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李基定 충남대학교 대학원 1977 論文集 Vol.9 No.-
Fasting venous gastrin concentration and plasma gastrin response to casein(Sanatogen-A) were determined in healthy six volunteers including three medical doctors and three medical students without recognized gastrointestinal abnormalities. Studies were also designed to determine whether simple oral acid administration could modify the secretion of gastrin. After an overnight fast of 10 or more hours, experiments were performed in the morning. The gastrin stimulation test employed a dose of 50gm of casein. On the next day, a dose of 1ml of 10㎎% hydrochloric acid was introduced orally 10 minutes before the test. Venous plasma sample were obtained before and 2, 15, 30 and 60 minutes after the casein loads. Gastrin concentrations were measured by a radioimmunoassay procedure. Net peak plasma gastrin response was obtained by substrating the fasting concentration from the peak gastrin value. The results were as follows;, 1) Fasting plasma gastrin concentration and net peak response following casein feeding were 45.9 ± 16.32 and 55.6±28.04pg/m1 in normal subjects. 2) Acid ingestion led to a conflicting results on the response; three stimulation, one no effct, and two inhibition was observed. 3) Acid ingestion didn't produce any significant change on mean gastrin response to casein stimulation. 4) Fasting plasma gastrin level and age variety within decade didn't alter the plasma gastrin response to casein feeding. With above results, author discussed the fact that secretion of gastrin in duodenal ulcer disease is not normally responsive to feedback inhibition of gastrin release by acid within the stomach.
李基定,崔東浩,金昌國,盧興圭 충남대학교 의과대학 지역사회의학연구소 1976 충남의대잡지 Vol.3 No.2
Authors experienced five cases of adult diphtheria which is relatively uncommon in Korea during last winter. All cases were pharyngeal diphtheria and had relatively mild symptoms an dclinical course. A particularly noticeable finding was massive cervical lymphadenopathy, so called "bull neck", which observed on four cases. Four cases were recovered with antiserum and penicillin therapy. One patient died with the complication of myocarditis.
4, 4′―Diaminodiphenylsulfone(D.D.S)로 인한 Methemoglobinemia의 임상적 고찰
신재승,김숙자,김태윤,이기정,노흥규 충남대학교 의과대학 지역사회의학연구소 1977 충남의대잡지 Vol.4 No.1
An analysis of 25 cases of methemoglobinemia due to ingestion of 4,4'-diaminodiphenylsulfone(D.D.S. ), who had been observed from January, 1973 to May, 1976 at Chungnam University Hospital, was reported. Results are as follows: 1. The incidence was highest in patients less than 5 year of age (8 cases) and next in 21 to 30 year of age (6 cases). There was no sex difference. The majority of cases (72%) occured during summer month. 2 The causes of intoxication were ingestion by accident in 11. cases, for suicidal purpose in 10 and misuse for skin disease in 4. 3 Common symptoms and signs were cyanosis, nausea, vomiting, semicoma, headache, dizziness, dyspnea and convulsion in the order of frequency. Consciousness disturbance was apparent in 6 cases out of 7 who ingested more than 2.0 gram. per square meter in a single dose. 4. Symptoms appeared within 12 hours after ingestion in 22 cases and the more the dosage, the earlier the onset. 5. Fifteen cases out of 16 who ingested less than 3.25 gram per square meter were improved. Three cases died, in 2 of them convulsion was noted.