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우종신 ( Jong Shin Woo ),김명곤 ( Myeong Kon Kim ) 대한내과학회 2009 대한내과학회지 Vol.76 No.6
Acute coronary syndrome (ACS) represents a broad spectrum of ischemic myocardial events, including unstable angina, non-ST elevation myocardial infarction, and acute ST elevation myocardial infarction, which are associated with high morbidity and mortality. Early diagnosis and risk stratification are essential for initiation of optimal medical and invasive management. Randomized clinical trials over the past decade have revolutionized the care of patients with ACS. Therapeutic measures consist of administration of aggressive antiplatelet, antithrombotic, and antiischemic agents. In addition, patients with high-risk features, notably positive troponin, ST segment changes, and diabetes, benefit from early invasive intervention as compared to conservative strategies. Lifestyle interventions, modification of risk factor profile, and long-term medical treatment are of pivotal importance in reducing the long-term risk of recurrence. (Korean J Med 76:661-676, 2009)
우종신 ( Jong Shin Woo ),맹치훈 ( Chi Hoon Maeng ),이재진 ( Jae Jin Lee ) 대한내과학회 2007 대한내과학회지 Vol.73 No.6
구강 종양은 대부분 원발성으로 발생하며, 구강 종양의 1~4%만이 전이성 암이다. 폐암의 치은으로의 전이는 뒤늦게 발생하며, 매우 드물게 보고되고 있다. 저자들은 56세 남자 환자가 비소세포폐암을 진단받은 후 1차와 2차 항암화학요법을 시행 받았으나, 원발암이 진행으로 다발성 전이와 함께 우연히 상악 치은에서 종양이 발견되어 절개 조직검사 시행 후 전이성 폐암이 진단된 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. About 5% of all malignancies involve the oral cavity. Metastatic cancers to the oral cavity from distant sites are very rare, and only a few cases have been reported in the clinical literature. The most common tumors that metastasize to the oral cavity originate in the breast, lung, and kidney. We recently experienced a patient who had a non-small cell lung cancer that metastasized to the gingiva. The patient was 56-year-old man. The disease status was a progressive condition, although the patient had received third-line chemotherapy. The patient had multiple bony metastases including vertebral bodies, femurs, and clivus as well as the gingival metastasis. The gingival tumor was histopathologically diagnosed as a poorly differentiated adenocarcinoma. The metastatic gingival tumor had the same pathology as the primary lung cancer. (Korean J Med 73:661-665, 2007)
우종신 ( Jong Shin Woo ),윤나리 ( Na Ri Yun ),이연아 ( Yeon Ah Lee ),이상훈 ( Sang Hoon Lee ),양형인 ( Hyung In Yang ),홍승재 ( Seung Jae Hong ) 대한내과학회 2008 대한내과학회지 Vol.74 No.2
Adult-onset Still`s disease (AOSD)에서 신경학적 이상이 동반되는 경우는 전세계적으로 드문 경우로 최근 저자들은 고열과 관절통, 피부 발진을 주소로 내원하여 AOSD로 진단된 환자에서 입원 치료도중 경련을 동반한 뇌수막염이 발생하여 AOSD의 신경학적 합병증으로 생각되는 환자 1예를 경험하였다. 환자는 보존적인 치료로 호전되었으며 별다른 후유증없이 회복하였다. 이는 국내에서 AOSD의 신경학적 이상으로 인한 뇌수막염에 대한 최초의 보고이다. Adult-onset Still`s disease (AOSD) is a rare systemic inflammatory disorder of unknown etiology, affecting mainly young adults, characterized by a high spiking quotidian fever, arthralgia or arthritis, evanescent salmon-colored maculopapular rash. It affects almost all organs, but neurological manifestations of AOSD are rare and could be responsible for a delay in diagnosis. We describe a case of AOSD who developed aseptic meningoencephalitis without any infectious cause. A 23-year-old woman was admitted because of high quotidian fever, arthralgia, maculopalpular rashes, leukocytosis with increased ferritin. During treatment by prednisolone, she suddenly developed status epilepticus. The brain image, electroencephalogram, and cerebrospinal fluid analysis did not show any abnormality including evidence of infection. After methyprednisolne pulse therapy, her clinical symptoms and laboratory tests including ferritin dramatically improved, and she could be discharged. To our knowledge, this is the first reported case of aseptic meningoencephalitis in a patient with AOSD in Korea. (Korean J Med 74:220-224, 2008)
즐례 : 베체트병 환자에서 면역억제치료 후 방실전도장애가 호전된 1예
김성윤 ( Seong Yoon Kim ),신승용 ( Seung Yong Shin ),양지현 ( Ji Hyun Yang ),우종신 ( Jong Shin Woo ),김덕경 ( Duk Kyung Kim ),차훈석 ( Hoon Suk Cha ),김성순 ( Sung Soon Kim ) 대한내과학회 2014 대한내과학회지 Vol.86 No.1
적기에 베체트병의 심혈관침범을 진단하여 면역억제치료를 시작함으로써 방실전도장애가 호전되어 영구형 심장박동기 삽입을 예방할 수 있었던 환자 1예를 보고하는 바이다. Atrioventricular conduction disturbance is a rare clinical manifestation of Behcet disease. We describe a case in which a 48-year-old man complaining of dyspnea on exertion presented with complete atrioventricular block with junctional escape rhythm caused by Behcet disease. He also had moderate aortic regurgitation and mitral regurgitation. MRI and PET scan revealed inflammatory changes involving the ventricular septum and the ascending aorta. Recovery of atrioventricular conduction and improvement of valvular regurgitation were achieved with immunotherapy. Timely diagnosis and treatment of cardiac Behcet disease can prevent unnecessary pacemaker implantation. (Korean J Med 2014;86:65-69)