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김진우 ( Jin Woo Kim ),김선빈 ( Seon Bin Gim ),오정민 ( Jeong Min2 Oh ),윤미영 ( Mi Young Yun ),이기무 ( Ki Moo Lee ),김동희 ( Dong Hee Kim ) 대전대학교 한의학연구소 2012 혜화의학회지 Vol.20 No.2
To investigate the clinical aspects of CHT in atopic dermatitis (AD) treatments, the effect of CHT in anti-oxidative and anti-inflammatory cytokines were tested. 100% or higher cell viability was observed in all tested groups from 25 to 200 ㎍/㎖using Raw 264.7 cells. CHT showed dose-dependent DPPH scavenging activity, with more than 90% scavenging activities at 800 ㎍/㎖concentrations. CHT showed dose-dependent suppression activity of ROS production, especially at 200 ㎍/㎖of 37.5%. CHT decreased NO production activity, with significant decrease of 33.2% at 200 ㎍/㎖. IL-6, MCP-1, TNF-α production rate were decreased by approximately 25% when Raw 264.7 cells were treated with LPS and with CHT of 200 ㎍/㎖. Also, IL-1β production rate was decreased by 25% at 100 ㎍/㎖. The results above indicate that CHT significantly reduces the effect of oxidative and inflammatory cytokines. The use of CHT in dermatitis can be widely suggested.