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사군자탕(四君子湯)의 활용(活用)에 대한 방제학적(方劑學的) 고찰(考察)
윤용갑,Yun, Young-Gab 대한한의학방제학회 2001 大韓韓醫學方劑學會誌 Vol.9 No.1
1. Crinical applicational of Sagoonjatang are frequently used in internal disease, G.I.T(Gastro Intestianl Tract) disease, chronical fatigue, athma, etc. 2. Sagoonjatang adjacent prescriptions in pathological organs are the stomach, the spleen, the kidneys, the heart, the lungs. 3. Sagoonjatang partake chronic fatigue disease, G.I.T disease, pulmonary disease, brain blood barrier disease, infertility, vomiting of pregnancy, sedation of brain, healing mechanism, sweating regulation, urination, peripheral blood ciraculation, electrolyte blance, etc.
아토피 피부염 치료제 개발에 활용할 수 있는 마우스 모델에 대한 고찰
윤용갑,황주민,김형률,장선일,Yun, Young-Gab,Hwang, Joo-Min,Kim, Hyung-Rul,Jang, Seon-Il 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.1
Atopic dermatitis (AD) is a chronic inflammatory skin disease associated with cutaneous hyperreactivity to environmental triggers. The clinical phenotype that characterizes AD is the product of interactions between susceptible genes, the environmental factors, defective skin barrier function, and immunologic responses. This review summarizes recent progress in our understanding of the immunopathophysiology of AD and the implications for mouse models of AD in drug discovery from medicinal plants.
마우스 모델에서 항백탕 투여에 의한 종양 증식의 억제 및 Apoptosis의 유도
윤용갑,김준희,송은정,황진기,남상윤,Yun, Young-Gab,Kim, Jun-Hee,Song, Eun-Jung,Hwang, Jin-Ki,Nam, Sang-Yun 대한한의학방제학회 2009 大韓韓醫學方劑學會誌 Vol.17 No.2
Objective : In vitro proapoptotic effect of Hangbaek-Tang (HBT) has been documented by one of us. In the present study, we aimed to demonstrate in vivo effect of HBT on tumor growth. Methods : In vitro selective cytotoxicity of HBT was examined by enumeration of viable cell numbers using BC3A mouse leukemic cells and normal spleen cells. In vivo effect of HBT (25 and 50 mg/mouse) on tumor growth was assayed using BC3A cells innoculated subcutaneously in the flank. Annexin-V apoptosis assay and PI staining was performed to determine the effective serum factor in HBT-treated mice. Leukocyte recruitment into peritoneum were analyzed by microscopy with a stained cytosmear of peritoneal lavage fluid. Results : HBT exhibited in vitro selective cytotoxicity to leukemic cells and did not show any toxicity on immune organs. In vivo i.p. administration of HBT induced significant reduction in tumor growth but not complete regression. Sera obtained from HBT-treated mice strongly inhibited BC3A cell growth in vitro and were revealed to markedly enhance apoptosis and accompanying cell death, when compared to those from PBS-treated mice. Abundant extravasation of leukocytes, especially neutrophils, into peritoneum was observed in HBT-treated mice. Conclusions : HBT causes leukemic, BC3A cell death in vivo via apoptosis as well as in vitro, for which functional involvement of leukocytes is suggested.
자음건비탕(滋陰健脾湯)의 방제구성(方劑構成) 및 임상활용(臨床活用)
윤용갑,Yun Young-Gab 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.1
JaYumKeonBiTang(滋陰健脾湯) was recorded in 'Manbyungwhachu'(萬病回春); medical treatment book 1587 at first. It was composed by some common - used basic prescriptions: 'PalJinTang'(八珍湯). 'YiJinTang'(二陣湯), 'JeonGjiWhan'(定志丸), 'EuckGunJaTang'(六君子湯). 'SaengMacSan'(生脈散) etc. Therefore, JaYumKeonBiTang(滋陰健脾湯) is very useful as fallow oriental pathological condition: 'SimBiHeoGeob'(心脾虛怯). 'KiHeoDamSung'(氣虛痰盛), 'GiHeyIGooHeo'(氣血俱虛), 'SimHeo'(心虛) so JaYumKeonBiTang(滋陰健脾湯) is clinically applicated with dizziness, nausea. restlessness.
윤용갑(Young Gab Yun),채규윤(Kyu Yun Chai),록란잔밭(Kyung Kwan Lee),이경관(Lok Ranjan Bhatt),백승화(Seung Hwa Baek) 대한약학회 2009 약학회지 Vol.53 No.6
Sakuranetin, prunetin and dihydroquercetin were isolated from the methanol extract of Sorbus commixta by 1D/2D-NMR and LC-MASS spectrometry. Medicating these compounds to RAW264.7 cell that was pre-treated by lipopolysaccharide revealed anti-inflammatory effects that greatly inhibited the production of NO (nitric oxide) and PEG2 (prostaglandin E2), which are well known to cause the expression of iNOS (inducible nitric oxide synthase) and COX-2 (Cyclooxygenase-2). These results suggest that these compounds can be used as stable anti-inflammatory materials.
장선일,윤용갑,최경호,Jang, Seon-Il,Yun, Young-Gab,Choi, Kyoung-Ho 대한한의학방제학회 2009 大韓韓醫學方劑學會誌 Vol.17 No.1
Objective : The purpose of this study is to indicate of problems in statistical analysis method of "The Korean Journal of oriental Medical Prescription" and we will be proposed the useful application of the statistical analysis method. Methods : In this paper, we were analysed statistical analysis methodology from published journal articles "The Korean Journal of Oriental Medical Prescription" December, year 2000 to December, year 2008. We were investigated of problems in application of structured analysis methods those journal articles that including statistical analysis techniques and analysis methods. Results : 1. A random allocation of the experimental group and control groups are important factors in the planning process of statistical analysis. However, there are less explanation those journal articles. 2. There are no consideration in specimen size that there will be considerate by the level of significance and statistical test. 3. Many article authors were confused between parametric methods and non-parametric methods that they were applied parametric statistical analysis methods although inapplicable sample size. 4. There were applied the parametric methods consists of t-test instead non-parametric methods in the comparison of average intergroup relations. 5. There were less understanding posterior analysis and were confused with t-test. Conclusion : Our goal was to outline the key methods with a brief discussion of problems(statistical analysis methods), avenues for solutions. we recommend authors to use an appropriate statistical analysis methods for obtaining a more cautions results.
오적산(五積散)의 임상(臨床) 활용(活用)에 대한 방제학적(方劑學的) 고찰(考察)
윤지연,윤용갑,Yun, Ji-Yeon,Yun, Young-Gab 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.2
Objectives : This study was intended to establish for medical treatment range of Ojeoksan and to help extending application of medical insurance through prescriptive research. Methods : We analyzed "Dongeuibogam", "Taepyeonghaeminhwajegukbang" and other books Result : 1. composition of Ojeoksan in "Dongeuibogam" is same as in "Gogeumeuigam" 2. Ojeoksan is composed of five kinds of basic prescripitions; Er Chen Tang, Ping Wei San, Ma Huang Tang, Si Wu Tang etc. and it used for five pathological factors; cold, energy, eating, phlegm, blood. 3. Property of Ojeoksan is warm so it can be used for any cold diseases. 4. Ojeoksan is used for 16 kinds of diseases including chest pain, abdominal pain etc. Conclusion : Ojeoksan can be used for cardiovascular disorders and Ojeoksan is possible to apply or to extend medical insurance coverage.
조대연,윤용갑,정명,이은혜,복영옥,정창옥,임규상,Cho, Dae-Yeoun,Yun, Young-Gab,Jung, Myung,Lee, Eun-Hye,Bok, Young-Ok,Jung, Chang-Ohk,Lim, Kyu-Sang 대한한방안이비인후피부과학회 2016 한방안이비인후피부과학회지 Vol.29 No.3
Objectives : Gal-Geun-Tang (GT) has been described from SANGHAN in Korean traditional medicine and known to act against cold, fever, hypertension, and nasal catarrh. However, little has yet been learned about the effect of GT on immune function. In the current study, in vitro and in vivo immunomodulatory activity of GT (water extract) was investigated.Methods : Water extract of GT induced in vitro proliferation of spleen cells and significantly increased their proliferative responses during anti-CD3 activation. Using purified splenic T and B cells, it was revealed that GT has a mitogenic activity to B cells and promotes their proliferation induced by lipopolysaccharide, whereas T cell proliferation was not triggered and GT was rather inhibitory to T cell activation caused by anti-CD3 antibody. In the presence of antigen presenting cells (APC), GT addition resulted in a significant increase of IFNγ and IL-4, but not IL-2, production. However, addition of high concentration (1,000㎍/㎖) of GT led to a marked reduction in T cell cytokine production and under such condition, GT facilitated apoptosis of T cells when examined by flow cytometry with propidium iodide staining.Results : In vivo immunomdulation of GT was also investigated using a mouse model. Following keyhole limpet hemocyanin (KLH) immunization, GT (1 ㎎/day) was orally administered for 9 days. Cell numbers in thymus, spleen and peripheral blood were not altered by GT administration, indicating that such dose is not immunotoxic. Cell numbers in draining lymph nodes (LN) and ex vivo Ag-specific proliferation of LN cells were significantly elevated by GT administration. However, any preferential stimulation of T or B and CD4<sup>+</sup> or CD8<sup>+</sup> T cell subpopulations was not observed in a flow cytometric analysis of LN cells. This result shows that GT does not promote in vivo B cell proliferation while GT enhances Ag-specific proliferation of LN cells, unlike what was observed in vitro.Conclusions : For a further understanding of in vivo immunomodulatory activity of GT, ex vivo cytokine production of LN cells obtained from KLH-immunized mice was evaluated. Ag-specific IFNγ production was significantly higher in GT-treated mice when compared to PBS-treated control mice. In contrast, IL-4 production in GT-treated group was comparable to control group unlike to in vitro data. In addition, GT administration did not result in any significant differences in serum levels of Ig (IgM, IgG1 and IgG2a) between GT-treated and control groups. Taken together, these data strongly support that GT promotes immune response, more profoundly type 1 helper T cell (Th1) activity and GT may be applicable for treatment of intracellular parasite infection such as viral diseases.