http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이돈행(Don Haeng Lee),최정현(Jung Hyun Choi),안홍석(Hong Suk Ahnn),윤일국(Il Kuk Youn),장태정(Tae Jung Chang) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.4
Type 2 Crigler-Najjar syndrome is a rare hereditary disorder characterized by chronic, nonhe- molytic and modest unconjugated hyperbilirubinemia. There are currently reported three types ot' syndrome: Gilbert, Type 1 and 2 Crigler-Najjar syndrome. Type 2 Crigler-Najjar syndrome is cau- sed by hereditary glucuronosyl transferase deficiency and it can be differentiated from the Gilbert and Type 1 Crigler-Najjar syndrome by the severity of hyperbilirubinemia and its response to phenobarbital administration. We expierienced a 22 year-old male patient who had shown persistent jaundice and unconjugated hyperbilirubinemia from adolescence. It was noted that several persons had shown jaundice among his maternal family. The plasma bilirubin concentration was elevated after fasting for 48 hours and was decreased dramatically by phenobarbital treatment. (Korean J Gastroenterol 1995;27:4S8 - 492)
이돈행(Don Haeng Lee),송시영(Si Young Song),전재윤(Chae Yoon Chon),한광협(Kwang Hyub Han),정재복(Jae Bock Chung),문영명(Young Myoung Moon),강진경(Jin Kyung Kang),박인서(In Suh Park) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.6
N/A Background/Aims: Intrahepatic cholangiocellular carcinoma is devided into the peripheral and hilar type according to the location. The clinical features of hilar type is similar to that of extrahe- patic bile duct cancer and the peripheral type similar to the hepatocellular carcinoma. We conducted this study to identify the differences of clinical characteristics and survival rates between the hilar and peripheral type. Methods: We analyzed 42 cases with intrahepatic cholangiocellular carcinoma who were histologically confirmed from January 1981 to December 1990 at Severance Hospital, Yonsei University. Results: The mean age was 57.2 years, the male to female ratio 2.2 to 1. The most common symptom was abdominal pain(83.3%), jaundice was more frequently encountered in hilar type(33.3%) than peripheral type(6.7%) and abdominal mass more common in peripheral type(48.4%) than hilar type(11.1%). Associated diseases were infestation of Clonorchis sinensis(19.0%), liver cirrhosis(19.0%) and intrahepatic bile duct stones(7.1%). The elevation of serum CEA(more than 5 ng/ml) was noted in 52.0%. On abdominal ultrasonography, the hypere- choic pattern in hilar type and the hypoechoic pattern in peripheral type were commonly noted. The hepatic arterial angiography showed mostly hypovascular pattem(72.7%). Local invasion was more frequent in hilar type than peripheral type, however distant metastasis was more common in peripheral type. The overall median survival of 36 cases was 5.5 months, and hilar type 5.3 months and peripheral type 5.9 months. According to the treatment modalities, the survival rates in cases underwent curative resection(median survival; 12.5 months) and in cases with combination of chemotherapy, radiotherapy and hyperthermia(median survival; 9.6 months) were significantly higher than that of no treatment group(median survival; 2.0 months)(pC0.05). Conclusions: To improve the survival in cases with intrahepatic cholangiocellular carcinoma, the efforts to diagnose in early stage should be recommanded, especially in the high risk group such as the patients with Clonorchiasis and intrahepatic bile duct stones. Additionally we should remind the differences including the pattern of metastasis between hilar and peripheral types in the management of these patients. (Korean J Gastroenterol 1995;27: 679 - 689)
이돈행 ( Don Haeng Lee ) 대한소화기학회 2007 대한소화기학회지 Vol.49 No.5
Gastrointestinal (GI) cancers cause obstruction of the GI tract including biliary tree. In advanced GI cancer, endoscopic stent insertion is the treatment of choice. However, the current stent allows only mechanical palliation of obstructed GI tract and has no anti-tumor effect. The primary role of a drug eluting stent (DES) in gastrointestinal malignancy is that it decreases the tumor re-growth and sustains the stent patency. This might not be as impressive as the effect of a vascular DES which decreases the incidence of restenosis and thus increases the survival rate of the patient. However, in terms of improving the quality of life of the patient, maintaining the stent patency is one of the most important task of GI doctors. With an advanced technology in stent production, Korea would be able to play an active role in the field of DES especially with more advanced anti-tumor effect. Moreover, advances in this type of drug delivery system will enable the development of local treatment of GI malignancy using endoscopy. (Korean J Gastroenterol 2007;49:294-299)
소아용 대장내시경을 이용한 소장내시경 검사로 진단한 원발 공장 선암종 1예
이충훤 ( Chung Hwon Lee ),김범수 ( Pum Soo Kim ),이정일 ( Jung Il Lee ),정석 ( Seok Jeong ),이진우 ( Jin Woo Lee ),권계숙 ( Kye Sook Kwon ),이돈행 ( Don Haeng Lee ),김형길 ( Hyung Gil Kim ),신용운 ( Yong Woon Shin ),김영수 ( Youn 대한소화기학회 2006 대한소화기학회지 Vol.48 No.5
A 39-year-old man presented with dizziness and melena for 2 months. Abdominal CT scan showed constrictive wall thickening with enhancement and proximal loop dilatation of the jejunum. On endoscopic examination, there was large amount of bile stained fluid in duodenum. Enteroscopy using pediatric colonoscope demonstrated an encircling mass with obstruction approximately 20㎝ distal to the ligament of Treitz. Endoscopic jejunal biopsy showed moderately differentiated adenocarcinoma. Small intestinal adenocarcinoma is uncommonly encountered in clinical practice. Because small intestine is relatively inaccessible via routine endoscopy, diagnosis of small intestinal neoplasm is often delayed for several months after the onset of symptoms. Most of the patients are diagnosed in advanced stage. Therefore, when a small bowel neoplasm is suspected, enteroscopy is the most useful study. If enteroscope is not available, enteroscopy using pediatric colonoscope may permit earlier preoperative diagnosis. We report a case of primary jejunal adenocarcinoma diagnosed by endoscopic biopsy using pediatric colonoscope. (Korean J Gastroenterol 2006;48:365-368)
Measurement of Hepatic Functional Reserve by Functional Liver Imaging
이진우 ( Lee Jin U ),조혜진 ( Jo Hye Jin ),김정은 ( Kim Jeong Eun ),이정일 ( Lee Jeong Il ),정석 ( Jeong Seog ),권계숙 ( Kwon Gye Sug ),이돈행 ( Lee Don Haeng ),김범수 ( Kim Beom Su ),김형길 ( Kim Hyeong Gil ),신용운 ( Sin Yong U 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<Purpose> To evaluate the feasibility of functional liver imaging (FLI) as a new method for measuring hepatic functional reserve (HFR). <Materials and Methods> Twenty-two patients with cirrhotic liver with various functional impairments (Child-Pugh [CP] c
덱사메타손을 함유한 폴리카보네이트 폴리유레탄 피막의 약물 방출 형태에 대한 연구$^1$
강성권,이돈행,이규백,이철갑,송호영,Gang, Seong-Gwon,Lee, Don-Haeng,Lee, Gyu-Baek,Lee, Cheol-Gap,Song, Ho-Yeong The Korean Radiological Society 2003 대한영상의학회지 Vol.48 No.1
목적: 덱사메타손을 포함한 폴리우레탄 피막으로부터 방출되는 약물의 양과 속도를 알아보고자 하였다. 대상과 방법: 수용성 및 지용성 덱사메타손을 사용 하였으며,지용성 덱사메타손을 포함하는 필름은 여러 가지 두께 (78-211 $\mu$m)로 제작하여 두께에 따른 방출 속도를 측정하였다.덱사메타손의 양은 폴리우레탄 피막 무게의 10%를 사용하였다. 각각의 필름은 25 mL의 0.1 M 포스페이트 버퍼가 들어있는 튜브에 넣고 세이킹 인규베이터에서 방출시킨 후 스펙트로스코피(λmax=242 nm)를 이용하여 방출된 약물의 양을 측정하였다. 결과: 수용성 덱사메타손을 포함한 필름에서는 2시간 만에 60%의 덱사메타손이 방출되었으나 지용성 덱사메타손을 포함한 필름에서는 1일,3일,7일에 각각 40%,60%,75%의 덱사메타손이 방출되었다. 수용성과 지용성 필름 모두에서 28일까지 소량의 약물이 지속적으로 방출되었다. 지용성 덱사메타손을 포함하는 서로 다른 두께의 필름에서는 두께가 두꺼운 필름에서 초기 방출량이 두께가 얇은 필름과 비교하여 적었으며 방출량이 서서히 증가하였다. 결론: 덱사메타손을 포함하는 폴리우레탄 피막으로부터 방출되는 약물의 양은 약제의 성상(수용성/지용성)과 피막의 두께에 의하여 조절될 수 있을 것으로 생각된다. Purpose: To evaluate the release behavior of dexamethasone embedded in a polycarbonate polyurethane membrane. Materials and Methods: Both water-soluble and water-insoluble dexamethasone were tested, and the release behavior of five water-insoluble dexamethasone films of different thickness (78 to 211 ${\mu}$m) was also evaluated. The amount of Dexamethasone used was 10% of the total weight of the polyurethane film mass. Each film was placed in a centrifuge tube containing 25 ml of 0.1-M neutral phosphate buffer, and the tubes were placed in a shaking incubator to quantify the amount of drug released into the buffer, absorption spectroscopy (λmax=242 nm) was employed. Results: In the test involving water-soluble dexamethasone, 60% of the drug was released during the first two hours of the study. Films containing water-insoluble Dexamethasone, on the other hand, released 40%, 60% and 75% of the dexamethasone in one, three and seven days, respectively. Both types of film maintained low-dose drug release for 28 days. When release behavior was compared between water-insoluble films of different thickness, thicker film showed less initial burst and more sustained release. Conclusion: Dexamethasone release behavior varies according to drug solubility and membrane thickness, and may thus be conrolled.