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오정탁,한애리,손석우,최승훈,한석주,황의호,양우익,Oh, Jung-Tak,Han, Ai-Ri,Son, Suk-Woo,Choi, Seung-Hoon,Han, Seok-Joo,Hwang, Eui-Ho,Yang, Woo-Ick 대한소아외과학회 2001 소아외과 Vol.7 No.1
The pathophysiology of Hirschsprung's disease (HD) is not fully understood, but recent studies have disclosed that neural cell adhesion molecule (NCAM) and glial cell line-derived neurotrophic factor (GDNF) play important roles in the formation of aganglionic bowel of Hirschsprung's disease. To evaluate the roles of NCAM and GDNF in HD, immunohistochemical analysis was performed using formalin-fixed and paraffin-embedded tissue sections. On the basis of the results, we tried to evaluate them as diagnostic markers. The specimens were obtained from 7 patients with HD who underwent modified Duhamel operation. The diagnosis was based on the clinical findings and the absence of ganglion cells in the nerve plexuses by routine microscopy. NCAM immunoreactivity was found in the nerve plexuses and scattered nerve fibers in the smooth muscle layers of ganglionic segments. In aganglionic segments, the number of NCAM positive nerve fibers in the smooth muscle layers was significantly reduced compared with ganglionic segments. In two cases the nerve plexuses in aganglionic segments, NCAM was negligible. The smooth muscle cells showed diffuse immunoreactivity for GDNF and the staining intensity was not different in the aganglionic and ganglionic segments. However, higher expression of GDNF in the nerve plexus of the ganglionic segments was noted comparing to aganglionic segments. These data suggest that both NCAM and GDNF may play important roles in pathogenesis of Hirschsprung's disease and immunohistochemical staining for NCAM can be used as an ancillary diagnostic tool for HD.
오정탁,이우정,한석주,황의호,Oh, Jung-Tak,Lee, Woo-Jung,Han, Seok-Joo,Hwang, Eui-Ho 대한소아외과학회 1997 소아외과 Vol.3 No.2
Three cases of laparoscopic splenectomy for hereditary spherocytosis are reported. The average operation time was 100 minutes. This was longer than traditional open splenectomy for the same entity(63 minutes). Average hospitalization period was 3 days. This was shorter than the hospitalization period for the traditional group(6.2 days).
오정탁,최재영,박국인,Oh, Jung-Tak,Choi, Jae-Young,Park, Kook-In 대한소아외과학회 2007 소아외과 Vol.13 No.1
The use of subcutaneously tunneled, cuffed central venous catheters like Broviac's or Hickman's has increased and complications related to catheter removal has also increased. However, there are only few reports of complications that occur at the time of removal. The authors report an unusual case of catheter fracture during removal of Broviac catheter.
오정탁,김인규,한석주,황의호,Oh, Jung-Tak,Kim, In-Gyu,Han, Seok-Joo,Hwang, Eui-Ho 대한소아외과학회 1997 소아외과 Vol.3 No.2
Bacillus Calmette-Guerin(BCG) lymphadenitis is a complication of post-BCG vaccination and its treatment is still controversial. Eighty patients who had been operated for BCG lymphadenitis from 1987 to 1996 were reviewed. Thirty-one of them were treated with antituberculous drugs(mean duration: 3 months) preoperatively and 49 patients were not given preoperative antituberculous medication. No one was treated with antituberculous drugs postoperatively. Operation methods were excision(72) and partial excision with curettage(8). There was no statistical difference in recurrence rate between groups In two patients(2.5 %) treated with preoperative antituberculous drugs, the lesions recurred after operation. The results suggest that preoperative antituberculous medication does not play any role in the treatment of BCG lymphadenitis and in preventing recurrence in surgically excised cases.
오정탁,김희진,손석우,한애리,한석주,최승훈,황의호,Oh, Jung-Tak,Kim, Hee-Jin,Son, Suk-Woo,Han, Ai-Ri,Han, Seok-Joo,Choi, Seung-Hoon,Hwang, Eui-Ho 대한소아외과학회 2000 소아외과 Vol.6 No.1
Evaluation of the sacrum in anorectal malformations (ARMs) is important because there is an association between sacral abnormalities and poor functional outcome after corrective surgery for ARM. Sacral defects are not easily detected because of immaturity of sacrum in children and defects are often overlooked by pediatric surgeons. The authors utilized the sacral ratio in normal children (N=61) and patients with ARMs (N=26). In normal children, the mean true sacral ratio and mean sacrococcygeal ratio were $0.60{\pm}0.08$ and $0.72{\pm}0.13$ respectively. The sacral ratio was not correlated with age and did not changed with age in the same patient. However, true sacral ratio and sacrococcygeal ratio were significantly lower in patients with high type ARMs than those of normal children (p<0.001). There was no difference between patients with low type ARMs and normal children. These results suggest that abnormal sacrums are more frequently encountered in patients with high type ARMs than in normal children, and that true sacral ratio and sacrococcygeal ratio can be used in the evaluation of the abnormal sacrum.
Hyperimmunoglobulin E 증후군에서의 결장천공 - 증례보고 -
오정탁,김인규,한석주,김호근,황의호,Oh, Jung-Tak,Kim, In-Gyu,Han, Seok-Joo,Kim, Ho-Guen,Hwang, Eui-Ho 대한소아외과학회 1996 소아외과 Vol.2 No.2
Hyperimmunoglobulin E syndrome is a relatively rare primary immunodeficiency syndrome characterized by recurrent infection, abscess formation and marked elevation of serum IgE level. The common infectious organism is Staphylococcus aureus and recurrent infection indicates some defects in the immunologic system. Although the infection can affect various organs, gastrointestinal tract involvement is rare and only one case of colon perforation has been previously reproted. Herein we report another one case of colon perforation which ocurred in an 8-year-old girl with hyper immunoglobulin E syndrome. The patient was admitted to the hospital due to an abscess on right neck. The diagnosis of hyper immunoglobulin E syndrome was made because she had eczematoid dermatitis on the face, pneumatocele on left upper lung field and markedly elevated serum IgE level(>15,000 IU/ml) with a past histories of frequent scalp abscesses and otitis media. Abdominal pain developed on the 13th day of admission and abdominal plain X-ray revealed free air. An exploratory laparatomy was performed and two free perforations of the transverse colon were noted. Segmental resection and double barrel colostomy were performed. Colostomy closure was done 4 month later and she had no gastrointestinal problem during a follow up period of 15 months.
오정탁,박준성,최승훈,황의호,Oh, Jung-Tak,Park, Jun-Seong,Choi, Seung-Hoon,Hwang, Eui-Ho 대한소아외과학회 1999 소아외과 Vol.5 No.2
The surgical treatment of intussusception during two periods, 1975-1978 and 1995-1998 (Group B) were compared. There were 48 patients in Group A and 75 cases in Group B. Male were predominant in both group (2.7:1 vs 1.6:1). The mean age at operation was $6.7{\pm}5.0$ months (Group A) and $8.1{\pm}7.0$ months (Group B). The major signs and symptoms in both Groups included vomiting, hematochezia and irritability. There was a significantly higher bowel resection rate for group B (31.3 % vs 14.7 %, p=0.041). There were two operative deaths in group B but no deaths in group A. Hospitalization was significantly shorter in group B($7.5{\pm}2.7$ days vs $5.4{\pm}2.1$ days, p<0.001). We conclude that there were no differences in patient characteristics but surgical treatment in the 1990s results in more rapid recovery and reduced hospital stay.