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인체 폐암종의 C - JUN 및 세포주기 조절과 관련된 CDC - 2 의 발현에 관한 명역조직화학적 연구
윤호주(Ho Joo Yoon),신동호(Dong Ho Shin),박성수(Sung Soo Park),이동후(Dong Hoo Lee),이정희(Jung Hee Lee),이중달(Jung Dal Lee) 대한내과학회 1994 대한내과학회지 Vol.47 No.2
N/A Objectives: C-jun structural and functional properties of transcriptional factor, activator protein 1 (AP- 1). The cdc2 kinase is known to be a key regulator of eukaryotic cell cycle and is believed to act in both G1 and G2 phases. The aim of this study is to evaluate the role of c-jun and cdc2 in human primary lung cancers. Methods: Expression of c-jun and cdc2 was investigated in tissue sections of twenty three cases with lung cancers and seven cases with non-cancerous lung tissues by immunohistochemical method. Recombinant cloned polyclonal antibodies of c-jun/AP-1 and cdc2 were employed as primary antibodies after dewaxing the formalin-fixed, paraffinized tissue sections. Results: C-jun was expressed in the nuclei of tumor cells of lung cancers in twenty cases of twenty three primary lung cancers (87.0%). The expression of c-jun was disclosed in six cases of seven small cell lung carcinomas and forteen cases of sixteen non small cell lung carcinomas. Also, expression of cdc2 was noted in the nuclei of tumor cells of lung cancers in ninteen cases of twenty three primary lung cancers (82.6%). The expression of cdc2 was disclosed in six cases of seven small cell lung carcinomas and thirteen cases of sixteen non small cell lung carcinomas. Expression of c-jun and cdc2 was not discernibie in the fourteen with non- cancerous lung tissues. Conclusion: These findings suggest that upregulation of c-jun and cdc2 is involved during development and growth of primary lung cancers.
특집: 주요 알레르기질환의 진단과 치료 : 기관지천식의 최신 약물 치료 지침
윤호주 ( Ho Joo Yoon ) 대한내과학회 2009 대한내과학회지 Vol.76 No.3
Asthma is a serious health problem throughout the world with high prevalence and increased socioeconomic burden. So in order to have a better understanding and medication for this illness, many scientific advances have been made. To specify, Global Initiative for Asthma (GINA) and National Asthma Education and Prevention Program (NAEPP) have played a leading role in disseminating information about the care for patients based on a process of continuous review of published scientific investigations. For these outstanding accomplishments, GINA and NAEPP guidelines are now being widely adopted, translated and reproduced, forming the basis for many national guidelines throughout the world. These guidelines recommend a change in approach to asthma management with asthma control, rather than asthma severity, being the focus of treatment decisions. Most importantly, these provide stepwise drug therapy of asthma based on the level of control. This session will mainly focus on updated stepwise drug therapy. (Korean J Med 76:260-267, 2009)
정량분무식 에어러졸 사용시 propellant에 의한 기도수축반응
반준우,윤호주,손지웅,조상헌,최동철,민경업,김유영 (Jun Woo Bahn,Ho Joo Yoon,Jee Woong Son,Sang Heon Cho,Dong Chull Choi,Kyung Up Min,Yon Young Kim) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.1
Background: Bronchoconstriction associated with aerosolized agents delivered by a metered dose inhaler (MDI) is relatively uncommon, but has been of particular interest. Material and Method: In this study, we investigated to what extent the inert ingredients and propellants (freons) influence pulmonary function in 25 asthmatic patients. Forced expiratory volume in one second(FEV,) was measured by spirometry, Autospira HI 498(Chest, Japan) before and 1, 3, 5 and 10 minutes after the inhalation of saline control and MDI-placebo containing freons and inert ingredients. Res ult: Twenty four % (6/25) of asthmatics experienced a decrease in FEV20 by 10% or greater when compared to saline control. Number of positive cases in steroid dependent asthmatics is significantly higher compared to non-steroid dependent asthmatics. (p <0.05) Bronchoconstriction associated with the use of MDI-placebo appeared within 3 to 5 minutes and resolved spontaneouly at 10 minutes after the inhalation. Conclusion: The bronchoconstrictive response induced by MDI might be caused by the pro- pellants and/or the other inert ingredients contained in MDIs.
류마티스 관절염 환자에서 Adalimumab 사용 후 발생한 사르코이드증
이승호 ( Seung Ho Lee ),김사일 ( Sa Il Kim ),송준석 ( June Seok Song ),김태형 ( Tae Hyung Kim ),손장원 ( Jang Won Sohn ),김상헌 ( Sang Heon Kim ),윤호주 ( Ho Joo Yoon ),김태환 ( Tae Hwan Kim ),신동호 ( Dong Ho Shin ),박성수 ( Sung 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.71 No.6
Adalimumab is a full human monoclonal antibody that inhibits tumor necrosis factor-alpha (TNF-α). This has recently been shown to be effective in the treatment of rheumatoid arthritis (RA), ankylosing spondylitis, and other conditions. Sacoidosis is known to be the target for adalimumab but we describe a patient who has developed sarcoidosis with lung involvement during adalimumab therapy for RA. A 48-year-old woman, who was treated with adalimumab for 5 months, was admitted because of chronic cough and both hilar lymphadenopathy on chest radiography. Chest computed tomography revealed the enlargement of multiple lymph nodes in the right supraclavicular, subcarinal, both hilar and right axillary area. She was diagnosed with sarcoidosis based on the biopsy of supraclavicular lymph node, skin and lung through video-associated thoracoscopic surgery, which was non-caseating epitheloid cell granuloma and excluded from a similar disease. She was treated for sarcoidosis with prednisolone and methotrexate instead of adalimumab.
기관지 결핵의 임상상과 내시경소견 (1990-2001)
박은주 ( Eun Joo Park ),김미옥 ( Mi Ok Kim ),양석철 ( Seok Chul Yang ),손장원 ( Jang Won Sohn ),윤호주 ( Ho Joo Yoon ),신동호 ( Dong Ho Shin ),박성수 ( Sung Soo Park ) 대한내과학회 2003 대한내과학회지 Vol.64 No.3
목적: 기관지 결핵은 반흔으로 치유되어 기관지 협착증, 무기폐, 이차적으로 폐렴을 초래할 수 있다. 기관지 결핵은 조기 진단 또는 결핵균 검출이 절실한 질환중 하나이지만 그 임상 증상이나 흉부 X-선상 천식이나, 폐암 등 다른 질환들과 유사하며, 객담 도말 항산균검사에서도 음성인 경우가 많아 진단이 용이하지 않다. 이에 저자들은 1990년도 1월부터 2001년 6월까지 한양대학교 부속병원 호흡기내과에서 시행한 굴곡성 기관지경을 통해 기관지결핵으로 진단된 Background: Endobronchial tuberculosis is a serious complication of pulmonary tuberculosis and may result from rupture of an infected lymph node through the bronchial wall or from lymphatic spread to the mucosal surface of the bronchial tree. It is a majo