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옥순애,공경엽,최기영,허주령,유은실,이인철,Oak, Soon-Ae,Gong, Gyung-Yub,Choe, Ghee-Young,Hch, Jur-Yung,Yu, Eun-Sil,Lee, In-Chul 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.1
We reviewed 93 cases of fine needle aspiration of skin/subcutaneous and soft tissue lesions with histologic confirmation. On the basis of the most prominent cytologic features, morphologic classification of the aspirates was done. Skin and subcutaneous lesions included endometriosis, epidermal inclusion cyst, fat necrosis, pilomatrixoma and nodular fasciitis. Neoplastic lesions of soft tissue were categorized as ; round cell, spindle cell, polygonal cell, well-differentiated and myxoid tumor. This classification is convenient to recognize and categorize most soft tissue tumors.
옥순애,정재걸,공경엽,최기영,유은실,이인철,Oak, Soon-Ae,Chung, Jae-Gul,Gong, Gyung-Yub,Choe, Ghee-Young,Yu, Eun-Sil,Lee, In-Chul 대한세포병리학회 1994 대한세포병리학회지 Vol.5 No.2
There has been a marked increase in the utility of aspiration cytology for pathologic diagnosis. It may be applied to any kinds of organs and substitutes surgical biopsy. Be cause of the high risk of complication and difficulties In localization, aspiration cytology in the central nervous system (CNS) has been used with less frequency compared to other sites. However, with the advent of sophisticated imaging instruments, aspiration cytology of lesions in the CNS is being used increasingly. We present cytologic features of brain tumors as well as corresponding histologic findings. Eight types of tumors were aspirated intraoperatively and stained with the Papanicolaou method; 1 anaplastic astrocytoma, 1 glioblastoma multiforme, 1 ependymoma, 1 malignant ependymoma, 1 central neurocytoma, 1 primitive neuroectodermal tumor, 1 benign neurogenic tumor and 1 germinoma. Cytologic features of the CNS neoplasms were quite similar to those of histology except one spindle cell tumor. Reviewing various CNS neoplasms, it appears that cytology may be a useful diagnostic method.
임신 시 비정상 자궁경부 세포진 검사를 보이는 여성에 대한 임상적 고찰
정순지 ( Soon Ji Jeong ),서성숙 ( Sung Suk Seo ),김정헤 ( Jeong Hye Kim ),옥순애 ( Soon Ae Oak ),문은정 ( Eun Jeong Moon ) 대한주산의학회 2008 Perinatology Vol.19 No.2
목적: 본 연구는 임신 시 비정상 자궁경부 세포진 검사의 임상적 중요성과 이들의 추적 관찰을 위한 세포진 검사와 질확대경검사의 효용성을 평가하기 위해 시행되었다. 방법: 2002년 1월부터 2007년 12월까지 ASCUS 이상의 비정상 자궁경부 세포진 검사의 결과로 질확대경 클리닉에 전원되어진 임산부들을 후향적으로 분석하였다. 첫 질확대경검사는 임신 제 1 삼분기 말에 시행되었다. 남은 임신 기간 동안 1~2회 그리고 산후 6~8주에 자궁경부 세포진 검사와 질확대경검사가 반복 시행되었다. 질확대경검사상 이상소견을 보이면 질확대경하 조준 생검이 시행되었다. 침윤의 증거가 없다면 임신 중에는 어떠한 침습적 시술도 시행치 않았고 지속적 CIN2 이상의 병변은 산후에 치료되었다. 산후 진단 결과를 최종 산전진단명 및 초기 세포학적 진단과 비교하였다. 결과: 5년 동안 103명의 임산부가 질확대경검사 클리닉에 의뢰되었다. 산전에 침윤성 자궁경부암은 보이지 않았다. 53명의 환자가 산후 확진을 위해 추적 관찰되었고 이중 CIN2이상의 병변을 가지는 17명의 환자가 치료되었다. 2례의 미세침윤성 펀평상피세포암, 1예의 침윤성 샘상피암이 산후에 진단되었다. 처음 세포학적 진단상 ASCUS 소견을 보인 33명군에서는 7례의 CIN2, 3 병변과 3례의 침윤성 암이 진단되었다. 11 LSIL군에서는 1례의 CIN3 병변을 보인 반면 모든 HSIL 환자는 CIN3 병변을 보였다. 임신 중 CIN2, 3로 진단되어진 16명에서는 산후 2례의 미세침윤성 편평상피세포암이 진단되었다. 결론: 임신 시 자궁경부 세포진 검사장 ASCUS 소견을 보인 환자는CIN2, 3 그리고 암으로의 진행 가능성이 30%이다. LSIL은 85%에서 정상소견을 보였고 HSIL군은 100% CIN3였다. 산전 CIN2, 3가 미세침윤성 편평상피세포암으로 진행될 위험성은 12.5% 이나 조준 생검상 침윤 소견이 보이지 않으면 세포학적 검사와 질확대경 검사에 의한 추적 관찰 그리고 보전적인 관리는 합리적인 치료 방법이다. Purpose: This study was performed to evaluate the clinical significance of abnormal cervical cytology in pregnancy and the effectiveness of cytologic and colposcopic surveillance of these women. Methods: A retrospective analysis was conducted in pregnant women referred to the colposcopic clinic with abnormal cervical cytologic results above ASCUS between Jan. 2002 and Dec. 2007. The Initial colposcopy was performed at the end of 1st trimester. Cervical cytology and colposcopy were repeated once or twice during remaining period of pregnancy and at postpartum 6~8 weeks. Colposcopy directed cervical biopsies were taken in case of colposcopic abnormalities. Without evidence of invasion, no invasive procedure was attempted during pregnancy. Above CIN2 patients were treated postnatally. The postpartum diagnoses were compared to the worst antepartum impressions and initial cytologies. Results: One hundred three pregnant women were referred to colposcopic clinic for 5 years. There was no invasive cervical cancer antenatally. After delivery, 53 patients were followed up and 17 patients above CIN2 lesions treated. Two microinvasive squamous cell carcinoma and 1 invasive adenocarcinoma were found postnatally. In 33 initial ASCUS cytologies, there were 7 CIN2,3 lesions and 3 invasive cancers. One CIN3 was found in 13 LSIL cytologies. All 7 HSIL patients had CIN3 lesions. There were 2 microinvasive cancers postnatally in 17 antenatal CIN2,3 patients. Conclusion: ASCUS cervical cytologic results in pregnancy have 30% possibility of CIN2,3 and cancer. LSIL results are normal in 85% and HSIL group 100% CIN3. Even though there is 12.5% risk of microinvasion in antenatal CIN2,3 lesions, noninvasive conservative management is reasonable.
연부조직의 말초신경상피암종의 세침흡인 - 1예 보고 -
박양순,옥순애,공경엽,최기영,허주영,유은실,이인철,Park, Yang-Soon,Oak, Soon-Ae,Gong, Gyung-Yub,Choe, Ghee-Young,Huh, Joor-Yung,Yu, Eun-Sil,Lee, In-Chul 대한세포병리학회 1995 대한세포병리학회지 Vol.6 No.1
Peripheral neuroepithelioma (PNE) of soft tissue is a malignant neuroectodermal tumor arising from peripheral (nonautonomic) nerve. It nay occur in both children and adults, and are highly aggressive neoplasms that rapidly give rise to metastatic disease and death. We exprienced a case of peripheral neuroepithelioma of soft tissue in the upper arm in a 18-year-old female. Cytologic features revealed small round cells with scanty cytoplasm occurring both singly and in clusters. The clusters frequently tended to form Homer-Wright rosettes. The cells had a round to oval nucleus with fine chromatin and inconspicuous nucleoli in a hemorrhagic background.
폐쇄와(obturator fossa)에 착상된 후복막임신
유지연 ( Ji Yeon You ),이예리 ( Ye Ri Lee ),옥순애 ( Soon Ae Oak ),박종훈 ( Jong Hoon Park ),이은희 ( Eun Hee Lee ) 대한산부인과학회 2011 Obstetrics & Gynecology Science Vol.54 No.12
Ectopic pregnancy occurs in approximately 1.5 to 2.0% of pregnancies and accounts for 6% of all maternal deaths. Nearly all ectopic pregnancies are implanted in the fallopian tube. However, they may rarely occur within the retroperitoneal area in 1.3% of the ectopic pregnancy. Early diagnosis is difficult because it is not easy to differentiate symptoms of ectopic pregnancy in obturator fossa with in fallopian tube. Treatment is the removal of ectopic tissue through laparotomy or laparoscopy. A 26-year-old woman was diagnosed with left ectopic pregnancy and amenorrhea for 9+0 weeks and visited our hospital. A diagnosis of ectopic pregnancy in obturator fossa was made by laparoscopy, ectopic conceptus removal and the ligation of left hypogastric artery was performed. We report this case with a brief review of the literatures.
정상 염색체 여성에서의 성선 이형성과 난소 미분화세포종이 동반된
윤소연 ( So Yeon Yoon ),박향기 ( Hyang Gi Park ),국진이 ( Jin Yi Kuk ),옥순애 ( Soon Ae Oak ),박종훈 ( Jong Hoon Park ) 대한산부인과학회 2012 Obstetrics & Gynecology Science Vol.55 No.10
Gonadal dysgenesis occurs in rare case of ovarian tumor. Most tumors associated with gonadal dysgenesis were gonadoblastomas and dysgerminomas. In addition, premature ovarian insufficiency associated with these ovarian tumors in normal chromosomal type had not reported in many cases. A 29-year-old nulligravida woman who was concurrented with ovarian dysgerminoma and fibroma is presented. Measurements were made on serum lactate dehydrogenase, CA-125, CA 19-9 and pelvis ultrasonography and computed tomography. The clinical stage was IA and right salpingo-oophorectomy and wedge resection of the left ovary were done. On laboratory finding after operation on her serum follicular stimulating hormone was increased and E2 was decreased. The result of chromosomal analysis was 46,XX, normal. We represent here with brief review of literature one case of gonadal dysgenesis in nulligravida woman, associated with dysgerminoma, with normal karyotype.
자궁경부질세포진 검사에서 고식적 세포진 검사와 액상 세포진 검사 (PrepStain(TM) System)의 비교
이승아 ( Seung A Lee ),김정혜 ( Jung Hye Kim ),김조은 ( Jo Eun Kim ),박현주 ( Hyun Ju Park ),최원영 ( Weon Young Choi ),옥순애 ( Soon Ae Oak ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.11
목적 : 자궁경부 세포진 검사에 있어서 기존의 고식적 세포진 검사와 액상 세포진 검사와의 세포 진단 결과를 비교 분석하고, 그 차이를 알아보고자 하였다. 연구 방법: 2003년 8월 1일부터 2005년 7월 31일까지 본원 산부인과에 내원하여 세포진 검사를 시행받은 환자 중 고식적 세포진 검사를 시행받은 군 12,757명과 액상 세포진 검사를 시행받은 6,870명의 결과들을 비교하였으며, 이 중 질확대경하 생검을 통해 조직학적으로 확진된 고식적 세포진 검사를 시행받은 군 252명과 액상 세포진 검사를 시행받은 군 227명에 있어서 세포진 검사 결과와 조직학적 결과와의 일치도를 비교 분석하였다. 결과: 고식적 세포진 검사에 비해 액상 세포진 검사에서 ASCUS, LSIL, HSIL 그리고 CIS가 더 높은 빈도를 차지하였고, ASCUS/LSIL의 수치는 고식적 세포진 검사에서 3.32, 액상 세포진 검사에서 3.04를 나타내었다. 고식적 세포진 검사의 경우 민감도 71.8%, 특이도 93.9%, 양성 예측도 82.3%, 음성 예측도 89.4%, 위음성률 28.2%을 보였으며, 액상 세포진 검사는 민감도 72.6%, 특이도 96.1%, 양성 예측도 89.8%, 음성 예측도 88.0%, 위음성률 27.4%을 보였다. 결론: 액상 세포진 검사는 고식적 세포진 검사에 비해 세포진 검사의 양성 예측도를 향상시켜 세포진 검사의 정확도를 높일 수 있는 방법으로 자궁경부암의 선별 검사로써 진단율을 높이는 유용한 방법이라 할 수 있다. Objective: To Compare the conventional Pap smear with the Liquid Pap smear in screening of cervical cancer and to evaluate the correspondence of their biopsy results. Methods: From August 1, 2003 to July 31, 2005, the conventional Pap smears and the Liquid Pap smears were performed in 12,757 and 6,870 women, respectively. The results of 252 conventional Pap smear and 227 Liquid Pap smear were confirmed by colposcopic biopsy and evaluated for sensitivity, specificity, positive predictability, negative predictability and false negativity. Results: In Liquid Pap smear, there were higher proportions of ASCUS, LSIL, HSIL and CIS. And the ratio of ASCUS/LSIL were 3.32 and 3.04 in conventional Pap smear and Liquid Pap smear respectively. The conventional Pap smear showed sensitivity 71.8%, specificity 93.9%, positive predictability 82.3%, negative predictability 89.4%, and false negativity 28.2%, while the Liquid Pap smear showed higher sensitivity (72.6%), specificity (96.1%), and positive predictability (89.8%), and lower negative predictability (88.0%), and false negativity (27.4%). The positive predictability was significantly higher (95% C.I.: 1.3-13.7). Conclusion: The positive predictability was significantly improved in the Liquid Pap smear. Therefore, the Liquid Pap smear is a more useful method in screening of cervical cancer.