고중성지방혈증 환자에서 Fenofibrate가 C-reactive protein 농도에 미치는 효과

이성호 ( Sung Ho Lee ),이경헌 ( Kyung Heon Lee ),최여진 ( Yeo Jin Choi ),이광호 ( Kwang Ho Lee ),최수희 ( Soo Hee Choi ),이경은 ( Kyung Eun Lee ),이광제 ( Kwang Je Lee ),김태호 ( Tae Ho Kim ),고홍숙 ( Hong Sook Ko ),김치정 ( Chee 대한내과학회 2006 대한내과학회지 Vol.70 No.6

목적: 염증반응은 죽상동맥경화와 이에 의한 급성관 증후군의 발생에 중요한 역할을 하며, 염증반응의 대표적인 지표인 C-reactive protein (CRP)의 농도가 다른 위험인자와 독립적으로 향후 심혈관계질환이 발생할 위험도를 예측하는데 유용한 것으로 확인되었다. 피브린산 유도체는 CRP 농도를 감소시킨다고 주장되고 있으나, 지금까지의 연구는 대상의 선정에 문제점이 많으며 결과도 일치하지 않았다. 본 연구에서는 고중성지방혈증 환자에게 피브린산 유도체를 Background: High levels of C-reactive protein (CRP) are associated with an increased risk for cardiovascular diseases. Most reports on the effect of fibrate on CRP level have inadequate study designs and the results are inconsistent. This study was designe

펨토초레이저 백내장 수술과 고식적 백내장 수술에서 수정체낭원형절개의 비교

박재홍,이경헌,이동준,Jae Hong Park,MD,Kyung Heon Lee,MD,Dong Jun Lee,MD 대한안과학회 2014 대한안과학회지 Vol.55 No.12

Purpose: To compare parameters of femtosecond laser and manual continuous curvilinear capsulorhexis (CCC) using anterior segment optical coherence tomography (AS-OCT). Methods: Femtosecond laser cataract surgery was performed in 30 eyes of 30 patients, and conventional cataract surgery with a manual CCC in 30 eyes of 30 patients. One month after surgery, CCC diameters, circularity of capsulotomy, and distance between the CCC and pupil center were analyzed using the AS-OCT. Results: Mean maximal CCC diameter was 4.96 ± 0.23 mm in the femtosecond laser group, and 4.70 ± 0.82 mm in the manual CCC group. Mean minimal CCC diameter was 4.91 ± 0.23 mm in the femtosecond group, and 4.48 ± 0.64 mm in the manual CCC group showing significant difference between the two groups (<EM>p</EM> = 0.000). Circularity of capsulotomy was 0.99 ± 0.01 in the femtosecond group and 0.91 ± 0.13 in the manual CCC group and was statistically different between the 2 groups (<EM>p </EM>= 0.000). The distance from the CCC center to the pupil center was 0.18 ± 0.09 mm in the femtosecond group and 0.26 ± 0.17 mm in the manual CCC group. The CCC center was closer to the pupil center in the femtosecond than in the manual CCC group (<EM>p</EM> = 0.038). Conclusions: Properly sized and shaped capsulotomy can be expected in femtosecond laser CCC compared with manual CCC. J Korean Ophthalmol Soc 2014;55(12):1800-1807

난시교정인공수정체 삽입술 후 오교정에 대한 분석

전혜민,이경헌,Hye Min Jeon,Kyung Heon Lee 대한안과학회 2014 대한안과학회지 Vol.55 No.11

Purpose: To evaluate the efficacy and stability of AcrySof Toric intraocular lens (IOL) implants and to analyze the miscorrection that resulted after implantation. Methods: This retrospective study included 422 eyes of 348 patients who underwent cataract surgery with implantation of the AcrySof toric IOL between December 2011 and June 2013. We evaluated uncorrected visual acuity (UCVA), best corrected visual acuity (BCVA), keratometry and refraction preoperatively and 3 months postoperatively. The axis of implanted AcrySof Toric IOL was measured using the KR-1W aberrometer before mydriasis. At 3 months postoperatively, patients with a residual cylindrical power of 0.50 diopters (D) or more, and having an IOL rotation of 10 degrees (°) or more were considered having miscorrection. Results: UCVA (log MAR) improved from 0.58 ± 0.35 to 0.18 ± 0.26. Preoperative corneal astigmatism was 1.46 ± 0.72 D and postoperative refractive cylindrical power was 0.45 ± 0.30 D. The postoperative miscorrection was 50.5% in the T3 group, 35.7% in the T4 group, and 27.2% in the T5 group. The incidence of overcorrection was significantly higher in the T3 group than in the T4 and T5 group. In eyes with with-the-rule (WTR) astigmatism, overcorrection was found in 36.4% (32/88 eyes), while in eyes with against-the-rule (ATR) astigmatism, undercorrection was found in 37.6% of cases (44/117 eyes). There were five cases of IOL rotation at 3 months postoperatively. Conclusions: AcrySof Toric IOL was effective in correcting corneal astigmatism and had good rotational stability. However, the incidence of miscorrection, especially for overcorrection, was higher with lower power toric IOL. Patients with WTR astigmatism tend to have overcorrection, while those with ATR show a tendency toward undercorrection, suggesting that these changes considered at the time of cataract surgery.J Korean Ophthalmol Soc 2014;55(11):1636-1641

Shield TBM 챔버 내 mixing bar 교반 효율에 대한 기본연구

황병현,김상환,이경헌,안준규,조성우,김연덕,Hwang, Beoung-Hyeon,Kim, Sang-Hwan,Lee, Kyung-Heon,An, Jun-Kyu,Cho, Sung-Woo,Kim, Yeon-Deok 한국터널지하공간학회 2020 한국터널지하공간학회논문집 Vol.22 No.1

본 연구는 Shield TBM의 챔버 내 교반봉의 영향범위 및 배토효율 향상을 위한 기초연구이다. 현재 국내Shield TBM의 연구에 있어 디스크 커터, 커터 비트, 세그먼트에 관한 연구는 많이 이루어져 있다. 하지만 Shield TBM 굴착 시 막장면에서 유입되는 토사 및 암반들을 교반시켜 스크류 컨베이어로 배토시키는 연구는 해외에 비해 미비하다. 본 연구에서는 기존 Shield TBM 챔버를 축소모형으로 제작하여 실험을 진행하였다. 챔버 내부는 크기(4 mm, 6 mm, 8 mm, 10 mm)와 색(검은색, 흰색, 빨간색, 파란색)이 다른 시료를 사용해 층을 형성하였다. 이에 대하여 RPM과 교반봉의 형상 및 크기에 차이를 두어 실험을 진행하였다. 또한 중력의 방향이 교반 효율에 끼치는 영향을 파악하기 위하여 축소모형을 세웠을 때와 눕혔을 때의 교반 차이를 확인해 보았다. 이는 중력방향의 차이 외의 다른 조건은 모두 동일하게 진행하였다. 본 실험을 통해 챔버모형의 설치 방향, 내부의 교반봉 크기 및 형상, RPM에 따른 교반효과 및 Torque를 파악하였다. 교반효과 및 Torque를 비교 검토한 결과 교반봉의 형상 및 크기는 시료의 교반에 영향을 끼치며, 중력방향은 Torque에 영향을 끼치는 것을 확인하였다. This study is the basic study for improving the range of influence and potency of mixing bars in the chamber of Shield TBM. Currently, there are many studies on disk cutters, cutter bits and segments in the study of the domestic Shield TBM. However, studies that mix soil and rocks that come from the membrane during the Shield TBM excavation and scatter them with screw conveyors are not as good as those abroad. In this study, the existing Shield TBM Chamber was manufactured as a miniature and the experiment. Inside the chamber, different sizes (4 mm, 6 mm, 8 mm, 10 mm) and colors (black, white, red, and blue) were used to form layers. This experiment was carried out by different shapes and sizes of RPM and mixing bars. In addition, the difference between a miniature model and a reclining one was checked to determine the effect of the direction of gravity on the mixing efficiency. This was done in the same way for all other conditions other than differences in the direction of gravity. Through this experiment, we identified the orientation of the chamber model, the size and shape of the mixing bar inside, and the mixing effect and torque depending on RPM. A comparative review of the mixing effect and torque confirmed that the shape and size of the mixing bar affect the mixing of samples, and that the direction of gravity affects torque.

4가지 각막곡률측정 시스템을 이용한 굴절교정수술 후 인공수정체도수계산법 비교

이우석,문상정,이경헌,이동준,Woo Seok Lee,Sang Jeong Moon,Kyung Heon Lee,Dong Jun Lee 대한안과학회 2013 대한안과학회지 Vol.54 No.12

Purpose: To report the evaluation and comparison of true corneal power after corneal refractive surgery through ARK, Orbscan II<SUP>®, Pentacam and IOL master. <br /> Methods: Target IOL (Intraocular lens) power calculated with the SRK/T formula using SMK (Sungmo Eye Hospital keratometry), which is a new method for measuring corneal refractive power, was compared with the back-calculated ideal IOL power after cataract surgery for 30 eyes that required cataract surgery and had previously undergone refractive surgery. Target IOL powers calculated using 4 systems were compared with IOL power calculated using the clinical history method for 64 eyes that had undergone refractive surgery. <br /> Results: Using SMK with the SRK/T formula, the actual refraction was within ±0.5 diopter (D) of the intended refraction for 63.8% of eyes and within ±1.0 D for 90.9% of eyes. Compared with target IOL power calculated with the clinical history method, target IOL power calculated by SMK with the SRK/T formula had a difference of 1.95 ± 0.86 D, which was similar to the results calculated by the Haigis-L formula and by TNP with Haigis. <br /> Conclusions: The difference in characteristics of intraocular lenses subtly affects the vision quality as measured by values such as MTF cut-off and Strehl ratio after cataract surgery. OQAS based on the double-pass technique is considered useful in more objective estimates of the real retinal image quality after cataract surgery which is difficult to explain simply by measuring visual acuity.<br /> J Korean Ophthalmol Soc 2013;54(12):1818-1823

성공적인 펨토초레이저 백내장수술을 위한 수술 중합병증 위험인자 분석

양 헌(Heon Yang),한상엽(Sang Youp Han),이경헌(Kyung Heon Lee) 대한안과학회 2017 대한안과학회지 Vol.58 No.5

목적: 펨토초레이저 백내장수술 시 발생하는 합병증의 위험인자를 알아보고자 하였다. 대상과 방법: 2012년 7월부터 2017년 1월까지 본원에서 펨토초레이저 백내장수술을 시행한 337명 598안을 대상으로 연구를 실시하였 다. 모든 안에 투명각막절개, 수정체전낭절개, 수정체분할을 시행하였으며, 필요시 윤부이완절개술을 추가하였다. 수술 중 합병증은 녹화된 영상을 이용하여 결과를 확인하였고, 합병증 관련 위험인자는 의무기록을 후향적으로 분석하였다. 결과: 대상 환자군의 나이는 평균 62.1 ± 11.9세였으며, 불완전한 투명각막절개 18안 중 위험인자는 각막중심혼탁, 각막주변부변성, 익상편, 결막이완이 있었고, 불완전한 수정체전낭절개 43안 중 위험인자는 과숙백내장, 전극백내장, 각막중심혼탁, 비정상동공, 수정 체탈구, 산동불량이 있었으며, 불완전한 수정체분할 22안 중 위험인자는 과숙백내장, 수정체이탈, 각막중심혼탁, 전극 백내장, 비정상 동공이 있었다. SoftFit™ 인터페이스 사용 후 합병증 발생률은 투명각막절개(3.56%에서 2.24%, p=0.367), 수정체전낭절개(9.31%에서 4.03%, p<0.05), 수정체분할(5.20%에서 1.34%, p<0.05) 모두 감소하였으며, 초기 사례와 후기 사례의 합병증 발생률 비교 시 투명각 막절개, 수정체전낭절개, 수정체분할 모두 초기보다 후기에 발생률이 유의하게 감소하였다(p<0.05). 결론: 펨토초레이저는 백내장수술을 안전하고 효과적으로 할 수 있는 장점이 있다. 그러나 관련된 위험인자가 존재하는 경우 합병증의 가능성을 고려하여 접근해야 할 것으로 보이며, SoftFit™ 인터페이스를 사용하고, 술자의 숙련도가 높을수록 합병증 발생을 감소시킬 수 있을 것으로 생각된다. <대한안과학회지 2017;58(5):539-545> Purpose: To determine the risk factors of intraoperative complications in femtosecond laser-assisted cataract surgery. Methods: This study included 598 eyes of 337 patients who underwent femtosecond laser-assisted cataract surgery (FLACS) between July, 2012 and January, 2017. All eyes had corneal incisions, anterior capsulotomy, nuclear fragmentation, and limbal relaxing incisions (if required). Intraoperative complications were analyzed by watching videos, and the related factors of each complication were retrospectively reviewed alongside the medical records. Results: The mean age of the patients was 62.1 ± 11.9 years. Among the study group, 18 eyes required manual creation of corneal incisions; because the corneal incisions could not be made due to corneal central opacity, corneal peripheral degeneration, ptreygium, conjunctival chalasis, or idiopathic. The anterior capsulotomy was incomplete in 43 cases and manual capsulorrhexis was required for completion. These cases were associated with various conditions, including hypermature cataract, anterior polar or subcapsular cataract, corneal central opacity, pupillary abnormality, lens subluxation, poor pupil dilation, and idiopathic. Overall, 22 eyes had difficulties with nuclear fragmentation, with either mature cataract, lens subluxation, corneal central opacity, anterior polar or subcapsular cataract, or pupillary abnormality. Using the Laser SoftFit™ patient interface decreased the incidences of incomplete corneal incision (from 3.56% to 2.24%, p = 0.367), anterior capsulotomy (from 9.31% to 4.03%, p < 0.05), and nuclear fragmentation (from 5.20% to 1.34%, p < 0.05). The incidences of complications in the experienced group was statistically lower compared with the novice group (p < 0.05 for all comparisons). Conclusions: The femtosecond laser platform was effective and safe for cataract surgery. However, in the presence of related factors, use of this platform might need to be re-assessed and should be considered for intraoperative complications. Additionally, with the Laser SoftFit™ patient interface and improved surgeon experience, better intraoperative results can be expected for FLACS surgery. J Korean Ophthalmol Soc 2017;58(5):539-545

망막아세포종으로 오진되어 안구적출을 시행한 백색동공 2예

이윤석(Yoon Seok Lee),이경헌(Kyung Heon Lee) 대한안과학회 1985 대한안과학회지 Vol.26 No.5

GIS용, 에폭시/나노/마이크로 혼합 콤포지트의 부분방전 저항성의 침식특성

이일화(Il-Hwa Lee),김진원(Jin-Won Kim),이경헌(Kyung-Heon Lee),김철희(Chul-Hee Kim),한태호(Tae-Ho Han),김선진(Sun-Jin Kim),신동준(Dong-Jun Shin),임대혁(Dae-Hyuk Lim),이현지(Hyun-Ji Lee) 대한전기학회 2018 대한전기학회 학술대회 논문집 Vol.2018 No.-

투명각막절개술과 공막주머니절개술의 각막내피세포의 변화

이상엽(Sang Yeop Lee),박인철(In Chul Park),이경헌(Kyung Heon Lee) 대한안과학회 1998 대한안과학회지 Vol.39 No.12

무봉합 백내장수술에서 상측부와 이측부 투명각막 절개로 유도되는 각막난시변화의 비교

허영재(Young Jae Hu),이경헌(Kyung Heon Lee),추천기(Choun Ki Joo) 대한안과학회 1998 대한안과학회지 Vol.39 No.3