加減攝營煎(가감섭영전)의 Gardnerella vaginalis에 대한 시험관내 항균력 및 Clindamycin과의 병용효과

오자영 ( Ja Young Oh ),김동철 ( Dong Chul Kim ) 대한한방부인과학회 2014 大韓韓方婦人科學會誌 Vol.27 No.1

The object of this study was to observe the in vitro antibacterialeffects of Gagam-seopyoungjeon aqueous extracts (GGSYJ) against Gardnerellavaginalis and the possible synergic combination effects with clindamycin. Methods: Antibacterial activities against Gardnerella vaginalis of GGSYJ weredetected using minimal inhibition concentration (MIC), and the effects on the bacterialgrowth curve were also monitored at MIC and MIC×2 levels. The combinationeffects of GGSYJ with clindamycin were observed by checkboard microtiter assay, and the effects of bacterial growth curve treated with GGSYJ MIC+clindamycinMIC, 1/2 MIC and 1/4 MIC, respectively. The effects on the bacterial invasion andintracellular killing of GGSYJ were also observed using human vaginal epithelial(VK2) and murine macrophage (Raw264.7) cells with combination effects withclindamycin after treatment of GGSYJ MIC+clindamycin 1/2 MIC, 1/4 MIC and1/6 MIC, respectively. Results: The MIC of clindamycin and GGSYJ against Gardnerella vaginaliswere detected as 0.012±0.006 (0.004~0.016) μg/ml and 1.016±0.524 (0.391~1.563)mg/ml, respectively. Clindamycin and GGSYJ were also showed marked dosagedependentinhibition of bacterial growth, and significant decreases of viable cells weredetected in clindamycin MIC+GGSYJ MIC and clindamycin 1/2 MIC+GGSYJMIC treatment as compared with each of single clindamycin MIC and GGSYJMIC treatments. And significant decreases of intraepithelial and intra-macrophageviable bacteria numbers were detected in clindamycin 1/2 MIC+GGSYJ 1/2 MICand clindamycin 1/4 MIC+GGSYJ 1/2 MIC treatment as compared with eachof single clindamycin GGSYJ 1/2 MIC treatments, respectively. Conclusions: GGSYJ showed slight antibacterial effects against Gardnerellavaginalis, but they showed dosage-dependent inhibitory effects on the bacterial grow thand VK2 epithelial invasions of bacteria with favorable accelerating effects of intracellularkilling activities of macrophages. In addition, combination of GGSYJ also increasedthe inhibitory effects of clindamycin on the epithelial invasions of Gardnerella vaginalisand intracellular killing activities of macrophages against Gardnerella vaginalis as2-fold higher as compared with clindamycin single treatment, respectively. Therefore, we expected that the clinical dosages of clindamycin can be reduced as 1/2 levelsas combination with GGSYJ.

갑상샘눈병증에 동반된 위눈꺼풀뒤당김 환자에서 눈꺼풀올림근후전술의 치료 효과

오자영(Ja Young Oh),이정규(Jeong Kyu Lee) 대한안과학회 2021 대한안과학회지 Vol.62 No.8

목적: 갑상샘눈병증이 동반된 위눈꺼풀뒤당김 환자에서 눈꺼풀올림근후전술 시행 후 수술의 효과 및 결과에 영향을 미치는 인자에 대해 분석한다. 대상과 방법: 갑상샘눈병증을 진단받은 환자들 중 2010년 2월부터 2018년 9월까지 눈꺼풀뒤당김으로 눈꺼풀올림근후전술을 시행받은 환자 24명(36안)을 대상으로 의무기록을 이용한 후향적 분석을 시행하였다. 의무기록상의 수술 전과 수술 6개월 후의 marginal reflex distance (MRD)1, 2, 위아래 눈꺼풀의 길이와 면적을 눈꺼풀 분석 소프트웨어로 측정하여 비교하였다. 또한 수술 전후 MRD1의 차이에 영향을 미치는 인자를 다변량 선형 회귀 분석을 이용하여 분석하였다. 결과: 24명의 환자가 연구에 포함되었다. 수술 전과 수술 후 6개월째에서 MRD1은 5.12 ± 1.26 mm에서 3.48 ± 1.08 mm (p<0.001)로 유의하게 감소하였다. 이외 모든 위눈꺼풀 변수인 위눈꺼풀길이(p<0.001), 위안쪽 눈꺼풀틈새넓이(p<0.001), 위중간 눈꺼풀틈새넓이(p=0.004), 위바깥쪽 눈꺼풀틈새넓이(p<0.001)가 수술 전후 유의하게 감소하였고, 아래눈꺼풀 변수 중에는 유의하게 감소한 변수는없었다. 다변량 로지스틱 회귀분석을 시행하였을 때, 수술 전 MRD1이 작을수록 수술의 성공과 유의하게 관련되었다(교차비 0.31, 신뢰구간 0.09-1.01). 결론: 갑상샘눈병증에 동반된 위눈꺼풀뒤당김 환자에서 눈꺼풀올림근후전술은 위눈꺼풀뒤당김을 교정할 수 있는 객관적으로 증명된 효율적인 수술 방법이며, 수술 전 MRD1이 작을수록 성공할 확률이 높다. Purpose: We analyzed factors that affect the outcome of levator recession surgery for upper eyelid retraction in patients with thyroid- associated ophthalmopathy. Methods: Retrospective analysis was performed based on the medical records of 24 patients with thyroid-associated ophthalmopathy who underwent upper eyelid levator recession surgery between February 10, 2010, and September 18, 2018. The margin to reflex distance (MRD), length and area of the upper and lower eyelids were measured and compared with the eyelid analysis software before and after 6 months of surgery on medical records. In addition, factors affecting the difference in MRD1 before and after surgery were examined by multivariate linear regression analysis. Results: Twenty-four patients were included in the study. The MRD1 decreased significantly from 5.12 ± 1.26 mm before surgery to 3.48 ± 1.08 mm at 6 months after surgery (p < 0.001). All upper eyelid measurements, i.e., UEL (p < 0.001), UMA (p < 0.001), UCA (p = 0.004), and ULA (p < 0.001), were significantly decreased after surgery, while none of the lower eyelid measurements showed significant changes. Multivariate logistic regression analysis indicated that lower preoperative MRD1 was associated with the success of the surgery (odds ratio, 0.31; 95% confidence interval, 0.09-1.01). Conclusions: Levator recession surgery is an efficient surgical method that can correct the upper eyelid retraction associated with thyroid-associated ophthalmopathy.

인지행동집단치료가 사회공포증 경향이 있는 대학생들의 공적 자의식, 대인불안 및 부정적 평가에 대한 두려움의 감소에 미치는 영향

오자영 ( Ja Young Oh ),손정락 ( Chong Nak Son ) 전북대학교 사회과학연구소 2009 지역과 세계 Vol.33 No.2

본 연구의 목적은 인지행동 집단 치료가 사회공포증 경향이 있는 대학생들의 공적 자의식, 대인불안 및 부정적 평가에 대한 두려움에 미치는 영향을 탐색하기 위한 것이다. 전북대학교 학생 580명을 대상으로 사회적 회피 및 불안 척도를 실시하여, 절단점 91점 이상인 학생들을 인지행동치료 집단과 대기통제 집단에 무선 배정하였다. 집단인지행동치료가 공적 자의식, 대인불안 및 사회공포증의 핵심 특징인 부정적 평가에 대한 두려움의 감소에 미치는 영향을 살펴보았다. 인지행동집단치료 프로그램은 총 8회기로 이루어졌으며, 프로그램을 끝까지 마친 7명의 내담자 자료가 분석되었다. 주요 결과는 다음과 같다. 인지행동집단치료를 받은 집단은 치료 후 공적 자의식과 사회공포증의 핵심 특징인 부정적 평가에 대한 두려움 및 대인불안이 유의미하게 경감되었으며, 1개월 후 추적 조사에서도 치료 효과는 유지되었다. 끝으로 본 연구의 제한점과 시사점이 논의되었다. The purpose of this study was to explore the effects of cognitive-behavioral group therapy on public self-consciousness, Interpersonal anxiety and fear of negative evaluation of social phobia- prone college students. Participants joined in this study were those who scored 91 or more of Social Avoidance and Anxiety Scale among 580 college students, and they were randomly assigned in cognitive-behavioral therapy group and in the waiting list control group. This study examined the factors in focus the fear of negative evaluation which is the core mark of Public Self-consciousness, Interpersonal Anxiety. Cognitive-behavioral therapy group consisted of all 8 sessions. After the therapy program, the data of 7 who attended to the end included in analysis. The main results were as follows: Public self-consciousness, the fear of negative evaluation which is the core mark of social anxiety, and interpersonal anxiety of the cognitive-behavioral group were significantly decreased after therapy. At 1 month follow-up, the therapeutic effects were still lasted. Finally, the limitations and the suggestions of this study were discussed.

고프로락틴혈증 환자 치험 1례

오자영 ( Ja Young Oh ),장세란 ( Se Ran Jang ),김동철 ( Dong Chul Kim ) 대한한방부인과학회 2013 大韓韓方婦人科學會誌 Vol.26 No.3

Objectives: The purpose of this study is to report the effect of Traditional Korean Medicine (TKM) on hyperprolactinemia Methods: The patient in this case was a 26-year-old female. The patient was diagnosed as hyperprolactinemia with oligomenorrhea a month ago. We treated by Ickibohyoultang-gami and evaluated treatment effect by serum prolactin and basal body temperature. Results: After treatment, the Hyperprolactinemia value reduced and returned normal approach. And disorder of menstruation and basal body temperature became stable. Conclusions: TKM treatment is effective in patients with Hyperprolactinemia and disorder of menstruation.

간호대학생의 의료관련 감염관리 표준주의지침 수행에 미치는 영향요인

오자영 ( Ja-young Oh ),문지연 ( Ji-yeon Mun ),오혜경 ( Hye-kyung Oh ) 한국보건정보통계학회(구 한국보건통계학회) 2016 보건정보통계학회지 Vol.41 No.3

Objectives: The purpose of this study was to investigate the affecting factors on nursing students` performance of standard precautions for Healthcare associated Infection Control and Prevention. It was conducted to offer basic data for education of nursing students concerning Healthcare associated Infection Control and Prevention. Methods: The subjects were 199 nursing students. Data collected from October 1 to October 30, 2015. Collected data were analyzed with Independent t-test, Pearson`s correlation coefficient and Multiple Regression analysis. Results: Mean score of Knowledge, Awareness and Performance about standard precaution were 18.34±1.90, 4.59±0.32, 4.34±0.36, respectively. Statistically significant differences were shown in the Knowledge (p=0.007) related to the experience of exposure to sources of infection, the Knowledge (p=0.026) related to Post exposure procedure and the Awareness (p=0.020) related to gender. There was positive correlation between the Awareness and Performance of Standard Precautions. Awareness of standard precautions only stood out significantly among the factors affecting the performance of standard precautions, accounting for 25% in the performance variance of standard precautions. Conclusions: Based on the results of this study, expanding the Awareness of Standard Pre-cautions could lead to the increase of the Performance of Standard Precautions. It is suggested to develop effective educational programs to improve the Awareness and Performance of Standard Precautions.

사회성 기술 중재프로그램과 효과에 관한 국내 실험연구 분석

오자영 ( Ja Young Oh ),김진호 ( Jin Ho Kim ) 한국정서.행동장애아교육학회(구.한국정서학습장애아교육학회) 2008 정서ㆍ행동장애연구 Vol.24 No.4

TTC검정을 이용한 박 종자 발아세 검정

문자영(Ja Young Moon),이활진(Hwal Jin Lee),오대근(Dae-Geun Oh) 한국원예학회 2010 한국원예학회 학술발표요지 Vol.2010 No.10

발효 균주에 따른 삼채뿌리 열수추출물의 항산화능 비교연구

장자영,이지은,최은지,최학종,오영준,이성현,김현주,Jang, Ja-Young,Lee, Jieun,Choi, Eun-Ji,Choi, Hak-Jong,Oh, Young Jun,Lee, Sung Hyun,Kim, Hyun Ju 한국식품조리과학회 2015 한국식품조리과학회지 Vol.31 No.1

Allium hookeri, a member of the onion family, has long been mainly cultivated for food and medicinal use in Southeast Asian countries, owing to its various biological properties. However, no studies of the anti-oxidative effects of fermented A. hookeri root extracts have been conducted to date. Therefore, this study investigated the effect of different starter cultures on the antioxidant activities of hot water extract of A. hookeri root by using the following five strains: Lactobacillus acidophilus, Bifidobacterum longum, Enterococcus faecium, Streptococcus thermophilus, and Saccharomyces cerevisiae. DPPH and ABTS radical scavenging activity, total phenolic acid contents, and total antioxidant capacity were higher in the hot water extract of A. hookeri root fermented with starter cultures than those of A. hookeri root. Among hot water extract of A. hookeri root fermented with starter cultures, fementing with S. cerevisiae showed the highest antioxidant activities. The results of this study provide new evidence of the anti-oxidative properties of A. hookeri root with starter cultures, indicating that it may be highly valuable as a natural product owing to its high-quality functional components.

직물디자인의 감성공학적 분석 방법론 연구

최자영 ( Ja Young Choi ),이현주 ( Hyun Joo Lee ),오대욱 ( Dae Wook Oh ),임춘성 ( Choon Seong Leem ) 한국감성과학회 1998 춘계학술대회 Vol.1998 No.-

본 연구에서는 감성공학적 분석 방법론을 고안하여 직물 디자인 분야에 적용하고 그 효용성을 규명하였다. 방법론을 개발하기 위한 기초자료로서 직물 디자인요소와 이와 관련된 감성어휘를 수집하고 직물디자인요소계층도를 구축하였다. 수립된 직물디자인요소계층도상의 디자인요소에 관한 상대적인 중요도를 조사하여 디자인 요소별 가중치를 산출하고, 특정 디자인에 대하여 총체적인 감성수준과 디자인 요소별 감성수준을 측정한다. 측정된 요소별 감성수준을 Analytic Hierarchy Process 기법으로 종합한 감성수준을 비교한 결과 높은 상관관계를 보였다. 이 분석 방법론은 사전정보와 기술요소정보를 유기적으로 결합한 기반이 될 수 있는 합리적, 과학적인 개발 방법론을 제시하였다는데 큰 의의를 갖는다.

직물디자인의 감성공학적 분석 방법론 연구

최자영 ( Ja Young Choi ),이현주 ( Hyun Joo Lee ),오대욱 ( Dae Wook Oh ),임춘성 ( Choon Seong Leem ),이병도 ( Byung Doh Yi ),정경연 ( Kyung Yeun Chung ) 한국감성과학회 1998 감성과학 Vol.1 No.2