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인체 폐암종의 C - JUN 및 세포주기 조절과 관련된 CDC - 2 의 발현에 관한 명역조직화학적 연구
윤호주(Ho Joo Yoon),신동호(Dong Ho Shin),박성수(Sung Soo Park),이동후(Dong Hoo Lee),이정희(Jung Hee Lee),이중달(Jung Dal Lee) 대한내과학회 1994 대한내과학회지 Vol.47 No.2
N/A Objectives: C-jun structural and functional properties of transcriptional factor, activator protein 1 (AP- 1). The cdc2 kinase is known to be a key regulator of eukaryotic cell cycle and is believed to act in both G1 and G2 phases. The aim of this study is to evaluate the role of c-jun and cdc2 in human primary lung cancers. Methods: Expression of c-jun and cdc2 was investigated in tissue sections of twenty three cases with lung cancers and seven cases with non-cancerous lung tissues by immunohistochemical method. Recombinant cloned polyclonal antibodies of c-jun/AP-1 and cdc2 were employed as primary antibodies after dewaxing the formalin-fixed, paraffinized tissue sections. Results: C-jun was expressed in the nuclei of tumor cells of lung cancers in twenty cases of twenty three primary lung cancers (87.0%). The expression of c-jun was disclosed in six cases of seven small cell lung carcinomas and forteen cases of sixteen non small cell lung carcinomas. Also, expression of cdc2 was noted in the nuclei of tumor cells of lung cancers in ninteen cases of twenty three primary lung cancers (82.6%). The expression of cdc2 was disclosed in six cases of seven small cell lung carcinomas and thirteen cases of sixteen non small cell lung carcinomas. Expression of c-jun and cdc2 was not discernibie in the fourteen with non- cancerous lung tissues. Conclusion: These findings suggest that upregulation of c-jun and cdc2 is involved during development and growth of primary lung cancers.
시멘트형 대퇴스템 부정정렬 예방을 위한 수술 중 방사선 촬영의 유용성
윤호현 ( Ho Hyun Yun ),윤정로 ( Jung Ro Yoon ),이용인 ( Yong In Lee ),윤세혁 ( Se Hyeok Yun ),김경호 ( Kyoung Ho Kim ) 대한고관절학회 2013 Hip and Pelvis Vol.25 No.2
목적: 시멘트형 대퇴스템을 사용한 인공고관절 치환술을 시행 중 임시 대퇴삽입물(broach)을 삽입한 상태에서 c-arm 촬영을 통하여 대퇴스템 정렬 상태를 예측하여 부정정렬을 예방하였던 저자들의 방법의 유용성을 평가하고자 하였다. 대상 및 방법: 2011년 10월부터 2013년 2월까지 일차 인공 고관절 부분치환술이나 인공 고관절 전치 환술을 시행 받은 103예를 대상으로 후향적으로 연구를 시행하였다. 수술 중 예측된 대퇴스템 정렬각 및 최종 대퇴스템 정렬각들을 세 군 분류하였고, 수술 중 예측된 대퇴스템 정렬각에 영향을 미칠 수 있다고 예상된 요인들(나이, 성별, 진단명, 체질량 지수, 대퇴스템 크기, 골다공증, 근위대퇴골 형태)에 대한 분석을 위해서 multinomial logistic regression analysis를 시행하였다. 결과: 수술 중 예측된 대퇴스템 정렬각은 중립위 군이 80예, 내반위 군이 18예, 외반위 군이 5예 등으로 분포하였다. 최종 대퇴스템 정렬각은 중립위 군이 100예, 내반위 군이 2예, 외반위 군이 1예 등으로 분포하였다. 수술 중 예측된 대퇴스템 정렬각에 통계적으로 유의하게 영향을 미치는 요인은 없었다. 결론: 저자들이 시행하였던 방법이 시멘트형 대퇴스템의 부정정렬을 예방하는데 있어서 유용하였다고 생각한다. Purpose: The purpose of this study was to evaluate the usefulness of our method, which estimated femoral stem alignment using a c-arm when the broach was inserted, for prevention of femoral stem malalignment. Materials and Methods: A total of 103 hips were enrolled in this study. All patients underwentprimary hip arthroplasty from October 2011 to February 2013. The study was conductedretrospectively. Intraoperative estimated femoral stem alignments and final femoral stem alignments were classified into three groups. Multinomial logistic regression analysis was performed for analysis of factors (age, sex, diagnosis, body mass index, femoral stem size, osteoporosis, and proximal demur geometry) thatmight affect intraoperatively estimated femoral stem alignment. Results: The distribution of intraoperative estimated femoral stem alignment was 80(78%) in the neutral group, 18(17%) in the varus group, and 5(5%) in the valgus group. The distribution of final femoral stem alignment was 100(97%) in the neutral group, 2(2%) in the varus group, and 1(1%) in the valgus group. There was no statistically significant factor affecting the intraoperatively estimated femoral stem alignment. Conclusion: Intraoperative estimated femoral stem alignment using a c-arm is an effective method for prevention of femoral stem malalignment.
윤호열 ( Ho-yeol Yoon ),김미해 ( Mee-hea Kim ) 한국고등직업교육학회 2003 한국고등직업교육학회논문집 Vol.4 No.1
This study analyzed teacher's belief system about aggressiveness and social withdrawal of pre-school aged children. The results are summarized as follows: First, teachers attributed aggressiveness of pre-school aged children to external factors and social withdrawal to temporal state. Second, teachers showed stronger emotional responses toward aggressiveness than social withdrawal of children, particularly showed more anger and embarrassed toward aggressiveness. And they worried more about social withdrawal than about aggressiveness of children. Third, teachers used more various social strategies toward aggressiveness than toward social withdrawal of children, and they more showed no response to the latter. However, they used supportive and constructive strategies most toward both aggressiveness and social withdrawals of children. Fourth, when the differences of teachers belief system was compared with according to the levels of aggressiveness and social withdrawals of children, the difference showed only with the disposition of aggressiveness in the case of attribution, and not in the emotional responses and social strategies of teachers.
특집: 주요 알레르기질환의 진단과 치료 : 기관지천식의 최신 약물 치료 지침
윤호주 ( Ho Joo Yoon ) 대한내과학회 2009 대한내과학회지 Vol.76 No.3
Asthma is a serious health problem throughout the world with high prevalence and increased socioeconomic burden. So in order to have a better understanding and medication for this illness, many scientific advances have been made. To specify, Global Initiative for Asthma (GINA) and National Asthma Education and Prevention Program (NAEPP) have played a leading role in disseminating information about the care for patients based on a process of continuous review of published scientific investigations. For these outstanding accomplishments, GINA and NAEPP guidelines are now being widely adopted, translated and reproduced, forming the basis for many national guidelines throughout the world. These guidelines recommend a change in approach to asthma management with asthma control, rather than asthma severity, being the focus of treatment decisions. Most importantly, these provide stepwise drug therapy of asthma based on the level of control. This session will mainly focus on updated stepwise drug therapy. (Korean J Med 76:260-267, 2009)