원저 : 백서에서 유도한 지방간에서 Peroxisome Proliferator-Activated Receptor-δ의 치료 효과

김선미 ( Seon Mee Kim ),윤도경 ( Do Kyoung Yoon ),양범석 ( Beom Seok Yang ),조경환 ( Kyung Hwan Cho ) 대한비만학회 2005 The Korean journal of obesity Vol.14 No.1

연구배경: 백서에 에탄올 식이와 고지방 식이를 시켜 알코올성 지방간과 비알코올성 지방간을 유발하고 이들에 peroxisome proliferators-activated receptor δ(PPAR-δ)를 투여하여 PPAR-δ 작용제가 백서의 지방간에서 병리학적 소견과 혈액의 생화학적 소견에 어떤 영향을 주는지 알아보고자 하였다. 방법: 대조군, 고지방 식이를 시킨 군, 고지방 식이를 하면서 PPAR-δ 작용제인 L-165041로 치료한 군, 에탄올 식이 Background: Author used the rat model of alcoholic and nonalcoholic liver disease in which feeding dietary with ethanol and high fat result in the development of fatty liver, necrosis, and inflammation. Author used PPAR-δ agonist in study group. Author in

Cyclooxygenase-2 선택적 억제제를 복용 중 자궁암 환자에 발생한 심부정맥혈전증 1예

고병준,김수현,김정아,홍정익,윤도경,김정환,손근주,최윤선,Ko, Byung-Joon,Kim, Su-Hyun,Kim, Jeong-A,Hong, Jeong-Ik,Yoon, Do-Kyoung,Kim, Jung-Hwan,Sohn, Keun-Ju,Choi, Youn-Seon 한국호스피스완화의료학회 2005 한국호스피스.완화의료학회지 Vol.8 No.1

Cyclooxygenase-2 (COX-2) selective inhibitors were specifically developed to reduce the risks of gastrointestinal bleeding associated with other NSAID drugs. However, the APPROVe (Adenomatous Polyp Prevention on VIOXX) trials revealed that rofecoxib sometimes exerts prothrombotic effects. Meanwhile, cancer patients, who also carry a risk of thrombosis due to a variety of mechanisms, are often treated with COX-2 selective inhibitors, due to their relative gastrointestinal safety. This report concerns the case of a 46-year old woman with advanced cervical cancer, who had been treated with opioids and a COX-2 selective inhibitor (celecoxib) for 2 months, for the relief of pain associated with her cancer. The patient was admitted due to swelling of the left leg, which was also accompanied by pain. A computerized tomography scan revealed deep vein thrombosis occurring in multiple veins of both legs. After the administration of low-molecular weight heparin and oral warfarin, the patient's symptoms were relieved initially. However, her prothrombin time was found to be prolonged, necessitating the discontinuation of anticoagulation therapy. The patient's dyspnea worsened, ultimately resulting in her death. In conclusion, the administration of cox-2 selective inhibitors should be carefully considered in patients with a number of different risk factors, and assessed on a case-by-case basis.

신입생의 기숙형 대학(Residential College) 생활 지원을 위한 통합 서비스 디자인 연구

정인혜(Inhye Jung),이설아(Seolah Lee),이세영(Se Young Lee),윤도경(Do Kyung Yoon),유지웅(Jiwoong Yoo),김현경(Hyoun Kyoung Kim),백준상(Joon Sang Baek) 한국HCI학회 2021 한국HCI학회 학술대회 Vol.2021 No.1

본 연구의 목적은 신입생의 기숙형 대학(Residential College, 이하 RC) 생활을 지원하는 통합 어플리케이션 서비스를 제안하는 것이다. 특히 서비스 이용자인 신입생이 RC 생활을 통해 건강증진 생활습관까지 함양하도록 하는 데 중점을 두고자 한다. 자아정체감 확립 및 심리·사회적 성장이 촉진되는 초기 성인기에 정착된 건강행동은 개인의 향후 건강행위 및 사회보건 문제와도 연관된다. 그러나 전인적 발달을 목표로 하는 RC 제도에서 지속적인 건강행동에 대한 중재는 아직 부족한 것으로 보인다. 이에 본 연구는 단일 사례연구를 통하여 RC 구성원의 요구를 파악하고 기존 서비스를 분석하여 통합 플랫폼 모형을 제시한 다음 MVP 테스트를 수행하였다. 본 연구를 토대로 한 서비스개발은 RC 를 구성하는 주체(신입생, Residential Assistant, RC 교육원)의 편의성을 고려하는 한편, 초기 성인기에 진입한 신입생의 균형 잡힌 건강발달에 기여할 수 있을 것으로 기대된다.

한국 성인에서 혈중 C 형 간염 바이러스 항체의 발현율과 의의

권소영(So Young Kwon),박이병(Ie Byung Park),박상훈(Sang Hoon Park),연종은(Jong Eun Yeon),박영태(Young Tae Bak),김진호(Jin Ho Kim),변관수(Kwan Soo Byun),이창홍(Chang Hong Lee),윤도경(Do Kyoung Yoon),조경환(Kyung Hwang Cho) 대한내과학회 1995 대한내과학회지 Vol.48 No.3

N/A Objectives : The prevalence of anti-HCV among blood donors is about 0.3 to 1.5% when assessed by first or second generation EIA. The significance of anti-HCV in a low risk population such as blood donors is unclear, To estimate the prevalence and significance of anti- HCV (second generation EIA) in Korean adults, we tested 4-RIBA and HCV-RNA RT-PCR in the sera of anti-HCV positive cases with normal serum ALT level. Methods : Serum samples from 5707 adults who visited Health Counseling Center were tested for ALT, HBsAg and anti-HCV by second genration EIA (UBI). Anti-HCV positive cases with normal serum ALT participated in a brief questionnaire and serum samples of them were tested for HCV by a 4-RIBA and HCV-RNA by RT-PCR. Results: The overall prevalence of anti-HCV among Korean adults is 1.77% and among adults with normal serum ALT is 1,45%. History of prior blood transfusion was more frequent in anti-HCV positive cases than anti- HCV negative cases. In 28 anti-HCV positive cases with normal serum ALT level, 4-RIBA was reactive in 35.7% and HCV- RNA was detected in 39.3%. HCV-RNA was detected in 9 of 10 4-RIBA reactive cases but in only 2 of 18 indeterminate or nonreactive cases. All 9 cases with sample/cut-off ratio of greater than 5 in anti-HCV EIA were 4-RIBA reactive and contained HCV-RNA, but only 2 of 19 cases with sample/cut off ratio less than 5 contained HCV-RNA. Conclusion: The overall prevalence of anti-HCV among Korean adults is 1,77%. About 40% of anti-HCV positive cases with normal sALT level contained serum HCV-RNA by RT-PCR. Reactive results of 4-RIBA and high sample/cut-off ratio in anti-HCV EIA correlated well with detection of HCV-RNA by RT-PCR.

한국 성인에서 C형 간염 바이러스 항체의 발현율

홍명호,권소영,조경환,변관수,이창홍,윤도경 대한감염학회 1994 감염 Vol.26 No.3

목적 : C형 간염 바이러스(HCV)감염은 수혈후성간염, 특발성 간염, 간경변증, 원발성 간암과 같은 간질환의 주요 원인 중의 하나로 알려져 있다. C형 간염 바이러스 항체(anti-HCV)의 발현율은 anti-HCV 1세대 효소 면역 검사법(EIA)로 0.3-1.5%로 알려져 있으나 2세대 anti-HCV EIA는 민감도와 특이도가 1세대 검사보다 우수한 것으로 알려져 있다. 저자는 2세대 anti-HCV EIA를 이용하여 한국인에서 anti-HCV의 발현율과 역학적 특성을 조사하고자 연구를 시작하였다. 방법 : 고려대학교 부속병원 건강 검진 센터에 내원한 성인중 총 5707예를 대상으로 2세대 anti-HCV EIA,혈청 ALT(alanine aminotransferase), HBsAg, anti-HBs, anti-HBc를 검사하였으며, 양성인 예중 추적이 가능했던 36예에서 설문을 시행하고 음성인 예중 105예를 대조군으로 비교하여 다음과 같은 결과를 얻었다. 결과: 1)우리나라 성인에서 anti-HCV의 발현율은 1.8%였다. 2) Anti-HCV의 발현율은 연령이 증가할수록 증가하였다(P<0.01). 3)혈청 ALT가 상승되어 있는 예들의 anti-HCV 발현율은 3.7%로 혈청 ALT 정상 예들에서의 anti-HCV 발현율 1.5% 보다 유의하게 높았다(P<0.01). 4)HBsAg 음성인 예들에서 anti-HCV의 발현율은 1.8%로 HBsAg 양성인 예들에서의 0.9%보다 높았으나 통계적 유의성은 없었다. 5)비A비B형 간염의 대리 표지자인 anti-HBc양성이면서 혈청 ALT가 상승되어 있는 예들에서 anti-HCV 발현율은 4.4%로 그렇지 않은 군보다 유의하게 높았지만(P<0.01), 양성 예측치가 낮아 대리표지자를 국내에 적용하기는 어려웠다. 6) Anti-HCV양성인 예들과 음성인 예들의 설문에서 수혈의 기왕력만이 anti-HCV 양성인 예들에서 유의하게 많았고(P<0.05), 수술 경력, 가족내 간 질환자의 유무, 성병과거력, 음주력, 침이나 문신 경력은 유의한 차이를 보이지 않았다. 결론: 건강 검진자들에서의 2세대 EIA를 이용한 anti-HCV 발현율은 1.8%(101/5707)로 우리나라에서의 anti-HCV 발현율은 외국에 비해 비교적 높은 것으로 추정되며, 특히 연령이 증가할 수록 발현율은 더욱 증가함을 알 수 있었다. 앞으로 이러한 anti-HCV 양성자를 대상으로 RIBA나 HCV-RNA의 직접 검출등의 방법을 이용하여 항체 양성의 의미를 규명하는 연구가 계속 진행되어야 할 것으로 생각된다. Background : Hepatitis C Virus(HCV) infection is known as one of the most important causes of liver diseases such as post-transfusion hepatitis, sporadic hepatitis, liver cirrhosis and hepatocellular carcinoma. The prevalence of antibody to Hepatitis C Virus)anti-HCV) among blood donors was about 0.3-1.5% by first generation enzyme immunoassay(EIA). Second generation anti-HCV EIA was known as superior to first generation anti-HCV EIA in the aspects of sensitivity and specificity. To estimate the prevalence of anti-HCV among Korean adults and identify the route of ECV transmission, 5707 serum samples were tested. Methods : Serum samples from 5707 adults who visited Korea University Hospital Health Care Center for general check up were tested for second generation anti-HCV EIA, serum ALT(alanine aminotranferase), HBsAg, anti-HBs and anti-HBc. Questionnaires including presumptive risk factors of HCV were obtained from 36 anti-HCV positive cases, and those results were compared to the results from 105 anti-HCV negative cases. Results: 1) The overall prevalence of anti-HCV was 1.8%(101/5707). 2)The prevalence of anti-HCV increased with aging significantly(P<0.01). There was little difference in the prevalence of anti-HCV between male and female(1.8% vs1.7%). 3)The prevalence of anti-HCV in elevated(ALT>40IU/L)serum ALT cases was significantly higher than in normal(ALT≤40IU/L) cases(3.7% vs 1q.5%, P<0.01). 4)The prevalence of anti-HCV in HBsAg negative cases was higher than HBsAg positive cases(1.8% vs 0.9%), but it was not statistically significant. 5)The prevalence of anti-HCV was 4.4% in cases with anti-HBc and elevated serum ALT(ALT>40IU/L), and it was significantly higher than the prevalence of anti-HCV in cases of anti-HBc negative and/or normal serum ALT(P<0.01). 6)Anti-HCV status was associated with history of transfusion significantly(P<0.05), but the following factors such as operation history, family history of liver diseases, history of sexually transmitted disease, alcohol in take and history of acupuncture or tatooing were not associated with status of anti-HCV. Conclusion : Prevalence of anti-HCV among Korean adults was 1.8% Age matched prevalence of anti-HCV in Korean adults was higher than the other countries in North Europe or North America, but similar to that of Spain or Japan. Prevalence of anti-HCV was increased with aging. To elucidate the meaning of anti-HCV positivity in these groups, further studies using direct virus detection method or recombinant immunoblot assay are needed.