백서(白鼠)에 유도된 알러지성 피부염에 대한 초감탕(椒甘湯)의 효과

윤희성,박외숙,김희정,김규석,김윤범,Yoon, Hui-Sung,Park, Owe-Suk,Kim, Hee-Jeong,Kim, Keoo-Seok,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.3

Background and Objectives: Allergic contact dermatitis is a common environmental health issue and seriously affect the patient's quality of life. The more our environment industrialized, the number of material that could cause the allergic contact dermatitis has been increased, consequently the prevalence of allergic contact dermatitis has been increased. In oriental medicine, clinically Chogam-Tang has been used fur the treatment of allergic dermatitis, eczema, atopic dermatitis etc. The objective of this study is to investigate the effects of Chogam-Tang on allergic contact dermatitis Meterial and Methods: Fifteen Sprague-Dawley rats were divided into three groups: normal, control, experimental group. Control and experimental group were induced allergic contact dermatitis, by DNCB. Experimental group was orally administered the Chogam-Tang. Each group was observed after 24, 48 and 72 hours. Contact hypersensitivity assay, melanin-erythema measurement, pH measurement skin moisture measurement and biopsy were performed. Results: 1. In contact hypersensitivity assay, experimental group showed decreased ear swelling compared with control group at 48hours. 2. ln melanin measurement there was no difference in three groups. 3. In erythema measurement experimental group showed reduction at 48. 72 hours. 4. In pH measurement, experimental group and control group showed increase in pH but there was no statistical significance. 5. In skin moisture measurement, experimental group showed higher skin moisture level than control group at 24 hours and showed lower skin moisture level at 72 hours, but there was no statistical significance. 6. In biopsy, experimental group showed decrement of Iymphocyte as time goes by, and regeneration of keratin layer was increased compared with normal group. Conclusions: Chogam-Tang shows anti-inflammatory effect in biopsy, improves hydration levels of skin, decreases erythema level on allergic contact dermatitis.

발양통음탕(發陽通陰湯)이 살리실산나트륨 이독성에 대한 흰쥐 와우의 형태학적 변화에 미치는 영향

윤희성,남혜정,김윤범,Yoon, Hui-Sung,Nam, Hae-Jeong,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.1

Background and Objectives : Despite of high prevalence, Tinnitus remains obscure because the cause and mechanism is poorly understood. In the absence of a suitable animal model, past investigations tool place in humans. Recently, the animal model with sodium salicylate ototoxicity is broadly used because of its reversibility. Balyangtongum-Tang had been used clinically to treat tinnitus and other hearing problems. We investigated the effects of Balyangtongum-Tang on cochlear morphologic change induced by sodium salicylate ototoxicity and were to find out its therapeutic effects on ototoxicity in rat model. Materials and Methods : Healthy ten Sprague-Dawley rats were divided into normal(2), control(4) and sample(4) groups. The sample group was given extract of Balyangtongum - Tang(1cc/100g) once a day for 4 days. After 3 hours when last medication were given, the sample and control groups were injected intraperitoneally with sodium salicylate(500mg/kg). We observed the cochlear morphologic changes of rats every 1, 2, 3 and 5 hours after injection. Results : The electron microscopic finding of outer hair cell shows some changes in the curticular plate and cytoplasm. Some vacuoles were found in the control and sample groups. Vacuolization in the curticular plate and cytoplasm of the sample group after 3, 5 hours were similar to the control group. But the curticular plate of the sample group after 1, 2 hours did not from vacuole. On the other hand the control group after 1, 2 hours formed vacuoles in the curticular plate. Light microscopic findings of cochlear duct in control and sample groups didn't find any difference. Conclusion : The results suggest that extract of Balyangtongum-Tang reduces the morphologic changes induced by sodium salicylate ototoxicity and the effects are remarkable in frist 2 hours. However the effective times are different with previous studies, it seems to due to the difference of tolerance and sensitivity of laboratory animals.

蘆회 Dressing을 활용한 급성기 아토피피부염 환자 치험 8례

윤희성,이길영,김윤범,Yoon, Hui-Sung,Lee, Gil-Young,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2004 한방안이비인후피부과학회지 Vol.17 No.3

In addition to antiseptic/antibiotic regimens, current therapies such as topical and systemic corticosteroids, anti-histamine agents, immune suppressing agent are generally used in the western medicine to treat atopic dermatitis(AD). However, there is almost a complete lack of effective strategies to achieve long-term control of disease, oriental medical treatments are proposed an alternative measure. It has been proved by experimental and clinical study that Oriental medical atopic dermatitis(AD) treatments such as herb-medicine, acupuncture and moxibustion therapy, and steam therapy are effective in long-term treatment. Nevertheless, oriental medical therapy has some limitations to treat acute stage of the disease. Recently developed No-Hoe(蘆?: Aloe vera L.) extract dressings will be a supplementary methods to the oriental medical therapy. The dressing can subside pruritus, exudation, erythema and scaling in the acute stage of atopic dermatitis(AD). We applied the No-Hoe(蘆?: Aloe vera L.) extract dressings to eight atopic dermatitis patients and got some good effects. This reports will provide an alternative choice for the oriental and westernal medical therapy for long-term AD treatment.

Tympanometry를 이용한 삼출성 중이염의 임상적 관찰에 대한 연구

박외숙,윤희성,김희정,김규석,김윤범,Park, Owe-Suk,Yoon, Hui-Sung,Kim, Hee-Jeong,Kim, Keoo-Seok,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.3

Objective: In order to help clinical approach on OME patient in progress observation and decision on improvement by clinical research results using tympanometry. Methods: Data was collected from 163 ears of 96 patients who were treated in Dept. of Oriental Medical Ophthalmology & Otolaryngology & Dermatology, Kyung-Hee Medical Center from 2001-2-12 to 2005-4-29 for Otitis Media with Effusion(OME). Tympanometry was applied to all patients and the test result was used to evaluate progress and improvement. F/U cases below 3 times were excluded. Results & conclusion: 1. Age and sex distribution was as follows: Mean Age 5.5years old(Standard deviation: 2.1), age distribution 2-61years old, below 10years old 151cases(92.6%) and above 10years old 12cases(7.4%). Male and female ratio was 1.81:1. 2. There were 67people(69.8%) with bilateral affected ear. Unilateral was 29people(30.2%). Affected ear distribution according to sex came out similarly. 3. Affected period distribution was as follows: over 12weeks 71cases(43.6%), under 12weeks 92cases(56.4%). Out of under 12weeks cases, 2-4weeks was 34cases(20.9%), 0-1weeks and 5-8weeks 20cases(12.3%), 9-12weeks 18cases(11.0%). There was evident difference about affected period between male and female. 4. All patients who served previous Tx in medical clinic(118 cases) took antibiotics. Only 6cases took tube insertion. The period of Taking antibiotics was as fellows: over 6weeks 42cases(35.6%), under 5weeks 37cases(31.4%). unknown 25cases(21.2%), jntermittent 14cases(11.9%). 5. In Period of Tx distribution, 5-6weeks showed 40cases(24.5%) which was highest number. In Improved cases(85cases), 3-4weeks and 5-6weeks each 22cases(25.9%) which was highest number. 1-2weeks 3cases(3.5%), 7-8weeks 12cases(14.1%), 9-10weeks 9cases(10.6%), 11-12weeks 10cases(11.8%), over 12weeks 7cases(8.2%). 6. The cases which have gastrointestinal Sx were 71cases(43.6%), the others 92cases(56.4%). Details of gastrointestinal Sx were as follows: Sx associated with appetite 47cases(47.5%), constipation 15cases(15.2%), abdominal pain and diarrhea 14cases(14.1%), frequent vomitting Teases(7.1%), etc 4cases(4.0%). 7. The cases which have accompanying disease were 116case(71.2%), the other 47cases(28.8%). Details a accompanying disease were as follows: sinusitis 57cases(35%), rhinitis 55cases(3.7%), allergic rhinitis 20cases(12.3%), atopic dermatitis 19cases(1.7%), urticaria 4cases(2.5%), asthma 3cases(1.8%), nasal polyp and conjunctivitis 2cases(1.2%) each, laryngitis 1case(0.6%).

삼출성 중이염 환자의 경과 관찰 시(時) tympanometry 사용의 유용성

김희정,윤희성,박외숙,김규석,김윤범,Kim, Hee-Jeong,Yoon, Hui-Sung,Park, Owe-Suk,Kim, Keoo-Seok,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.2

Background: Otitis media with effusion(OME) is one of the most common disease in childhood. Patient suffers from OME in many quarters. For example hearing loss, effects on speech, language, learning, behaviouralchanges etc. But the diagnosis of OME is difficult using only medical history and otoscopy. So, many other diagnostic tools are developed and tympanometry is one of them. When OME is treated by oriental medical Tx, tympanometry would be useful instrument. Objectives: To gain insight into the usability of tympanometry in F/U of OME treated by oriental medial Tx. Methods: Data was collected from 123 ears of 74 children who was treated by oriental medical Tx. Data includes sex, age, period of Tx, elapsed time to be improved, tympanograms and accompanied symptoms. The relationship between items was analysed by statistical methods. Results: There is no relationship between age, sex and period of Tx/elapsed time to be improved. When cough and phlegm is accompanied, the period of treatment and elapsed time to be improved are expanded. When improvement was seen on tympanogram, the period of treatment is expanded but the improvement was seen within 30days, the period of treatment is reduced. Conclusion: The application of tympanometry in oriental medical treatment of OME would provide us many informations about the status of patient so it will be helpful to predict the history of a case and to make a decision whether keep up treatment or not.

현훈(眩暈) 치험(治驗) 2례(例)

김규석,윤희성,박외숙,김희정,김윤범,Kim, Keoo-Seok,Yun, Hui-Sung,Park, Owe-Suk,Kim, Hee-Jeong,Kim, Yoon-Bum 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.3

Damum(痰飮) is a kind of pathologic secretion products that excessive water is accumulated in a part of body. Damhun(痰暈) is the vertigo induved by Damum(痰飮). We experienced two clinical cases treated vertigo by orietal medicine(herbal medication, acupuncture). 33-years old male and 63-years old female patients had Damhun(痰暈), vertigo by Damum(痰飮). We administered Banhabaechulcheoma-tang(Pansiabaichutienma-tang) and Yeonggyechulgam-tang(Lingguishugna-tang) to each Patient, and two Patients improved vertigo and referred symptoms. In other words, this study is that We did not limited peripheral vertigo to vestibular system, made a diagnosis of Damum(痰飮) and treated vertigo by orietal medicine(herbal medication, acupuncture) referred to many medical practitioner of many generations. We suggest that digestive sypmtom(related to Damum(痰飮), abdominal examination and stool frequency are closely associated with vertigo and could be estimated prognosis of vertigo.

인공수정체 공막고정술 후 발생한 푸르처 유사 망막병증 1예

한상엽,강재훈,최영락,천희종,윤희성,Sang Youp Han,Jae Hoon Kang,Yeung Rak Choi,Hui Jong Chun,Hee Sung Yoon 대한안과학회 2006 대한안과학회지 Vol.47 No.9

Purpose: We report a case of Purtscher-like retinopathy following the removal of a dislocated IOL and scleral fixation of a new IOL. Methods: A 60-year-old man presented with sudden visual loss of the right eye. An ophthalmologic examination revealed IOL dislocation. He underwent removal of the dislocated IOL and scleral fixation of the new IOL. Visual acuity was 0.02 in the right eye on the second postoperative day. A fundus examination and fluorescein angiography were performed. Results: A peripapillary multiple cotton wool spot, pale macula and cherry red spot were noted in the right eye. Fluorescein angiography showed arteriolar obstruction around the macula and leakage of the mild arteriolar fluorescein dye. At one month follow-up, macular edema, hemorrhage and peripapillary cotton wool spots were increased. Conclusions: This case of Purtscher-like retinopathy following scleral fixation of the IOL did not have any obvious etiologic cause.

블루투스 터치센서 입력기를 이용한 시각 장애인용 음성 기반 메신저

이정일(Jung-Il Lee),이동환(Dong-Hwan Lee),박승제(Sueng-Je Park),윤희성(Hui-Sung Yoon),김수희(Su-Hui Kim),황병곤(Byung-Kon Hwang),원희철(Hui-Chul Won) 한국멀티미디어학회 2008 한국멀티미디어학회 학술발표논문집 Vol.2008 No.1

컴퓨터 기술의 발달과 함께 인스턴트 메신저의 종류와 기능이 다양해지면서 인터넷이 가능한 어디에서나 멀리 떨어져 있는 상대방과 실시간으로 메시지를 주고받을 수 있게 되었다. 하지만, 이러한 기술의 발달도 시각 장애인들에겐 아무런 도움이 되지 못했다. 이에 본 논문에서는 시각 장애인을 위한 음성 기반 메신저를 개발하였다. 먼저, 메신저를 통해 정보가 수신되면 TTS (text to speech) 라이브러리를 이용하여 수신된 내용을 음성으로 변환시켜 소리로 들려줌으로써, 상대방이 입력한 대화 내용을 볼 수 없는 시각장애인의 불편함을 일부 해소시켰다. 또한, 대화 내용을 입력하여 상대방에게 전송하기 위해, 키보드 대선 NXT 터치센서 장비와 연동시켰다. NXT 터치센서 장비에 블루투스 무선통신 기능을 포함시켜 시각장애인을 위한 무선 점자 입력기로 사용 가능하도록 하였다. 시각장애인이 각 알파벳에 해당하는 터치센서를 누르면 블루투스 무선통신을 통해 사용자 메신저에 입력된다. 상대방에게 전송하기 전에 메신저에 입력한 내용을 확인하고자 할 때는, 엔터키에 해당하는 터치센서를 눌러 입력된 내용을 소리로 들을 수 있게 하였다. 엔터키 터치 센서를 한번 더 누르면 상대방 메신저로 전송되게 함으로써 시각 장애인도 쉽게 메신저를 이용할 수 있다.