편광 민감 광결맞음 단층 촬영 장치를 이용한 자궁경부의 조기 진단(A Preliminary Study)

강진호,이상원,유지영,강문식,김법민,윤보성,김영태,조남훈,Kang, Jin-Ho,Lee, Sang-Won,Yoo, Ji-Yeong,Kang, Moon-Sik,Kim, Beop-Min,Yoon, Bo-Sung,Kim, Young-Tae,Cho, Nam-Hoon 한국광학회 2007 한국광학회지 Vol.18 No.5

자궁경부 상피이형성증(cervical dysplasia)은 세포핵/세포질(nuclear/cytoplasmic, N/C) 면적비의 변화를 포함하는 자궁경부 상피에서의 형태학적 변화를 일으킨다. 세포핵은 중요한 산란 원인중에 하나이기 때문에 N/C 면적비의 변화는 깊이에 따른 원형 편광장도를 반영한다. 따라서 우리는 편광 민감 광결맞음 단층촬영장치(polarization-sensitive optical coherence tomography, PS-OCT)를 이용하여 산란에 의해 발생하는 편광의 변화를 측정하였다. 자궁 경부 조직 샘플은 고등급 상피내종양(high-grade squamous intraepithelial, H-SIL)을 가진 한 명의 환자와 정상인 네 명의 환자에게서 얻어졌다. 우리는 자궁경부의 깊이에 따른 원형 편광의 유지 정도(degree of circular polarization, DOCP) 평균을 구하였고, 상피층의 깊이에서 최소 제곱 1차 선형 함수(least-square linear fit)를 사용하여 기울기를 획득하였다. 획득된 기울기를 가지고 DOCP의 변화율을 정량화 하였다. 그 결과 H-SIL에서의 DOCP의 감쇄가 정상 조직에서 보다 빠르게 나타남을 확인할 수 있었다. 이는 PS-OCT를 이용하여 산란 변화에 따른 DOCP의 변화율을 측정하는 것이 자궁경부상피 이형성증의 진단을 하는데 있어서 유용한 진단법이 될 수 있음을 의미한다. Cervical dysplasia induces morphologic changes in the cervical epithelium which involve changes in the nuclear/cytoplasmic (N/C) ratio. Since the nucleus is one of the significant scattering sources, the N/C ratio change reflects the degree of circular polarization (DOCP) with the depth of signals. Therefore, we used the polarization-sensitive OCT (PS-OCT) technique to measure the polarization changes caused by scattering. Cervical tissues were obtained from a high-grade squamous intraepithelial lesion (H-SIL) of one woman and from low normal women. We obtained the mean of the DOCP as a function of depth in the cervix and quantified the change ratio of the DOCP using slopes that were determined by linear fits in the epithelium layer. We found that DOCP of H-SIL decayed faster than that of normal tissue because of the higher scattering in H-SIL as expected. This result indicates that the PS-OCT system might be useful in measurements of change ratio of DOCP with depth for screening of cervical dysplasia.

중,고생의 치아우식증과 구강건강행태와의 관련성 연구 : 제9차(2013년) 청소년 건강행태 온라인 조사

이종화 ( Jong Hwa Lee ),백지민 ( Ji Min Baek ),유지영 ( Jin Yeong Yoo ) 한국치위생학회 2015 한국치위생학회지 Vol.15 No.1

Objectives: The purpose of the study is to investigate the relationship between dental caries and oral health behaviors in middle and high school students by web-based survey of the ninth(2013) Korean youth risk behavior. Methods: The subjects were 75,149 students from 400 middle schools and 400 high schools. Finally, the survey participation rate was 96.4%(72,435 students from 799 schools) by complex sample design. The questionnaire consisted of general characteristics of the subjects, oral health behaviors, and oral health status. General characteristics included gender, types of schools, economic condition, and residential types. Oral health behaviors included subjective oral health condition, frequency of tooth brushing, tooth brushing after meal within recent 7 days, sealant within 12 months, fluoride application within 12 months, scaling within 12 months, and oral health education experience within 12 months. Oral health condition included dental caries incidence within 12 months. Results: Oral health behavior influenced on dental caries in the middle and high school students in Korea. This study showed the relationship between the sociodemographic characteristics, tooth brushing frequency, sealant experience, dental caries and halitosis experience, and scaling within 12 months. Scaling is the best prevention method for dental caries and halitosis in the students. Conclusions: The study showed the necessity for practical oral health education and the effect of fluoride application for dental caries prevention.

전략자원의 글로벌 Tech-Knowledge 패권 경쟁과 한국의 경쟁력 확보

박환일(Hwanil Park),권소현(So Hyun Kwon),성경모(Kyung-Mo Sung),최해옥(HaeOk Choi),유지영(Ji Yeong Yoo),김영진(Young-Jin Kim),김태경(Tae Kyung Kim),김소은(So Eun Kim),박동운(Dongun Park),유제현(Je Hyun Yu),장진규(Jin Gyu Jang),김화년(Hwa 과학기술정책연구원 2020 정책연구 Vol.- No.-

Strategic resources are becoming increasingly important from the viewpoint of innovation beyond economic, social, and security values. They are generally defined as resources that need to be secured stably in order to promote the stability and development of a nation’s industries in a sustainable way. This research focused on oil and grains, for which the Korean economy and industries rely heavily on imports, as the country’s strategic resources. Strategic resources have seen increasingly growing supply-demand imbalance and price volatility due to the COVID-19 pandemic combined with environmental changes such as the worsening climate crisis. At the same time, various innovation initiatives have resulted in notable achievements as digitalization and environmental sustainability are rapidly progressing throughout the development, production, and distribution stages of the oil and grains industry. This study sought to survey the innovation activities taken by global major companies participating in the development, production, and distribution stages of strategic resources such as oil and grains in particular to figure out how they have come to secure global technological supremacy. The ultimate goal of this research is to suggest areas on which the Korean government and businesses should focus their strategic resources in order to maintain their competitive edge given the changing domestic and international environment such as the COVID-19 pandemic and climate change as well as the level of technological competitiveness of the country with regard to the strategic resources it can deploy. Global oil and grain majors are rapidly promoting digitalization and environmental sustainability, leading innovation in the areas through heavy investments in research and development. As a result, it is possible for businesses to create various types of markets and expand into related industries. Korea has been designing and promoting policies aimed at securing overseas resources. Now, it is time to look at its strategic resources from the perspective of innovation and strive to create opportunities to secure tech-knowledge competitiveness in the areas as well. This study chose the digital oil field(DOF) as a strategic position for Korea to create new growth opportunities in the global upstream oil industry, and it is proposing that the country secure competitiveness in the digital oil field through policy efforts in the following areas: First, Korea needs to establish a government-led digital oil field policy and research platform; Second, Korea has to cultivate experts in the digital oil field; Third, it must come up with an incentive system for its resources sector and digital tech companies. Grain majors’ innovation activities provide two main implications for the Korean government and companies. First, it is necessary to respond to the digital transformation spreads in the grains industry. Second, there is a need to concentrate on the development of digital twin technology as a means to responding to global risks. When the development sector is linked to the production sector of the strategic resources, the Digital New Deal and the Green New Deal policies being promoted by the Korean government will become twice as effective. Strategic resources will continue to be developed, produced and utilized, with the combination of digital technology and eco-friendly technology expected to further improve productivity and reduce pollution down the road. Lastly, this study proposes conducting specific follow-up research on the digital oil field with an aim to boost the country’s tech-knowledge competitiveness in the area together with in-depth research on the impact of the application of innovative technologies in the field of grain trading.