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김유라,이경욱,Kim, Yoo-Ra,Lee, Kyoung-Uk 대한불안의학회 2011 대한불안의학회지 Vol.7 No.1
Cognitive models of panic disorder have emphasized cognitive distortions' roles in the maintenance and treatment of panic disorder (PD). However, the patient's difficulty with identifying and managing emotional experiences might contribute to an enduring vulnerability to panic attacks. Numerous researchers, employing emotion processing paradigms and neuroimaging techniques, have investigated the empirical evidence for poor emotion processing in PD. For years, researchers considered that abnormal emotion processing in PD might reflect a dysfunction of the frontal-temporal-limbic circuits. Although neuropsychological studies have not provided consistent results regarding this model, a few studies have tried to find the biological basis of dysfunctional emotion processing in PD. In this article, we examine the possibility of dysregulation of emotion processing in PD. Specifically we discuss the neural basis of emotion processing and the manner in which such neurocognitive impairments may help clarify PD's core symptoms.
전태연,이경욱,이혁재,배치운,채정호,박원명,김광수,Jun, Tae-Youn,Lee, Kyoung-Uk,Lee, Hyuk-Jae,Pae, Chi-Un,Chae, Jeong-Ho,Bahk, Won-Myong,Kim, Kwang-Soo 대한생물정신의학회 2003 생물정신의학 Vol.10 No.1
Objective : Bipolar disorder is known to have strong genetic background and cellular immune activation. Based on the hypothesis that abnormalities of normal inhibitory control of T cell immunity can contribute to the pathophysiology of bipolar disorder, we investigated the relationship between the first exon at position +49(A/G) polymorphism of cytotoxic T lymphocyte antigen 4(CTLA4) gene and bipolar disorder. Method : Among the Korean patients diagnosed as bipolar disorder according to DSM-IV, 90 patients without serious medical illness, neurologic illness, hormonal disorder, or concomitant mental illness were selected. The normal control group consisted of 149 age-and sex-matched subjects without current or past history of autoimmune diseases or mental disorder. DNA was extracted from whole blood and the exon 1 region of CTLA-4 gene was amplified by polymerase chain reaction. Gene typing was performed using single strand conformation polymorphism. Results : There were no significant differences in genotype frequencies of G/G, G/A, and A/A between the patients with bipolar disorder and the control group(48.9% vs 46.3%, 44.4% vs 39.6%, and 6.7% vs 14.1%, respectively). There were no significant differences in allelic frequencies of G and A between the patients with bipolar disorder and the control group(71.1% vs 66.1%, and 28.9% vs 33.9%, respectively). Conclusion : This study did not show the association of exon 1 polymorphism of CTLA-4 gene with bipolar disorder.
기분장애 뇌신경기저에 대한 이해 : 뇌영상 연구를 중심으로
김유라,이경욱,Kim, Yoo-Ra,Lee, Kyoung-Uk 대한생물정신의학회 2011 생물정신의학 Vol.18 No.1
Mood disorder is unlikely to be a disease of a single brain region or a neurotransmitter system. Rather, it is now generally viewed as a multidimensional disorder that affects many neural pathways. Growing neuroimaging evidence suggests the anterior cingulate-pallidostriatal-thalamic-amygdala circuit as a putative cortico-limbic mood regulating circuit that may be dysfunctional in mood disorders. Brain-imaging techniques have shown increased activation of mood-generating limbic areas and decreased activation of cortical areas in major depressive disorder(MDD). Furthermore, the combination of functional abnormalities in limbic subcortical neural regions implicated in emotion processing together with functional abnormalities of prefrontal cortical neural regions probably result in the emotional lability and impaired ability to regulate emotion in bipolar disorder. Here we review the biological correlates of MDD and bipolar disorder as evidenced by neuroimaging paradigms, and interpret these data from the perspective of endophenotype. Despite possible limitations, we believe that the integration of neuroimaging research findings will significantly advance our understanding of affective neuroscience and provide novel insights into mood disorders.
정나영,채정호,이경욱,Jung, Na-Young,Chae, Jeong-Ho,Lee, Kyoung-Uk 대한불안의학회 2012 대한불안의학회지 Vol.8 No.1
Patients with panic disoder (PD) show recollection of their first panic attack, which resembles a trauma that is perceived as an unexpected frightening and subjectively life-threatening event. Information-processing models suggest that anxiety disorders may be characterized by a memory bias for threat-related information. This paper reviews the previous researches that investigated the implicit and/or explicit biases in patients with panic disorder. Among the 17 studies, which addressed the explicit memory bias in PD patients, 11 (64.7%) were found to be explicit memory bias in PD patients. In regards to the implicit memory bias, 4 out of 9 studies (44.4%) were found to support the memory bias. The result shows that evidence of explicit memory bias in PD patients was supported by a number of previous researches. However, evidence of implicit memory bias seems less robust, thus, needs further research for replication. Also, development of new paradigms and applications of various methods will be needed in further researches on memory bias in PD patients.
정서가 및 각성수준에 대한 자가 평가 마네킹 척도개발 및 표준화
강은호,최정은,함병주,석정호,이경욱,김원,이승환,임현국,박영민,양종철,안미경,이재선,채정호,Kang, Eun-Ho,Choi, Jeong-Eun,Ham, Byung-Joo,Seok, Jeong-Ho,Lee, Kyoung-Uk,Kim, Won,Lee, Seung-Hwan,Lim, Hyun-Kook,Park, Young-Min,Yang, Jong-Chul,Ahn 대한불안의학회 2011 대한불안의학회지 Vol.7 No.2
Objectives : The Self-Assessment Manikin (SAM) developed by Bradley and Lang is a non-verbal pictorial assessment tool that measures human emotion and has been widely used. However, the pictures in SAM have not been easy for Korean subjects to understand or relate to. The authors developed a new manikin (Emotional Valence and Arousal Manikin, EVAS) modeling it after Korean faces while modifying and standardizing the SAM. Methods : Forty-one healthy subjects participated in this study. They were asked to rate the emotional valence and level of arousal using both the SAM and EVAS after being exposed to pictures of facial expressions for affective neurosciences-Korean version. The internal consistency of the EVAS and the correlation between EVAS and SAM were examined. Resuts : Internal consistencies of the valence using the EVAS were from 0.63 (surprise) to 0.82 (happiness) and those of the arousal were from 0.90 to 0.95. Correlation coefficients of the valence and arousal between the SAM and EVAS were from 0.61 (both surprise and disgust) to 0.84 (neutral) and from 0.82 (sadness) to 0.94 (fear), respectively. Conclusions : We developed a new manikin (the EVAS) for the Korean population modifying and standardizing the SAM. The EVAS demonstrated a good internal consistency and validity. As such, it can be used in the field of human emotion research.
정신분열형 인격 성향이 정상인의 안면 표정 인식 능력에 미치는 영향
이현륭,김승연,추정숙,이경욱,채정호,박영민,김현,이강준,정영조,이승환,Yi, Hyeon-Lyung,Kim, Seung-Yeon,Choo, Jung-Suk,Lee, Kyoung-Uk,Chae, Jeong-Ho,Park, Young Min,Kim, Hyun,Lee, Kang Joon,Chung, Young-Cho,Lee, Seung-Hwan 대한생물정신의학회 2008 생물정신의학 Vol.15 No.4
Objectives : The purpose of this study is to investigate whether the ability of facial affect perception is associated with schizotypal personality traits in healthy normal controls. Methods : 241 normal subjects were recruited in this study. The age range of all subjects was from 19 to 63 years. The schizotypal personality questionnaire(SPQ) and facial affect identification test(FAIT), which were developed and standardized in Korea, were applied. Subjects from high 1 standard deviation(H group, N=40) and low 1 standard deviation(L group, N=26) on SPQ score were compared. Results : We found that the H group showed significantly reduced ability on the correctness of sadness and neutral compared with the L group. But, no significant association between SPQ and intensity or reaction point was observed in all subjects. Conclusion : This study suggests the individuals with high schizotypal personality trait have impairments on the facial affect identification. Also, these findings may provide the reasonable explanation of social cognition deficit of schizotypal personality disorder.
소방공무원에서 우울 및 불안에 작용하는 대인관계 민감성/리질리언스의 영향
김선영,정나영,연보라,황선영,이경욱,Kim, Sun-Young,Jung, Na Youn,Yeon, Bora,Hwang, Sun-Young,Lee, Kyoung-Uk 대한불안의학회 2011 대한불안의학회지 Vol.7 No.2
Objective : This study aimed to ascertain the effect of interpersonal sensitivity/resilience on depression and anxiety in firefighters whose frequency of exposure to traumatic events is high. Method : A survey was performed and data related to 75 firefighters were analyzed. Questionnaires included the Beck Depression Inventory (BDI) and Impact of Event Scale-Revised (IES-R). To assess the susceptibility or protector roles with respect to psychopathology, the Interpersonal Sensitivity Measure (IPSM) and Conner-Davidson Resilience Scale (CD-RISC) were used. Results : The personality characteristic, interpersonal sensitivity (IPSM) showed a significant positive correlation with depression (BDI, r=0.557, p<0.001) and posttraumatic stress symptoms (IES-R, r=0.316 ; p<0.001). In contrast, resilience and symptom parameters (BDI, IES-R) were negatively correlated with each other, but not statistically significant. However, an adaptive factor for change, a third sub-factor of CD-RISC, had significant negative correlation with depression and anxiety symptoms (BDI, r=-0.275, p<0.005 ; IES-R, r=-0.254, p<0.005). Conclusion : The results of the present study showed that some personality traits may act as vulnerability or protective factors with respect to the psychopathologies of depression and anxiety.
조중범(Joong-Bum Jo),이정태(Chung-Tai Lee),권용실(Yong-Sil Kweon),이경욱(Kyoung-Uk Lee),이해국(Hae-Kook Lee),조선진(Sun-Jin Jo),김한오(Hano Kim) 한국중독정신의학회 2011 중독정신의학 Vol.15 No.2
Objective : The aim of this study was to estimate the prevalence of hazardous drinking in a representative community sample of Seoul, Korea and to assess the sociodemographic and psycho-logical factors associated with hazardous drinking. Methods : Sociodemographic data, scores for AUDIT-K and other psycho-logical screening instruments were collected from a sample of 798 individuals from one of the municipal areas of Seoul. Recruitment was done based on a stratified-multistage-cluster sampling. Results : The 12-month prevalence of hazardous drinking was 36.6% (60.5% of males and 18.5% of females). Considering the sample as a whole, multiple logistic regression analysis showed that the risk factors of hazardous drinking were male (adjusted OR=7.96, 95% CI 5.36-11.83), young age (18-29 years old, adjusted OR=3.84, 95% CI 1.81-8.17) and high stress level (adjusted OR=1.72, 95% CI 1.19-2.49). Among males, the widowed/separated/divorced (adjusted OR=5.76, 95% CI 1.17-28.27) and high stress level (adjusted OR=1.68, 95% CI 1.03-2.75) were significant risk factors for hazardous drinking. In the case of females, young age (adjusted OR=6.22, 95% CI 2.04-18.94), high stress level (adjusted OR=2.01, 95% CI 1.12-3.61) and low resilience (adjusted OR=2.15, 95% CI 1.19-3.89) were risk factors for hazardous drinking. Conclusion : The prevalence of hazardous drinking in Seoul in this study was demonstrated to be one of the highest in the world. Our results also suggested that hazardous drinking was further associated with sociodemographic factors than with psychological factors. Preventive measures and intervention pro-grams should be tailored to males, young females and people with stressful life events to reduce the hazardous drinking in the community.