http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
원현정,박성영,이기백 한국공업화학회 2019 한국공업화학회 연구논문 초록집 Vol.2019 No.1
A cancer-selective probe and drug delivery system was developed by loading disulfide-modified carbon dot (CD) onto manganese oxide (MnO<sub>2</sub>) nanosheet, followed by loading paclitaxel (PTX). High fluorescence CD was synthesized via carbonization process of disulfide cross-linked hyaluronic acid and further loaded onto MnO<sub>2</sub> nanosheets, causing fluorescence quenching of CD. The resulting CD-PTX@MnO<sub>2</sub>2 was further cleaved in the presence of glutathione (GSH) in cancer cell due to reduction of MnO<sub>2</sub> and disulfide bond, allowing recovery of fluorescence and release of PTX in cancer cell. Furthermore, CD-PTX@ MnO<sub>2</sub> demonstrated good biocompatibility towards normal cells and high selectivity towards tumor cells, indicating this system was suitable for cancer targeting both in bioimaging and chemotherapy. Thus, this system provides promising strategy for highly selective cancer bioimaging and smart drug delivery system. This work was supported by Korea National University of Transportation in 2019.
Functionalized Polymer dots based Pluronic for Cancer Target Imaging Guided Anticancer Drug Delivery
강은비,박성영,이기백 한국공업화학회 2016 한국공업화학회 연구논문 초록집 Vol.2016 No.1
We prepared concentration-mediated multicolor fluorescence based polymer dots (PDs) from sulfuric acid-treated dehydration of Pluronic F-within simple method. Pluronic-based PDs (P-PDs) showed high dispersion stability in solvent media and exhibited a fluorescence emission that was widely tunable from red to blue by adjusting both the excitation wavelengths and the P-PD concentration in an aqueous solution. Based on these facts, we further explore P-PDs for target drug delivery with bio-imaging system. We prepared P-PDs surface decorated drug doxorubicin (DOX) via acid-cleavable hydrazone linkages with tumor target folic acid to obtain the nanoparticles. This system possessed dual function as a deliver and a function of bio-imaging of cancer cells for more advance target delivery system with physiological stability. <sup>**</sup>This was supported by Korea National University of Transportation in 2016.
김성한,이기백,박성영 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
This paper reports the development of pH responsive molecular pattern belong to specificity and selective affinity with host-guest interaction as pH fluorescent sensor. The pH responsive boronate ester via interaction between the diol group of β-Cyclodextrin (CD) and phenylboronic acid of poly ethylene glycol are strategically design to create and erase the molecular lining pattern. Pattern on versatile substrate have provided a handle to monitor the positioning of different molecules with pH-responsive boronate ester and host-guest interaction on any surface. The confocal laser scan microscope, fluorescence spectroscopy and 1H-NMR direct evidence that assembles CD monolayer have removed by washing acidic pH buffer, demonstrating the boronate ester connective bridge. This was supported by Korea National University of Transportation in 2015.
정찬진,이기백,박성영 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
We report exfoliated montmorillonite (MMT) for near infrared (NIR) active hyperthermal antibacterial adhesive-nanocomposites constructed using IR825/catechol/sultone quaternized poly(dimethylamino) ethylmethacrylate [(IR825/catechol/sultone)-q-PDMA] polymeric assemble. Different ratio of MMT has been taken in the zwitterionic structure of [(IR825/catechol/sultone)-q-PDMA]-to-MMT that was convenient to enlarge and exfoliate with the clay layers of MMT. The surface coating has simultaneously performed owing to remaining adhesive catechol of [(IR825/catechol/sultone)-q-PDMA]/MMT, and confirmed in contact angle and XPS measurements. The reported hyper-thermal nanocomposites show effective antibacterial activity against both S. aureus (grampositive) and E. coli (gram-negative) bacteria, respectively. This was supported by Korea National University of Transportation in 2015.