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자궁경부질 도말 검사 정도 관리과정으로서의 세포 및 조직진단의 비교 분석과 10% 무작위 재선별과의 비교 분석
윤길숙,허주령,손경희,김온자,공경엽,Yoon, Ghil-Suk,Huh, Joo-Ryung,Son, Kyung-Hee,Kim, On-Ja,Gong, Gyung-Yub 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.2
Although the success of the Papanicolaou test as a screening tool of cervical cancer is evident, there still exists $2{\sim}5%$ of discrepancy rate by both human and machine. To improve the qualilty of cervico-vaginal cytology, the authors compared cervicovaginal smear with cervical biopsy diagnoses, and analysed the causes of discrepancies. Among 30,922 cervicovaginal smears from June 1996 to April 1997 at our hospital, there were 271 cases of cervicovaginal smear with subsequent cervical punch or LEEP cone biopsies within several months. The biopsies and smears from a total of 98 discordant cases were reviewed. The discrepancy was attributed to sampling errors in 43 cases(43.9%), and to cytologic diagnosis in 49 cases(50.0%). Among these, 43 cases were interpretative errors(categories A;19, B;16 and C;8) whereas six cases were screening errors(categories B:2 and C:4). Among cervical biopsy cases, errors were present in four. As for 10% random rescreening, cytotechnologists reviewed 3,196 of 30,922 smears during the same period, There were 43 cases of screening error(categories A;27, B;16). Cytologic/histologic correlation was superior to 10% random rescreening of negative cases. The most effective method for quality improvement in cervicovaginal cytology was to implement both quality control(rescreening) and qualify assurance(cytologic/histologic correlation) programs.
인설성 반의 양상으로 침윤된 T-cell lymphoblastic lymphoma
우민정 ( Min Jung Woo ),이성우 ( Sung Woo Lee ),김상원 ( Sang Won Kim ),윤길숙 ( Ghil Suk Yoon ) 대한피부과학회 2003 대한피부과학회지 Vol.41 No.2
Lymphoblastic lymphoma(LRL) is non-Hodgkin`s 1ymphoma with a high tendency of rapid progression to acute leukemia, but cutaneous infiltration is rare. Cutaneous lesions in LBL were largely red papules and nodules. We herein report a case of 24-year-old wo
난소에서 발생한 Malignant struma ovarii 2 예
김은진(Eun Jin Kim),한치동(Chi Dong Han),허창규(Chang Kyu Huh),윤길숙(Ghil Suk Yoon),고석봉(Suk Bong Koh),이태성(Tee Sung Lee) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.12
N/A Struma ovarii consists of thyroid tissue which is derived from germ cells in a mature teratoma. Five percent of struma ovarii are malignant, and of these only five percent metastasize. The rarity of this disease has resulted in difficulty in agreeing on treatment regimens and in limited imaging and monitoring difficulties encountered in their management. We have experienced two cases of malignant struma ovarii with brief review of the literature.
김민 ( Min Kim ),차승익 ( Seung Ick Cha ),신경민 ( Kyung Min Shin ),윤길숙 ( Ghil Suk Yoon ),배정현 ( Jung Hyun Bae ),윤원경 ( Won Kyung Yoon ),이신엽 ( Shin Yup Lee ),김창호 ( Chang Ho Kim ),박재용 ( Jae Yong Park ),정태훈 ( Tae 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.68 No.4
Hot tub lung is a lung disorder associated with exposure to hot tub water contaminated with Mycobacterium avium complex (MAC). Although its pathogenesis remains unclear, it may be considered hypersensitivity pneumonitis (HP) rather than an infectious disease. We report a case which fulfilled the current diagnostic criteria of hot tub lung. A patient had worked as a cleaner in the public bath for approximately one year and presented with dyspnea for over one month. The computed tomographic finding of bilateral ground glass attenuation and pathologic finding of granulomatous inflammation were consistent with HP. MAC was isolated from bronchoalveolar lavage fluid and hot tub water. After corticosteroid treatment without antimycobacterial medication, the patient improved and there has been no recurrence. The patient has since discontinued working in the public bath.
원발성 전신형 Ki-1 ( CD30 ) 양성 대형세포 림프종 1 예
우민정(Min Jung Woo),이성우(Sung Woo Lee),정현(Hyun Chung),김상원(Sang Won Kim),윤길숙(Ghil Suk Yoon) 대한피부과학회 2002 대한피부과학회지 Vol.40 No.5
We report a case of Ki-J(CD30) positive large cell lymphoma which developed on the skin of the right inguinal area in an 8-year-old boy. The lesion was a 3.0×5.0㎝ sizde ulecrative tumor with elevated margin, rapidly growing during 2 week period and was associated with enlargement of the left ingutinal lymph nodes. Histopathologic feature showed anaplastie cells with abundant cytoplasm and multinueleated giant cells with wreath-like muelei in the dermis and subeutis. Immunohistoehimieally, tumor cells were CD30 positive. He was treated with ehemotheraty through RFM-NHI. protocol, with good response.
사마귀양혈관종과 혈관각화종: 임상병리조직학적 유사점과 차이점
정홍대 ( Hong Dae Jung ),박경덕 ( Kyung Duck Park ),지성근 ( Seong Geun Chi ),이석종 ( Seok Jong Lee ),최윤석 ( Yoon Seok Choe ),김병수 ( Byung Soo Kim ),김도원 ( Do Won Kim ),정호윤 ( Ho Yun Chung ),윤길숙 ( Ghil Suk Yoon ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.4
Background: Verrucous hemangioma (VH) and angiokeratoma (AK) are vascular birthmarks of an unclear nosology and these birthmarks commonly show a superficial hyperkeratotic vascular component. There are both similarilities and differences between VH and AK with some confusion concerning their overlapping features. Objective: This study was undertaken to review the clinicopathological features of VHs and AKs and to determine the similarilities and differences between them. Methods: We retrospectively reviewed 11 VHs and 7 AKs at the Vascular Anomaly Clinic of our hospital over the past 10 years. They were evaluated from the clinicopathologic point of view for factors such as the age of onset, location, size, symptoms, the histopathological epithelial change and involvement of deeper tissue. Results: These birthmarks share common clinical features with the exception of gender and lesion size. Histopathologically, hyperkeratosis, acanthosis and capillary dilatation in the upper dermis were commonly seen. Yet lobular proliferation and dilatation of blood vessels in the deep dermis, or more importantly, the subcutis were detected in VH only. Furthermore there was a case of VH that showed diffusely scattered increased blood vessels in the subcutis, suggesting an evolving stage of VH and there was another case of VH that was erroneously diagnosed as AK via the initial biopsy, and the final diagnosis was changed according to the excised lesion. Conclusion: The two diseases share most of their clinicopathological features, but small parts of features like gender, the clinical size and the histological deep dermis/subcutis involvement were differences. Making the correct differential diagnosis between VH and AK through a deep biopsy with appropriate timing and long term follow up and/or radiological examination is helpful to avoid erroneous management. (Korean J Dermatol 2009;47(4):419~424)
면역적격환자에서 발생한 위막성 아스페르길루스 기관기관지염
차승익 ( Seung Ick Cha ),신경민 ( Kyung Min Shin ),유승수 ( Seung Soo Yoo ),정지윤 ( Ji Yun Jeong ),윤길숙 ( Ghil Suk Yoon ),이신엽 ( Shin Yeop Lee ),김창호 ( Chang Ho Kim ),박재용 ( Jae Yong Park ),정태훈 ( Tae Hoon Jung ) 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.5
Aspergillus tracheobronchitis (ATB), a variant of invasive pulmonary aspergillosis, is characterized by extensive tracheobronchitis and pseudomembrane formation. ATB usually occurs in immunocompromised patients with a high fatality rate. We report a case of ATB in a previously healthy patient who responded well to antifungal therapy.
유아혈관종의 임상병리조직학적 고찰: GLUT-1염색의 진단적 유용성
지성근 ( Seong Geun Chi ),정홍대 ( Hong Dae Jung ),이석종 ( Seok Jong Lee ),김병수 ( Byung Soo Kim ),이원주 ( Weon Ju Lee ),김도원 ( Do Won Kim ),정호윤 ( Ho Yun Chung ),윤길숙 ( Ghil Suk Yoon ) 대한피부과학회 2009 大韓皮膚科學會誌 Vol.47 No.4
Background: Hemangioma of infancy (HOI) is one of the most common tumors in childhood. Their clinical features can on occasion look like those of other vascular tumors and malformations, so the correct differentiation of HOI may not always be easy. Objective: The purpose of this study was to review the clinicopathological features of HOIs and to particularlyexamine the usefulness of glucose transporter protein isoform-1 (GLUT-1) immunohistochemical stain (IHS) as a specific marker of HOI. Methods: This study was conducted at the Vascular Anomaly Clinic of Kyungpook National University Hospital during 11 years (1998~2008). Sixty-two cases were selected in addition to selecting other tumors and malformation as a control group. We then reviewed their clinical features and the results of H&E and GLUT-1 IHS for making the differential diagnosis.Results: The male to female ratio was 1: 2.88. The head and neck were the most commonly involved sites. The complications included ulceration and/or bleeding (12.9%), scarring (9.7%), infection (4.8%), ocular complications (4.8%) like visual axis occlusion, and pain (1.6%). Three phases of proliferating, involuting and involuted of a HOI comprised 11.3%, 37.1% and 51.6% of the lesions, respectively, from the clinical view point and 11.3%, 48.4% and 40.3% of the lesions, respectively, from the pathological point of view. GLUT-1 was positively expressed on almost all of the HOIs (47/57, 82.5%), except for 10 HOIs of the involuted phase and the other controls. Conclusion: The clinicopathological findings of this study were similar with those of the previous reports. The expression of GLUT-1 by a HOI can be helpful to make the correct diagnosis from other vascular tumors and malformations. (Korean J Dermatol 2009;47(4):386~394)
피부를 침범한 비강 원발성 CD56 양성 T/NK-세포 림프종의 임상 및 병리조직학적 고찰
최지호(Jee Ho Choi),성경제(Kyung Jeh Sung),문기찬(Kee Chan Moon),고재경(Jai Kyoung Koh),장성은(Sung Eun Chang),윤길숙(Ghil Suk Yoon),허주령(Joo Ryung Huh) 대한피부과학회 2000 대한피부과학회지 Vol.38 No.6
Background:There are recently increasing reported cases of patients with malignant lymphoma with unique characteristics, designated nasal-type T/natural killer (NK) cell lymphoma (NKTL), which usually expresses the NK cell marker and shows frequent extra-nodal involvement including skin and poor prognosis. The CD56+ NKTL can be divided into nasal and non-nasal types. Nasal and non-nasal (nasal type) CD56+ NKTL share the same pathologic features such as angiocentricity and necrosis. Objective:We have studied clinicopathologic features of 5 cases of nasal CD56+ NKTL with cutaneous involvement to further elucidate the behaviour of nasal CD56+ NKTL. Results:Clinically, the cutaneous lesions were variable. Four of the five cases died with rapidly progressive disease within 25 months. Histologically, variable sized pleomorphic lymphoid cells with or without prominent angiodestruction were observed. Severe necrosis was consistent features. The results of immunophenotypes(both CD56+ and CD3+) and TCR gene rearrangement study showed these 5 cases are of NK cell origin(4 cases) or NK-like T-cell origin (1 case). A firm association with Epstein-Barr virus (EBV) infection was confirmed in our study. Conclusion:Although the prognosis of nasal CD56+ NKTL was not so bad, higher stage of nasal CD56+ NKTL with cutaneous metastasis seemed to be very fatal. The term NKTL has to be further specified according to immunophenotypes such as CD56+ or true T-cell, NK-like T cell lymphoma since biologic behaviour of each subgroup can be different. (Korean J Dermatol 2000;38(6):713~720)
귀 이개에 발생한 근혈관주위세포종(Myopericytoma)
김호연 ( Ho Youn Kim ),임현정 ( Hyun Jung Lim ),박병철 ( Byung Cheol Park ),이석종 ( Seok Jong Lee ),김병수 ( Byung Soo Kim ),이원주 ( Weon Ju Lee ),김도원 ( Do Won Kim ),윤길숙 ( Ghil Suk Yoon ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.11
The concept of perivascular myomas was recently proposed to designate perivascular myoid tumors arising from pleuripotent perivascular cells like smooth muscle cell cells, pericytes and glomus cell. They represent a histological continuum between three categories; myofibromatosis, glomangiopericytoma and myopericytoma. Myopericytoma is a rare, soft tissue tumor that primarily occurs in the skin and the subcutaneous and soft tissues of the extremities, but very few cases have been reported in other locations, which occurred in our present case. We herein report on a rare case of myopericytoma that developed on an unusual location, that is, the ear. The patient was a 35-year-old man who had a painless, slowly-growing red nodule on the upper auricle of the right ear for 5 years. The nodule was revealed to be a well-circumscribed mass composed of round to oval cells that strongly expressed smooth muscle actin. These cells were arranged in the concentrically multilayered pattern and they were surrounded by small to medium-sized vessels. (Korean J Dermatol 2009;47(11):1304~1308)