Olanzapine이 백서의 Schedule-Induced Polydipsia에 미치는 영향

이기철,이경규,장환일,이정호,김현우,하준명,정재현,정홍경,Lee, Gi-Chul,Lee, Kyung-Kyu,Chang, Hwan-Il,Lee, Jung-Ho,Kim, Hyun-Woo,Ha, Jun-Myung,Jeong, Jae-Hyun,Jeong, Hong-Kyung 대한생물정신의학회 1999 생물정신의학 Vol.6 No.2

Object : This study was designed to evaluate the effects of olanzapine on the schedule-induced polydipsia(SIP) which is one of animal model of obsessive-compulsive disorder in rats. We administered olanzapine as a serotonin and dopamine blocking agent, fluoxetine as a selective serotonin reuptake inhibitor, and haloperidol for the dopamine antagonist to rats which showed schedule-induced polydipsic behavior. Methods : Spraque-Dawley rats weighing 200-250gm were individually housed and maintained and allowed free access to water. The rats were placed on a restricted diet. To induce polydipsia, rats were placed in the cage where a pellet dispenser automatically dispensed 90mg pellets on a fixed-time 60 seconds(FT-60s) feeding schedule over 150 minute test session per day. Water was available at all times in the cage. After 4 weeks of daily exposure to the FT 60s feeding schedule, experimental rats met a predetermined criterion for polydipsic behavior(greater than 3 times of water per session on average). 5 groups of rats were administered olanzapine(3mg/kg, i.p), olanzapine(10mg/kg, i.p), fluoxetine(5mg/kg, i.p.), haloperidol(0.1mg/kg, i.p.), and vehicle(1cc/kg, i.p.) for 3 weeks. The rats were tested once a week to access schedule induced polydipsic behavior. Water bottles were weighed before and after the 150-minute test session. The chronic effects of administration of experimental drugs on schedule induced polydipsic behavior were analyzed with ANOVA and Scheffe test as a posthoc comparison. In order to measure water consumption in non-polydipsic food-deprived rats, a separate group of rats(N=8) were individually housed and given a single bolus(14.5gm) of food per day which maintained them at their average body weight. Results and Conclusion : The results were as follows ; 1) After 4 weeks of scheduled feeding procedure, the experimental group showed significant differences than the bolus control in the amount of water consumption as compared with their average water intakes for 4 weeks. At the same periods, there were no differences between the experimental group and the bolus control in the body weight. 2) The fluoxetine group showed significant decrease in the amount of water intake over the 3 weeks of drug treatment as compared with their average amount of polydipsic water intakes. The olanzapine 3mg group showed significant decrease in the amount of water intake at 3rd weeks of drug treatment as compared with their average amount of polydipsic water intakes. The olanzapine 10mg group showed significant decrease in the amount of water intake at 2nd and 3rd weeks of drug treatment as compared with their average amount of polydipsic water intakes. However, the haloperidol group and the vehicle control group showed no changes of amounts of water intake for 3 weeks of treatment as compared with their average amount of polydipsic water intakes. 3) The fluoxetine group showed significantly lower amounts of water intake than the haloperidol group at 2nd weeks of drug treatment. And also the fluoxetine group showed significantly lower amounts of water intake than the haloperidol group and the vehicle control at 3rd weeks of drug treatment. The olanzapine 3mg group and the olanzapine 10mg group showed significantly lower amounts of water intake than the haloperidol group and the vehicle control at 3rd weeks of drug treatment. Above findings suggest that the fixed time feeding procedure for schedule-induced polydipsia as an animal model of obsessive compulsive disorder was effective to the evaluation of pharmacological challenge study. The authors assume that the serotonin hypothesis and the serotonin-dopamine interaction hypothesis are preferred to the dopamine hypothesis in the biological etiology of obsessive-compulsive disorder.

회원작품 - 펀펀하우스

이기철,Lee, Kichul 대한건축사협회 2019 建築士 Vol.598 No.-

건축담론 - 좋은 건축

이기철,Lee, Kichul 대한건축사협회 2019 建築士 Vol.606 No.-

상악동화농병치험예보고

이기철,Lee, Gi-Cheol 대한한약협회 1997 大韓漢藥 Vol.1 No.-

군집분석을 통한 전국 자연휴양림 유형분류

이기철,강기래,Lee, Kee-Cheol,Kang, Kee-Rae 한국조경학회 2009 韓國造景學會誌 Vol.37 No.1

자연휴양림이 도입된지 20년이 지나는 동안 휴양림마다의 특징성이 부각되어 각각의 휴양림이 가진 개성이 있음에도 불구하고 자연휴양림의 유형에 대한 분류가 거의 없는 실정이다. 본 연구는 자연휴양림의 공급적 측면과 이용적 측면을 고려한 유형분류를 실시하여 유형에 따른 효율적인 자연휴양림 운영관리 또는 자연휴양림에 관한 연구 시 연구지 선정의 기초 자료로서의 제공에 그 목적이 있다. 자연휴양림 유형분류를 위한 방법으로는 자연휴양림 유형분류를 위한 최적의 변수로 생각되는 항목들을 선정하기 위한 전문가 설문을 실시하여 전국 자연휴양림을 대상으로 현황설문조사를 실시하였다. 공통성 추출을 위한 요인분석 결과, 4개 요인으로 구분되어 각각의 명명을 변수의 속성과 크기에 따라 이용실적 지표요인, 교육적 지표요인, 내부 활동적 지표요인, 수용 잠재적 지표요인으로 명명하였다. 그리고 추출된 요인점수를 통하여 $85{\times}4$행렬의 군집분석을 시도하였다. 그 결과 5개 군집으로 최종 유형이 분류되었다. 본 연구를 통한 결과는 유형별 휴양림 운영방안 및 관리의 기초자료로 제공되어질 수 있을 것이다. 그리고 향후 자연휴양림의 조사지에 대한 선정 시 기초자료로 참고할 수도 있을 것이며, 또한 전국 자연휴양림의 유형을 제시함으로써 향후 휴양림 적지 선정에 있어서도 기초자료로 제공될 수 있을 것이다. Twenty years have passed since the adoption of natural recreation forests and each forest has its own characteristics. However, there is hardly any classification among the natural recreation forests. The purpose of this study is to classify the forests by considering the supplier's perspective as well as the user's perspective in order to provide fundamental materials for the operation of the natural recreation forests. A factor analysis was conducted to identify the common characteristics of the selected twelve variables by pre-selection and survey of experts. K-means cluster analysis was conducted among those factors to classify the natural recreation forests in Korea. Four factors were drawn after the factor analysis and the factors were named according to the variables and sizes as 'The use performance and visiting condition factor', 'Education and settlement factor', 'Internal activation factor' and 'Potential factor' In addition, the cluster analysis of an $85{\times}4$ matrix was conducted for the points of the drawn factors and the final classification consists of five groups. The results of this study may contribute to providing fundamental materials for the operation and management of natural recreation forests. Also, it may act as a reference when investigating the natural recreation forests of Korea. Proposing the classification natural recreation forests could be helpful in selecting the proper recreation forest in the future. Based on the established model, fundamental materials could be provided to improve the profitability of the natural recreation forests by effectively expanding the number of tourists, creating new natural recreation forests and proper maintenance and management.

선택적 세로토닌 재흡수차단제들이 만성 경도 스트레스 후의 백서에서 수동적 회피학습에 미치는 영향

이기철,장환일,Lee, Gi-Chul,Chang, Hwan-Il 대한생물정신의학회 1997 생물정신의학 Vol.4 No.2

The study was designed to evaluate the significant roles of SSRI in rat of depression model. Chronic exposure to mild unpredictable stress has been found to depress the consumption of sweet 1% sucrose solutions in the Sprague-Dawley rats. We applied the variety of 11 types of stress regimens and identified depressive behaviours(developed by Willner) in 70 Sprague-Dawley rats. Rats in experiments were stratified into 6 groups, ie ; 3 kinds of SSRI(paroxetine, fluoxetine, sertraline), clomipramine, choline and saline control. Memory function was evaluated by passive avoidance learning and retention test. The authors determined how long memory retention would remain improved with 24 hour, 1 week, 2 weeks, 3 weeks, and 4 weeks at training-testing interval in depressive states of the Sprague-Dawley rats. The results were as follows ; 1) There were no significant differences between the 6 groups at the 24 hour training-testing interval. 2) The paroxetine treated group showed significant differences from the control group at the 1 week and 2 weeks training-testing interval. 3) The paroxetine and the fluoxetine treated groups showed singificant differences from the control group at 3 week training-testing interval. 4) The paroxetine and the choline treated groups showed significant differences from the control group at 4 week training-testing interval. In summary, paroxetine had an effect on long term memory processing from 1st week to 4th week. Also, fluoxetine(at 3rd week) and choline(at 4th week) had effect on long term memory processing. Sertraline, clomipramine were ineffective on memory processing during 4 weeks observation. Possible explanations why paroxetine had early effect on memory processing than the other selective serotonin reuptake inhibitors are rapid bioavailability, which is the characteristics of pharmacokinetics of paroxetine. In clinical situation, author carefully suggest that SSRI would be beneficial to improve the memory function caused by depressive neurochemical changes.

자연휴양림 숙박시설만족도 모형연구

이기철,강기래,Lee, Kee-Cheol,Kang, Kee-Rae 한국조경학회 2007 韓國造景學會誌 Vol.34 No.6

Research into the use of recreation forest accommodations, the main facilities in these forests, and user satisfaction with them has been carried out for recreation forests in the suburbs of Daegusi and Gyongsangbukdo. This study aimed at providing background material to support the increasing demand to improve the facilities of recreation forests and to educate recreation forest staff about how to provide better service. User satisfaction with recreation forests as determined through regression analysis was affected by the following factors in this order: indoor recreation, the indoor space, outdoor recreation, time satisfaction factor, and activity opportunities. The level of satisfaction is affected by the force of factors above. The order of effective offerings of accommodations is presented according to the results.

아편양 순응제가 백서의 억제된 자발적 교대행동에 미치는 영향

이기철,전성일,장환일,이정호,최영민,김성호,류정환,최미,Lee, Gi-Chul,Jeon, Seong-Il,Chang, Hwan-Il,Lee, Jung-Ho,Choi, Young-Min,Kim, Seong-Ho,Ryu, Jeong-Hwan,Choi, Mi 대한생물정신의학회 1999 생물정신의학 Vol.6 No.2

This study was designed to evaluate the effects of opioid receptor agonists on the spontaneous alternation behaviour in an animal model of obsessivecompulsive disorder in rats. According to the theory that dopamine is related to the biological etiology of obsessive-compulsive disorder, the effect of the nalbuphine(opioid kappa agonist) and the tramadol(opioid mu agonist), which act as manipulating agents on the inhibition or stimulation of dopamine release, in the spontaneous alternation behaviour were evaluated. 24 hours prior to the experiment, rats were food-deprived. These rats were put into the T-maze, in which white and black goal boxes were baited with small amounts of chocolate milk. Each rat was given 2 set of 7 trials during which it was placed in the start box and allowed to choose the one of the goal boxes for each time. After identifying the stable baseline of spontaneous alternation behaviour, nonselective 5-HT agonist 5-MeODMT(1.25mg/kg/IP) disrupted spontaneous alternation. Rats were stratified into fluoxetine(10mg/kg/IP), nalbuphine(10mg/kg/IP), tramadol(46.4mg/kg/IP), and saline(0.5cc/IP) injection group with experimental drug treatment for 21 days. The effects on the 5-MeODMT(1.25mg/kg/IP) induced disruption of spontaneous alternation behaviour were checked at the next day of discontinuation of drug treatment. The results were as follows ; 1) At the day after 21 days of the drug treatment, the nalbuphine treated group and the fluoxetine treated group showed significant difference from the tramadol treated group and the saline treated group in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. 2) Within each drug treatment group, the fluoxetine treated group showed significant difference between before and after the treatment of fluoxetine in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. And also, the nalbuphine treated group showed significant difference between before and after the treatment of nalbuphine in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. There was no difference between the baseline and after the treatment of nalbuphine in the 5-MeODMT(1.25mg/kg/IP) induced suppression of spontaneous alternation behaviour. We indentified that the opioid kappa agonist that act as dopamine release inhibitor affect the spontaneous alternation behaviour which is an animal model of obsessive-compulsive disorder in rat.

환경인의 자세

이기철,Lee, Gi-Cheol 환경보전협회 2001 환경정보 Vol.23 No.11

전력계통의 안정도 해석

이기철,Lee, Gi-Cheol 한국전자통신연구원 1982 전자통신 Vol.4 No.3