중증 재생불량성 빈혈환자의 구강악안면외과적 관리

윤현중,박재억,Yoon, Hyun-Joong,Park, Je-Uk 대한구강악안면외과학회 2001 대한구강악안면외과학회지 Vol.27 No.5

Aplastic anemia is a hematopoietic disorder characterized by marked reduction or absence of erythoid, granulocytic, and megakariocytic cells in the bone marrow with resultant pancytopenia. To control of infection & bleeding secondary to leukopenia and thrombocytopenia, the inflammatory lesions in oral & maxillofacial area should be removed. Material & Method: The extractions were performed on 21 patients with severe aplastic anemia. The initial, pre-operative and postoperative CBCs were checked up. Amount and kind of transfused platelet in each patient and increment of platelet level were recorded. The complications were documented. Result : A mean of 2.9 teeth were extracted from each patient(ranging between 1 and 13). Furthermore, surgical extractions including ostectomy and odontectomy of the third molar were performed on 11 patients. The preoperative WBC levels presented between $600/{\mu}L$ and $5000/{\mu}L$(mean $2376/{\mu}L$). The WBC values decreased by an average of $145/{\mu}L$ per patient after extractions had been performed. The teeth of 16 patients were extracted under 10.0g/dL, and the mean change in postoperative hemoglobin levels in comparison with preoperative hemoglobin levels was -0.06 per patient. The initial platelet levels were between 1000/(L and $81,000/{\mu}L$(mean $20,174/{\mu}L$). In five patients, extractions were performed with platelet levels less than $50,000/{\mu}L$. Conclusion : The results suggest that more active and preventive treatments in the oral and maxillofacial area are possible and are necessary to remove the infectious foci on the patients with severe aplastic anemia. We report the results of our experiences and literature reviews in treatment of the patients with severe aplastic anemia in our department.

가상현실을 이용한 심리치료 기술 동향과 전망

윤현중,정성엽,Yoon, Hyun Joong,Chung, Seong Youb 한국교통대학교 융복합기술연구소 2012 융ㆍ복합기술연구소 논문집 Vol.2 No.2

Recently, peoples are suffering from various psychological disorders such as addiction, phobia, depression, and bipolar disorder. Moreover, children with ADD/ADHD and autism are increasing. Korean tends to regard the psychological disorders as taboo. Therefore, it is unusual case that the mental patient gets the psychological therapy. Virtual reality has come to the spotlight as a useful tool for the therapy due to its anonymity and easy accessibility. The therapy in the virtual reality is called cyber-therapy. Emotion of the patient is important for the treating process. The objective of this paper is to review the researches on the treatment of psychological disorders using the virtual reality and prospect the affective interaction technology for the cyber-therapy.

제3대구치 발치 시 epinephrine과 동통이 수축기 혈압과 맥박에 미치는 영향

윤현중,이상화,송현철,Yoon, Hyun-Joong,Lee, Sang-Hwa,Song, Hyun-Chul 대한구강악안면외과학회 2001 대한구강악안면외과학회지 Vol.27 No.6

The aim of the present study was to evaluate the influences of epinephrine and pain on the changes of blood pressure and pulse rates in mandibular 3rd molar extraction. A total of 80 patients(aged between 10 and 30) without systemically compromised conditions were selected and divided into two groups(I, II). 2% lidocaine with 1:100,000 epinephrine was administered in group I (male 20, female 20), and 2% lidocaine without epinephrine was administered in group II (male 20, female 20). Systolic blood pressure and pulse rates were checked by a digital monitor during the pre-local anesthesia state(stage 1), 5 minute later in the post-local anesthesia state(stage 2), the extraction state(during odontectomy, stage 3), and during the post-suture state(stage 4). The measurement of pain perceived by patients was made using a three-point visual analog scale. The results suggest that local anesthetic with epinephrine is better at decreasing pain preventing the severe elevation of systolic blood pressure than local anesthetic without epinephrine. However, these results should be confirmed by additional studies on cardiac patients.

조혈모세포 질환 환자에서의 다발치

윤현중,김진,Yoon, Hyun-Joong,Kim, Jin 대한구강악안면외과학회 2001 대한구강악안면외과학회지 Vol.27 No.1

On patients with disorder of hematopoiesis such as leukemia, aplastic anemia, MDS(Myelodisplastic Syndromes), removal of infectious foci prior to the BMT(Bone Marrow Transplantation) is a necessity and what is more, there is no sufficient time to control the infections because the chemotherapy for BMT should be started as soon as possible. And the transfusion should be minimized to prevent the alloimmunization. In those reasons, oral & maxillofacial surgeons are often in need of multiple extractions, and should take into consideration the possibility of complications after multiples extractions such as infection, severe bleeding because those situations can be fatal on patients with disorder of hematopoiesis. We present our experience in multiple extractions on 30 patients with disorder of hematopoiesis referred from Catholic Hematopoiesis Stem Cell transplantation Center at St. Mary's Hospital, The Catholic University of Korea.

狂言의 飮酒敎化에 대한 考察

尹玄重(Yoon Hyun Joong) 중앙대학교 일본연구소 2001 日本 硏究 Vol.0 No.16

Extract of Rubus coreanus Fruits Increases Expression and Activity of Endothelial Nitric Oxide Synthase in the Human Umbilical Vein Endothelial Cells

Hyun Joong Yoon(윤현중),Soo Young Park(박수영),Sung-Tack Oh(오성택),Kee Young Lee(이기영),Sung Yeul Yang(양성렬) 한국생명과학회 2011 생명과학회지 Vol.21 No.1

본 연구는 복분자의 수용성 추출물(RCE) 이 배양된 제대정맥내피세포에서 내피세포 NO 합성 효소(eNOS)의 발현과 활성에 미치는 효과를 연구하고, 이러한 RCE의 효과가 어떤 신호전달 과정을 거치는지를 밝히기 위한 것이다. 연구에 따르면 RCE가 제대정맥내피세포에서 NO의 생성을 증가시키는데 이는 iNOS 보다는 eNOS의 활성화에 의한 것임을 이들의 특이 억제제를 사용한 실험으로 확인할 수 있었다. 나아가 eNOS에 의한 NO 생성증가는 이 효소의 활성 증가뿐만 아니라 mRNA 수준에서의 발현증가에도 기인함을 확인할 수 있었다. PKC-특이 억제제인 RO-317549는 RCE에 의한 NO 생성의 증가에 별다른 영향을 주지 않았으나, 에스트로젠 수용체-특이 억제제인 Tamoxifen, ERK-특이 억제제인 PD98059와 PI3K/Akt-특이 억제제인 LY-294002는 제대정맥내피세포에서 RCE에 의해 증가된 NO 생성을 억제하였으며, 이는 두 저해제가 eNOS의 활성형인 pSer1177의 양을 감소시키며, 특히 PD98059는 비활성형인 pThr495의 양도 증가시키기 때문임을 알 수 있었다. 이상의 결과로써, 복분자수추출물은 사람의 제대정맥내피세포에서 NO 생성을 증가시키며, 이는 eNOS의 발현을 증가시킬 뿐만 아니라, ERK와 PI3K/Akt의 신호전달과정을 거쳐서 eNOS의 활성도 증가시키기 때문임을 확인할 수 있었다. This study aimed to investigate the effects of water extract of Rubus coreanus (RCE) on the expression and activity of endothelial nitric oxide synthase (eNOS), as well as its signal transduction pathways in human umbilical vein endothelial cells (HUVECs). The specific inhibitors of NOS show RCE treatment increases NO production in HUVECs due to the up-regulation of eNOS rather than iNOS. The real-time expression level of eNOS mRNA was also increased upon RCE treatment in HUVECs. While a PKC-specific inhibitor, RO-317549, did not alter RCE-induced NO production in HUVECs, tamoxifen (estrogen receptor-specific inhibitor), PD98059 (ERK-specific inhibitor) and LY-294002 (PI3K/Akt-specific inhibitor) did have suppressive effects. Increased NO production by RCE seems to result from a higher level of active eNOS (pSer1177). Specifically, inhibition of ERK not only decreased the level of active eNOS, but also increased the inactive form of the enzyme (pThr495) in HUVECs. This study suggests that RCE treatment increases NO production in HUVECs due to the increased expression and activity of eNOS. It is also shown that RCE-induced eNOS activation occurs partly through the binding of RCE to the estrogen receptor, along with ERK and PI3K/Akt-dependent signal transduction pathways. In addition, the regulatory binding proteins of eNOS including Hsp90 and caveolin-1 were related to these effects of RCE on eNOS activity in HUVECs.

Simulation Software for Semiconductor Photolithography Equipment

윤현중(Yoon, Hyun-Joong),김진곤(Kim, Jin-Gon) 한국산학기술학회 2012 한국산학기술학회논문지 Vol.13 No.8

본 논문은 반도체 포토장비의 이산 이벤트 시뮬레이터인 TrackSim의 개발에 관한 것이다. TrackSim은 포토 장비의 시뮬레이션 엔진과 사용하기 쉬운 사용자 환경을 포함하는 시뮬레이터로, 다양한 프로세스 모듈의 구성 및 운 영 방법을 효율적으로 평가, 검증, 스케쥴링할 수 있는 3차원 시뮬레이션 환경을 제공한다. TrackSim은 반도체 산업 에서 많이 사용되는 이산 사건 시뮬레이션 소프트웨어인 AutoMod를 기반으로 개발되어 시뮬레이션 신뢰성이 보장되 며, AutoMod로 개발된 반도체 제조라인 시뮬레이션 모델 속에 함께 연동하여 사용이 가능하다는 특징이 있다. This paper describes the development of the TrackSim, which is a discrete event simulation tool for photolithography equipment of semiconductor industry. The TrackSim is focused on the accurate simulation model of the photolithography equipment and easy-to-use user interfaces. TrackSim provides 3D simulation environment for evaluating, validating, and scheduling the photolithography process. One of the major characteristics of TrackSim is in that it is developed based on Applied Materials' AutoMod, a discrete event simulation software broadly used in semiconductor industry. Accordingly, the photolithography model of TrackSim can be used to perform simulation connected with other simulation models built with AutoMod.

다발성 타석증 2 예

윤현중(Hyun Joong Yoon),박형식(Hyung Sik Park),최우환(Wo Whan Choi) 대한악안면성형재건외과학회 1992 Maxillofacial Plastic Reconstructive Surgery Vol.14 No.3

This is a report of two rare cases, that authors have experienced, one being four sialoliths within a wharton`s duct, Which is a relatively frequent site of sialolith, and the other a multiple occurrance of 16 sialoliths at the orifice of stensen`s duct, which has very low frequency of sialolith occurance. Both pathosis were removed using transoral sialolithotomy.

자폐스펙트럼장애 진단 및 치료를 위한 감성 컴퓨팅 기술 동향 분석

윤현중 ( Hyun Joong Yoon ),정성엽 ( Seong Youb Chung ) 한국감성과학회 2010 감성과학 Vol.13 No.3

자폐스펙트럼장애는 91명당 1명이 문제를 보인다고 보고되었으며 이는 우리나라 암 발생률보다도 높은 수준이지만, 국내에서는 제대로 된 진단 및 치료가 이루어지고 있지 않아 사회적으로 심각한 복지 사각지대에 있다. 자폐스펙트럼장애 아동의 경우 자신의 정서 상태를 제대로 표현하지 못하여 기존의 치료 및 교육 방법에 제약이 많기 때문에, 장애 아동의 정서를 실시간으로 인지하여 활용할 수 있는 새로운 개념의 치료 시스템의 개발이 요구된다. 본 논문에서는 생체신호 감지를 통한 정서 상태 인지 기술 및 가상 감성 에이전트(agent) 모델링 기술을 포함한 감성 컴퓨팅 기술에 대하여 기술 동향 분석 결과를 제시하고, 새로운 자폐스펙트럼장애 진단 및 치료를 위한 시스템 구성방식을 제안한다. 제안된 시스템은 뇌파 등의 생체신호로 부터 자폐아동의 정서 상태를 인지하기 위한 생체신호 감지 모듈, 가상현실 환경에서 자폐아동이 감성 에이전트와 사회적 상호작용을 하면서 다양한 진단 및 치료 시나리오를 수행하기 위한 가상 감성 에이전트 환경 모듈, 역감 교류(haptic interface)장치를 이용하여 자폐아동의 행동 입력이 가능하게 하고, 힘 반력을 자폐아동에게 전달해 주기 위한 역감 교류 모듈로 구성된다. 본 논문에서 제안한 시스템을 통해 자폐스펙트럼장애를 객관적으로 진단할 수 있으며, 생활 속에서 지속적인 치료를 가능하게 할 수 있을 것으로 기대된다. It is known that as many as 1 in 91 children are diagnosed with an autistic spectrum disorder, and the incidence rate of the autistic spectrum disorder is much higher than that of cancer in Korea. It is necessary to develop a novel technology to sense their emotional status and give proper psychological diagnosis and therapy, since the children with autistic spectrum disorder usually do not express their own emotional status. This article presents the state-of-the-arts on the affective computing technologies that include recognition of emotional status through bio-sensing and virtual affective agent modeling, and then proposes a novel system architecture for diagnosis and therapy of autistic spectrum disorder. The diagnosis and therapy system of autistic spectrum disorder is composed of bio-sensing module, virtual environment module with affective agents, and haptic interface module. The architecture proposed in this paper will enhance the objectivity to diagnose autism spectrum disorders, and enable continuous treatment in daily life.

생쥐와 RAW264.7 대식 세포주에서 C. albicans-유도 염증반응에 관한 키토산올리고당의 방어효과

윤현중 ( Hyun Joong Yoon ),문명이 ( Myoung E Moon ),박행순 ( Haeng Soon Park ),임선영 ( Sun Young Im ),이준행 ( Jun Haeng Lee ),김영호 ( Young Ho Kim ) 한국키틴키토산학회 2007 한국키틴키토산학회지 Vol.12 No.1