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抗生物質 amoxicillin 原料 및 salinomycin 添加劑의 安定性 調査
Tae Haeng Cho(趙太行),Kwang Jick Lee(李光稙),Sun Namgoong(南宮旋),Jae Chin Lee(李在鎭) 한국예방수의학회 1994 예방수의학회지 Vol.18 No.2
The amount of consumption of antibiotics including salinomycin and amoxicillin trihydrate has been growing day by day as a variety of disease occured in recent years. But the terms of validity of amoxicillin and salinomycin was not determined in Korea as yet. We examed the stability of amoxicillin trihydrate by checking the change of potency, pH, content of water and property under the ambient and stress condition (40℃, humidity 30~70%) and there was little change in potency, pH, content of water and property till the 30 months during the preservation time and salinomycin was same here so it will be possible to establish the terms of validity about 24 months in case of amoxicillin trihydrate and salinomycin feed additives.
Enramycin 單一 및 複合抗生物質製劑의 檢定法 改善
Tae Haeng Cho(趙太行),Kwang Jick Lee(李光稙),Sun Namgoong(南宮琁) 한국예방수의학회 1993 예방수의학회지 Vol.17 No.1
In Korea the use of Enramycin has begun since 1981 and the amount of use has increased due to its efficacy against gram-positive bacteria and little absorption into the gastro intestinal organ. At now Enramycin potency is being assayed by microbiological method like this : extraction solvent ; 2% HCI in MeOH or acetone : 4N HCI : D.W (40 : 15 : 45) and bacteria for assay ; Bacillus subtillus ATCC 6633. But this method is not suitable for products as treated with specially processed raw matarial or contaminated with lipid or protein which is a sort of media for cultivating enramycin producing bacteria. So improved method is needed and researched as follow. Such a condition as 1N HCI : acetone : D.W : 0.01% EDTA(4.3 : 29.7 : 51 : 15) shows best recovery rate. For assaying colistin potency in enramycin-colistin complex products such conditions as pH 6.0, 10% phosphate buffer or acetone : 1N HCI : pH 6.0, 10% phosphate buffer(5 : 0.5 : 94.5) show best recovery rate instead of pH 6.0, 1% phosphate buffer.
테트라사이클린系 抗生物質의 分析技法 開發 및 殘留調査에 關한 硏究
Tae Haeng Cho(趙太行),Kwang Jick Lee(李光稙),Nam Sup Jin(秦南燮),Sun Namgoong(南宮琁),Jong Myung Park(朴鍾鳴),Mun Han Lee(李文漢) 한국예방수의학회 1993 예방수의학회지 Vol.17 No.3
A method for the isolation and liquid chromatographic determination of tetracyclines (Oxytetracycline, OTC ; Tetracycline, TC; Chlortetracycline, CTC ; and Doxycycline, Doxy) in beef, pork and chicken samples is presented. Tetracyclines-fortified muscles(0.5g) were blended with octadecylsilyl(C₁₈) derivatized silica (2g). The C₁₈/muscle matrix was used to prepare a column that was washed with hexane(10ml) and then eluted with benzene(10ml) and 10ml of methanolic oxalic acid(0.01M oxalic acid in methanol). The method uses small volume of solvents, has a limited number of sample manipulation, and require no pH adjustment, making this method attractive when compared to classical isolation procedures for tetracyclines.
Tae Haeng Cho(趙太行),Kwang Jick Lee(李光稙),Jong Myung Park(朴鍾鳴),Sun Namgoong(南宮琁),Keun Sik Park(朴根植) 한국예방수의학회 1993 예방수의학회지 Vol.17 No.1
This report was results to be analyzed for quality control to animal using antibiotics of 28, 741 lots during the periods of 1963 to 1992. Among them, 28, 574 lots are passed and 167 lots rejected through national assay. The preparation forms of animal using antibiotics of total 14, 071 lots examined for 6 years(1987-1992) were classified as feed additives 4, 781 (34.0%), injectables 3, 871 (27.5%) and soluble powders including oral suspensions 3,426(24.3%), respectively. Of the antibiotics of 14,071 lots, 1,182 lots(8.4%) were applied for raw materials, 733(5.2%) as implantations for therapy of bovine mastitis and 78 lots (0.6%) as the other antibiotics. In 1992, 2, 282 lots of animal using antibiotics were examined by regulations of national assay. Among them, mono-antimicrobial drugs were 1, 697 lots (74%) and combined antibiotics 585 lots (26%), respectively. The nomo-antibiotics and combined antibiotics were constituted with 58 kinds of chemical components. During the periods of 1985 to 1992, 18, 230 lots of antibiotics were tested by regulations of national assay. Among them, 167 lots were rejected by results of national assay. By the preparation forms, the soluble powders including the oral suspensions were highly rejected as 54 lots, and injectables, feed additives, implantations and the others were orderly rejected 49, 45, 17 and 2 lots, respectively. By reason of the rejection, 129 of 167 lots were insufficiently potency, 24 excessively humidity, 11 highly pH and 3 adequately characteristic tests, respectively.
抗콕시듐劑 抗生物質의 닭 體內代謝 및 殘留에 關한 硏究
Tae Haeng Cho(趙太行),Kwang Jick Lee(李光稙),Sun Namgoong(南宮琁),Jong Myung Park(朴鍾鳴),Mun Han Lee(李文漢) 한국예방수의학회 1993 예방수의학회지 Vol.17 No.3
Detection for residues of polyether antibiotics(Salinomycin, Monensin, Lasalocid and Naracin) in chicken tissues-kidney, fat, liver and muscle was performed by the TLC and bioautography. B. subtillis ATCC 6633 strain, ethyl acetate and chlorform : methanol : conc. NH₄OH(95/5/0.5) solvent and addition of MgCl₂ in media were used in these experiments. Eighty chickens were divided four groups : 2 normal level feeder groups (monensin 110ppm, salinomycin 50ppm), 2 high level feeder groups(monensin 550ppm, salinomycin 250ppm) for five weeks. The recovery rate of monensin, salinomycin, lasalocid and naracin was 85.9~100.5%, 88.8%, 86.8% and 87.8% in chicken tissues at each. In high level feeder groups, monensin and salinomycin were detected about 0.052ppm and 0.085ppm at each in fat tissue at 24hours after feeding The duration of residues in high level feeder groups lasted longer than that of normal level feeder groups. Besides this test we have performed the amount of contamination of polyether antibiotics in twenty market chickens, so there is no residue of polyether antibiotics in the chiken tissue.
Jong Myung Park(朴鍾鳴),Kwang Jick Lee(李光稙),Tae Haeng Cho(趙太行),Young Min In(印英玟),Sun Namgoong(南宮琁),Keun Sik Park(朴根植) 한국예방수의학회 1991 예방수의학회지 Vol.15 No.3
Antibiotic residues of domestic beef, pork and poultry were tested by EEC 4-plate method to improve and monitoring the quality of meats. Antimicrobial substances were not detected from 128 cattle, 155 swine and 93 chicken muscle tissues. A weak antibacterial inhibition zones were appeared from 3 out of 128 cattle kidney samples and 35 out of 155 swine kidney samples but considered nonspecific reaction.
고속액체크로마토그래피를 이용한 항원충제 분석법 개발: 톨트라주릴 및 디클라주릴
정경훈,정미영,박해철,아킬후세인,김대균,이광직,강정우,Jeong, Kyung Hun,Jeong, Miyoung,Park, Hae-Chul,Hossain, Md Akil,Kim, Daegyun,Lee, Kwang-Jick,Kang, Jeong Woo 대한수의학회 2017 大韓獸醫學會誌 Vol.57 No.4
This study was undertaken to develop new analytical methods for assessment of anticoccidials. High-performance liquid chromatography (HPLC) was found to be a fast, reliable, and practical method. The anticoccidials used in this experiment were toltrazuril and diclazuril, and the analysis factors were specificity, linearity, accuracy, repeatability, and intermediate precision. The linearity of each anticoccidial was better than 0.99, and the accuracies were 99.5% and 99.1% with relative SD of 0.5 and 0.4, respectively. To assess whether the developed HPLC method could be effectively applied, toltrazuril and diclazuril post-market veterinary products (five products) that are currently sold were tested. The results revealed no non-compliant items and the method was applied successfully. Therefore, the newly developed HPLC method for anticoccidial assessment described in this study may be useful as a reference method in the Korean Standards of Veterinary Pharmaceuticals for the analysis of toltrazuril and diclazuril.