한공각화증 79예에 대한 임상 및 병리조직학적 연구

원영호,김대영,김성진,전인기 ( Young Ho Won,Dae Young Kim,Seong Jin Kim,Inn Ki Chun ) 대한피부과학회 1997 大韓皮膚科學會誌 Vol.35 No.1

Background: Porokeratosis is a rare disorder characterized by an abnormal keratinization. Five different clinical types have been described, however most reports are on a small scale and rest,ricted to a particular type. Objective : We tried to distinguish clinical and histopathologi'cal feat.ures of each type of porokeratosis. Methods: All patients with porokeratosis visiting the Dermatological Department of Chonnam University Hospital were retrospectively reviewed and finally 79 patients were evaluated. Results . Disseminated superficial actinic porokeratosis(DSAP) was most common it was present in 44 patients(56%). This was f'ollowed by the plaque type(28%), linear type(14%) and punctate type(2%). The:;oungest average age of onset was in the linear type at 13 years old (range 2-34 years old), and the oldest in DSAP which appeared in all patients after the age of 20. The plaque type was predominant in males 2.6 times rnore than in females. The predilection sites were the trunk in the plaque type, the unilateral lower limbs in the linear type and the face lower limbs in DSAP. 1tching was a complaint in 71% of DSAP and pain was in 14% of t.he plaque type. DSAP revealed a family history in 23% and a solar exacervation in 41%. Three cases of the plaque type t ad a malignant change. The average number of cornoid lamella per section was 1.8(ranging from one to seven). The height and invagination depth of cornoid lamellae were most prominent in the plaque type, and the le~ast in DSAP. Dysk(ratotic cells and vacuolar cell degenerat,ion in t.he underlying epidermis were most frequent in the plaque type. However dermal melanophage were present in DSAP. The Epidermis inside ring of:o~rnoid lamella was acanthotic chiefly in the plague type and atrophic chiefly in DSAP. Conclusion : These resuts demonstrate that each type of porokeratosis is somewhat, different in clinical and histopathological features. (Kor J Dermatol 1997;35(1): 33-40)

Symposium 2-2-2 (SYP 2-2-2) : A walnut sized protruding tumor on right upper posterior thigh in 63-year-old woman

원영호 ( Young Ho Won ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1

A 63-year-old women presented with a walnut-sized protruding tumor. It was first noticed as a small nodule 5 months ago, which was removed simply without any skin biopsy. However the wound had a delayed healing with continuous discharge and grow up into a larger nodule. At other clinic the recurred nodule was removed again. But, the tumor recurred again on the area as a larger nodule than before and she visits our hospital. The measurements of the tumor are roughly 5 cm wide and 6 cm long and 3cm height in size. It was erythema on the surface and peripheral skin, had a smooth surface with some white scales, and crusted lesions with mild discharge. She feels mild tender, but no pain. The two skin biopsies from the lesion reveals non-specific chronic granulomatous findings with various inflammatory infiltrate and wide-ranging fibro-collagenous proliferation. Staphylococcus aureus was cultured from discharge. She taken a complete surgical remove with split thickness skin graft from left posterior thigh, and local advanced flap, without any recur for 3 years follow-up.

AIDS의 선별검사 ( ELISA와 Particle Agglutination Test ) 에 대한 비교 연구

원영호(Young Ho Won),전인기(Inn Ki Chun),김영표(Young Pio Kim) 대한피부과학회 1989 대한피부과학회지 Vol.27 No.2

There are several ELISA(enzyme linked immunosobent assay) kits to be highly sensitive and specific in the screening test for antibodies to HIV. However, these have several problems such as high false-positive rate, low reproducibility and complex test procedures. A new serological test, the gelatin particle agglutination test(PAT), was developed and reported as good test having the same sensitivity with ELISA, and simple and easy procedure. The purpose of this study is com parison of two screening tests, ELISA and PAT, for detection of antibodies to HIV In one hundred two prostitutes, who used to contact with foreigners such as U.S. army personels, 10 syphilitic patients in Chonnam University hospital and 3 HIV infected patients, the serological results were equal in both tests, so there. was 100% concordance rate of seroreactivity between ELISA and PAT. Among 13 serum samples with false positive in ELISA test, only one sample revealed also reactive in PAT, which suggest indirectly us for PAT to be more specific than ELISA. The quantitative test with PAT of 4 consecutive serums during 4 months in the AIDS patient with Kaposi's sarcoma. However, in overall serum titer, the AIDS patient was higher than asymptomatic infected person. Thus the PAT test should be also useful for the mass screcning and quantitative test of anti-HIV antibody, and is highly recommedable for detection of HIV infection because the test can be performed with simple procedure and techique in addition ecoomically low cost and shortened time for the test.

조갑진균증에서 Ciclopirox 8 Nail Lacquer의 치료효과

원영호 ( Young Ho Won ),이지범 ( Jee Bum Lee ),이승철 ( Seung Chul Lee ),전인기 ( Inn Ki Chun ) 대한피부과학회 1995 대한피부과학회지 Vol.33 No.6

Background : Ciclopirox 8% nail lacquer is a new topical antifungal agent which is charact.er ized by excellent penetration into the nail plate to the infected koratin and remains there for a prolonged period. We per formed a st,udy to assess the therapeutic efficacy and safety of ciclopirox 8% nail lacquer in the treatment of onychomycoses. Methods : We used 20 satients wit,h onychomycoses, which was confirmed by KOH ancl fungus culture. The ciclopirox nail lacquer was applied once daily for 1 month, and followed by two times weekly for the next 5 months. The clinical observat.ion was perforrned every month for any clinical improvement and side-dffects. The involved percent of a target nail was measured by using a adhesive tape at.ached to the selected nail plate. All involved nails(n=68) were also evaluated by a severity score(severe>50%. moderate 25-50%, mild<25%). Results : Seventeen patients were finally assessed because of the deletion of 3 patients througl loss of contact. The involved percent of target nail was significantly decreased from 57.4% at baseline to 27.9% througli the 6 month-treatment(p<0.01, ANOVA). The total reduced precent of target nail involvement at the end of the treatment was 52+22% on average. The precent of severly involved nail(>50%) in all 68 involved nails was also decreased from 56% at baseline to 7% by the end of the treatment The mycologieal cure rate was 82.4% by the end of the treatment. The overall efficaor assessed by the physician and patients was improvement by 82.4% Tolerability was excellent or good in all patients, but cosmetic acceptance was good or excellen by 53%. Only one patient complained of a prickling sensation, but no systemic adverse effect were found, Conclusion : These data suggest that ciclopirox 8% nail lacquer may be safe and effective ir the treatment of onychomvcoses. (Kor J Dermatol 1995;33(6): 1079-1084)

PSCAD/EMTDC와 PSS/E를 활용한 시송전계통 과도현상 비교 및 분석

원영호(Young-Ho Won),송태용(Tae-Yong Song) 대한전기학회 2022 대한전기학회 학술대회 논문집 Vol.2022 No.4

최근 10년간 악성흑색종의 임상 및 병리조직학적 연구

원영호(Young Ho Won),허수경(Soo Gyoung Hur),이승철(Seung Chull Lee),전인기(Inn Ki Chunn),김영표(Young Pio Kim) 대한피부과학회 1991 대한피부과학회지 Vol.29 No.2

A total of 39 malignant melanoma cases diagnosed at Chonnam National University Hospital for past 10 years from 1980 to April, 1990 were included for the clinicopathologic study. Among the 29 primary cutaneous melanomas, 18 cases(62.1 % ) occurred on the hands and the feet, especially on the heel. The average age of the patients was 54.3 years at the time of diagnosis and the male to female ratio was 1 to 1,4. Acral lentiginous melanoma was the most common (h2.1% ) histopathologic type and the invasion level c)f 22 cases(78.4% ) was over 1.50mm by Rreslows thickness. (Kor J Dermatol 29(2):193 202)

흄관 매설 자동화 장비 개발을 위한 기술적ㆍ경제적 타당성 분석에 관한 연구

원영호(Won Young Ho),손석호(Son Seok Ho),김영석(Kim Young Suk),이준복(Lee Jun Bok) 대한토목학회 2002 대한토목학회논문집 D Vol.22 No.6D

피하 유피낭종 (類皮囊腫) 의 가족 2예 ( 모녀 )

원영호(Young Ho Won),김영표(Young Pio Kim) 대한피부과학회 1988 대한피부과학회지 Vol.26 No.5

Dermoid cyst is rare developmental anomaly with sequestration of embryonic closure line, but there is no suggestian that such an anomaly is inherited. The patients were 41 year old mother and 10 year old daugliter whose skin lesions have been noticed since puberta.lstae in the mother and since birth in the daugther It was interesting for those lesions to be appeared typically on the superior orbital area.

최근십년간 피부진균증의 임상 및 균학적 연구 ( 1976 ~ 1985 )

원영호(Young Ho Won),김승훈(Soung Hun Kim),김성훈(Sung Hun Kim),김영표(Young Pio Kim) 대한피부과학회 1987 대한피부과학회지 Vol.25 No.6

This study was done with 5,980 cases of dermatomycosis of dermatological patients in Chnnnam University Hospital for 10 years(1976~1985). And the literatures concerning all fungal diseases reported in Korea were reviewed. The results were summarized as follows ; Among total dermatological patients, the average annual incidence of dermatomycosis was about 15+3%. Dermatophytosis was the most prevalent(77.34%), followed by candicliaais(14.38%), tinea versicolor(7.78%), sporotrichosis(0.45%). Of dermatophytosis, the decreasing orders of clinical localization by the incidence were T.pedis(42.2%), T.cruris(25.9%), T. manum(10.3% ), T. corporis(10.0%), T. ungium (6.2%), T.facialis(4.2%), and T. capitis(2.2%). The organisms identified from dermato phytoses were generally 9 species ; the decreasing orders of frequency were Trichophyton rubrum(59.4%), T. mentagrophyte(27.9%), Microsporum canis(8.5%), Epidermophyton floccosum(2.4%), T. ferrugineum(0.9%), and others(M. gypseum, T. schonleinii, T. violaceum, T. verrucosum). The most common causative organisrn was T. rubrum, but that of T. corporis and T. capitis was M. canis, which showed a continuous increase on the annual variation of dermatophytes. Of candidiasis, the rnost common clinical form was cutaneous candidiasis, which was prevalent under 10 years old. But vulvo-vaginitis and paronychia highly developed between 3rd and 5th decades. The occasion with precipitating faetors was 10.4% of total candidiasis, of which tuberculosis and diabetes mellitus were prevalent. Of T. versicolor patients, the peak age was 3rd decades but some cases were infant and child. Of sporotrichosis, the most common clinical location and form were hand and lym phatic respectively. The peak age was between 4th and 5th decades, and the most prevalent occupation was farmer. Of other deep mycosis, there were each case of cryptococcosis, systernic candidiasis, and Wangiella derm,atitidies infection.

아토피 피부염 환자에서 임상증상 및 가족력과 면역학적 검사의 상관관계

원영호(Young Ho Won),이승철(Seung Chul Lee),김성진(Sung Jin Kim),신삼식(Sham Sik Shin) 대한피부과학회 1999 대한피부과학회지 Vol.37 No.10

N/A Background : Atopic dermatitis is an acute, subacute, or chronic pruritic dermatosis related to hereditary factors. However, pathogenesis and immunologic mechanism is not clear. The correlations between clinical status and abnormal immunologic findings have been widely studied. However, different and contrary results were reported according to researchers and environmental conditions. Objective : This study is to evaluate the relationship between immunologic findings including peripheral blood eosinophil count, IgE level, immediate skin reaction, and clinical status including severity or/and family history. Methods : Two hundred patients with atopic dermatitis for 4 years(1994-97) were grouped according to clinical severity of skin lesions, and analysed in view of clinical and immunologic findings. Three groups were classified according to modified Rajka`s and Hanifin`s severity grading. Results : Family history of atopy was recognized in 41.5%(83/200). A high eosinophil count in the blood and a high total serum IgE level were 46.3%(88/190), and 65%(47/72) in patients respectively. Each one tends to be higher in severe clinical status, and both were simultaneously elevated in moderate and severe patient groups. Both of eosinophil count and serum IgE level were significantly correlated in the severe patient group(r=0.284), and patients with(r=0.333) or without(r=0.314) family history. Pin prick test positivity was 70%, and MAST allergen test 53.1%. Atopic dermatitis patients showed relatively higher prevalence in A type of ABO blood groups. Immunohistochemical stains revealed that most of the infiltrated cells in atopic skin lesions were T lymphocytes. Conclusion : This study supports that clinical severity of atopic dermatitis was closely related to immonologic abnormalities such as elevated perupheral eosinophil count and serum IgE level, especially in patients with familial background. (Korean J Dermatol 1999;37(10) : 1399∼1406)