지주막하출혈에 의한 뇌기저동맥의 형태학적 변화에 미치는 양격산화탕(凉膈散火湯)의 효과

이동원,이원철,Lee, Dong-Won,Lee, Won-Chul 대한한의학회 1999 대한한의학회지 Vol.20 No.2

The present study was performed to investigate the effect of Yangkyuksanhoa-tang on the morphological changes of the basilar artery after experimentally induced subarachnoid hemonrrhages(SAH). Yangkyuksanhoa-tang has been used freguently for cerebrovascular accident Sprague Dawley rats weighing between 350-400 g were used. The 6 normal rats and 24 SAH elicited rats were used, The SAH induced by injection of the fresh autologus heart blood (0.3-0.4 ml) into the cisterna magna through the posterior atlanta-occipital membrane, Sample group was given 3.3 ml/kg/day of Yangkyuksanhoa-tang extracts for 2 days after SAH. The experimental animals were killed at 48hrs after SAH. The morphological changes of the arterial walls were examined by light and electron microscopy. Following are the obtained results: 1. In SAH elicited rats, the size of the lumen in basilar artery was diminished by about 45% and the thickness of arterial wall was increased by about 82%. In SAH elicited rats with Yangkyuksanhoa-tang treatment, the size of the lumen in basilar artery was merely diminished by about 18% and the thickness of arterial wall was merely increased by about 19%. 2. In light microscopic examination, the endothelium was swollen into a cuboid shape and the layer of smooth muscle was increased in the basilar artery of SAH elicited rats. In SAH elicited rats with Yangkyuksanhoa-tang treatment, the size of the lumen in basilar artery was enlarged and the thickness was decreased than in SAH elicited rats. The endothelium was flattened into a squamous shape and the layer of smooth muscle was decreased more than in SAH elicited rats. 3. In electron microscopic examination, the endothelial cells with fragmentation nuclei were changed into a cuboid shape and the internal elastic lamina were folded at the basilar artery of SAH elicited rat. The nuclei of smooth muscle cells were changed into a round or crumpled shape. The length of smooth muscle was shorten and thickness was increased. But all kinds of morphologic changes were diminished in SAH elicited rats with Yangkyuksanhoa-tang treatment. Conclusion : Yangkyuksanhoa-tang extracts were effective to treat cerebral vasospasm after experimentally induced subarachnoid hemorrhage in rats.

SHS 공정에 의해 제조된 Mo_xW_1-xSi₂ 발열체의 열화메커니즘

이동원,이상헌,김용남,이성철,구상모,오종민,Lee, Dong-Won,Lee, Sang-Hun,Kim, Yong-Nam,Lee, Sung-Chul,Koo, Sang-Mo,Oh, Jong-Min 한국전기전자재료학회 2017 전기전자재료학회논문지 Vol.30 No.10

The degradation mechanism of $Mo_xW_{1-x}Si_2$ ultrahigh-temperature heating elements fabricated by self-propagating high-temperature synthesiswas investigated. The $Mo_xW_{1-x}Si_2$ specimens (with and without post-annealing) were subjected to ADTs (accelerated degradation tests) at temperatures up to $1,700^{\circ}C$ at heating rates of 3, 4, 5, 7, and $14^{\circ}C/min$. The surface loads of all the specimen heaters were increased with the increase in the target temperature. For the $Mo_xW_{1-x}Si_2$ specimens without annealing, many pores and secondary-phase particles were observed in the microstructure; the surface load increased to $23.9W/cm^2$ at $1,700^{\circ}C$, while the bending strength drastically reduced to 242 MPa. In contrast, the $Mo_xW_{1-x}Si_2$ specimens after post-annealing retained $single-Mo_xW_{1-x}Si_2$ phases and showed superior durability after the ADT. Consequently, it is thought that the formation of microcracks and coarse secondary phases during the ADT are the main causes for the degraded performance of the $Mo_xW_{1-x}Si_2$ heating elements without post-annealing.

Spherodization of Granuled Cr₂O₃ Fine Ceramic Powder by Plasma Spray

이동원,이학성,유지훈,왕제필,Lee, Dong Won,Lee, Hak Sung,Yu, Ji-Hun,Wang, Jei-Pil The Korean Institute of Resources Recycling 2016 資源 리싸이클링 Vol.25 No.6

Spray dried $Cr_2O_3$ powder having an agglomerated structure of particles was twice treated into a plasma flame to increase its apparent density. The powder subjected to the first densification treatment did not show the entirely melted state keeping inner particle hollows, and it was fully melted after the second processing only. The powder size as a result of the second treatment decreased, and the apparent density as well as flowability were increased due to melting and surface smoothing effects. But a part of particles after the second densified treatment showed the hollow structure, especially those which were above $30{\mu}m$ in size. This densification behavior of the powder has been qualitatively discussed in terms of the thermal conductivity and inner gas pressure within aggregates exposed to the plasma flame. Spray dried $Cr_2O_3$ 분말은 겉보기밀도를 향상시키기 위해 plasma flame에 투입하여 실험을 진행 하였다. 첫번째 고밀도화 공정에서의 분말은 입자내부 공간까지 완전히 용해되어지지 않았으며, 두번째 공정 이후 완전히 용해가 되었다. 두번째 공정 결과 분말 입도는 작아졌으며, 용해 및 표면 연화에 의해 겉보기 밀도와 유동도는 향상이 되었다. 두번째 고밀도화 공정이 후 부분적으로 입자들이 $30{\mu}m$ 이상의 hollow structure을 보여주고 있다. 분말의 이러한 고밀도화는 plasma flame에 의해 응집되어진 응집체내의 열전도율 및 내부 가스압의 관점에서 정량적으로 논의 하였다.

불완전 가와사끼병에서 NT-proBNP의 진단적 역할

이동원,김여향,현명철,권태찬,이상범,Lee, Dong-Won,Kim, Yeo-Hyang,Hyun, Myung-Chul,Kwon, Tae-Chan,Lee, Sang-Bum 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.4

목 적: 지속적인 발열과 3개 이하의 가와사끼병 진단 기준을 만족하는 환자군에서 불완전 가와사끼병을 감별하는데 있어 NT-proBNP가 가지는 진단적 의미를 살펴보고자 하였다. 방 법: 2008년 1월부터 2009년 6월까지 가와사끼병으로 진단 및 치료 받은 환자 96명을 대상으로 하였다. 진단은 입원 당일 열을 포함한 가와사끼병의 고전적인 진단 기준에 따랐고, 진단 기준의 만족 정도에 따라서 완전 가와사끼병 환자군과 불완전 가와사끼병 환자군으로 구분하였으며, NT-proBNP를 포함한 혈액검사를 시행하였다. 지속되는 열과 함께 3개 미만의 진단 기준을 만족하였지만 임상 경과와 여러 검사들을 통해 환자 19명을 대조군으로 하여 분석하였다. 결 과: 96명의 가와사끼병 환자 중 고전적인 진단 기준을 3가지 이하로 만족한 불완전 가와사끼병 환자는 33명으로 전체 가와사끼병 환자의 34% 였다. 임상 양상으로 구강 점막의 변화와 안검 충혈이 가장 많았는데 완전 가와사끼병에 비해 발생 빈도는 적었다(76% vs 98%, 76% vs 90%). 불완전 가와사끼병 환자의 NT-proBNP는 대조군에 비해 유의하게 높았으며($1407.7{\pm}1633.5pg/mL$ vs $126.2{\pm}135.5pg/mL$, $P$<0.001), cutoff value를 158 pg/mL으로 하였을 때 민감도 81%, 특이도 74% 로 C 반응성 단백 ${\geq}3mg/dL$의 민감도 74%, 특이도 68% 보다 높았지만, 적혈구 침강 속도 ${\geq}40mm/hr$의 민감도 70%, 특이도 84%로 특이도에서 적혈구 침강 속도보다 낮았다. 결 론: 지속되는 열, 안검 충혈, 구강 점막의 변화가 있어 불완전 가와사끼병으로 의심해야 하는 환자에서 NT-proBNP 검사를 시행하고 진단에 이용하는 것이 가와사끼병의 빠른 진단과 치료에 도움이 될 것이다. Purpose : To determine the efficacy of the N-terminal fragment of B-type natriuretic peptide (NT-proBNP) as a useful diagnostic method in children with incomplete Kawasaki disease (KD). Methods : Ninety-six patients who were diagnosed as having KD between January 2008 and June 2009 were enrolled in the study. American Heart Association recommendations for diagnosis were used, and patients were divided into the complete KD and incomplete KD groups. Blood tests including NT-proBNP were performed on admission day. Nineteen patients who had other febrile diseases other than KD were enrolled as control. Results : Thirty-three patients (34%) had incomplete KD. Change in the lips and oral cavity and conjunctivitis were the most common clinical features, but their frequency was lower than complete KD (76% vs 98%, 76% vs 90%). Patients with incomplete KD exhibited significantly higher NT-proBNP level than that of control ($1,407.7{\pm}1633.5pg/mL$ vs $126.2{\pm}135.5pg/mL$, $P$<0.001). An NT-proBNP cutoff value of 158 pg/mL provided a sensitivity of 81% and a specificity of 74% for diagnosis of incomplete KD. Conclusion : NT-proBNP assay can be clinically useful for the diagnosis of incomplete KD, if the patient has persistent fever, change in the lips and oral cavity, and conjunctivitis, and if the patient with those symptoms is suspected to have incomplete KD.

화학기상응축법으로 제조된 철 나노분말의 산화저항에 관한 연구

이동원,유지훈,배정현,장태석,김병기,Lee Dong-Won,Yu Ji-Hun,Bae Jeoung-Hyun,Jang Tae-Suk,Kim Byoung-Kee 한국분말야금학회 2005 한국분말재료학회지 (KPMI) Vol.12 No.3

In order to prevent the oxide formation on the surface of nano-size iron particles and thereby to improve the oxidation resistance, iron nanoparticles synthesized by a chemical vapor condensation method were directly soaked in hexadecanethiol solution to coat them with a polymer layer. Oxygen content in the polymer-coated iron nanoparticles was significantly lower than that in air-passivated particles possessing iron-core/oxide-shell structure. Accordingly, oxidation resistance of the polymer-coated particles at an elevated temperature below $130^{\circ}C$ in air was $10\~40$ times higher than that of the air- passivated particles.

레이저 열-압착 본딩 시스템의 Lateral Force 감소를 위한 유연 힌지의 설계

이동원,하석재,박정연,윤길상,Lee, Dong-Won,Ha, Seok-Jae,Park, Jeong-Yeon,Yoon, Gil-Sang 한국금형공학회 2020 한국금형공학회지 Vol.14 No.3

Laser Assisted Thermo-Compression Bonding (LATCB) has been proposed to improve the "chip tilt due to the difference in solder bump height" that occurs during the conventional semiconductor chip bonding process. The bonding module of the LATCB system has used a piezoelectric actuator to control the inclination of the compression jig on a micro scale, and the piezoelectric actuator has been directly coupled to the compression jig to minimize the assembly tolerance of the compression jig. However, this structure generates a lateral force in the piezoelectric actuator when the compression jig is tilted, and the stacked piezoelectric element vulnerable to the lateral force has a risk of failure. In this paper, the optimal design of the flexure hinge was performed to minimize the lateral force generated in the piezoelectric actuator when the compression jig is tilted by using the displacement difference of the piezoelectric actuator in the bonding module for LATCB. The design variables of the flexure hinge were defined as the hinge height, the minimum diameter, and the notch radius. And the effect of the change of each variable on the stress generated in the flexible hinge and the lateral force acting on the piezoelectric actuator was analyzed. Also, optimization was carried out using commercial structural analysis software. As a result, when the displacement difference between the piezoelectric actuators is the maximum (90um), the maximum stress generated in the flexible hinge is 11.5% of the elastic limit of the hinge material, and the lateral force acting on the piezoelectric actuator is less than 1N.

심장과 호흡의 연결성을 이용한 감성인식 방법

이동원,박상인,황민철,Lee, Dong Won,Park, Sangin,Whang, Mincheol 한국감성과학회 2017 감성과학 Vol.20 No.3

Physiological responses have been measured to recognize emotion. Although physiological responses have been interrelated between organs, their connectivities have been less considered for emotion recognizing. The connectivities have been assumed to enhance emotion recognition. Specially, autonomic nervous system is physiologically modulated by the interrelated functioning. Therefore, this study has been tried to analyze connectivities between heart and respiration and to find the significantly connected variables for emotion recognition. The eighteen subjects(10 male, age $24.72{\pm}2.47$) participated in the experiment. The participants were asked to listen to predetermined sound stimuli (arousal, relaxation, negative, positive) for evoking emotion. The bio-signals of heart and respiration were measured according to sound stimuli. HRV (heart rate variability) and BRV (breathing rate variability) spectrum were obtained from spectrum analysis of ECG (electrocardiogram) and RSP (respiration). The synchronization of HRV and BRV spectrum was analyzed according to each emotion. Statistical significance of relationship between them was tested by one-way ANOVA. There were significant relation of synchronization between HRV and BRV spectrum (synchronization of HF: F(3, 68) = 3.605, p = 0.018, ${\eta}^2_p=0.1372$, synchronization of LF: F(3, 68) = 5.075, p = 0.003, ${\eta}^2_p=0.1823$). HF difference of synchronization between ECG and RSP has been able to classify arousal from relaxation (p = 0.008, d = 1.4274) and LF's has negative from positive (p = 0.002, d = 1.7377). Therefore, it was confirmed that the heart and respiration to recognize the dimensional emotion by connectivity. 감성을 인식하는데 있어 생리적 반응은 중요하다. 생리적 반응은 인체의 주요 기관들과 밀접한 관련이 있지만 감성을 인식하는데 연결성은 고려되지 않고 있다. 자율신경계는 감성과 밀접한 관련이 있는데, 심장과 폐와 같은 인체 내 주요 내장기관에 분포되어 기능적 상보작용을 통해 생리적 반응을 조절하기 때문이다. 따라서 본 연구는 심장과 호흡의 연결성을 분석하고 감성을 인식하는 중요한 연결 변수를 찾고자 하였다. 피험자 18명(남 10명, 평균 나이 $24.72{\pm}2.47$)은 소리 자극을 이용한 감성 유발 실험에 참여하였고 심전도와 호흡 데이터를 측정하였다. 수집된 심장과 호흡 데이터는 스펙트럼 분석을 이용하여 HRV와 BRV spectrum을 구하였고, 감성에 따른 HRV와 BRV spectrum의 동기화 차이를 일원배치분산분석을 통해 통계적 유의성을 확인하였다. Tukey 검증 결과, arousal-relaxation은 HF 대역에서 심전도와 호흡의 동기화 차이로 인식 가능하였고(p = 0.008, d = 1.4274), negative-positive는 LF 대역에서 인식이 가능하였다(p = 0.002, d = 1.7377). 본 연구 결과로 심장과 호흡의 연결성을 통해 차원적 감성을 정량적으로 평가할 수 있음을 확인하였고, 복합적인 원인으로 발현되는 감성을 인식하는데 생리적 반응들의 연결성 변수의 활용도가 높을 것으로 기대된다.

POLICY & ISSUES 기획특집_3 -지속가능한 도시조성을 위한 빗물관리시설 설치

이동원,Lee, Dong-Won 환경보전협회 2012 환경정보 Vol.401 No.-

빗물은 생명의 보전과 문명의 발전에 기여하는 천연자원이다. 빗물관리시설의 설치는 물순환 개선을 통한 하천유지용수 확보, 지하수 함양을 통한 도시 물 자급율 개선, 도시 열섬화 개선 등의 효과와 하천의 수질오염 완화, 우수유출량 저감으로 침수피해 경감 등의 효과를 가져다 준다.

변화하는 교육과정과 그 속의 초등공학교육

이동원,Lee, Dong-Won 한국공학교육학회 2021 공학교육동향 Vol.28 No.4

탄탈륨 산화물의 마그네슘 가스환원에 의한 탄탈륨 금속분말 제조

이동원,Lee, Dong-Won 한국분말야금학회 2018 한국분말재료학회지 (KPMI) Vol.25 No.5

Metallic tantalum powder is manufactured by reducing tantalum oxide ($Ta_2O_5$) with magnesium gas at 1,073-1,223 K in a reactor under argon gas. The high thermodynamic stability of magnesium oxide makes the reduction reaction from tantalum oxide into tantalum powder possible. The microstructure after the reduction reaction has the form of a mixture of tantalum and magnesium oxide, and the latter could be entirely eliminated by dissolving in weak hydrochloric acid. The powder size in SEM microstructure for the tantalum powder increases after acid leaching in the range of 50-300 nm, and its internal crystallite sizes are observed to be 11.5 to 24.7 nm with increasing reduction temperatures. Moreover, the optimized reduction temperature is found to be 1,173 K as the minimum oxygen concentration is approximately 1.3 wt.%.