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운동생리학 : 식이 콜레스테롤과 식이섬유가 지구성 운동선수의 혈장 콜레스테롤 및 지단백질에 미치는 영향
이규성(KyuSungLee),김문희(MunHeeKim),조준용(JoonYoungCho),양춘호(ChunHoYang) 한국체육학회 2001 한국체육학회지 Vol.40 No.3
본 연구는 식이 콜레스테롤과 식이섬유 섭취가 혈중 콜레스테롤에 미치는 영향을 조사하기 위하여 성인 남성 20대를 대상으로 7주동안 실시하였다. 처음 1주간의 동일 식이투여, 다음 4주동안은 하루 860㎎/㎗ (4개의 계란) 의 식이 콜레스테롤을 투여하였고 (1, 2, 3기간), 다음 2주 동안은 식이 콜레스테롤과 식이섬유(펙틴 20g)을 병행 섭취시켰다 (4기간). 그 결과 TG를 제외한 HDL-C, TC, LDL근은 집단간에 유의한 차이가 나타나지 않았다. 또한 혈중 TC, TG, LDL-C, HDL-C 모두 기간간에는 유의한 차이가 나타나지 않았다. 식이콜레스테롤이 풍부한 용해성 섬유와 식이 콜레스테롤을 병행섭취한 후에는 지단백, TG, 체중의 감소를 가져왔고, 식이 콜레스테롤이 많이 들어있는 음식 (계란)을 단독으로 섭취하였을 경우에는 혈중 지단백, TG, 체중 등의 증가를 가져왔다. To investigate the effects of dietary cholesterol and dietary fiber on plasma cholesterol levels adult males (20, 30, 60age) who were classified into three different age group were fed diets containing 860㎎ of cholesterol (4eggs/day) per day for 7wks and also had them consumed dietary fiber (pectin 20g) with cholesterol during the end of 2wks out of 7wks under controlled condition. The entire investigation period was 49days, which was divided into four periods.Plasma total cholesterol, triglycerides, high-density, low density lipoprotein and body weights levels were measured. Blood samples were collected after 12hrs fast at the beginning of the study and at each period throughout the study. No significant difference was founded in plasma total cholesterol, triglycerides, low density lipoprotein cholesterol and body weight levels except high density lipoprotein-cholesterol (p<.01) were observed among age groups. However, plasma cholesterol (p<.001), triglycerides (p<.05), low density lipoprotein cholesterol (p<.05) and body weight (p<.001) levels varied considerably during the entire investigation periodThese observations indicate that feeding dietary fibers rich in soluble fiber (pectin) with dietary cholesterol produces lower plasma cholesterol including lipoprotein, triglycerides and body weight while feeding only dietary cholesterol rich in flood (egg) increases plasma cholesterol including lipoprotein, triglycerides and body weight.
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자연과학편 : 심장혈관 건강 Module의 개발과 평가
강상조(SangJoKang),이규성(KyuSungLee),권봉안(BongAnKwun) 한국체육학회 1989 한국체육학회지 Vol.28 No.1
This study was to aim at analyzing and verifying the results derived from the developed "Heart Health Module", after the needs assessment which dealt with the investigation of knowledge, altitudes, and practices pertaining to cardiovascular disease. There were 189 subjects for the study selected from seoul and local areas in Korea.The study employed Solomon-Four-Group design in order to analyze the data statistically and resulted in the following finding:1. The group exposed to the module demonstrated significantly higher cardiovascular knowledge scores than those in the control group.2. The group exposed to the module had positively higher scores in cardiovascular attitudes than those in the control group.3. The group treated with the module showed positively higher scores than those in the control group.
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운동생리학 : 운동수행에 따른 NSE/PS<sub>2m</sub>-Alzheimer's disease 모델 생쥐의 인지적·행동적 학습능력과 혈청 지질 수준의 변화
조준용(JoonYongCho),이규성(KyuSungLee) 한국체육학회 2002 한국체육학회지 Vol.41 No.2
Alzheimer's disease (AD) occurs when neurons in the memory and cognition regions of the brain are accompanied by accumulation of the 39 to 43 amino-acid long amyloid β-protein derived from the amyloid precursor protein (APP) by cleavage with β and γ-secretase. In particular, cholesterol promotes Aβ42 secretion causing increase of β-secretase activity. To test this, the Alzhimer's disease model mice were subjected to treadmill exercise through free access to running wheels during course of experiment. Upon treatment, behavioral deficits were improved. In addition, cholesterol, triglyceride and LDL-C levels were significantly reduced. The results of this study suggested that treadmill exercise in the Alzhimer's disease model mice resulted in the reduction of cholesterol levels, therby reducing Aβ42 secretions. Thus, the reduction of serum lipids through 12weeks treadmill exercise in Alzhimer's disease model mice might induce the promotion of learning and memory behaviors and exercise could be useful for the testing of compounds that have been shown to have considerable preventive effects.
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운동생리학 : 진세노사이드 투여가 스프린트 운동시 생쥐의 근조직별 항산화 효소 활성도 및 MDA, Hydrogen peroxide 수준에 미치는 영향
조준용(JoonYongCho),한현식(HyunSikHan),이규성(KyuSungLee) 한국체육학회 2002 한국체육학회지 Vol.41 No.3
Although endurance training enhances the antioxidant defence of different tissues, information on the effect of sprint training and ginsenoside is scanty. We examined the effect of ginsenoside and sprint training on the mice skeletal muscle (soleus and gastrocnemius) antioxidant defences. Male mice, 4 weeks old, were sprint trained on a treadmill for 7 weeks. Superoxide dismutase (SOD), caltalase (CAT), hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), malondialdehyde (MDA) was compared in trained and trained nice with ingesting ginsenoside. Compared with the sprint group, SOD and CAT activities were significantly increased in sprint trained mice with ingesting ginsenoside. However, production of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) and malond ialdehyde (MDA) in soleus and gastrocnemius muscles were reduced by sprint training with ingesting ginsenoside.
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운동생리학 : 장기간의 운동이 쥐의 심장근과 골격근의 HSP72 발현 변화에 미치는 영향
신영오(YoungOhShin),김문희(MunHeeKim),조준용(JoonYoungCho),이규성(KyuSungLee),오재근(JaeKeunOh) 한국체육학회 2001 한국체육학회지 Vol.40 No.2
이 연구는 운동적응에 따른 골격근과 심근에서의 HSP72 발현 변화를 구명하기 위해 운동적응 단계에 따른 HSP72 발현량을 심장근, 가자미근과 족척근에서 비교하였다.실험동물은 6 주령 된 수컷 쥐 (Sprague-Dawley ; 150-180g) 로서 안정시 5마리와 운동기간대 (1주, 2주, 3주, 4주, 5주) 별로 매주마다 5마리씩 총 30마리를 대상으로 하였다. 운동강도는 1주 운동군 (0%, 17.4m/min, 15min, 5days/wk), 2주 운동군 (1주 운동 후 10%, 21.5m//min, 25min, 5days/wk), 3주 운동군(2주 운동후 13%, 25.5m/min, 35min, 5days/wk), 4주 운동군 (3주 운동 후 16% 29.2m/min, 45min, 5days/wk), 5주 운동군 (4주 운동후 18%, 30.0m/min, 60min, 5days/wk)으로 나누었다. 이 연구에서 얻은 결론은 다음과 같다.운동강도가 높아짐에 따라 심근의 HSP72 발현량은 3주에 증가된 HSP72 농도를 4, 5주에서 그대로 유지하는 것으로 나타났다. 안정시 HSP72 농도는 족척근 (100%)을 기준으로 족척근과 심근 (178%) 보다 가자미근이 734%로 높게 나타났고 (p<.05), 점진적으로 증가된 운동강도에 대해 가자미근은 안정시 (100% )에 비해 각각 110%, 118%, 163%, 184%, 204% 증가된 발현량을 나타내었고, 족척근은 각각 175%, 191%, 394%, 407%, 593% 증가된 발현량을 나타내었다 (p<.05).운동으로 인한 스트레스는 가자미근, 족척근. 심근 모두에서 HSP72 발현을 유도하였으며, 운동강도에 비례해 증가하는 것으로 나타났다. 하지만 운동강도와 근섬유 형태에 따른 HSP72 발현에는 차이가 있는 것으로 나타났다. Heat Shock Proteins are considered to play an essential role in protecting cells from stress and preparing them to survive new environmental challenge. This study investigates the induced-synthesis and accumulation of HSP72 in soleus, plantaris and heart muscle of the rat following progressive exercise.70 male Sprague-Dawley rats were employed. Exercise speed, duration and treadmill incline were progressively increased from 1wk until 5wk. Progressive endurance exercise increased HSP72 accumulation level continuously in the soleus, plantaris and the heart muscle(p$lt;.05). There was a difference of the synthesis amounts and the expression pattern of the induced-HSP72 in muscle types.In summary, although the adaptive response to progressive exercise results in the elevation in the induction of the HSP72, there was a difference among muscle types.
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