집먼지진드기에 감작된 알레르기성 천식과 비염 환자에서 기도 염증 정도의 예측 인자로서의 혈청 c-kit 수용체의 역할

유혜수 ( Hye Soo Yoo ),김주희 ( Joo Hee Kim ),황의경 ( Eui Kyung Hwang ),남영희 ( Young Hee Nam ),진현정 ( Hyun Jung Jin ),신유섭 ( Yoo Seob Shin ),예영민 ( Yeong Min Ye ),남동호 ( Dong Ho Nahm ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2012 천식 및 알레르기 Vol.32 No.2

Background: Allergic rhinitis can progress to asthma. Both allergic rhinitis and asthma are characterized by Th2-dependent inflammation due to activated mast cells and eosinophils. Mast cells are dependent on kit-mediated activation, and the stem cell factor (SCF)/c-kit pathway leads to eosinophil infiltration. We investigated whether inflammation through the SCF/c-kit pathway would be associated with upper and lower airway inflammation. Methods: We enrolled 71 allergic asthma patients with rhinitis (group I) and 47 patients with allergic rhinitis alone (group II), and 59 non-atopic healthy controls (group III). Groups I and II showed positive responses to house dust mites in skin prick tests. The serum concentrations of c-kit receptor and SCF were measured by using ELISA. Eosinophil cationic protein (ECP) levels were measured by using the CAP system. Other clinical parameters were analyzed. Results: There were significant differences in the mean values of c-kit receptor levels between the 3 groups (117.27± 41.05 vs. 93.13±37.21 vs. 88.45±24.32 ng/mL, P<0.001). The c-kit receptor level was the highest in group I. However, no significant differences were found in SCF levels between the 3 groups. A positive correlation was found between c-kit receptor and ECP levels in groups I and II (r=0.31, P=0.016). Moreover, a positive correlation was found between c-kit receptor levels and total eosinophil counts in groups I and II (r=0.34, P<0.001). However, there were no significant associations between c-kit receptor levels and clinical parameters, such as forced expiratory volume 1% predicted value in group I. Conclusion: Serum c-kit receptor levels can be a useful serologic marker for predicting the extent of eosinophilic inflammation in upper and lower airway inflammation. (Korean J Asthma Allergy Clin Immunol 2012;32:92-100)

소아에서 늑막 삼출액을 동반한 외상성 췌장 절단 및 췌장 주관 손상 1예

이가연,유혜수,이지현,최연호,허진석,Lee, Ga-Yeun,Yoo, Hye-Soo,Lee, Jee-Hyun,Choe, Yon-Ho,Heo, Jin-Seok 대한소아소화기영양학회 2007 Pediatric gastroenterology, hepatology & nutrition Vol.10 No.1

An 8-year-old boy presented with abdominal pain and poor oral intake for two months. Serum amylase and lipase levels were elevated. CT of the abdomen and chest X-ray showed two pseudocysts at the pancreatic uncinate process, pancreatitis with a parenchymal defect, a large amount of ascites, and a right pleural effusion. MR cholangiography and endoscopic retrograde cholangiopanreaticography revealed a pancreatic duct disruption. The patient was successfully treated with a chest tube placement and percutaneous drainage. After surgery, his general condition improved; the serum level of amylase normalized and the pleural effusion resolved. Pancreatic injuries are rare in pediatric blunt trauma; however, diagnostic difficulty is common with isolated blunt trauma. Therefore, a high index of suspicion should follow such an injury. We report the case of an 8-year-old boy with pancreas transection, ductal disruption, ascites, and pleural effusion who was successfully treated. 췌장 손상은 소아에서는 흔하지 않으며 임상 증상과 이학적 소견이 뚜렷하지 않아 진단이 어려운 경우가 많은데 손상 정도와 위치에 대한 정확한 평가를 바탕으로 치료가 지연되지 않도록 하여 합병증 발생을 막도록 해야 할 것이다. 저자들은 8세 남아에서 가성 낭종, 늑막 삼출액을 동반한 췌장 절단 및 췌관 손상을 진단하고 경피적 배액술을 통하여 효과적으로 치료하였기에 문헌 고찰과 함께 보고하는 바이다.

극소 저체중 출생아에서 Synagis^Ⓡ (palivizumab) 접종이 respiratory syncytial virus 감염으로 인한 재입원에 미치는 영향

박수경,정유진,유혜수,안소윤,서현주,최서희,김묘징,전가원,구수현,이경훈,장윤실,박원순,Park, Soo Kyoung,Jung, Yu Jin,Yoo, Hye Soo,Ahn, So Yoon,Seo, Hyun Joo,Choi, Seo Hui,Kim, Myo Jing,Jeon, Ga Won,Koo, Soo Hyun,Lee, Kyung-Hoon,Chang, Yun 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.3

목 적 : 본 연구에서 저자들은 $Synagis^{(R)}$ 접종으로 극소 저체중 출생아에서 respiratory syncytial virus 감염으로 인한 재입원이 감소하는지 여부와 이러한 접종이 특히 효과적인 세부 그룹을 알아보고자 하였다. 방 법 : 2005년 1월부터 2007년 12월까지 3년간 서울 삼성병원 신생아 중환자실에서 입원 치료 후 생존하여 퇴원한 출생체중 1,500 g 미만의 극소 저체중 출생아 350명을 대상으로 퇴원후 1년까지 후향적으로 조사하여 생후 28일째 보조적 산소투여가 필요하였던 기관지폐이형성증 유무 및 $Synagis^{(R)}$ 접종 여부에 따라 RSV 재입원율을 비교하였고, BPD의 중증도 와 재태연령 및 출생체중을 세분하여 각 군별 RSV 재입원율의 차이를 비교 분석하였다. 결 과 : 전체 350명중 11명(3.1%)가 RSV로 인해 재입원하였고, 시나지스 미접종군에서 재입원율이 5.0%였던 반면, 접종군에 서 재입원율은 0.7%로 시나지스 접종에 의해 RSV 재입원율이 86% 감소하였다(P =0.02). 기관지폐이형성증이 있는 환아에서의 재입원율은 접종군에서 0.7%, 미접종군에서 5.2%로 접종군에서 유의하게 감소되었고(P =0.045), 기관지폐이형성증이 없는 환아에서의 재입원율 또한 통계학적 유의성은 확인할 수 없었으나(P =0.35), 접종군에서는 0%, 미접종군에서는 4.9%로 접종군에서 감소하였다. 결 론 : 극소 저체중 출생아에서 시나지스 접종은 RSV로 인한 재입원율을 감소시켰고, 기관지폐이형성증 유무 및, 출생주수, 출생체중에 상관없이 재입원율의 감소 추세가 확인되었다. Purpose : The aim of this study was to determine the efficacy of $Synagis^{(R)}$ (palivizumab) in reducing the respiratory syncytial virus (RSV) readmission rate in very low birth weight infants (VLBWI ) and the subgroup that showed the most effective vaccination. Methods : We enrolled 350 VLBWI who had been discharged alive from the neonatal intensive care unit of Samsung Medical Center from January 2005 to December 2007 and were followed up for at least one year. A retrospective study based on medical records was performed for a period of one year after discharge. RSV readmission rate was investigated according to BPD (bronchopulmonary dysplasia, requiring oxygen at postnatal day 28) and $Synagis^{(R)}$ prophylaxis. We categorized the subgroups by the severity of BPD gestational age, and birth weight and compared the RSV readmission rates between subgroups. Results : Eleven VLBWI were readmitted. $Synagis^{(R)}$ prophylaxis resulted in a 86% reduction in the rate of readmission due to RSV infection (prophylaxis group, 0.7% and no prophylaxis group, 5.0%; P =0.02). Readmission rate in BPD patients was also reduced in the prophylaxis group (0.7% in the prophylaxis group vs. 5.2% in the no prophylaxis group, P =0.03). The readmission rate in patients without BPD was reduced in the prophylaxis group (0% in the prophylaxis group vs. 4.9% in the no prophylaxis group, P =1.00), but this was not statistically significant.Conclusion : $Synagis^{(R)}$ prophylaxis was effective at reducing RSV readmission in VLBWI. Its efficacy was verified irrespective of BPD, gestational age, or birth weight.

제대정맥과 연관된 선천성 동정맥루 1례

성세인 ( Se In Sung ),유혜수 ( Hye Soo Yoo ),안소윤 ( So Yoon Ahn ),김은선 ( Eun Sun Kim ),조성기 ( Sung Ki Cho ),유소영 ( Young Yoo ),오수영 ( Soo Young Oh ),장윤실 ( Yun Sil Chang ),서정민 ( Jeong Meen Seo ),박원순 ( Won Soon Pa 대한주산의학회 2011 Perinatology Vol.22 No.1

Congenital arteriovenous fistulae, especially those involving the umbilical vein, are extremely rare. Here we report a case of prenatally diagnosed multiple congenital arteriovenous fistulae forming a communication between the left hepatic and both epigastric arteries to the umbilical vein, which was successfully treated with coil embolization and surgery shortly after birth in order to prevent cardiac failure and pulmonary hypertension for the first time in Korea.

임상 ; 생존한계인 재태연령 24주 이하 초미숙아의 분만장내 심폐소생술

최서희 ( Seo Heui Choi ),서현주 ( Hyun Joo Seo ),유혜수 ( Hye Soo Yoo ),안소윤 ( So Yoon Ahn ),장윤실 ( Yun Sil Chang ),박원순 ( Won Soon Park ) 대한주산의학회 2010 Perinatology Vol.21 No.2

목적: 본 연구는 단일 기관에서 초극소저출생체중아에게 자극을 최소화하며, 생징후의 빠른 안정화를 유도하기 위해 본원에서 고안된 변형된 분만장 심폐소생술을 통해 적극적인 심폐소생술을 시행함으로써 그 효과를 확인해 보고자 하였다. 방법: 2000년 1월부터 2008년 12월까지 9년간 삼성서울병원에서 출생하여 신생아 집중치료실에 입원하였던 재태주수 24주 이하의 초극소 저체중출생아 128명을 대상으로 의무기록을 후향적으로 조사하여, 변형된 심폐소생술을 시행한 62명의 환아에 대한 생존율, 시행한 분만장 심폐소생술의 정도, 아프가점수, 신생아 집중치료실까지 도착하는데 걸린 시간, 보육기 내로 안정화 할 때 까지 걸린 시간, SNAPPE-II score를 이용한 중증도, 초기 생징후, 초기 혈액 가스 분석 결과를 조사하여, 기존의 심폐소생술을 시행한 66명과 비교하였다. 결과: 변형된 심폐소생술을 시행한 환아의 생존 퇴원율은 고식적 심폐소생술을 시행한 환아군에 비해 통계적으로 유의하게 증가하였고(66% vs. 47%, P=0.034), 마스크를 이용한 양압환기가 의미있게 감소하였으며(29% vs 97%, P<0.001), 보육기까지 안정화한 시간이 짧았고(81±25 min vs 138±50 min, P<0.001), 1분과 5분 아프가 점수가 의미있게 호전되었다(1`: 3.9±1.5 vs 2.6±1.3, P<0.001, 5`: 6.6±1.7 vs 5.4±1.8, P<0.001). 결론: 재태주수 24주 이하 초극소 저체중 출생아에서 시행한 변형된 심폐소생술을 시행한 결과 생존율이 향상되었으며, 1분 및 5분 아프가 점수의 개선 효과가 있었다. Objective: This study investigated the effects of modified neonatal resuscitation program (M-NRP) which intends to keep minimal handling, to stabilize initial vital signs in extremely low birth weight infants (ELBWI) in Samsung Medical Center, NICU. Methods: Medical records of 128 ELBWI with gestational age (GA) ≤24 weeks who had been admitted to the NICU of SMC from January 2000 to December 2008 were reviewed retrospectively. The data of these patients with M-NRP (n=62) were compared with those with classic NRP (C-NRP) (n=66). Results: These patients who received M-NRP had significantly higher in survived discharge rate (66% vs 47%, P=0.034), lower in mask ventilation (29% vs 97%, P<0.001), shorter incubator-in time (81±25min vs 138±50min, P<0.001), and higher 1`/5` APGAR score (1`: 3.9±1.5 vs 2.6±1.3, P<0.001, 5`: 6.6±1.7 vs 5.4±1.8, P<0.001) than those who received C-NRP. Conclusion: Improvement in survived discharge rate and 1`/5` APGAR score were noted in M-NRP group compared to C-NRP group in the management of GA ≤24 weeks ELBWI.

임상 ; 초극소 미숙아(<1,000 g)에서 분만 형식 (제왕절개 vs. 질식분만)에 따른 예후

성세인 ( Se In Sung ),김진규 ( Jin Kyu Kim ),유혜수 ( Hye Soo Yoo ),안소윤 ( So Yoon Ahn ),김은선 ( Eun Sun Kim ),최석주 ( Suk Joo Choi ),장윤실 ( Yun Sil Chang ),박원순 ( Won Soon Park ) 대한주산의학회 2010 Perinatology Vol.21 No.4

목적: 최근 미숙아와 저체중 출생아의 생존율이 급격히 증가하고 있으며, 일부에서 제왕절개가 이들의 생존율을 향상시킨다고 주장한다. 본 연구는 단일기관에서 초극소 미숙아의 제왕절개 비율과 이들의 예후에 대해 알아보고자 하였다. 방법: 2000년 1월부터 2008년 12월까지 9년간 삼성서울병원에서 출생하여 신생아 집중치료실에 입원하였던 초극 소미숙아(<1,000 g) 415명 중 제왕절개를 시행 받은 325명의 특징, 예후를 조사하여 이들을 대조군인 질식분만을 통해 출생한 90명과 비교하였다. 결과: 초극소 미숙아 415명 중 325명(78%)이 제왕절개로 출생하였으며, 재태주수가 높을수록 제왕절개 비율도 상 승하였다. 재태주수, 부당경량아, 산모의 임신성 고혈압 유무, 산모의 산전 스테로이드 투여 여부가 초극소 미숙아의 예후와 연관이 있었으며 이들 교란 요인은 이후의 분석에서 교정되었다. 교란요인에 따라 층화분석하였을때, 제왕절 개군과 질식분만군에서 28일 이내 생존율의 차이가 없었다. 다중 로지스틱 분석에서도 두 군(제왕절개군과 질식분만군) 간의 생존율과 이환율(뇌실 내출혈, 기관지폐 이형성증 등)의 차이가 없었다. 결론: 단일기관 연구 결과 초극소 미숙아(<1,000 g)에서 제왕절개가 이들의 단기 예후를 향상시키지는 않았다. Objective: Some studies have suggested that delivery by Cesarean section is associated with a better prognosis for the extremely low birth weight infants (ELBWIs). The purpose of this study is to review neonatal outcomes according to the mode of delivery in ELBWIs. Methods: Medical records of 415 ELBWIs (<1,000 g) who were born and admitted to the neonatal intensive care unit (NICU) at Samsung Medical Center (SMC) from January 2000 to December 2008 were reviewed retrospectively. Clinical characteristics and outcomes of the ELBWIs delivered by Cesarean section (C-group, N=325) were compared with those of vaginally delivered infants (V-group, N=90). Logistic regression was performed to verify the significance of outcome difference, and to obtain odds ratios for mortality and morbidities according to the mode of delivery. Potential confounders were adjusted in this multivariate logistic regression analysis. Results: Among the 415 ELBWIs, 325 (78%) were delivered by C-section. Gestational age and the rate of Cesarean section delivery showed positive correlation. Gestational age, small-for-gestational age status, pregnancy-induced hypertension and antenatal steroid administration were found to interact with the outcomes of ELBWIs and were corrected in the subsequent analysis. The analysis was stratified by confounders, and comparison between the two groups showed no differences in mortality within 28 days. Multivariate logistic regression also showed no significant differences in mortality and morbidities according to the mode of delivery. Conclusions: In our study, Cesarean section was not associated with better outcomes for the extremely low birth weight infants.~

면역글로불린 G 아형 결핍이 동반된 Kartagener 증후군 1예

김기찬 ( Ki Chan Kim ),박주한 ( Joo Han Park ),반가영 ( Ga Young Ban ),유혜수 ( Hye Soo Yoo ),신유섭 ( Yoo Seob Shin ),박해심 ( Hae Sim Park ),예영민 ( Young Min Ye ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 1991 소아알레르기 및 호흡기학회지 Vol.1 No.3

Kartagener syndrome is characterized by the triad of situs inversus, bronchiectasis, and chronic paranasal sinusitis. Recurrent sinopulmonary infection, the major determinant for diagnosing immunodeficiency, is the most common clinical manifestation of the disease. A 17-year-old female patient presented with dyspnea, cough, sputum, nasal congestion, and rhinorrhea for more than 5 years. Nasal symptoms and dyspnea had not been controlled by intermittent treatment with mucolytics and antibiotics from primary clinics since 3 months before visiting our clinic. Chest X-ray and computed tomography showed situs inversus, dextrocardia and bronchiectasis. Paranasal sinus series revealed mucosal thickening and haziness on both maxillary sinus. Serum immunoglobulin (Ig) G4 was decreased, but total IgG was within normal range. Under the diagnosis of Kartagener syndrome with IgG4 deficiency, monthly intravenous IgG (IVIG) treatment was performed for 6 months. Her symptoms were well controlled and the frequency of antibiotics use was markedly decreased. We report a patient having the Kartagener syndrome with IgG4 deficiency that was successfully controlled with a 6-month-treatment of IVIG. (Allergy Asthma Respir Dis 2013;1:288-291)

임상 ; Goldenhar 증후군의 신생아기 임상적 특징과 추적 경과

이명숙 ( Myung Sook Lee ),박재현 ( Jae Hyun Park ),최수영 ( Soo Young Choi ),성세인 ( Se In Sung ),안소윤 ( So Yoon Ahn ),유혜수 ( Hye Soo Yoo ),박원순 ( Won Soon Park ),장윤실 ( Yun Sil Chang ) 대한주산의학회 2014 Perinatology Vol.25 No.1

목적: Goldenhar 증후군의 신생아 시기의 발현 향상과 이들의 동반 기형, 및 추적과정을 계통적으로 알아봄으로써 조기 진단의 필요성을 알아보고자 하였다. 방법: 1994년부터 2013년까지 삼성서울병원에서 Goldenhar 증후군으로 진단 받은 29명의 차트를 후향적으로 분석하였다. 신생아기에 진단된 13명(neonatal group)과 신생아기 이후에 진단된 16명(non-neonatal group)으로 나누어 동반 기형 및 시행된 시술을 계통적으로 비교하여 분석하였다. 결과 : 신생아시기에 진단된 환자들의 평균 재태 주수는 38+1±2+4주 평균 출생체중은 2,853±544 g 이었으며 3명(23%)은 미숙아였다. 신생아시기에 주로 전이주와 귀, 얼굴의 형성 이상으로 우선 진단되며, 동반되는 기형은 약 50%에서 심장 기형이 30%에서 비뇨생식기 이상이 15%에서 척추 기형이, 31%에서 기타 기형이 동반되었다. 이들의 장기 추적 결과 약 40%에서 청력이상을 발견할 수 있었으며 전체 환자의 약 1/4에서 양측 청력의 문제로 청력 보조 장치 등의 시술이 필요함을 알 수 있었다. 또한 행해지는 시술로 전이주의 제거가 가장 흔하게 이루어졌으며, 구강, 눈, 기타 연관 시술 또는 수술이 각각 1/4의 환자들에서 시행되었고 심장관련 수술이 15%에서 이루어 졌다. 동반기형 및 시술의 빈도에 있어서도 신생아 시기 및 신생아 시기 이후 진단된 두 군 사이에 간에 의미 있는 차이를 보이지 않았다. 결론: Goldenhar syndrome은 다양한 동반 기형들을 가지는 증후군으로 환자의 증상에 따라 여러 과들의 협진을 통해 지속적인 평가 및 적절한 교정이 필요하며, 특히 귀의 기형을 동반한 경우 청력 이상 등을 조기에 발견하고 적절한 치료가 필요하다. Purpose: Expression patterns, associated anomalies and progress of the patients with Goldenhar syndrome from the neonatal period were systematically investigated. This allows us to evaluate the need for early diagnosis. Methods: This is a retrospective study of 29 infants with Goldenhar syndrome whose diagnosed in Samsung Medical Center between 1994 and 2013. Associated anomalies and procedures between neonatal group (n=13) and non-neonatal group (n=16) were systematically compared. Results: Mean gestational age in the neonatal group were 38+1±2+4 weeks and 3 patients (23%) were preterm infants. The average birth weight in the neonatal group were 2,853±544 grams. Goldenhar syndrome was mainly diagnosed by ear and face anomalies during the neonatal period. The associated anomalies in neonatal group were cardiovascular anomaly (54%), genitourinary anomaly (30%), vertebral anomaly (15%), and others (31 %). About 40% of patients who had long-term follow-up revealed hearing abnormalities and about 1/4 of all patients had bilateral hearing problem, which resulted in requiring hearing aid devices. In addition, the most common procedure performed during follow-up was preauricular skin tag removal. And other procedures or surgery related to oral, eyes, and others were performed in each 1/4 of the patients. Cardiac surgery was done in 15% of total patients. Frequency of associated anomalies and performed procedures between the patients diagnosed at neonatal and non-neonatal period was not significantly different. Conclusion: A multidisciplinary approach should be undertaken by multi-departments when evaluating patients with Goldenhar syndrome. In particular if the patient has an ear anomaly, careful hearing test is required in early life.

면역글로불린 G 아형 결핍이 동반된 Kartagener 증후군

김기찬 ( Ki Chan Kim ),박주한 ( Joo Han Park ),반가영 ( Ga Young Ban ),유혜수 ( Hye Soo Yoo ),신유섭 ( Yoo Seob Shin ),박해심 ( Hae Sim Park ),예영민 ( Young Min Ye ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.3

Kartagener syndrome is characterized by the triad of situs inversus, bronchiectasis, and chronic paranasal sinusitis. Recurrent sinopulmonary infection, the major determinant for diagnosing immunodeficiency, is the most common clinical manifestation of the disease. A 17-year-old female patient presented with dyspnea, cough, sputum, nasal congestion, and rhinorrhea for more than 5 years. Nasal symptoms and dyspnea had not been controlled by intermittent treatment with mucolytics and antibiotics from primary clinics since 3 months before visiting our clinic. Chest X-ray and computed tomography showed situs inversus, dextrocardia and bronchiectasis. Paranasal sinus series revealed mucosal thickening and haziness on both maxillary sinus. Serum immunoglobulin (Ig) G4 was decreased, but total IgG was within normal range. Under the diagnosis of Kartagener syndrome with IgG4 deficiency, monthly intravenous IgG (IVIG) treatment was performed for 6 months. Her symptoms were well controlled and the frequency of antibiotics use was markedly decreased. We report a patient having the Kartagener syndrome with IgG4 deficiency that was successfully controlled with a 6-month-treatment of IVIG. (Allergy Asthma Respir Dis 2013;1:288-291)

초극소 미숙아(재태 연령 25주 이하)에서 발생한 조기 패혈증의 임상적 특징

윤신애 ( Shin Ae Yoon ),전지영 ( Ji Young Chun ),호요한 ( Yo Han Ho ),김지숙 ( Ji Sook Kim ),유혜수 ( Hye Soo Yoo ),성세인 ( Se In Sung ),안소윤 ( So Yoon Ahn ),장윤실 ( Yun Sil Chang ),박원순 ( Won Soon Park ) 대한주산의학회 2016 Perinatology Vol.27 No.1

목적: 재태 연령 25주 이하의 초극소 미숙아에서 조기 패혈증의 발생률 및 원인균, 임상적 특징을 알아보고자 하였다. 방법: 2013년 1월부터 2015년 8월까지 삼성서울병원에서 출생하여 신생아 집중치료실에 입원한 환자들 중 재태 연령 25주 이하의 미숙아 107명의 의무기록을 후향적으로 분석하였다. 조기 패혈증 군과 대조군 간의 재태 연령, 출생 체중, 주요 질환의 이환율과 사망률을 비교 하였으며, 주산기 인자와 생후 1주일 이내의 혈액학적 검사 결과를 비교 하였다. 결과: 총 107명의 환자들 중 11명이 조기 패혈증으로 진단되었으며 주 원인균은 Staphylococcus epidermidis (45.5%)이었다. 조기 패혈증 군과 대조군 간의 재태 연령, 출생 체중, 아프가 점수, 질식 분만 빈도, 조직학적 융모 양막염 빈도의 통계적 차이는 없었다. 조기 패혈증 군의 11명 중 9명에서 태아 빈맥을 보였으며(P=0.001), 조기 패혈증 군에서 생후 3일째와 생후 7일째에 낮은 혈소판 수치를 보였다(P=0.033, P=0.045). 주요 질환의 이환율과 사망률은 두 군간의 차이가 없었으나 조기 패혈증 군의 사망 환아 4명중 3명의 직접 사인이 조기 패혈증 이었다. 결론: 조기 패혈증의 초기 적절한 치료는 초극소 미숙아의 생존과 밀접한 관련이 있으며, 태아 빈맥과 낮은 혈소판 수치는 조기 패혈증과 연관성을 보였다. The aim of this study is to determine the clinical characteristics of early onset sepsis (EOS) in micropreemie. Methods: We retrospectively reviewed medical records of 107 extremely preterm infants born at 25 or less than 25 weeks of gestation and admitted to the neonatal intensive care unit of Samsung Medical Center from January 2013 to August 2015. Infants were divided into two groups based on the presence of culture-proven EOS in the first 7 days of life. Retrospective analysis of perinatal factors and laboratory findings within the first week of life was done between two groups. We compared the neonatal outcomes among two groups. Results: Culture-proven EOS was diagnosed in 11 of 107 infants (10.3%). Main pathogen of EOS was Staphylococcus epidermidis (45.5%). There were no significant differences between control group and EOS group in gestational age, birth weight, Apgar score, delivery type and pathologic chorioamnionitis. Among 11 infants with EOS, 9 showed fetal tachycardia (P=0.001). And EOS group presented lower platelet count at 3rd day and 7th day of life than that of control group (P=0.033, P=0.045). Neonatal outcomes in EOS group were compatible with control group. Main cause of death was sepsis in EOS group. Conclusion: In micropreemie, EOS is important factor of mortality. Our data suggest that fetal tachycardia and low platelet count during the first 7 days of life were associated with EOS.