http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
L - 3 [ 123I ] iodo - α - methyltyrosine 합성과 9L Glioma 이식 백서 분포조사
임상무(Sang Moo Lim),이종두(Jong Doo Lee),서용섭(Yong Sup Suh),전권수(Kwon Soo Chun),우광선(Kwang Sun Woo),정위섭(Wee Sup Chung),양승대(Seung Dae Yang),임종석(Jong Seok Lim),박현(Hyon Park),윤용기(Yong Ki Yun) 대한핵의학회 1995 핵의학 분자영상 Vol.29 No.1
N/A L-3[123I]iodo-methyltyrosine([123I] IMT) was synthesized by electrophilic radio-iodination using chloramine-T and Iodobead in phosphate buffered solution. And the biodistribution was examined in 9L glioma bearing rats. The radiosynthesis of [123I] IMT with iodobead was simpler and higher in radiochemical yield(88%) than the method using chloramine-T(83%) as radioiodinating reagent. The highest yield was obtained from the reaction using 1 piece of Iodobead, 200μg α- methyltyrosine in 100μl phosphate-buffered solution (pH 5.5) and the reaction was completed in 7min. 24hours after the injection, the biodistribution in 9L glioma transplanted rats revealed the in vivo deiodination, the excretion via kidney, and 3 times higher uptake in the tumor than normal brain. These results suggest the promising clinical use of [123I]IMT in the various ious malignancies.
上氣道感染에 對한 Solantal^(�)의 臨床的效果 觀察
한용철,노수환,윤광선,강홍모,김선영,허성호,김유영 최신의학사 1977 最新醫學 Vol.20 No.7
Clinical trial on the effectiveness of “Solantal” (Tiaramide.HCI) in upper respiratory infections was conducted. Fifty subjects, 30 male and 20 female consisting of the medical staffs, nursing staffs, and their families of the Seoul National University Hospital, with upper respiratory infections, and patients admitted to the same hospital with diseases other than respiratory origin who started to have symptoms during their admission. The clinical diagnoses on these 50 subjects were; influenza in 5, nasopharingitis in 35, tonsilitis in 2 and acute bronchitis in 6. Mean age of the subjects is 36.6 years old. The patients were given 300-600mg. of Tiaramide HCI per day in three divided dosages through oral route. The average duration of treatment was 4.25 days. Pre-and post-treatment status were compared on the following ten items, i. e. headache, odynophagia, sore throat hoarseness, cough, sputum, rhinorrhea, lassitude, arthralgia and fever, and the effectiveness was evaluated into 9 categories, i. e. excellent, good, fair, poor, worse and unknown. The ratio of excellent plus good to total number of patients who were suffered from each symptom is followings. 1) headache 75% 2) odynophagia 67% 3) sore throat 80.5% 4) hoarseness 58.3% 5) cough 57.5% 6) sputum 57.6% 7) rhinorrhea 81.5% 8) lassitude 67.5% 9) arthralgia 50% 10) fever 67.6% The tentative conclusions, pending more accurate double blind tests, are that Solantal has excellent anti-inflammatory action in upper respiratory infections, along with some analgesic and antipyretic actions.