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Protoberberine 화합물이 P815 세포중의 serotonin 함량에 미치는 영향
이명구,김응일,허재두,이경순,노재섭,Lee, Myung-Koo,Kim, Eung-Il,Hur, Jae-Doo,Lee, Kyong-Soon,Ro, Jai-Seup 한국생약학회 2001 생약학회지 Vol.32 No.1
The effects of protoberberine compounds on serotonin biosynthesis in P815 cells were investigated. Protoberberine compounds such as berberine, palmatine and coralyne decreased serotonin content dose-dependently, but coptisine did not. The $IC_{50}$ values of berberine, palmatine and coralyne were $3.0\;{\mu}M,\;16.5\;{\mu}M\;and\;14.5\;{\mu}M$, respectively. Protoberberine compounds at concentrations up to $20\;{\mu}M$ were not cytotoxic towards P815 cells. The activity of tryptophan hydroxylase, a ratelimiting enzyme in serotonin biosynthesis, was inhibited by the exposure of berberine, palmatine and coralyne in P815 cells (14.9-19.3% inhibition at $2-15\;{\mu}M$), but that of aromatic L-amino acid decarboxylase was not. These results suggest that the inhibition of tryptophan hydroxylase activity by berberine, palmatine and coralyne might partially contribute to the decrease in serotonin content in P815 cells.
방사선치료를 받는 암환자의 특성과 사회적지지 및 심리상태에 관한 연구
이명구(Myung Koo Lee) 대한방사선과학회(구 대한방사선기술학회) 2004 방사선기술과학 Vol.27 No.3
현대의학의 급속한 발전에도 불구하고 암은 아직도 인간에게 건강과 생명을 위협하는 주요인의 질환으로 인식되고 있다. 암은 세포조직의 과잉성장으로 인해 발생하는 악성종양으로 성별이나 연령에 관계없이 신체 어느 부분이나 발생하여 죽음에 이르게 하는 불치의 병으로 간주되고 있다. 암환자들이 치료를 받는 기간동안 겪게 되는 문제들은 심리적으로 우울하고, 죽음에 대한 불안감이 나타나며, 자아 존중 감의 상실을 경험하게 된다. 방사선 치료를 받는 암환자는 대부분 수술이나 화학요법과 더불어 추가적으로 방사선치료를 병행하는 것으로 알려져 있어, 방사선 치료를 받는 환자는 신체적 고통뿐만 아니라 경제적이나 심리적으로 불안하고, 치료에 대한 부담감이 더욱 가중되어 환자에 대한 심리상태의 안정이 절실히 요구되고 있다. 인간의 질병에 대한 치료는 신체적 치료와 심리정서적 치료를 병행하여 시행함으로써 좀더 완전하고 효율적인 전인치료가 되는 것으로 알려져 있다. 본 연구는 방사선치료를 받는 암환자의 특성과 사회적 지지에 따른 심리상태를 확인하여 환자의 전인치료를 위한 기초 자료로 제공하고자 실시하였다. By studying on the characteristics of cancer patients who receive radiotherapy and the attitudes of medical social workers, this thesis alms to suggest of requirements for medical social work intervention, The study was conducted using SPSS 10.0 for Windows to analyze data taken from a survey involving 90 cancer patients receiving radiotherapy in 4 general hospitals in Daejeon city. The data were collected form Oct. 1st to 15th, 2003, and its analyses used averages, correlation, and regression. The results were summarized as follows, 1 The average family income in 67 8% of the cases was less than 2,000,000 won, which is a lower income bracket. In the disease characteristics, fatigue wale the highest (2.78) in the side effects of radiotherapy, which most patients were receiving alongside other forms of treatment 2 It was shown that cancer patients receiving radiotherapy receive a high level of psychological and social support from doctors and other medical staffs, and that they also received a high average (4 38) of individual care and encouragement from family members. 3, In the psychosocial status, the need for financial assistance in the form of a national aid program or an expansion of medical insurance was great, especially in the need for house keeping service and night nurses, The need for psychosocial counselling rose following rises in treatment side effects and depression. information for cancer patients was especially needed in the areas of treatment plans, treatment costs, and side effects of radiotherapy The need for information rose in accordance with an elongation of hospital treatment and an escalation of care from family members.
GPS/RFID융합, 스마트폰을 이용한 수목원 수목관리 시스템 구축 및 서비스에 관한 연구
이명구(Lee Myung koo) 대한공간정보학회 2011 한국공간정보학회 학술대회 Vol.2011 No.10
모바일 RFID는 스마트폰에 탑재된 RFID 리더기를 이용하여 관심있는 사물과 장소에 부착된 RFID(태그)를 읽으므로써 복잡한 선택과정 없이 직접 필요한 정보를 획득 할 수 있게 하는 기술이며, 더 나아가 Ubiquitous 사회에서 없어서는 않되는 중요한 기술이라 할 수 있다. 모바일 및 RFID는 스마트폰의 도입에 따라 그 활용이 급속하게 변하고 있으며 특히 App의 개발과 Web을 통한 시설물관리 등에 활용이 보편화 되어 가고 있다. 최근 온실가스로 인한 대기오염의 방지를 위한 탄소배출의 관리를 위하여 정부는 탄소배출권의 거래제를 도입하기로 하고 빠르면 2013년부터 지자체별로 거래하도록 이미 발표 한바가 있어, 각 지자체에서는 도시 내 수목에 대한 Data를 준비하여야 할 것이다. 수목원에서는 수목의 개체별 DB를 구축하기 위한 수목의 위치와 그 수목에 대한 모양 및 Data를 관리하기 위하여 수목원 전체를 지역별로 폴리곤화 하여 RFID를 부착하고, 폴리곤내에 있는 수목에는 표찰과 GPS좌표를 부여하고 스마트폰과 WiFi통신을 통하여 관리자가 현장에서 쉽고 빠르게 수목에 대한 Data를 효율적이고 과학적으로 입력, 수정, 삭제 등의 관리를 할 수 있도록 하는 한편, 미래 이용객들이 App을 통하여 수목원의 수목개체들의 내용을 확인하고, 또한 이를 활용하는데 주안점을 두고 연구 검토하고자 한다.
수종의 생약이 PC12 Cells 중의 Catecholamines 생합성에 미치는 영향
이명구(Myung Koo Lee),황방연(Bang Yeon Hwang),정은희(Eun Hee Jung),이경순(Kyong Soon Lee),김학성(Hack Seang Kim) 한국생약학회 1995 생약학회지 Vol.26 No.1
MeOH extracts of eight herbal medicines were investigated for the effects on catecholamine biosynthesis and tyrosine hydroxylase (TH) activity in PC12 cells. Among them, the MeOH extracts of Polygalae Radix and Rehmaniae Radix showed 32 and 22% inhibition on the dopamine biosynthesis, respectively at a concentration of 40 ㎍/㎖ medium. But, the TH activity was reduced by the treatment of Polygalae Radix. These results suggest that Polygalae Radix has an inhibitory effect on the cate cholamine biosynthesis by the reduction of TH activity in PC12 cells.
외래 비만 클리닉에서 행해지는 비만 치료의 목적 및 타당성에 관한 평가
양정혜,이명구,임성진,이보름,권익혁,방준석,이종길,임성실,Yang, Jeong-Hye,Lee, Myung-Koo,Lim, Sung-Jin,Lee, Bo-Reum,Kwon, Ik-Hyun,Bang, Joon-Seok,Lee, Chong-Kil,Lim, Sung-Cil 대한약학회 2009 약학회지 Vol.53 No.1
Metabolic syndrome is increasing nowadays and one of causes is obesity. Therefore prevention and treatment of obesity is very important to decrease of Metabolic syndrome. However currently many pharmacotherapy for obesity are popular in Korea and it may be dangerous. The aim of this study is to evaluate the purpose and relevance of obese treatment in two areas (capital & local) of Korea and suggest to guide for the right directions of pharmacotherapy in obesity treatment. We selected and surveyed 90 patients (88 females, 2 males, age of $23{\sim}60$) at random who received a prescription after consulting with a doctor at several clinics of Cheongju-area and Seoul-area, from May thru June, 2007. And we evaluated their prescriptions. In results, only 26.7% were obese (13.3%, 23<BMI<25) or overweight (13.3%: BMI>25), most 73.3% patients were normal (65.6%, 18.5<BMI<23) or underweight (7.8%, BMI<18.5, p<0.01) by body mass index (BMI: Kg/$m^2$). The purpose of treatment was for appearance (38.9%), health (41.1%) or both (18.9%, p<0.01). 94% patients had the past history of obese treatment. Prescriptions were consisted of CNS stimulant, anticonvulsants, antidepressant, laxatives, diuretics, or antianxietics. Obese treatment is very important for health to prevent disease such as Metabolic Syndrome. However it should not be abused. In conclusion, some patients of obese treatment is not relevant to obesity and pharmacist role is important to guide them for the right directions in obesity treatment.
한국인 시각 장애우 환자의 복약지도 증진을 위한 점자용 보조라벨 개발의 필요성과 개발방법 제시
임성실,이명구,이종길,이보름,Lim, Sung-Cil,Lee, Myung-Koo,Lee, Chong-Kil,Lee, Bo-Reum 대한약학회 2008 약학회지 Vol.52 No.3
All pharmacists must provide the drug consultation whenever dispense drugs to patients by the Korean Pharmacy Law. Drug consultation is very important procedure for increasing pharmacotherapy. Because it maximizes the therapeutic effects or/and minimizes adverse drug reaction during the drug therapy. However, it is not easy to do because of the dynamic and hectic pharmacy environment. Especially, if someone has a disabling body function, they required more time and efforts to perform consultation by pharmacist. Currently several auxiliary labels for helping drug consultation are using in pharmacy practice but not for disabling patients. Therefore we developed the total 53 auxiliary labels with size of 0.7 cm (width) and 1 cm (length) by Braillewriter letters for blind patients. This research has been performed for total 12 months (Mar. 15ts, 2007$\sim$Feb. 25th, 2008) and the developing methods are consisted of 4 steps: 1) selection of essential informations, 2) simplification of information, 3) changing for Braillewriter letters, 4) application and revising by blindness patients. Also the labels are consisted of 12 for adverse reactions and precautions, 8 for directions, 2 for storages, 9 for duration, 9 for dosage forms, and 12 for common names. After developed those labels, we revised those labels by discussion with 2 blind people. In conclusion, the new auxiliary labels for blind patients can increase therapeutic effects and decrease risks from pharmacotherapy besides decreasing of pharmacist's work load in the future.