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난포액내에 존재하는 TNF - α 와 NO 의 농도가 난자의 질에 미치는 영향에 관한 연구
이규섭 ( K . S . Lee ) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.7
N/A Objective: Our objective was to explain a relationship between concentrations of tumor necrosis factor- α (TNF- α) and nitric oxide (NO) in follicular fluid, oocyte quality, and outcomes of in vitro fertilization- embryo transfer 0VF-ET). Method: The concentrations of TNF- α and NO were measured in 115 follicular fluid samples collected from 43 patients undergoing IVF-ET program, due to tubal obstruction, some with endometriosis (8 patients) or hydrosalpinx (5 patients). A correlation of these factors concentrations and the oocyte quality, the oocyte marurity, and infertility associated disease was analyzed Result: No correlation was found between concentrations of NO and TNF- α in follicular fluid. NO concentrations in follicular fluids were significantly higher in patients with endometriosis (P<0.001) or hydrosalpinx (P<0.01) compared to the patients with just tubal obstruction. Follicular NO concentration differences according to oocyte maturity and oocyte quality were not found. In contrast, TNF- α concentrations in follicular fluids were significantly higher in poor quality oocytes (P<0.05) but were not associated with infertility-associated diseases, such as hydrosalpinx or endometriosis, and the oocyte maturity. No significant differences in follicular levels of NO and TNF- α as well as IVF-ET parameters of pregnant and nonpregnant groups were revealed. Conclusions: There is no significant correlation between the concentrations of NO and TNF- α in follicular fluid. NO levels in follicular fluid are altered in infertility-associated disease. However, TNF- α levels but not NO levels influence oocyte quality. These results suggest that the production of NO and TNF- α in follicular fluid may be regulated via different pathways and can be tempered with infertility-associated disease, thereby influencing oocyte quality locally.