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유광하,김수현,유수정,오현택,함승시,Yoo, Kwang-Ha,Kim, Soo-Hyun,Yoo, Soo-Jung,Oh, Hyun-Taek,Ham, Seung-Si 한국식품영양과학회 2007 한국식품영양과학회지 Vol.36 No.2
메밀 함량이 높은 국수 개발 및 메밀 원료에서부터 제품에 이르기까지의 영양적 가치와 기능성에 대한 과학적 연구를 위해서 메밀가루 및 메밀가루 혼합분에 대해서 반죽 특성과 생리활성을 조사하였다. 아밀로그래프 및 파리노그래프를 사용한 리올로지특성은 호화온도와 최고 점도는 B1에 비하여 메밀 혼합분에서는 낮아졌고, 파리노그래프 측정 결과 B1이 $BF1\simBF4$에 비하여 수분 흡수율은 낮게 나타났으며 반죽형성시간은 BF2에서 9.2분으로 가장 길었다. 메밀 혼합분 에탄올 추출물의 MNNG$(0.4{\mu}g/plate)$에 대한 항돌연변이 효과에서 S. Typhimurium TA100 균주에 대해 B1, BF4 및 BF3의 추출물은 시료농도 160 g/plate에서 각각 45%, 42% 및 37.3%의 돌연변이 억제효과를 나타내었다. 동일 시료 농도에서 4NQO(0.15 g/plate)에 대해서는 S. Typhimurium TA98과 TA100 균주에서 B1 추출물의 시료농도가 $160{\mu}g/plate$일 때 각각 64%와 44.3%의 가장 높은 억제활성을 나타내었다. 그리고 유방암세포에 대한 암세포 성장 억제활성을 검토한 결과, B1, BF4 및 BF3 추출물의 시료 농도 1 mg/mL에서 67.9%, 63% 및 59%의 억제효과를 나타내었다. 동일시료 농도에서 간암세포의 경우 B1에서 72.6%, 위암세포의 경우 모든 시료에서 70% 이상의 암세포 성장 억제효과를 나타내었으며, 특히 BF3의 경우 81.1%의 높은 억제효과를 보였다. 폐암세포와 자궁암세포에서는 60% 이상의 암세포 성장억제 효과를 나타내었다. This study was to investigate the mixed buckwheat flour quality by observing antimutagenic and cytotoxic effects of mixed buckwheat flour extracts using Ames test and SRB (sulforhodamine B) assay. Samples were prepared to the ratio of 100% (B1), 90% (BF1), 80% (BF2), 70% (BF3) and 60% (BF4) (w/w) flour buckwheat based on wheat flour weight. The initial pasting temperature in an amylograph was increased according to the increase of the buckwheat flour. The water absorption in farinograph decreased with the addition of buckwheat flour. The inhibition rates of B1, BF3 and BF4 extract (160 g/plate) were 45%, 37.3% and 42% against the mutagenesis of Salmonella Typhimurium TA100 induced by MNNG $(0.4{\mu}g/plate)$, respectively. In addition, the B1 at the same concentration showed 64% and 44.3% inhibition on the mutagenesis of Salmonella Typhimurium TA98 and TA100 induced by 4NQO $(0.15{\mu}g/plate)$, respectively. In SRB assay, human breast adenocarcinoma (MCF 7), human hepatocellular carcinoma (Hep3B), human stomach adonocarcinoma (AGS), human lung carcinoma (A549) and human cervical adenocarcinoma (HeLa) proliferations were inhibited by the increase in the sample concentration.
Easy Asthma Management 프로그램을 이용한 천식 치료 약물 처방 형태의 변화
유광하 ( Kwang Ha Yoo ),정재원 ( Jae Won Jeong ),윤호주 ( Ho Joo Yoon ),조상헌 ( Sang Heon Cho ),장석일 ( Suk Il Chang ),문희범 ( Hee Bom Moon ),김유영 ( You Young Kim ),최병휘 ( Byoung Hwui Choi ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.4
Background: In order to induce primary care physicians (PCPs) to practice guideline-based treatment, various supplementary tools have been developed, but its effect on the change of actual prescription practice is still unsatis factory. Objective: This study was conducted to investigate and Easy Asthma Management (EAM) program helps PCPs to prescribe medications based on the guidelines. Method: Requested cases for health insurance review by physicians were analyzed. A Total of 542 cases were compared between the changes before and after the training, and they were also compared with 374 requested cases by the control group. Result: After the training, changes asthma medication prescription were observed as follows: in the trained physician group 24% reduction in beta2-agonists; 24% reduction in methylzanthines, and 16% increase in steroids, in case of steroids, 46% reduction in oral steroids only; 64% increase in inhaled steroids with beta2-agonists; in the control group, 4% increase in beta2-agonists, 3% increase in methylzanthines, and 3% reduction in steroids after the training. Conclusion: In this study, physicians who received EAM training program showed the changes of prescription according to guideline-based anti-inflammation prescription, compared with non-trained physicians. (Korean J Asthma Allergy Clin Immunol 2007;27:226-234)
호흡기내과 의사를 위한 Respiratory Review of 2011
유광하 ( Kwang Ha Yoo ) 대한결핵 및 호흡기학회 2011 Tuberculosis and Respiratory Diseases Vol.71 No.2
Asthma is the most common chronic illness to affect children and is a major cause of morbidity in adults, affecting 4~17% of children and 7.3~10.1% of adults, which translates to approximately 300 million people globally. This article reviews recently published data over the past 1~2 years on asthma, and covers the 3 aspects of current advancement for the diagnosis of severe asthma, including the controversy to long-acting bronchodilator treatment for treatment of asthma, and the role of long-acting anticholinergics treatment in asthma patients.
유광하 ( Kwang Ha Yoo ) 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.3
The relationship between asthma and infectious disease has long been studied. The Advisory Committee on Immunization Practices in U.S. has recently recommended a pneumococcal polysaccharide vaccine to adults with asthma ages 19∼64 years. This recommendation is based on 2 large epidemiologic studies which reported that individuals with asthma carry an increased risk of invasive pneumococcal diseases. There have been some reports which stated that asthma is the most common chronic disease in individuals who have been infected with novel H1N1 influenza virus, suggesting the potential role of asthma in infections. However, it is unclear how asthma increases the susceptibility of infections. Several mechanisms have been proposed, including disruption of the airway epithelium, increased and aberrant mucus production, and alterations in innate or adaptive immunity. This paper was conducted to examine the epidemiological relationship between asthma and infectious disease and to investigate the possible mechanisms and their implications in clinical practice, public health and research. (Korean J Asthma Allergy Clin Immunol 2011;31:170-174)
유광하(Kwang Ha Yoo),김수현(Soo Hyun Kim),함영안(Young An Ham),유수정(Soo Jung Yoo),오현택(Hyun Taek Oh),함승시(Seung Shi Ham) 한국식품영양과학회 2006 한국식품영양과학회지 Vol.35 No.10
This study was performed to determine the antimutagenic and anticancer effects of Fagopyrum esculentum Moenech noodles (FEMN) extracts using Ames test and cytotoxicity, respectively. FEMN made buckwheat wet noodles (BWN), buckwheat extruded noodles (BEN) and buckwheat dehydrated noodles (BDN) by 60% buckwheat flour and 70% buckwheat flour. The inhibitory effects of FEMN extracts on cell proliferation in A549, Hep3B, MCF?7, AGS and HeLa were investigated by SRB assay. The cytotoxic effects of FEMN against the cell lines with human lung carcinoma (A549), human gastric carcinoma (AGS), human hepatocellular carcinoma (Hep3B), human cervical adenocarcinoma (HeLa) and human breast adenocarcinoma (MCF?7) were inhibited with the increase of the extract concentration. The treatment of 1.0 mg/mL FEMN of 60% BEN extracts showed strong cytotoxicities of 74.7%, 75.3% and 70.5% against AGS, A549 and HeLa, respectively. The inhibition rate of 70% BWN of FEMN extracts in the S. Typhimurium TA100 strain showed 41% against the mutagenesis induced by MNNG. The inhibition rate of 70% BEN of FEMN extracts in the S. Typhimurium TA98 strain showed 45% against the mutagenesis induced by 4NQO.