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만성 B형 바이러스 간염에서 라미부딘 치료와 HLA 대립유전자
오지민 ( Ji Min Oh ),권규흠 ( Kyu Heum Kwon ),김장언 ( Jang Eon Kim ),최진호 ( Jin Ho Choi ),범선희 ( Sun Hee Beom ),이상혁 ( Sang Hyuk Lee ),이용직 ( Yong Jik Lee ),박미영 ( Mi Young Park ),정미경 ( Mee Kyung Jung ),이계희 ( Kye 대한소화기학회 2008 대한소화기학회지 Vol.52 No.6
목적: HLA 유전형은 숙주의 면역 반응과 관련이 있으므로 만성 B형 바이러스 간염의 항바이러스 요법의 치료 결과에도 영향을 줄 수 있을 것으로 추정된다. 이에 라미부딘 항바이러스 요법을 시행한 만성 B형 간염 환자를 대상으로 그 연관성을 알아보았다. 대상 및 방법: 라미부딘으로 항바이러스 요법을 시행받은 61명의 대상군을 치료 반응에 따라 비반응군, 돌파군, 재발군 및 혈청 전환군 등으로 구분하여 각 군에서 HLA-A, B, Cw, DRB1 및 HLA-DRB 유전형의 분포 양상을 알아보았다. 결과: 비반응군에서 반응군에 비하여 HLA-Cw*1, HLA-DRB1*4, HLA-DRB*4 유전형의 출현빈도가 유의하게 높았다(각각 p=0.015, 0.033, 0.004). 혈청 전환군에서 돌파 현상을 보인 군과 비교하여 HLA-A*2, HLA-DRB*4의 출현 빈도가 유의하게 높게 나타났다(p=0.048, 0.025). 결론: 이번 연구 결과 HLA-A*2 유전형은 라미부딘 치료에 반응이 좋을 것으로 생각하며 HLA-Cw*1, HLA-DRB1*4 유전형을 가진 경우 라미부딘 이외의 치료를 고려해야 할 것으로 생각한다. HLA-DRB*4 유전형의 경우는 추가 환자군의 확보 후 재평가해야 할 것이다. Background/Aims: The human leukocyte antigen (HLA) system is an integral component of immune response. Highly polymorphic HLA genes may play a pivotal role in the response of antiviral therapy. We investigated the effects of HLA gene polymorphism on the clinical outcome of chronic hepatitis B patients who received lamivudine treatment. Methods: Depending on their clinical response to lamivudine therapy, a total of sixty one patients were divided into following groups; non-responders, viral breakthroughers, relapsers, and seroconverters. HLA-A, -B, -Cw, -DRB and HLA-DRB1 alleles typing was performed on each group through the polymerase chain reaction and the sequence-specific oligonucleotide hybridization method. The distribution patterns of HLA-A, HLA-B, HLA-Cw, HLA-DRB, and HLA-DRB1 were then analysed. Results: When non-responders were compared to the other groups, high frequencies in HLA-Cw*1, HLA-DRB1*4 and HLA-DRB*4 (p=0.015, 0.033 and 0.004 respectively) were evident. When seroconverters were compared to viral breakthroughers, high frequencies in HLA-A*2 and HLA-DRB*4 (p=0.048, 0.025 respectively) were evident. Conclusions: Our data suggests that HLA-A*2, HLA-Cw*1, HLA-DRB1*4 genes are related to the clinical outcomes of lamivudine treatment in chronic hepatitis B patients. These genes may be used in the prediction of the clinical outcome of lamivudine therapy in chronic hepatitis B patients.
뮤지컬 『 헤드윅 』 , 『킹키부츠』 에 나타나는 젠더의 정체성
오지민(Ji min Oh),장혜원(Hye won Jang) 청운대학교 방송예술연구소 2017 미디어와 공연예술연구 Vol.12 No.3
1960년대 인권운동의 영향으로 동성애나 자유, 평화 등이 현대 사회문화 전반에 새로운 패러다임을 형성하였다. 퀴어 코드도 같은 맥락으로 볼 수 있다. 동성애, 드랙킹/퀸, 바이섹슈얼, 트랜스젠더, 기타 성소수자들의 정체성을 둘러싸고 다양한 담론들이 생산되었다. 이 담론들은 뮤지컬 에도 영향을 끼쳤고 그 중 뮤지컬 <헤드윅>, <킹키부츠>는 각각 트랜스젠더와 드랙퀸을 직접적인 소재로 삼았다. 여기서는 주디스 버틀러의 젠더 정체성 이론 가운데, 젠더의 역할, 모방성, 수행성, 에고 등의 키워드를 중심으로 작품을 분석하였다. <헤드윅>과 <킹키부츠>에 나타나는 젠더의 정체성은 사회의 보편적인 성을 표방하면서 주체의 재의미화를 도모하는 특징을 갖는다. 결국 두 작품의 주인공의 경우 주체가 호명에서 복종하지 않는 잉여물들이 현재의 권력에 대립하고 전복하지만, 이는 단순히 규범 속 권력의 재배치에 불과하다는 것이다. 즉 이미 사회규범상 정해져 있는 젠더의 역할 속에서 남자와 여자라는 보편적인 성 역할을 치환하는 것에 불과하다는 것을 볼 수 있다. 주인공의 정체성은 젠더와 같이 유동적인 의미를 가지며, 다중적인 젠더 정체성은 주체의 의미를 재구성하는 동시에 전복이 일어날 수 있는 가능성을 말해준다. 이러한 주체에 대한 재의미화 시도는 기존 성, 젠더, 섹슈얼리티까지 전복시키며 한 인간의 성향과 주체적 인 자아 정체성을 상징화한다. Homosexuality, liberty, and peace have created a new paradigm in the whole modern social culture due to the influence of the human rights movement in the 1960s. Typically, queer has a variety of discourses about their identity, collectively referring to homosexuality, drag queen, bisexual, transgender, and other sex minorities. These discourses also influenced musical theater, among those productions, <Hedwig> and <Kinky Boots> made transducers and drag queen respectively as direct material. In this study, Judith Butler s gender identity theory analyzed musicals focusing on the keywords of gender, imitation, performance, and ego. The identity of gender in <Hedwig> and <Kinky Boots> is characterized by promoting beautification of the ashes of the subject while expressing the universality of society.
강직척추염 환자에서 TNF-α 억제제 사용 후 악화된 건선
오지민 ( Ji Min Oh ),고은미 ( Eun Mi Koh ),김형진 ( Hyung Jin Kim ),이재준 ( Jae Joon Lee ),안중경 ( Joong Kyong Ahn ),차훈석 ( Hoon Suk Cha ),이주흥 ( Joo Heung Lee ),장기택 ( Kee Taek Jang ) 대한류마티스학회 2010 대한류마티스학회지 Vol.17 No.2
TNF-α antagonists have been successfully utilized in the treatment of autoimmune diseases, including psoriasis and psoriatic arthritis. Paradoxically, new onset or exacerbation of psoriatic lesions during treatment with TNF-α antagonists have been reported. It has been postulated that TNF-α blockade may cause disruption in the balance between TNF-α and type 1 interferon (IFN)-α, which are the key players in the pathogenesis of psoriasis. We report a case of psoriasis exacerbation during TNF-α antagonist therapy in a 53-years-old man with ankylosing spondylitis. The patient has been treated with etanercept for 3 years and 7 months when he developed accelerated deterioration of psoriasis. His condition was previously under control solely by local treatment. Physical examination revealed vigorous desquamative lesions with silvery scale in both lower legs. Deterioration of psoriasis was attributed to etanercept therapy and was subsequently discontinued. Clinical improvement of psoriasis has been observed 2 months following cessation of etanercept.
국가직무능력표준(NCS)을 활용한 피부미용분야 직업기초능력 교육 요구도 분석 : 산업체 근로자 중심으로
오지민(Ji-Min Oh) 한국인체미용예술학회 2020 한국인체미용예술학회지 Vol.21 No.1
This study attempted to set priorities for aesthetic job-related education by analyzing the awareness of the need for foundation competency education and educational needs among aesthetic salons. In terms of research methods and procedures, a survey was performed among graduates from the Department of Aesthetic Therapy of ‘G’ College, who have worked for at least 5 years as managers and owners at 60 different salons. Through analysis of previous studies on foundational competencies and development and application of a questionnaire which uses 10 different national competency standards (NCS)-based foundational competency units, the related data were collected and measured. For analysis of educational needs and priorities, this study adopted the locus for focus model (LfFM) to improve the limitations of the t-test through which statistical differences are only confirmable. This model suggests the coordinates of foundation competency units on the four quadrant model, which has ‘average of differences between the required and current levels’ at the cross of the horizontal (required level) and vertical (current level) axes. The results found that awareness of the need for foundational competency education was higher as work experience, job title, size of business and awareness of the NCS increased. According to priority analysis, ‘communication ability’ was the highest, followed by ‘international relationship ability’ and ‘information ability’. Therefore, it is concluded that there is a need for developing courses with a high priority.
증례 : 류마티스 ; 치료 불응성 성인형 스틸병: 아나킨라 사용 후 임상 호전을 보인 증례 보고
오지민 ( Ji Min Oh ),김형진 ( Hyung Jin Kim ),이재준 ( Jae Joon Lee ),안중경 ( Joong Kyong Ahn ),이유선 ( You Sun Lee ),고은미 ( Eun Mi Koh ),차훈석 ( Hoon Suk Cha ) 대한내과학회 2012 대한내과학회지 Vol.82 No.4
Adult-onset Still`s disease (AOSD) is a systemic inflammatory disorder with variable clinical features. The interleukin (IL)-1 receptor antagonist anakinra has been proposed as an alternative effective treatment in refractory AOSD. We report, for the first time in Korea, two cases of refractory AOSD in which anakinra treatment produced a clinical response. The first patient had frequent clinical flare-ups with fever, sore throat, myalgia, and pleuritic chest pain despite treatment with methotrexate and etanercept. In the second patient, treatments with various immunosuppressive agents failed to control the disease activity. Treatment with anakinra 100 mg/day was initiated in both cases. A complete clinical remission and improvement in the laboratory parameters were observed. The steroid dose was tapered without further clinical flare-ups. Anakinra appears to be an effective alternative treatment modality in patients with AOSD refractory to conventional disease-modifying anti-rheumatic drugs and corticosteroid therapy. (Korean J Med 2012;82:520-524)
피부미용 졸업생의 NCS 직업기초능력과 하위능력에 대한 산업체의 교육요구도 분석
오지민 ( Ji Min Oh ),오지영 ( Ji Young Oh ) 대한미용학회(구 대한미용과학회) 2020 대한미용학회지 Vol.16 No.4
The importance of flexibility and adaptability in the global knowledge-based economy is a primary concern in current education and training. The present work intended to investigate the current status and needs of the basic vocational competencies required from the graduates of G college. The study conducted surveys in aesthetic industries where the graduates are employed. The data were analyzed using Borich needs analysis and the Locus of Focus Model. According to redundancy analysis between top priority items in the formula for the priority decision of Borich and HH quadrant items in the Locus for Focus Model, the highest priority group comprised ‘customer service competency’, ‘language proficiency competency’, ‘basic foreign language competency’ and ‘negotiation competency’, while the next priority group included ‘teamwork competency’ and ‘conflict management competency’. The research results showed that basic vocational competencies need to be developed in the areas of ‘communication competency’, ‘interpersonal competency’ and ‘information competency’. Based on the results of this study, several tasks to improve the basic vocational competencies were suggested for education in colleges.
김지은 ( Ji Eun Kim ),오지민 ( Ji Min Oh ),병성미 ( Sung Mi Byun ),노홍균 ( Hong Kyoon No ) 대구가톨릭대학교 자연과학연구소 2012 자연과학연구논문집 Vol.10 No.1
Binding capacities of chitosan with three different particle size ranges (2.000∼0.841 mm, 0.841∼0.425 mm, and 0.425∼0.177 mm) were evaluated. Water- (WBC), fat- (FBC), and dye-binding capacities (DBC) of chitosan differed depending on the particle sizes. WBC decreased with decreasing particle size. FBC also decreased with decreasing particle size, irrespective of oil sources (olive, corn, grape seed, canola, and soybean oils). Among oil sources, differences in FBC were observed at 2.000∼0.841 mm and 0.841∼0.425 mm particle sizes, in contrast to comparable FBC at 0.425∼0.177 mm particle size. The highest DBC was observed with chitosan with the smallest particle size (0.425∼0.177 mm) for the three dyes (red, blue, and yellow). DBC between 2.000∼0.841 mm and 0.841∼0.425 mm particle sizes was comparable for each dye, except for blue.
류마티스관절염 환자에서 혈관염을 동반하여 발병한 다발성 골수종 1예
손경민 ( Kyeong Min Son ),김자경 ( Ja Kyung Kim ),김현아 ( Hyun Ah Kim ),박혜림 ( Hye Rim Park ),박은주 ( Eun Ju Park ),오지민 ( Ji Min Oh ),서영일 ( Young Ll Seo ) 대한류마티스학회 2013 대한류마티스학회지 Vol.20 No.1
류마티스관절염 환자에서 피부 병변을 주소로 내원하여 다발성 골수종을 진단한 경험을 하였기에 문헌고찰과 함께 보고하는 바이다. Paraneoplastic vasculitis is a part of secondary vasculitis, the hematological neoplasm, such as lymphoma or myelodysplastic syndrome, which is most frequently observed. However, in multiple myeloma, cutaneous vasculitis is a rare complication, particularly as an initial clinical symptom. We report one case where a purplish reticulated patch on the lower extremity and an ear lobe skin necrotic change developed in a rheumatoid arthritis patient. He was diagnosed with multiple myeloma and cutaneous vasculitis.