Darier 징후를 보인 동정맥 혈관종

유희준,권상진,조지형,양홍윤,박용욱,장세진 ( Hee Joon Yu,Sang Jin Kwon,Ji Hyeung Cho,Hong Yoon Yang,Yong Wook Park,Se Jin Jang ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.1

We experienced a case of arteriovenous hemangioma showing Dariers sign on the forehead of a 43-year-old man. He presented with a single, 1 * 1.5cm sized, violaceous, asymptomatic nodule with a history of an intermittent wheal at the lesional site. This skin lesion showed Dariers sign clinically and proliferation of mast cells histopathologically with the punch biopsy specirnen suggesting urticaria pig- mentosa. Howerer, we could diagnose it as a arteriovenous hemangioma on complete excision, as the specimen showed arteriovenous proliferation with increased mast cells in a perivascular pattern. This case showed confusing clinical signs and showed the importance of complete excision for the diagnosis of a small skin tumor especially when a vascular proliferating tumor is suspected. (Kor J Dermatol 1997;35(1): 209-213)

모낭선종

유희준 ( Hee Joon Yu ),양홍윤 ( Hong Yoon Yang ),김윤석 ( Yun Suck Kim ),은철 ( Chul Eun ),장세진 ( Se Jin Jang ),박용욱 ( Yong Wook Park ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2

Trichoadenoma is a rare cutaneous tumor that was first described by Nikolowski in 1958. It usually occurs as a single tumor on the face and its size varies from 3 to 50mm in diameter. It may arise any time during adult life. This tumor is less mature than trichofolliculoma and more differentiated than trichoepithelioma, and it is considered as a benign tumor with differentiation toward the infundibular portion of the pilosebaceous canal. In this report, we describe a 61-year-old women who developed trichoadenoma on the left shoulder of 3 years duration. The lesion was asymptomatic and had grown slowly. Histopathological findings showed numurous horn cysts with central keratinous material and solid tumor islands reaching to the deep dermis. Immunohistochemical studies showed negative findings for eccrine differentiation. (Korean J Dermatol 1998;36(2) . 372-375)

벌침 육아종 3예

유희준 ( Hee Joon Yu ),이창우 ( Chang Woo Lee ),양홍윤 ( Hong Yun Yang ),김정수 ( Joung Soo Kim ),김윤석 ( Yun Suck Kim ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.5

Most insects including the honeybee cause erythema and edema at the site of a sting in non-allergic individuals. This reaction usually resolves within a few days. However, in certain cases, the persistence of inciting materials in the cutaneous tissue may promote a local inflammatory foreign body reaction. Localized nodular lesions were seen in our two patients and erythemstous patches were present in one patient due to rarely encountered complications induced by retained sting materials. In these cases histopathology showed multiple foci of foreign body granuloma containing yellow refraetile material in the center surrounded by histiocytes and foreign body giant cells. The granulomatous skin lesions in these patients were treated with intralesional injections of triamcinolone acetonide and partial excisions of the nodular masses were performed (Korean J Dermatol 1998;36(5): 914-917)

탈색모반 104예의 임상 양상

유희준(Hee Joon Yu),여운철(Un Cheol Yeo),송민규(Min Gyu Song),유재학(Jae Hack Yoo),김방순(Bang Soon Kim),고우석(Woo Seok Koh),전덕규(Duk Kyu Chun),김병수(Byung Su Kim),최지호(Jee Ho Choi),박경찬(Kyoung Chan Park) 대한피부과학회 2000 大韓皮膚科學會誌 Vol.38 No.5

N/A Background:Nevus depigmentosus is known to be a congenital, stable hypomelanosis characterized by macules of varied size, of pale white color, and with discrete, regular, or occasionally serrated margins. The lesions are uniformly hypomelanotic but not amelanotic, and they show off-white accentuation with a Wood's lamp examination. It is important to differentiate nevus depigmentosus from vitiligo because both entities have different clinical courses. Objective:The purpose of this study is to investigate clinical features of nevus depigmentosus. Methods:Total 104 patients were included in this study. Data compiled were sex, age of onset, duration before visit, number of lesion, shape of lesion, and distribution of lesion. Results:In our study, there was no difference between male and female in incidence. In terms of age of onset, patients who had lesion at birth was 32.7%, below 1 year 34.6% and over 1 year 32.7%. They had variable duration before visit. Among patients, 56.7% had only one lesion, 34.6% had 2 to 5 lesions, and 2.0% of patients had more than 20 lesions. Polygonal(35.3%) or round to oval(25.9%) shape was more common than others. The trunk(41.5%) was the most common site of involvement and the neck(23.9%), face(20.1%), lower and upper extremity were involved in descending order of frequency. Conclusion:According to our study, lesions of nevus depigmentosus were found before the age of one in two thirds of patients. Almost half of patients had only one lesion. Polygonal shape was the most common shape and the trunk was the most common site in our study. These clinical features may be useful in differential diagnosis of nevus depigmentosus from other hypopigmentary disordes. (Korean J Dermatol 2000;38(5):612~615)

서울 지방 백선증의 원인균 분포 ( 1985 - 1991 )

유희준(Hee Joon Yu),최연상(Yeon Sang Choi),백영곤(Young Gon Baik),손숙자(Sook Ja Son) 대한피부과학회 1994 大韓皮膚科學會誌 Vol.32 No.1

Background : Dermatophytoses show marked differences in their incid.nces, distributions, and causative organisms by age, sex, occipations, environmental conditions and geographic dist.ributions. Objective : We evaluated the recent distributions of dermato

선천성 피부 칸디다증

유희준(Hee Joon Yu),천병남(Byung Nam Chun),김수조(Soo Jo Kim),손숙자(Sook Ja Son) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.4

We report, a 1-day-old male with congenital cutaneous candidiasis who had generalized erythematous papules and pustules on the whole body including palms and soles from birth. At 5th month of pregnancy, his mother had a history of vaginal candidiasis for a month KOH mount of pus from pustules of several different sites showed budding spores and pseudohrphae and fungus culture revealed the growth of Candida albicans We believe this to he the first documented case of congenital cutaneous candidiasis in Korean literature.

Bart 증후군

김희옥(Hee Ok Kim),백영곤(Young Gon Baik),유희준(Hee Joon Yu),손숙자(Sook Ja Son) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.4

Barts syndrome was desrribed by Bart(Bart et al, 1966) with hereditary congenital localized absence of skin from the lovrer legs associated with blistering of the sun and mouth and nail abnormalities. A newborn girl presented with a congenital localized absence of skn over both shins & dorsa of both feet which were covered with the thin, translucent, brown red glistening membranes. A number of blisters were seen on the back, thighs upper extremities, and both 2rd toe nails were absent. Electron microscopic examination of defected skin revealed dermo-epidermal . paration with focal disruption of basal lamina. (Kor J Dermatol 1993;31(4):620-623)

A Case of Epilepsy with Mental Retardation Limited to Females in a Patient with PCDH19 Mutation Confirmed using an Epilepsy Gene Panel

김효진,유희준,Kim, Hyo Jin,Yu, Hee Joon The Korean Society of Inherited Metabolic Disease 2019 대한유전성대사질환학회지 Vol.19 No.1

PCDH19-related epilepsy is an inherited disease occurring in female patients and characterized by early onset seizure, intellectual disability, and behavioral disturbances. It is caused by de novo or familial heterozygous variation of the PCDH19 gene located on Xq22.1. Our patient was hospitalized for multiple focal seizures. The magnetic resonance imaging was normal and electroencephalogram showed focal epileptiform discharges. The child's development did not progress; she began to manifest, cognitive, behavioral and language delays. Because of that, we performed an epilepsy gene panel test. We report a case of epilepsy with mental retardation limited to female patients with mutation of PCDH19. EFMR은 뇌전증을 보이는 여자 환자에게서 지적장애가 동반된 것이 특징적인데 이들 중 PCDH19 변이와 연관이 있는 경우를 PCDH19 연관성 뇌전증으로 분류하였다. PCDH19 연관성 뇌전증은 조기에 발병하며 열에 민감하고 잘 조절되지 않는 군집발작을 보이는 것이 특징이다. 발달장애나 인지 및 행동장애를 동반할 수 있으며 정상에서부터 중증까지 다양하게 나타날 수 있다. 최근 이러한 질환에서 유전적 원인을 찾고자 하는 노력으로 뇌전증 유전자 패널을 이용하는 경우가 많아지고 있다. 저자들은 EFMR 환자에서 뇌전증 유전자 패널을 이용한 유전자 검사상 PCDH19 돌연변이가 확인된 사례를 경험하였기에 보고하는 바이다.

매독진의 병리조직학적 고찰

김희옥(Hee Ok Kim),유희준(Hee Joon Yu),손숙자(Sook Ja Son),유태연(Tae Yun Yoo) 대한피부과학회 1993 대한피부과학회지 Vol.31 No.2

Background : The differentiation of syphilids from other skin decreases is frequently difficult due to considerable variations of clinical and histologic pattern. The most common histologic changes in secondary syphilis are swelling & proliferation of endothelial cells and the presence of a perivascular infiltrate containing plasmia cells. But often, these findings are absert or inconspicuous. Objectlve : We examined the histopathologic findings of secondary syphilis in relation to the clinical types of the skin lesion. Methods : 36 biopsy specimens from twenty-nine serologically and clinically confirmed cases of secondary syphilis (15 macules, 8 papules, 2 condylomata latas and 11 papulosquamous lesions) were examined. Raeults : The histopath,ologic findings of secondary syphilis showed comparative differences according to the clinical types of the skin lesion. The plasms cell infltrates were absent or sparse in 14 csses(39%) and the plasma cell infiltration was significantly correhted with the age of skin lesions(p=0.02197). Vascular changes were seen in 32 cases (89%), but the incidence of endothelial proliferation was less(25%). Conclvsion : This study demonstrates the histopathologic findirigs of secondary syphilis in accordance to the clinical morphology of the eruption and thus, help to differentiate syphilids from other skin diseases. (Kor J Dermatol 1993; 31(2): 197-203)

모세혈관 확장성 윤상 자반병양 피부 병변을 보인 매독진

김희옥(Hee Ok Kim),최연상(Yeon Sang Choi),유희준(Hee Joon Yu),손숙자(Sook Ja Son) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5

The skin manifestations of secondary syphilis, termed syphilid, show macular, papular and papulosquamous rashes in most cases, but may show lots of other clinical findings. We report a case of syphitid simulating purpura annulsris telangieitodes in 25-year-old male who had a history of genital ulcer 2 months ago. The skin lesion showed diffuse erythematous, 1-3 cm sized, telangiectatic annular patchea and purpuric plaques on both lower extremities and discrete papulosquamous rashes on both soles. The results of the serologic test for syphili was found to be reactive to 32 dilution in serum VDRL test and positive in serum TPHA test. Histovathologically, we could observe the obscuring of dermoepidermal juction, coat-sleeve-like perivascular infiltrate composed of mononuclear cells and a few plasma cells, and endothelial swellings. Afte the treatment with benzathine penicillin G, the titer of serurn VDRL test was decreased abruptly to 4 dilution and the skin lesions disappeared completely. (Kor J Dermatol 1994;32(5):926-930)