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유방암의 감시림프절 검사에서 유방크기와 체질량지수에 따른 검사시간 변화
이다영,남궁혁,조석원,오신현,임한상,김재삼,이창호,박훈희,Lee, Da-Young,Nam-Koong, Hyuk,Cho, Seok-Won,Oh, Shin-Hyun,Im, Han-Sang,Kim, Jae-Sam,Lee, Chang-Ho,Park, Hoon-Hee 대한핵의학기술학회 2012 핵의학 기술 Vol.16 No.2
유방암 환자의 감시림프절 생검을 위하여 현재 방사성동위원소와 blue dye를 이용한 감시림프절 매핑(Mapping)이 선행되고 있다. 현재 모든 환자에 대하여 일괄적인 검사방법이 적용되므로 환자의 유방의 크기나 비만도와 같은 특성이 고려되지 않아 림프절의 흐름이 느린 환자의 경우, 림프절을 충분히 형성하지 못한 채 검사가 종료되는 경우가 종종 발생한다. 본 연구에서는 환자의 신체적 특성인 체질량지수와 유방의 크기에 따른 림프액의 속도차이를 관찰하였다. 이를 통해 방사성동위원소를 이용한 유방의 감시림프절 신티그래피 에서 환자의 특성을 고려한 최적의 검사시간을 도출하는데 목적을 두었다. 본 연구는 2011년 10월부터 2011년 12월까지 수술직전 유방의 감시림프절 신티그래피를 시행한 100명(여성 100명, 평균연령 $50.34{\pm}10.26$)를 대상으로 하였다. 장비는 감마카메라 Forte (Philips Medical Systems, Nederland B.V.)를 사용하였으며, 방사성의약품은 $^{99m}Tc$-Phytate 18.5 MBq, 0.5 ml를 피내주사하였다. 먼저 80명의 환자를 대상으로 기존의 5분 검사방법대신 충분히 림프절을 형성할 때까지 시간의 제한 없이 영상을 획득하였다. 이를 통해 환자의 유방크기와 체질량지수 별 그룹을 나누어 평균 검사시간을 구하였다. 이 결과를 바탕으로 검사시간을 변화시킨 변형 유방 림프신티그래피를 20명의 환자에게 시행하여 유용성을 확인하였다. 80명의 대상 중 유방의 크기에 따른 평균 검사시간은 A그룹 2.48분, B그룹 7.69분, C그룹 10.43분이었다. 80명의 대상 중 체질량지수에 따른 평균 검사시간은 저 체중 1.35분, 표준 2.56분, 과 체중 5.62분, 비만 15분이었다. 앞서 얻어진 정보를 바탕으로 각 그룹별 적절한 검사시간을 적용하여 검사를 시행하였다. 결과는 20명 중 성공평가를 받은 경우는 17회 실패평가를 받은 경우는 3회로 총 85% 성공률을 나타내었다. 유방의 크기와 체질량지수에 따른 총 검사 시간은 체질량지수가 높을수록, 유방의 크기가 클수록 증가하였으며, 얻어진 정보를 바탕으로 기존 검사방법에서 검사시간만을 변화시킨 변형 유방 림프신티그래피를 적용하였을 때 대부분의 경우 검사시간 내 림프절을 형성할 수 있었다. 이를 통해 모든 환자에게 일괄적으로 적용하던 검사방법보다 개인의 신체적 특성을 고려한 적절한 검사시간을 각각 다르게 적용하였을 때 검사에서 높은 성공률을 보임을 알 수 있었다. Purpose : At this time, the sentinel lymph node mapping using radioisotope and blue dye is preceded for breast cancer patient's sentinel lymph node biopsy. But all patients were applied the same protocol without consideration of physical specific character like the breast sizes and body mass indexes. The purpose of this study is search the optimized scan time in breast sentinel lymphangiography by observing how much the body mass index and breast size influence speed of lymphatic flow. Materials and Methods : The Object of this study was 100 breast cancer patients(Female, 100 persons, average age $50.34{\pm}10.26$ years old)at Severance hospital from October 2011 to December 2011. They were scanned breast sentinel lymphangiography before operation. This study was performed on Forte dual heads gamma camera (Philips Medical Systems, Nederland B.V.). All patients were intra-dermal injected $^{99m}Tc$-Phytate 18.5 MBq, 0.5 ml. For 80 patients, we have scanned without limitation of scan time until the lymphatic flow from the lymph node since injection. We measured how long the lymphatic flow time between departures from injects site and arrival to lymph node using stopwatch. After we calculated patient's Body mass Index and classified as 4 groups. And we measured patient's breast size and classified 3 groups. The modified breast lymphangiography that changing scan time according to comparison study's result was performed on 20 patients and was estimated. Results : The mean scan time as breast size was A group 2.48 minutes, B group 7.69 minutes, C group 10.43 minutes. The mean scan time as body mass index was under weight 1.35 minutes, normal weight 2.56 minutes, slightly over 5.62 minutes, over weighted 5.62 minutes. The success rate of modified breast lymphangiography was 85%. Conclusion : As the Body mass index became higher and breast size became bigger, the total scan time is increased. Based on the obtained information, we designed modified breast lymphangiography protocol. At the cases applying that protocol, most of sentinel lymph nodes were visualized as lymphatic pool. In conclusion, we found that the more success rate in modified protocol considering physical individuality than study carrying out in the same protocol.
이다영,심민영,Lee, Da Young,Sim, Minyoung 대한불안의학회 2017 대한불안의학회지 Vol.13 No.1
We reviewed the scientific literature on psychological effects of Chemical, Biological, Radiological, Nuclear, Explosive (CBRNE) disaster, which is one of the biggest threat to modern society. CBRNE disaster has the potential to cause specific physical symptoms and psychological distress in victims ; moreover, various toxic symptoms and carcinogenesis/mutation would be an important issue. Bioterrorism can cause localized outbreaks of infectious disease or pandemic disaster. Somatization as well as posttraumatic stress symptoms and depression are the characteristic psychological symptoms in CBRNE disaster's victims. CBRNE disasters could lead to large-scale public fear and social chaos due to the difficulties involved in verifying the extent of exposure and unfamiliar area to the common people. In the evacuation process, problems associated with adjustment and conflict between victims and residents should be considered.
이다영,김남석,김하림,김민선,이창현,오미진,오찬호,김종석,김명순,권진,Lee, Da young,Kim, Nam Seok,Kim, Ha Rim,Kim, Min Sun,Lee, Chang Hyun,Oh, Mi Jin,Oh, Chan Ho,Kim, Jong Suk,Kim, Myung Soon,Kwon, Jin 한국식품영양학회 2018 韓國食品營養學會誌 Vol.31 No.2
This study was investigating the anti-obesity effects of diets with a mixture of cheese, red ginseng and fermented mature fruit of Rubus coreanus Miquel. We fed the experimental diets (SC5, SC10) supplemented with 5% or 10% cheese containing of fermented mixture, then orally administered the extract of fermented mixture (RB100, RB300) at a concentration of 100 or 300 mg/kg body weight to SD rats with high fat diet (HFD). The results were as follows: Sample cheese groups decreased visceral fat mass and adipocyte size of stomach compared to that of HFD group. Additionally, lipid droplets of liver in sample cheese groups were smaller than that in HFD group. The serum triglyceride (TG), total cholesterol (tChol), glucose, leptin, and insulin levels in sample cheese group were lower than that in HFD group. But, the serum adiponectin and HDL-cholesterol (cHDL) levels were higher than that in HFD group. These results suggest that fermentation of red ginseng and Rubus coreanus mixed with cheese might be helpful in preventing obesity in high fat diet-fed rats.
레이디가가 무대디자인에 나타난 포스트 아방가르드 특성연구
이다영 ( Da Young Lee ),윤재은 ( Jae Eun Yoon ) 한국기초조형학회 2012 기초조형학연구 Vol.13 No.3
현재 대중들로부터 관심을 받는 글로벌 팝스타로 레이디가가(Lady Gaga)를 들 수 있을 것이다. 그녀가 세계적으로 부각 받을 수 있었던 것은 끊임없는 도전 정신과 새로움을 추구하는 의상, 전위적인 감각의 무대를 보여주기 때문이다. 대립보다는 공존을, 분화보다는 융합을 지향하며 다양하고 이질적인 것들이 상호 자유로운 결합을 시도하고 있는 그녀의 파격적인 의상과 무대는 대중의 폭발적인 반응을 이끌어내고 있다. 아방가르드(Avant-guarde)는 사회적 변혁과 더불어 끊임없이 변화를 추구하며 역사와 예술, 사회문화적 상황에 민감하게 작용하는 혁신성과 실험성을 기반으로 한다. 시대별로 다른 모습을 보이며 발전해온 포스트 아방가르드(Post Avantguarde)는 과거와의 단절을 시도하기보다 역사성에 기반 하는 새로움의 미학을 추구하는 형태로 나타나고 있다. 새로움의 추구라는 기본 성향 아래 비판과 부정에서 시작해 절충하는 양상으로, 시대의 흐름에 따라 조금씩 그 특성을 달리하는 아방가르드와 연관성을 보이는 레이디가가의 미적특성에 관해 연구하고자 한다. 본 연구에서는 포스트 아방가르드의 개념과 특성을 토대로 레이디가가의 의상과 무대 분석을 통해 무대디자인에 포스트 아방가르드가 어떤 식으로 표출되었는지를 보여준다. 행위예술에 가까운 의상과 실험적인 무대를 통해 예술이 함께 공존하는 무대디자인을 분석하고 연구한다. 그럼으로 인해 레이디가가 무대디자인에 나타난 포스트 아방가르드의 표현특성과 가능성을 함께 알아본다. We can point out Lady Gaga as global pop star who is received attention from the public cosmopolitanly. There are some reasons why she could become a world star. She always tries to make something new like costume which is different with existing one and a stage that looks antiform with her challenging spirit. Many young people in the world are fanatical about her preposterous costume and stage seeking coexistence and fusion rather than confrontation. Also she tries to show people her effort for combination among things once that were totally different through her performance. Avantguarde, based on innovation and experimentation that can respond to sociocultural circumstance including art and history sensitively, purses not only constant change but also social revolution. Post Avantguarde that has been developing while reinventing with the times appears to be some form which seeks esthetics for newness based on historicity but not braking with the past. On pursuit for newness I will study Lady Gaga`s aesthetical peculiarities showing a link with Avantguarde which has been changed its attribute according to the passing of time. This study was conducted on the concept and character of Post Avantguarde as showing how Post Avantguarde is expressed to the stage designs through Lady Gaga`s costume and an analysis of her stage. The stage designs coexisting with the art was analyzed by costume to performance and an experimental stage. By this approach it will be able to let us know expression characteristics of Post Avantguarde in Lady-Gaga`s stage.
재조합 미생물 바이오센서를 이용한 chlorotoluene과 nitrotoluene 화합물의 검출
이다영(Da Young Lee),조재호(Jae Ho Cho),임운기(Woon Ki Lim),신혜자(Hae Ja Shin) 한국생명과학회 2014 생명과학회지 Vol.24 No.1
방향족 화합물은 독성 환경오염물질로 생태계와 인간의 건강에 해로운 영향을 미친다. 그중 chlorotoluene과 nitrotoluene 화합물은 수생생물에 독성을 나타내며 인간의 피부, 눈, 호흡기를 자극한다. 본 연구에서는 폐수의 chlorotoluene과 nitrotoluene 화합물을 저렴하고 간단하게 검출하고자 재조합 미생물 바이오센서를 개발하였다. BTEX (benzene, toluene, ethylbenzene, xylene) 분해 조절 유전자 xylR를 Po’ (upstream activating sequences를 제거한 DmpR 조절단백질 promoter Po) 또는 Pu (XylR 고유의 프로모터)::lacZ 유전자(β-galactosidase 유전자)의 upstream에 연결한 플라스미드를 제작한 후, E. coli DH5α에 형질 전환하였다. 유도 화합물 존재 하에서, 아가로스에 고정된 이 재조합 바이오센서 세포는 유도 화합물에 의해 β-galactosidase를 발현하고 기질인 chlorophenol red β-D-galactopyranoside (CPRG)를 분해하여 1~2시간에 붉은색을 나타내었다. BTEX 화합물 중, 특이적으로 o-, m-, p-chlorotoluene (0.1 ㎛-100 mM) 그리고 o-, m-, p-nitrotoluene (0.1 mM-100 mM)에서 높은 반응을 나타내었으며 Po’가 Pu보다 높은 반응성을 보여주었다. 아가로스에 고정된 바이오센서는 4℃에서 21일간 보존 후에도 활성의 큰 변화 없이 안정하였으며, chlorotoluene과 nitrotoluene 화합물들로 spike된 전처리 하지 않은 폐수 시료중에서도 좋은 반응을 보여 주어 폐수 중 chlorotoluene과 nitrotoluene 화합물의 간단한 초기 검출에 활용될 수 있음을 제시하였다. Aromatic hydrocarbons are toxic environmental pollutants that are detrimental to the ecosystem and human health. Among them, chlorotoluene and nitrotoluene are toxic to hydrobios and irritate the skin, eyes, and respiratory organs of humans. We herein report the development of recombinant microbial biosensors for cheap and rapid monitoring of chlorotoluene and nitrotoluene compounds. Plasmids were constructed by inserting the xylR regulatory gene for BTEX (benzene, toluene, ethylbenzene, and xylene) degradation into upstream of Po’ (the DmpR activator promoter Po with the deletion of its own upstream activating sequences) or Pu (the cognate promoter of XylR)::lacZ (the β-galactosidase gene) and transformed into Escherichia coli DH5α. In the presence of inducers, the biosensor cells immobilized in agarose developed a red color in 1-2 h due to the hydrolysis of chlorophenol red β-D-galactopyranoside (CPRG), a substrate of β-galactosidase that was expressed by the inducers. Among BTEX, high responses were specifically observed with o-, m-, p-chlorotoluene (0.1 ㎛-100 mM) and o-, m-, p-nitrotoluene (0.1 mM-100 mM). Po’ demonstrated higher responses than those with Pu. The biosensors immobilized in agarose showed good stability after 21 days’ storage at 4℃, and responses in untreated wastewater spiked with chlorotoluene and nitrotoluene, suggesting they can be used to detect compounds in wastewater.
스마트시티 설계 시 제로에너지건축물 인증 취득을 위한 패시브/액티브 인자별 평균성능 및 참조모델 제시 - 교육연구 및 업무시설을 중심으로 -
이다영(Lee, Da-Young),유동철(Yoo, Dong-Chul),조수영(Jo, Su-Young),박창영(Park, Chang-Young),장향인(Jang, Hyang-In) 한국건축친환경설비학회 2020 한국건축친환경설비학회 논문집 Vol.14 No.5
To implement the zero-energy building policy in establishing the smart city, reference models of zero-energy buildings were suggested in this study. Reference models that reflect the average performance of energy-related factors were designed. Passive and active influencing factors were selected from the literature review. Then, the values of influencing factors in reference models were derived from the average performance of the 1++ rating certification cases. The building purposes of the reference models were selected as education & research and office, and were then subdivided according to the detailed purpose or size. To validate the models, the energy performance of the reference models was simulated and the results of simulation showed that all reference models achieve the 1++ rating which meets the criteria of zero-energy building certification. The influencing factors and reference values that were suggested in this study are expected to be used in designing the zero-energy building and further studies that develop the reference models of other cases.
20대 소비자의 기초화장품 구매 전 이용한 정보원천 활용도에 따른 구매 후 만족도
이다영 ( Da Young Lee ),이승신 ( Seung Sin Lee ),이영희 ( Young Hee Lee ) 대한가정학회 2017 Human Ecology Research(HER) Vol.55 No.6
Cosmetics market information is important due to advances in information communication technology and the growth of cosmetics market. This study analyzed the relationship between the pre-purchase utilization of information (commercial, neutral, personal and experiential) and the post-purchase satisfaction of skin care cosmetics, categorized as functionality, safety, economic feasibility, information reliability, purchase convenience, condition of purchase place, packaging/design of product and service. This study analyzed reliability, frequency, differences, correlation and regression analysis using SPSS ver. 24.0. The study results are summarized as follows. First, gender was a significant variable in the level of information source utilization. Women used commercial, neutral, and experiential information sources more actively than men. However, women had lower post-purchase satisfaction that could be understood through expectation disconfirmation theory. Women have very high expectations that can lower post-purchase satisfaction. Second, information source utilization can improve post-purchase satisfaction for cosmetics. The consumer post-purchase satisfact the lowest in the commercial information source; however, consumers were satisfied when the commercial informationinformation sourceenon and regre. Third, the consumeried itnformation sourceenon and regression analysis ial, neutral,source and reflected the characteristics of experiential goods. Therefore, companies should provide accurate commercial, personal and experiential information to increase consumervide accurate commercial, per as well as conduct experiential marketing