궁근종과 자궁평활근 세포분열에 있어 Interferon-${\alpha}$ 및 basic Fibroblast Growth Factor (bFGF)의 효과
이병석,박정식,김진영,배상욱,박기현,조동제,이국,김재욱,송찬호,Lee,,B.S.,Park,,J.S.,Kim,,J.Y.,Bae,,S.W.,Park,,K.H.,Cho,,D.J.,Lee,,K.d,Kim,,J.W.,Song,,C.H. 대한생식의학회 1997 Clinical and Experimental Reproductive Medicine Vol.24 No.3
Leiomyomas, which are the commonest pelvic tumors in women, are originated from myometrial cells. Although the exact initial pathophysiologic event of the leiomyoma is not known, recent evidences suggested that the effects of sex steroid hormones in the process of tumor growth are mediated by local production of growth factors including epidermal growth factor (EGF), insulin-like growth factor-I (IGF-I) and insulin-like growth factor-II (IGF-II). If we look at the effects of other cytokines, it was suggested that basic fibroblast growth factor (bFGF) may stimulate the proliferation of myometrial and leiomyomas cells. And it was reported that interferon-${\alpha}$ inhibit the action of bFGF. Therefore, we examined the effect of bFGF and interferon-${\alpha}$ on the proliferation of leiomyoma and myometrial cells. bFGF stimulated the myometrial and leiomyoma cells significantly at the concentration of 1ng/ml (p<0.05) and 5ng/ml (p<0.05). However, Interferon-${\alpha}$ inhibited the cell proliferation of myometrial and leiomyoma cells significantly at the concentration of 100U/ml (p<0.05) and 1000U/ml (p<0.05). And the stimulated effects of bFGF with the various concentration on the myometrial and leiomyoma cells ware inhibited by interferon-${\alpha}$ with 100U/ml. Therefore, we concluded that bFGF may stimulate the myometrial and leiomyoma cell proliferation and interferon-${\alpha}$ may inhibit the myometrial and leiomyoma cell proliferation through blocking the effect of basic fibroblast growth factor.
NDSL
