진무탕(眞武湯)이 Gentamicin-유도 신독성에 미치는 영향

이규현,김길훤,Lee, Kyu-Hyun,Kim, Gil-Whon 대한동의생리학회 1999 동의생리학회지 Vol.14 No.2

Aminoglycosides, including gentamicin, have been used as antibiotics for the various infections by gram-negative bacteria. However, there are some restrictions for using these drugs. Gentamicin, a typical aminoglycoside, has the side effect of nephrotoxicity, including polyuria, glycosuria, proteinuria, glomerulonephritis, and uremia. The aims of this study were to examine the prevention or reduction effects of Jinmootang on the gentamicin-induced nephrotoxicity and to investigate the possible mechanisms on the effect of Jinmootang. The subcutaneous injections of 60mg of gentamicin per kg of boby weight to Sprague-Dawley rats for 8 days induced typical symptoms of nephrotoxicity by aminoglycosides. 0.6ml of water extract Jinmootang (100ml/chup) was orally treated in the experimental animal. 24-hour urine was collected with the metabolic cage and plasma was sampled from the abdominal aorta. The plasma concentration of sodium was significantly decreased by the treatment of gentamicin but it was not-significantly changed by the treatment of Jinmootang to the animal. The concentration of potassium was greatly decreased in the gentamicin-treated animals. However. it was returned to the normal level in the Jinmootang-treated animals. The concentrations of creatinine and urea were increased by gentamicin treatment. But, Jinmootang reduced these concentrations. Nevertheless, the osmolalities of plasma in both group were not different from each other. Even though the plasma concentration of aldosterone was not significantly changed, the mean value was increased by the gentamicin intoxication. The concentration of aldosterone was decreased by the treatment of Jinmootang. The reduction of aldosterone level in plasma could be a factor to improve the hypokalemia. The fractional excretion of potassium was much higher than normal by the treatment of gentamicin and it was decreased by 50% in the Jinmootang-treated rats. Therefore, the reabsorption of potassium was significantly increased by the treatment of Jinmootang, even though the filtered load of potassium in the experimental group was much highter than control. Even though the concentration of plasma aldosterone was decreased by the treatment of Jinmootang, the fractional excretion of sodium was not increased, slightly lower. These data suggested that Na reabsorption was increased in the proximal tubule by Jinmootang. The filtered load of glucose in the Jinmootang-treated group was greater than in control. Nevertheless, the fractional excretion of glucose in the experimental group was not different from that in control. These results indicate that glucose reabsorption was increase in the proximal tubule by Jinmootang treatment. The results of this study suggest that Jinmootang could improve the some nephrotoxic symptoms induced by gentramicin treatment. Hypokalemia, the reduced glomerular filtration rate, and dysfunctions of renal proximal tubule and distal nephron were significantly recovered to normal level. The increase of glomerular filtration rate by Jinmootang might contribute to eliminate the waste product, including creatinine and urea, and/or gentamicin through the kidney.

아프타성 구내염 치료용 구강 패취의 설계 : 약물층

이규현,박은석,지상철 ( Kyu Hyun Lee,Eun Seok Park,Sang Cheol Chi ) 한국약제학회 1995 Journal of Pharmaceutical Investigation Vol.25 No.4

For the effective treatment of aphthous stomatitis, the matrix type mucoadhesive patches containing triamcinolone acetonide have been formulated. The drug layer was obtained by drying the polymer gel which was prepared with carbomer 934P, ammoniomethacrylate copolymer, titanium dioxide and polyethylene glycol 400. The effects of the content of additives on physical characteristics of the polymer gel and the drug layer were evaluated. The addition of carbomer increased the yield point and the zero-shear viscosity of polymer gel as well as the thickness, the water absorption ratio, the adhesive time and T_(50%) of drug layer. The adhesive time and the water absorption ratio of drug layer were also improved by the addition of ammoniomethacrylate copolymer, but the addition of titanium dioxide had decreased the zero-shear viscosity of polymer gel and the adhesive time of drug layer.

차등서비스 코드의 분석 및 다양한 활용을 위한 라이브러리 구현

이규현(Kyu Hyun Lee),김대영(Dae Young Kim) 한국통신학회 2000 한국통신학회 학술대회논문집 Vol.2000 No.7

DDS 개발과 약물의 생체내 동태 : 음식물이 약물흡수에 미치는 영향에 대한 기전

이규현(Lee Kyu Hyun),국중석(Cook Chyung S .) 한국약제학회 1997 과학의 달 기념 심포지움 Vol.- No.9

지오텍스타일 매트를 적용한 가설도로 시공사례

이규현(Kyu-Hyun Lee),이종성(Jong-Sung Lee) 한국토목섬유학회 2010 한국지반신소재학회 학술발표회 Vol.2010 No.4

지오텍스타일 매트(Geotextile Mat) 공법은 지오텍스타일 매트와 토사의 마찰력을 이용하여 성토를 실시하는 공법으로 보강토 옹벽공법과 개념이 유사한 공법이다. 본 논문에서는 기존암거 확장을 위한 가설도로 시공사례와 기존도로에 확장구간에 대한 지오텍스타일 매트를 적용한 시공사례에 대해 설계방안 및 안정성 검토방안 그리고 시공성에 대해 분석을 실시하였다. 총 2개의 현장사례를 통해 지오텍스타일 매트 적용시, 유의사항 및 적용 방향에 대한 사례를 소개 하여 향후 유사 공법을 통한 시공시 참고자료를 소개하고자 한다.

기술상용화시대의 도래 - 클러스터와 네트워크의 진화

이규현(Lee Kyu Hyun) 한국마케팅과학회 2005 한국마케팅과학회 학술대회 발표 논문집 Vol.- No.-

고정화효소와 그 이용

이규현(Kyu Hyun Lee),김계용(Kea Yong Kim) 한국고분자학회 1984 폴리머 Vol.8 No.3

한류의 확산과 저항

이규현(Kyu Hyun Lee) 한국마케팅과학회 2006 한국마케팅과학회 학술대회 발표 논문집 Vol.- No.-

혁신확산과정에서 사회네트워크이론의 적용 - 복음의 사회 확산을 중심으로

이규현(Lee Kyu-Hyun) 한국마케팅과학회 2004 한국마케팅과학회 학술대회 발표 논문집 Vol.- No.-

어떻게 사랑이 마케팅 연구대상이 될 수 있는가?

이규현(Lee Kyu Hyun),김형길(Kim Hyoung Gil) 한국로고스경영학회 2017 로고스경영연구 Vol.15 No.1

최근의 마케팅연구는 미시와 거시, 영리와 비영리, 실증과 규범을 포함하여 그 범위가 크게 확대되어왔으며, 경제학, 심리학, 사회학, 문화인류학 등 행동과학영역이 광범위하게 도입되어 적용되어왔고, 마케팅의 주요 연구 영역인 소비자로서의 인간에 대한 이해의 폭을 넓혀 왔다. 그러나 마케팅의 과학적 연구를 기반으로 한 연구위에 마케팅의 본질과 문제점을 규명하고, 성경적 관점과 사회학, 윤리학 등과 관련성을 갖고 사회생활의 보편타당성을 탐구하는 사회철학 관점에서 사랑이 마케팅에서 중요함을 밝히는 연구는 나타나지 않고 있다. 본 연구에서는 마케팅의 본질인 교환과 관계의 내부 흐름의 밑바탕에 깔려있는 가치인 자기이해와 보상은 사회 전체적으로 갈등을 초래 할 수 있다는 근원적인 문제점을 지적하고, 이를 극복하기 위해서 기존의 교환 개념을 사회가치의 교환으로 확대를 제시하고, 사랑을 정점으로 한 사회가치의 피라미드를 제시하였다. 이 피라미드에서 조직의 진보, 인간성의 정의, 지식에서의 자유가 연계됨을 제시하였다. 경제적 효율성과 사회정의를 달성하기 위해서 이제까지 시장 메커니즘 내부에 강조한 자기이해의 개념을 확대하여, 사회전체의 이해와 상대편의 이해를 함께 생각하는 자기개념으로 제시하였다. 또한, 마케팅시스템에서 시장지향성과 고객지향성을 진정으로 달성하기 위해 자유와 정의에 기반을 둔 사회철학적 요소를 담아내야함을 강조하고, 이를 위해 마케팅 주체자와 마케팅 가치 사용자로서의 공존하고 있는 다원적 구조속에 이웃을 내 몸 같이 사랑하는 가치사용자 중심적 사고를 통해 전체적인 균형관계를 제시하였다. 이를 실천하기 위해, 단순한 이성간의 에로스적인 사랑이나 친구 간의 우정, 가족간의 사랑을 넘어 예수그리스도의 아가페적인 사랑을 지향해야 함을 강조하고, 이를 사랑마케팅이라 명명하였으며, 이를 실현하기 위한 마케팅 실무에서 사랑의 실천적 과제들을 제시하였다. The scope of marketing has been extended with profit/nonprofit, micro/macro, and positive/normative approaches. This paper suggests the direction of marketing studies from the social psychology perspective which explains total social life in relationship of sociology and ethics. Beyond self-interest and reward in explaining the internal mechanism of exchange and relationship, the love concept with pyramid of social value is suggested as new social value in marketing. Three major elements of basic importance to marketing are knowledge, organization, and the value of humanity. knowledge has a high value as a kind of high-level organization, and developing humanity to its highest potential using knowledge is essential. Knowledge is the means toward freedom, Organization is the direction for progress, and Justice arises from placing a high value on man. We suggest the love as the ultimate value including these three values, that is, freedom in knowledge, progress in organization, and justice in humanity. Apostle Paul sought the universal ethics by seeing the concept of love as universal truth, which Jesus Christ had showed to our human. Dealing with the concept of love including concept of freedom, progress, and justice would make marketing as a major tool to explain and solve the structural contradiction capitalism in current our society. In this paper we suggest more comprehensive socio-philosophical perspective for the extension of marketing concept. In addition, this paper suggests practical tasks for love marketing studies. This research areas include future research potentials with more concrete qualitative and quantitative studies.