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ChondroT 투여가 FeCl<sub>3</sub>로 유발된 혈전에 미치는 영향
김지훈 ( Ji Hoon Kim ),김선길 ( Sun Gil Kim ),김주일 ( Joo Il Kim ),윤창석 ( Chang Suk Yoon ),최지민 ( Ji Min Choi ),나창수 ( Chang Su Na ),김선종 ( Seon Jong Kim ) 한방재활의학과학회 2020 한방재활의학과학회지 Vol.30 No.3
Objectives This study was designed to investigate the effects of ChondroT on thrombus in FeCl<sub>3</sub>-induced rats. Methods We exposed FeCl3 to rat’s carotid artery to induce thrombus. Specimens were divided in 5 groups; Intact, Control, ASA10 (aspirin 10 mg/kg), CT100 (ChondroT 100 mg/kg), and CT200 (ChondroT 200 mg/kg), each n=6. We investigated thromboxane, platelet activating factor (PAF), histological change, lipid metabolism, transaminase, leukocyte, erythrocyte and thrombocyte level. Results In ASA10, CT200 groups, there was significants decrease in both thromboxane level and total cholesterol level, compared to control group and there were significant histological changes of blood vessel, compared to control group. In CT200 group, there was significant decrease in PAF level, compared to control group (p<0.05). In ASA10, CT200 groups, triglycerides level tended to decrease, compared to control group. Conclusions Based on these results, it could be suggested that ChondroT was effective on thrombus in FeCl<sub>3</sub>-induced rats, and further study is needed to conduct a rigorous clinical research. (J Korean Med Rehabil 2020;30(3):45-56)