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제2형 남자 당뇨병환자에서 비만과 비비만에 따른 아디포넥틴의 혈중 농도와 다중결합체의 차이
장상아 ( Sang Ah Chang ),손호영 ( Ho Young Son ),이정민 ( Jung Min Lee ),손태서 ( Tae Seo Sohn ),권혁상 ( Hyuk Sang Kwon ),손현식 ( Hyun Shik Son ),윤건호 ( Kun Ho Yoon ),김희승 ( Hee Seung Kim ),차봉연 ( Bong Yun Cha ),이광우 ( K 대한당뇨병학회 2007 Diabetes and Metabolism Journal Vol.31 No.3
배성미,양성희,최선,한옥연,권혁상,윤건호 한국병원약사회 2002 병원약사회지 Vol.19 No.4
Despite the potential utility of calcium supplements in menopausal women, there are few data concerning the absorbability of different calcium salts. This four phase cross over study was conducted to compare pharmacokinetic indices of calcium absorption after a single oral administration(600㎎ as an elemental calcium). We selected calcium lactate and calcium gluconate, calcium carbonate, ergocalciferol complement(A), calcium carbonate and cholecalciferol complement(B) as calcium salts and vitamin D complexes, and calcium carbonate (C), calcium citrate(D) as mono calcium salts. In 8 healthy postmenopausal women aged 45-61(mean:54.9years), venous blood samples were obtained for the measurement of serum calcium concentration before and at 1, 3, 5 hours after preload, at 3 hours A(0.613±0.557) and C(0.5±0.472) showed higher than D(-0.113±0.398), and at 5 hours A(0.650±0.607) and B(0.588±0.146) were higher than D(0.075±0.296) (p<0.05). Among the four supplements only A(2.17±1.99) had greater change in area under the curve (ΔAUC_(1~5hr)of C with D, and C with B, and A with B. Only C(1.57±1.42) had higher ΔAUC_(1~5hr) than D(-0.25±1.27, p=0.018). Comparing bioavailability of four commercial calcium supplements by ΔAUC_(1~5hr) calcium citrate(D) had relatively lower bioavailability and we couldn't convince that vitamin D complexes had higher bioavailability than mono calcium salts. Considering the similarity in bioavailability of each calcium supplements, it is favorable so select calcium supplements according to the patient compliance, simplicity of taking the medicine or medical cost.