http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
신체부위별 측정변인에 따른 경신강지환16의 비만 개선효과 평가
정양삼,윤기현,최승배,윤미정,신순식,Jung, Yang-Sam,Yoon, Ki-Hyeon,Choi, Seung-Bae,Yoon, Mi-Chung,Shin, Soon-Shik 대한한의학방제학회 2008 大韓韓醫學方劑學會誌 Vol.16 No.1
In this study, we measured body mass index, visceral fat ratio and 6 parts of body, neck circumference, circumference of upper arm, chest circumference, abdomen circumference, hip circumference, and thigh circumference by bioimpedence analysis system, after taking Gyeongshingangjeehwan16 (GGEx16) in five months except the first period before taking GGEx16 on 49 women who are obesity or high-level obesity. In order to examine the significance test for the effect of obesity improvement of GGEx16, we practices repeated measure ANOVA with values of measurement variables in 6 monthly times. As a result of all measurement variables, there were significant difference (P-value=0.001). Therefore, we can say that GGEx16 is effective about obesity improvement. As it dramatically decreased between second measure period and first measure period for all measure variables, we can see that there were the most effect of GGEx16 in the first time after taking GGEx16. It is known that a important measurement variable to have a effect for obesity improvement about two variable which are body mass index and visceral fat ratio is waist circumference through correlation analysis. The result of whether there are differences to effect of obesity improvement for GGEx16 around the climacteric, there were significant difference for the effect of obesity improvement for GGEx16 around the climacteric about all parts of body (P-value=0.001). There were also powerfully difference in effect of obesity improvement for GGEx16 around the climacteric about all parts of body (P-value=0.001). Especially, the climacteric before is more effective than the climacteric after in the aspect of the effect of GGEx16.
고지방식이 수컷 마우스 비만모델에서 micro-CT를 이용한 마황(麻黃)과 마우(魔芋)의 복부비만 조절효과
원찬욱,정양삼,윤기현,이희영,윤미정,김보경,박선동,신순식,Won, Chan-Uk,Jung, Yang-Sam,Yoon, Ki-Hyeon,Lee, Hee-Young,Yoon, Mi-Chung,Kim, Bo-Kyung,Park, Sun-Dong,Shin, Soon-Shik 대한한의학방제학회 2008 大韓韓醫學方劑學會誌 Vol.16 No.2
Objectives : We investigated the effects of Herba Ephedrae and Rhizoma Amorphophalli on high fat diet induced obese male mice. Methods : 8 weeks old, high fat diet induced obese male mice were divided into 5 groups: C57BL/6 normal control, obese vehicle control, GGEx55 (Herba Ephedrae), GGEx61 (Rhizoma Amorphophalli), GGEx62 (Herba Ephedrae + Rhizoma Amorphophalli). After mice were treated with GGEx for 8 weeks, we measured body weight gain, food intake, feeding efficiency ratio, rectal temperature, fat weight, plasma leptin and lipid levels. We also took micro-computerized axial tomography (micro-CT) on the mice. Results : 1. GGEx55 and GGEx62 groups significantly decreased body weight gain and feeding efficiency ratio compared with vehicle control. But they significantly increased rectal temperature. 2. Plasma total cholesterol and LDL-cholesterol concentrations were significantly increased by GGEx55 groups, whereas were significantly decreased by GGEx62 groups compared with vehicle control. 3. GGEx55 and GGEx62 groups significantly decreased total, subcutaneous and visceral fat as well as fat areas in micro-CT analysis of abdomen compared with vehicle control. 4. Plasma GOT and GPT concentrations were significantly increased by GGEx55 groups compared with vehicle control. Conclusions : These results demonstrate that GGEx55 and GGEx62 effectively reduces body weight gain, feeding efficiency ratio in high fat diet induced obese mice, leading to the modulation of obesity. In addition, GGEx55 and GGEx62 decreases visceral adipose tissue mass and improves plasma lipids, suggesting that GGEx55 and GGEx62 may act as a therapeutic agent for obesity.
생체전기임피던스 측정법에 의한 경신강지환16의 비만개선 효과 평가
정양삼 ( Yang Sam Jung ),윤기현 ( Ki Hyeon Yoon ),최승배 ( Seung Bae Choi ),윤미정 ( Mi Chung Yoon ),신순식 ( Soon Shik Shin ) 대한한방신경정신과학회 2008 동의신경정신과학회지 Vol.19 No.1
Objective : Obesity threatens not only the problem of beauty but also health. Furthermore, it could be harmful a chronic disease to increase mortality rate. A purpose of this study is to show a effect of obesity control as developing a herbal medicine, Gyeongshingangjeehwan16 (GGEx16), in order to control obesity that is a harmful factor for healthy. Method : In order to prove the effect of GGEx16, BMI, fat distribution, fat control and fitness score which are closely related with obesity are considered as variables. Each variable is measured, for statistical analysis, using measurement implement of InBody 3.0 which applied a theory of bioimpedence analysis. Result and Conclusion : As a result of statistical analysis for four variables, it was improved that there are the improved effect for obesity because GGEx16 is statistically meaningful better than prior to taking.
Ob/Ob 마우스에서 경신강지환(輕身降脂丸)18의 비만조절
신순식 ( Soon Shik Shin ),윤기현 ( Ki Hyeon Yoon ),이희영 ( Hee Young Lee ),정양삼 ( Yang Sam Jung ),서부일 ( Bu Il Seo ),박규열 ( Gyu Ryeol Park ),윤미정 ( Mi Chung Yoon ) 대한본초학회 2010 大韓本草學會誌 Vol.25 No.3
Objectives: This study was undertaken to verify the effects of Gyeongshingangjeehwan18 (GGEx18) on obesity using ob/ob male mice. Methods: Eight-week old mice (wild-type C57BL/6J and ob/ob) were used for all experiments. Wild-type C57BL/6J mice were used as lean control and obese ob/ob mice were randomly divided into 5 groups: obese control, GGEx15, GGEx16, GGEx17, and GGEx18. After mice were treated with several kinds of GGEx for 11 weeks, body weight gain, feeding efficiency ratio, plasma lipid and glucose metabolism. Results: 1. Compared with obese controls, GGEx-treated mice had lower body weight gain and feeding efficiency ratio, the magnitudes of which were prominent in GGEx16 and GGEx18. 2. Consistent with their effects on body weight gain, GGEx16 and GGEx18 not only decreased plasma triglycerides levels, but also increased HDL-cholesterol concentration. 3. CT analysis revealed that visceral fat areas were decreased in all treatment groups compared with obese control mice. The decrease in visceral fat area was prominent in GGEx16 and GGEx18, although they were not statistically significant. 4. The size of adipocytes were significantly decreased by GGEx18, whereas the adipocyte number per unit area was significantly increased, suggesting that GGEx18 decreased the number of large adipocytes. Hepatic lipid accumulation was decreased by GGEx16 and GGEx18, and the inhibitory effect was most effective in GGEx18. 5. Plasma GOT and GPT concentrations were significantly lower following GGEx16 and GGEx18 treatment compared with obese controls. Organ weights were not changed by GGEx treatment, indicating GGEx do not show any toxic effects. Conclusions: These results suggest that GGEx may regulate obesity. Of the 4 compositions, GGEx18 seems to be most effective in improving obesity and lipid disorders.
고지방식이 C57BL/6N 모델에서 降脂丸의 농도별 비알콜성 지방간질환 개선효과
안예지 ( Ye Ji Ahn ),윤기현 ( Ki Hyeon Yoon ),조주흠 ( Ju Heum Jo ),장두현 ( Du Hyon Jang ),정양삼 ( Yang Sam Jung ),김종훈 ( Jong Hoon Kim ),김병출 ( Byeong Chul Kim ),석화준 ( Hoa Jun Seok ),유재상 ( Jae Sang Yoo ),구자룡 ( Ja R 대한본초학회 2014 大韓本草學會誌 Vol.29 No.2
Objectives : This study was undertaken to verify the effect of Gangjihwan(Di-fatty, DF) composed with Pakistani Ephedra Herba on nonalcoholic fatty liver disease(NAFLD) using high fat diet-fed male mice. Method : Eight-week old C57BL/6N mice were used for all experiments. Standard chow diet-fed mice were used as normal group and high fat diet-fed NAFLD mice were randomly divided into 5 groups: control, atorvastatin, DF(1), DF(2) and DF(3). After 8 weeks, mice were treated with water, atorvastatin(10mg/kg) and DF(40, 80, 160mg/kg) for 8 weeks. And we investigated body weight gain, plasma lipid and glucose metabolism, histological analysis for liver on the mice. Results : Compared with controls, DF-treated mice had very significantly lower body weight gain and lower visceral adipose tissue weight, the magnitudes of which were prominent in DF(3). Consistent with their effects on body weight gain, DF-treated mice had lower blood total cholesterol and triglyceride level compared with controls. Consistent with their effects on body weight gain and blood plasma lipid level, DF-treated mice had lower liver weight and hepatic lipid accumulation of DF-treated groups was significantly decreased than control group. Also Blood plasma AST, ALT and γ-GT concentration were not changed by DF, and these results may indicate DF do not show any toxic effects. Conclusions : These results suggest that DF effectively improves NAFLD. DF reduces liver weight and prevents lipid accumulation of hepatocyte by reducing body weight gain and modulating blood plasma lipid metabolism levels.
경신강지환(輕身降脂丸)18의 분자생물학적인 비만조절 기전에 관한 연구
이희영 ( Hee Young Lee ),윤기현 ( Ki Hyeon Yoon ),서부일 ( Bu Il Seo ),박규열 ( Gyu Ryeol Park ),윤미정 ( Mi Chung Yoon ),심지빈 ( Zhi Bin Shen ),최홍화 ( Hong Hua Cui 崔紅花 ),신순식 ( Soon Shik Shin ) 대한본초학회 2011 大韓本草學會誌 Vol.26 No.1
Objectives: This study was undertaken to verify the modulation mechanism of Gyeongshingangjeehwan18 (GGEx18) in ob/ob male mice. Methods: Eight-week old mice (wild-type C57BL/6J and ob/ob) were used for all experiments. Wild-type C57BL/6J mice were used as lean control and obese ob/ob mice were randomly divided into 5 groups: obese control, GGEx15 (Ephedra sinica Stapf + Rheum palmatum L.), GGEx16 (Ephedra sinica Stapf + Laminaria japonica Aresch), GGEx17 ( Rheum palmatum L. + Laminaria japonica Aresch), and GGEx18 ( Ephedra sinica Stapf + Laminaria japonica Aresch + Rheum palmatum L.). After mice were treated with several kinds of GGEx for 11 weeks, the mRNA expression of peroxisome proliferator-activated receptor (PPAR) target genes and uncoupling protein (UCP) were measured. In addition, PPARα and PPARβ transactivation was examined in NMu2Li hepatocytes, C2C12 myocytes, and 3T3-L1 preadipocytes using transient transfection assays. Results: 1. Hepatic PPARα target genes, such as ACOX and VLCAD mRNA levels were significantly increased by GGEx18 compared with obese controls. In skeletal muscle, LCAD mRNA expression was stimulated by GGEx16, GGEx17, and GGEx18, whereas MCAD mRNA expression by GGEx17 and GGEx18. PPARβ target LPL mRNA levels were also increased by GGEx16, GGEx17, and GGEx18 in skeletal muscle, but adipose LPL mRNA levels were decreased. In addition, GGEx18 upregulated UCP mRNA expression in skeletal muslce. 2. PPARα reporter gene expression was increased by GGEx18 in NMu2Li cells compared with vehicle. PPARα and PPARβ reporter activities were also increased by all GGEx treatments in C2C12 and 3T3-L1 cells. Conclusions: These results suggest that GGEx can act as PPARα and PPARβ activators, and that GGEx may regulate obesity by stimulating PPARα, PPARβ, and UCP activity. Of the 4 compositions, GGEx18 seems to be most effective in improving obesity and lipid disorders.
고지방식이 비만마우스 모델에서 파키스탄산 마황으로 조성된 강지환(降脂丸)의 단독 투여와 강지환합가미소체환(降脂丸合加味消滯丸)의 병용 투여의 체중감량 효과 비교
석화준,유재상,구자룡,윤기현,조주흠,장두현,정양삼,김종훈,김병출,노종성,이혜림,이형희,윤미정,신순식,Seok, Hoa Jun,Yoo, Jae Sang,Ku, Ja Ryong,Yoon, Ki Hyeon,Jo, Ju Heum,Jang, Du Hyon,Jung, Yang Sam,Kim, Jong Hoon,Kim, Byeong Chul,Roh, Jong Seong 대한한의학방제학회 2014 大韓韓醫學方劑學會誌 Vol.22 No.2
Objectives : This study was investigated the improvement effects of Gangjihwan (DF) and combination of Gangjihwan and Gamisochehwan (GSH) on obesity in a high fat diet-fed obese mouse model. Methods : Eight-week-old C57BL/6N mice were divided into four groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF and DF+GSH groups given a high fat diet with DF (40 mg/kg), and DF+GSH (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio, blood lipid markers, fat weight and histology were examined. Results : 1. Body weight gain and fat mass were significantly decreased in DF and DF+GSH groups compared with control. The extent of decreases was eminent in DF+GSH group. 2. Feeding efficiency ratio and circulating concentration of leptin were decreased in DF and DF+GSH groups compared with control. These decreases were significant in DF+GSH group. 3. Consistent with their effects on body weight gain and fat mass, circulating concentrations of triglyceride, glucose and insulin were decreased in DF and DF+GSH groups compared with control. 4. The size of adipocytes was decreased by DF and DF+GSH compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF and DF+GSH decreased the number of large adipocytes. 5. Consistent with their effects on body weight gain, liver fibrosis was also improved in DF and DF+GSH groups compared with control. Conclusions : In conclusion, these results suggest that DF and DF+GSH groups decrease feeding efficiency ratio, plasma leptin concentration, blood anti-obesity biomarkers and fat mass, improves body weight gain contributing to the inhibition of liver fibrosis. In addition, these effects were more effective in DF+GSH combination group than in DF-only group.
고지방식이 비만마우스 모델에서 파키스탄산 및 중국산 마황으로 조성된 강지환(降脂丸)의 체중감량 효과 비교
김병출,석화준,유재상,구자룡,윤기현,조주흠,장두현,정양삼,김종훈,안예지,우상이,윤미소,신순식,Kim, Byeong Chul,Seok, Hoa Jun,Yoo, Jae Sang,Ku, Ja Ryong,Yoon, Ki Hyeon,Jo, Ju Heum,Jang, Du Hyon,Jung, Yang Sam,Kim, Jong Hoon,Ahn, Ye Ji,Woo, San 대한한의학방제학회 2014 大韓韓醫學方劑學會誌 Vol.22 No.2
Objectives : This study investigated the improvement effects of Pakistani (DF-a) and Chinese Ephedra herba-containing Gangjihwan (DF-b) on obesity in a high fat diet-fed obese mouse model. Methods : Eight-week-old C57BL/6N mice were divided into four groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF-a and DF-b groups given a high fat diet with DF-a (80 mg/kg), and DF-b (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio, blood lipid markers, fat weight and histology were examined. Results : 1. Body weight gain and fat mass were significantly decreased in DF-a and DF-b groups compared with control. The extent of decreases was eminent in DF-a group. 2. Feeding efficiency ratio and circulating leptin concentration were significantly decreased in DF-a and DF-b groups compared with control, whereas circulating adiponectin concentration was increased in DF-a and DF-b groups compared with control. 3. Consistent with their effects on body weight gain and fat mass, circulating concentrations of triglyceride, glucose and insulin were decreased in DF-a and DF-b groups compared with control. 4. The size of adipocytes were decreased by DF-a and DF-b compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF-a and DF-b decreased the number of large adipocytes. 5. Consistent with their effects on body weight gain, liver fibrosis was reduced in DF-a and DF-b groups compared with control. Conclusions : In conclusion, these results suggest that DF-a and DF-b not only decrease feeding efficiency ratio, plasma leptin concentration, and blood anti-obesity biomarkers, but also reduce fat mass, contributing to the improvement of obesity. DF-a and DF-b also inhibit liver fibrosis. In addition, these effects were similar between Pakistani Ephedra herba and Chinese Ephedra herba-containing Gangjihwan.