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비대칭적 유사도와 CSV를 이용한 심볼릭 클러스터링 알고리듬
박찬웅(Chanwoong Park),오승준(SeungJoon Oh) 한국정보기술학회 2012 한국정보기술학회논문지 Vol.10 No.11
Dealing with symbolic data has become quite common in data mining as well as data analysis. Symbolic data analysis deals with variables that can have intervals, histograms, and even functions as values. Much of previous work has been based on numeric data only. This paper investigates the problem of clustering symbolic data which are described by interval attributes and multivalued attributes. We propose a nonsymmetric proximity measurement for estimating the degree of similarity between symbolic data. Similarity between two interval attributes is proportional to the length of the common part between interval attributes, and similarity between two multivalued attributes is proportional to the intersection between their attributes. Also, a method for hierarchical clustering based on the combined similarity value(CSV) is explored. The efficacy of the proposed algorithm is experimentally shown and its validity is verified by comparing with the related methodologies.
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말단비대증 환자에서 소마토스타틴 유사체 사용에 대한 권고안
진상욱 ( Sang Ouk Chin ),구철룡 ( Cheol Ryong Ku ),김병준 ( Byung Joon Kim ),김성운 ( Sung-woon Kim ),박경혜 ( Kyeong Hye Park ),송기호 ( Kee Ho Song ),오승준 ( Seungjoon Oh ),윤현구 ( Hyun Koo Yoon ),이은직 ( Eun Jig Lee ),이정민 대한내과학회 2019 대한내과학회지 Vol.94 No.6
Acromegaly is a chronic disorder caused by excessive growth hormone (GH) secretion. In most cases, the excess GH originates from GH-producing pituitary adenomas. Surgery is the preferred first-line treatment for patients with acromegaly, but medical man-agement is considered when the disease persists after surgery or in cases where patients refuse surgery or are poor candidates for surgery. Somatostatin analogues are commonly used to treat acromegaly. The Korean Endocrine Society and the Korean Neuroendocrine Study Group have developed a position statement for the use of somatostatin analogues in the medical treatment of acromegaly. This position statement is based on evidence from the current literature and expert opinions. In the case of discrep-ancies among expert opinions, the experts voted to determine the recommended approach. (Korean J Med 2019;94:485-494)
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정상 한국인에서 CRH, GHRH와 TRH를 이용한 복합뇌하수체 자극시험에 대한 성별 연령별 반응
이상훈,김성운,고관표,오승준,우정택,양인명,김진우,김영설 대한내분비학회 2004 Endocrinology and metabolism Vol.19 No.1
연구배경: 인슐린을 대신하여 부신피질 자극호르몬 방출호르몬 (CRH)과 성장호르몬 방출호르몬 (GHRH)으로 복합뇌하수체 자극검사가 시행되고 있으나, 한국인에 있어서 정상 반응치에 관한 연구가 없고, 각각의 자극 호르몬의 연령이나 성별에 대한 반응의 차이는 보고되었지만 복합 자극검사에서의 연령별 성별 차이가 확립되지 않아 이를 알아보고자 본 연구를 시행하였다. 방법: 정상인 50대 남자 7명, 20대 남자 7명과 50대 여자 7명, 20대 여자 7명을 대상으로 CRH 100㎍,GnRH 100㎍, GHRH 100㎍, TRH 200㎍을 순서대로 동시에 정맥주사한 후 ACTH, GH, TSH, PRL, LH, FSH를 15∼30분 간격으로 2시간 동안 측정하였다. 결과: 1) TSH, PRL, LH의 분비 정도는 20대 남성과 50대 남성간의 유의한 차이가 관찰되지 않았으나, ACTH와 FSH는 50대 남성에서, GH는 20대 남성에서 통계학적으로 유의하게 높게 나타났다. 2) 20대 여성과 50대 여성을 비교했을 때, FSH만 50대 여성에서 통계학적으로 유의하게 높았고, 나머지 호르몬들의 결과에서는 통계학적으로 유의한 차이는 없었다. 3) 50대군에서 GH와 LH는 남녀간의 유의한 차이를 보이지 않았으나, ACTH는 남성에서 높게 나타났으며, Prolactin, FSH, TSH는 여성에서 통계학적으로 의미 있게 높았다. 결론: 연령, 성별과 월경주기 등에 따른 한국인의 복합뇌하수체 반응에 관한 더 자세한 연구가 요망된다. Backgroud: It has been already known that each trophic hormone in combined pituitary responsiveness according to gender and age brings about variable response, but in Korea, there has been no actual data. In this study, in order to assess the pituitary responsiveness, a combined pituitary stimulation test was performed in Korean subjects with the variation in CRH, GHRH, GnRH, and TRH according to their age and gender. Were these the variables that were changed according to age and gender? Clarify that. Also, it might be good to write out the abbreviations.) Method: Fourteen physically and mentally healthy male subjects and fourteen female subjects, also physically and mentally healthy, underwent the combined anterior pituitary stimulation test by CRH, GHRH, LHRH, and TRH. Each gender group was divided further into young (meanSE; male: 231, female: 221) and old (mean; male: 513, female: 522) groups. Results: There were significant differences between the gender and age groups. The Peak GH level and maximal GH increment were significantly increased in young men compared to old men. The Peak ACTH level and maximal ACTH increment were significantly increased in old men as opposed to young men. The Peak PRL level, maximal PRL increment, Peak TSH level, and maximal TSH increment were significantly increased in old women compared to old men. The Peak FSH level was significantly increased in the two old groups compared to the young groups, which showed independence in gender, and the maximal FSH increment was significantly increased in old men when compared with the young men. Conclusion: These results show that in order to for accurate interpretation of the response from the combined pituitary stimulation test, it is necessary to consider age and gender of the subjects. We suggest response values of the combined pituitary stimulation test in terms of age and gender in healthy Korean subjects (J Kor Soc Endocrinol 19:24∼32, 2004).
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SUH, Kwang Sik,NAM, Yeon Ho,AHN, Young Min,KIM, Nam Jae,PARK, Cheol Young,KOH, Gwanpyo,OH, Seungjoon,WOO, Jeong Taek,KIM, Sung Woon,KIM, Jin Woo,KIM, Young Seol WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-
Endothelial cell apoptosis has been postulated as the initial trigger of the progression of progression disease in patients with diabetes mellitus. To investigate the role of Scutellariae radix extract, we examined its effect on the endothelial cell proliferation using the [(3)^H]-thymidine incorporation method. Scutellariae radix extract significantly stimulated endothelial cell proliferation in a dose-dependent manner. We focused on the protective action of Scutellariae radix extract on the endothelial tell apoptosis induced by high glucose concentrations. Determination of endothelial cell apoptosis was performed using DNA gel electrophoresis, terminal deoxynuclotidyl transferase-mediated dUTP nick end-labeling(TUNEL) assay, and an ELISA kit. Exposure of vascular endothelial cell to high glucose (16.7mM) for 72h resulted in a significant increase in apoptosis, compared with the normal glucose concentrations (5.5mM). Scutellariae radix extract inhibited high glucose-induced endothelial cell apoptosis. This result suggests that Scutellariae radix extract may contribute to antiapoptotic action against vascular endothelial cells, resulting in a beneficial effect in preventing diabetes-associated microvascular complications.
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