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각막 간질내 공기 주입과 평형염액 주입이 간질세포 자멸사에 미치는 영향 비교
이민정,이현주,위원량,이진학,김미금,Min Joung Lee,M,D,Hyun Ju Lee,Won Ryang Wee,M,D,Jin Hak Lee,M,D,Mee Kum Kim,M,D 대한안과학회 2007 대한안과학회지 Vol.48 No.4
Purpose: To evaluate the effects of intrastromal air injection and intrastromal balanced salt solution (BSS) injection on corneal keratocyte apoptosis. Methods: Twelve right eyes of New Zealand White rabbits were divided into an air-injected group (n=6) and a hydro-injected group (n=6). Contralateral eyes served as a control. Air or Balanced salt solution (BSS?, Alcon, USA) was injected into the deep corneal stroma at the paracentral area to propagate into nearly the entire cornea. To reduce the intraocular pressure, anterior chamber paracentesis was performed. The animals were sacrificed 4 hours (n=6) and 24 hours (n=6) after surgery. Central cornea buttons were retrieved to stain with Hematoxylin & Eosin and TUNEL (Apoptag?, Chemicon). The mean number of apoptotic keratocytes was counted in 24.67±4.04 consecutive high power field (HPF). Results: The mean number of TUNEL-positive cells at 4 hours was 12.85±7.25/HPF and 0.25±0.44/HPF in air-injected and hydro-injected eyes, respectively. It was reduced to 6.25±4.02/HPF and 0.15±0.37/HPF in air-injected and hydro-injected eyes after 24 hours. The air-injected group showed significantly more TUNEL-positive cells compared with the hydro-injected or control group until 24 hours (p=0.001, p=0.001, Mann-Whitney U test). Conclusions: Intrastromal air injection induces significant apoptosis of keratocytes suggesting some damages in the peripheral cornea when used in deep lamellar keratoplasty.
Therapeutic effect of chitosan modification on salmon-calcitonin-loaded PLGA nanoparticles
이민정,최광진,Da-Young Seo,Hea-Eun Lee 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.6
Although salmon-calcitonin (s_CT) has been known as a potent drug for the treatment of osteoporosis, its oral dosage form products have not been commercially available primarily due to a poor oral bioavailability. Chitosan has been extensively examined as a potential oral absorption enhancer, whereas encapsulation with PLGA has been widely studied to address the delivery problems of typical peptide drug molecules. We investigated the mechanism and therapeutic effect of chitosan modification on the s_CT-loaded PLGA nanoparticles. Chitosan was added onto these particles in two ways: by incorporation during W/O/W emulsification and by solid dipping. Particles were characterized by particle size analyzer, Zeta potential analyzer, scanning electron microscopy, and so forth. Nano-sized particles of 430-590 nm in fairly spherical shape with a narrow size distribution were produced. The PLGA encapsulation efficiency greater than 50% of added s_CT was achieved regardless of chitosan modification. It turned out that s-CT-loaded PLGA particles with chitosan modified during W/O/W emulsification (referred to as s_CT-PLGA-CHT1) showed better therapeutic behavior in terms of sustained release effects as well as short-period hypocalcemic effects than the others. It was concluded that the beneficial effect was greatly associated with the formation of embedded structure of chitosan molecules when particles were modified with chitosan.
A Case of Cystitis with Bilateral Hydronephrosis Presenting with Gross Hematuria
이민정,곽병옥,송민경,정소정,김교순,Lee, Min Jung,Kwak, Byung Ok,Song, Min Kyung,Chung, Sochung,Kim, Kyo Sun Korean Society of Pediatric Nephrology 2012 Childhood kidney diseases Vol.16 No.2
평소 건강했던 아이들에서 육안적 혈뇨는 드물게 나타나며, 수신증과 동반된 경우 또한 드물다. 3세 남아가 육안적 혈뇨와 배뇨통을 주소로 내원하였다. 소변검사에서 농뇨, 혈뇨 보였으나 소변 배양 검사에서 균이 배양되지 않았으며, 혈액검사와 신체 검진상에서는 특이 소견 관찰되지 않았다. 초음파 검사상 양쪽 수신증과 함께 방광 벽이 두꺼워진 소견 보였다. 배뇨 요도 방광 조영술상 방광 요관 역류는 관찰되지 않았으나 방광 벽 비후가 심했으며, 방광 용적이 줄어들고 모양이 찌그러져있었다. 진단 후 ceftriaxone을 2주간 치료하였다. 항생제 치료 일주일 후 혈뇨 소실되어 초음파 검사를 다시 시행하였고 양쪽 수신증의 호전과 방광 용적 및 모양이 정상으로 호전됨을 관찰하였다. 환아의 배뇨통 증상도 호전되어 퇴원하였다. 외래 추적 관찰 중에 역류 검사 재 시행하였으며 정상 소견 보였다. 육안적 혈뇨 및 현미경적 혈뇨는 더 이상 관찰되지 않았다. 본 저자들은 육안적 혈뇨를 보인 소아에서 양측성 수신증을 동반한 방광염 1례를 경험하여 보고하는 바이다. Gross hematuria is uncommon, and rarely associated with hydronephrosis in healthy children. We describe a 3-year-old boy who complained of gross hematuria and dysuria. He was diagnosed as cystitis with bilateral hydronephrosis, and treated with antibiotics and conservative therapy. Our experience suggests that cystitis with hydronephrosis can occur in healthy children presenting with gross hematuria.
이민정,장규태,한윤정,Lee, Min-Jeong,Chang, Gyu-Tae,Han, Yun-Jeong 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.2
Objectives : The study was designed to find out the relationships between rhinitis, quality of sleep, growth among children with chronic rhinitis. Methods : This research was performed in 50 children from November 2007 to May 2008. We measured height, weight, body mass index of those children and asked to answer to the questionnaires that consist of nasal symptoms, period of time with rhinitis, sleep symptoms, parent's height, present illness, and medical history. We also analyzed correlations with this factors obtained from questionnaires. Results : 1. In 50 subjects, there were significant correlations between nasal obstruction, the quality of sleep, and the between quality of sleep and growth. But, there were not significant correlations between nasal symptoms and growth. 2. In 24 preschool children, frequency of waking up during sleeping and the number of snorers were higher and quality of sleeping was worse than those in the children who were attending school. And there were significant correlations between quality of sleep and nasal obstruction. An average of RH-MPH(Recent Height-Mid-Parental Height) is $-7.74{\pm}36.51(%)$ which means they aren't as tall as MPH(Mid-Parental Height). 3. In 26 school children, there were significant correlations between symptoms and period of rhinitis, quality of sleep and growth. Conclusions : Children with chronic rhinitis have low quality of sleep and low growth. But more studies are needed.
한약 단독 치료로 호전된 소양인 환자의 도한 : 후향적 증례보고 6례
이민정,이지연,황민우,Lee, Min-jung,Lee, Jiyeon,Hwang, Min-woo 사상체질의학회 2021 사상체질의학회지 Vol.33 No.3
Introduction This study is the first to report a significant improvement of Soyangin patients with persistent night sweats through herbal medicine treatment. Methods We reviewed the total of 6 Soyangin patients with moderate to severe persistent night sweats who visited the outpatient clinic. The patients received herbal medicine treatment alone for 4 to 9 weeks. We evaluated the treatment outcome using Night Sweats Degree criteria, developed by Lea and Aber(1985), every other 2 to 4 weeks. In addition, we recorded the treatment period from the first visit to symptom alleviation. Results Persistent night sweats improved significantly in all 6 Soyangin patients, and 4 out of 6 patients had better sleep quality after the treatment. It took 1 to 3 weeks until the symptom alleviated from moderate or severe to mild, and 3 to 7 weeks until the patients have no sign of night sweating. The progression of persistent night sweats and treatment period until no sign of symptom varied according to the Soyangin External and Internal disease diagnosis. Discussion The Soyangin patients having persistent night sweats treated with herbal medicines showed a significant improvement in their symptoms. This result proposes the possibility of using herbal medicine in primary care patients experiencing persistent night sweats.
다직종 암환자 교육·상담에 대한 설문 개발과 환자 만족도 조사
이민정,금민정,김재송,김수현,손은선,이상글,송수경,최혜진,Lee, Min Jeong,Geum, Min Jung,Kim, Jae Song,Kim, Soo Hyun,Son, Eun Sun,Lee, Sang Geul,Song, Su Kyung,Choi, Hye Jin 한국임상약학회 2018 한국임상약학회지 Vol.28 No.2
Background: Presently, a multidisciplinary team of doctors, pharmacists, nurses, and dietitians provides patient education to impart information on chemotherapy. However, studies on multidisciplinary education satisfaction are inadequate. In this study, we aimed to contribute to the improvement of quality of multidisciplinary education counseling for patients with cancer by developing a satisfaction questionnaire and analyzing the satisfaction survey. Methods: A questionnaire was developed by an expert group, and the responses were recorded using the 5-point Likert scale. After conducting a pre-test, factor analysis was performed to evaluate validity. The reliability of the questionnaire was measured by Cronbach's alpha coefficient. A satisfaction survey was conducted by self-administration method. Results: Based on the results of factor analysis, factors can be divided into two parts: "overall education" and "each team member's education" (total 14 questions). The construct validity and reliability of the questionnaire are sufficiently high. Fifty-one patients took the survey between January 2, 2018 and January 20, 2018. Twenty-six (51%) patients responded that they were "very satisfied" and 22 (43.1%) patients responded that they were "satisfied". Conclusion: By developing a questionnaire on multidisciplinary education counseling for patients with cancer, it is possible to perform evaluation and research of cancer patient education. This study will contribute to the management and improvement of quality of multidisciplinary education.
아르곤레이저 치료후 재발한 중심와아래 맥락막신생혈관에 대한 광역학치료
이민정,송수정,정흠,유형곤,Min-Joung Lee,M,D,Su-Jeong Song,M,D,Hum Chung,M,D,Hyeong-Gon Yu,M,D 대한안과학회 2005 대한안과학회지 Vol.46 No.12
Purpose: To evaluate the effects of photodynamic therapy for subfoveal recurrences of juxtafoveal or extrafoveal choroidal neovascularization (CNV), previously treated with argon-laser photocoagulation. Methods: Seven eyes, previously treated with argon-laser photocoagulation for juxtafoveal or extrafoveal choroidal neovascularization, received photodynamic therapy for subfoveal recurrence. Changes in visual acuity and fluorescein angiographic findings were analyzed. Results: The average time of appearance of recurrent CNV after laser photocoagulation was 43.14±29.62 months (range, 2-77 months). After photodynamic therapy, fluorescein leakage and neovascular lesion size decreased in all patients on fluorescein angiography. Visual acuity was stabilized or improved in 5 of 7 eyes. Conclusions: Photodynamic therapy was effective in patients with subfoveal recurrences of juxtafoveal or extrafoveal choroidal neovascularization previously treated with argon-laser photocoagulation.