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치료저항성 정신분열병 환자에서 반복적 경두개자기자극술 병행치료시 혈장 BDNF 농도 변화 : 예비 연구
오소영,김용구,Oh, So-Young,Kim, Yong-Ku 대한생물정신의학회 2009 생물정신의학 Vol.16 No.3
Objectives : To assess clinical improvement and change in plasma brain-derived neurotrophic factor(BDNF) level after repetitive transcranial magnetic stimulation(rTMS) in patients with treatment-resistant schizophrenia. Methods : Seven patients with DSM-IV schizophrenia, who were proven to be treatment-resistant, were treated with 15 sessions of rTMS for three weeks as an adjuvant therapy to antipsychotic treatment. Clinical improvement and change in plasma BDNF level were measured after the treatment period. The symptom severity was assessed with the Positive and Negative Syndrome Scale(PANSS) and the Korean Version of Calgary Depression Scale for Schizophrenia(K-CDSS) at baseline and 7 days after the treatment. Plasma BDNF level was measured by enzyme-linked immunosorbent assay(ELISA) at baseline and 7 days after the treatment. Results : After the rTMS treatment, there was no significant improvement in PANSS total score(Z=-1.693, p=0.090) and no significant change in plasma BDNF was found(Z=-1.183, p=0.237). Negative correlations were found between percentage change in PANSS positive subscale score and duration of illness(rho=-0.991, N=7, p<0.0005, two-tailed), and PANSS negative subscale score at baseline and percentage change in plasma BDNF level(rho=-0.821, N=7, p=0.023, two-tailed). Conclusion : This preliminary study suggests that rTMS didn't make a significant change in clinical symptoms nor in plasma BDNF level in treatment-resistant schizophrenia. Percentage change in plasma BDNF, however, might be correlated with treatment resistance in schizophrenic patients. This is a pilot study with a small sample size, therefore, a further study with a larger sample size is needed.
폴리에틸렌글리콜 상이동 촉매상에서 니트로벤젠과 Fe(CO)<sub>5</sub>로부터의 아닐린 합성
오소영,천승우,박대원,박상욱,신정호,Oh, So-Young,Chun, Sung-Woo,Park, Dae-Won,Park, Sang-Wook,Shin, Jung-Ho 한국공업화학회 1992 공업화학 Vol.3 No.4
Ironpentacarbonyl에 의한 니트로벤젠의 환원반응에 PEG를 상이동 촉매로 사용한 결과 상온에서 90% 이상의 아닐린 수율을 얻을 수 있었다. 니트로벤젠의 반응속도는 PEG의 사슬길이와 결합점의 수에 의존하였으며 NaOH의 농도가 높고 용매의 극성이 커질수록 증가하였다. 그러나 아닐린의 수율은 NaOH농도가 2N일때 최대였으며 그 이상의 농도에서는 감소하였다 PEG phase transfer catalyzed reduction of nitrobenzene with $Fe(CO)_5$ afforded aniline up to over 50% yield al room temperature. The reaction rate of nitrobenzene was dependent on the chain length and number of binding sites of PEG, and it was increased with the concentration of NaOH and solvent polarity. But the yield of aniline was maximum) with 2N NaOH solution and it was decreased at higher concentrations.
지방모세포종의 세침흡인 세포학적 소견 - 2예 보고 -
오소영,정명자,문우성,강명재,이동근,Oh, So-Yeong,Chung, Myoung-Ja,Moon, Woo-Sung,Kang, Myoung-Jae,Lee, Dong-Geun 대한세포병리학회 1998 대한세포병리학회지 Vol.9 No.2
Lipoblastoma is a rare benign neoplasm occurring exclusively in children below the age of three years. It affects chiefly the upper and lower extremities, and less commonly head and neck area, trunk, mediastinum, mesentery, and retroperitoneum. We present two cases of lipoblastoma occurring in the mediastinum of a 21-month-old boy and in the back of a 15-month-old boy. The characteristic features of Fine needle aspiration cytology smears were the presence of immature fat cells in the form of spindle-shaped cells, stellate cells and vacuolated lipoblasts along with lipocytes against a myxomatous background. Two tumors were histologically confirmed to be lipoblastomas. Lipoblastoma can be cytologically diagnosed by considering the cytologic findings and the age of the patient.
PEG / γ- Al2O3 상이동 촉매상에서 니트로벤젠과 Fe(CO)5 로부터의 아닐린 합성
오소영,이화수,박대원,박상욱,신정호 ( So Young Oh,Hwa Su Lee,Dae Won Park,Sang Wook Park,Jung Ho Shin ) 한국공업화학회 1993 공업화학 Vol.4 No.1
γ-Al_2O_3, γ-Al_2O_3, SiO_2, TiO_2 등에 고정화된 폴리에틸렌글리콜을 Fe(CO)_5에 의한 니트로벤젠의 상온 환원반응에 상이동 촉매로 사용하였다. 고정화된 PEG의 몰수는 담체의 비표면적에 따라 증가하였고 PEG/γ-Al_2O_3가 가장 좋은 활성을 나타내었다. PEG의 사슬길이가 길고 NaOH농도가 높을수록 반응속도가 증가하였다. 적외선분광기를 이용하여 반응기구에 대한 고찰도 함께 실시하였으며 폴리에틸렌글리콜 상이동 촉매는 본 반응의 활성물질로 알려진 HFe(CO)_4,-이온의 생성과 이의 유기상으로의 이동을 촉진시키는 것으로 판단되었다. Immobilized polyethylene glycols onto metal oxides such as γ-A1_2O_3, α-Al_2O_3, SiO_2 and TiO_2 were used as phase transfer catalysts for the room temperature synthesis of aniline from nitrobenzene and ironpentacarbonyl. The amount of attached PEG molecules increased with specific surface area of metal oxides. Among the immobilized catalysts tested PEG/γ-Al_2O_3 showed the highest activity. The reaction rate increased with the chain length of PEG molecules and the aqueous NaOH concentration. Mechanistic study carried out using infrared spectrometer revealed that the role of PEG was to increase the formation of HFe(CO)_4^- ion, which is known as active species, and its movement from aqueous to organic phase.
폴리에틸렌글리콜 상이동 촉매상에서 니트로벤젠과 Fe(Co)5 로부터의 아닐린 합성
오소영,천승우,박대원,박상욱,신정호 ( So Young Oh,Sung Woo Chun,Dae Won Park,Sand Wook Park,Jung Ho Shin ) 한국공업화학회 1992 공업화학 Vol.3 No.4
Ironpentacarbonyl에 의한 니트로벤젠의 환원반응에 PEG를 상이동 촉매로 사용한 결과 상온에서 90% 이상의 아닐린 수율을 얻을 수 있었다. 니트로벤젠의 반응속도는 PEG의 사슬길이와 결합점의 수에 의존하였으며 NaOH의 농도가 높고 용매의 극성이 커질수록 증가하였다. 그러나 아닐린의 수율은 NaOH농도가 2N일때 최대였으며 그 이상의 농도에서는 감소하였다. PEG phase transfer catalyzed reduction of nitrobenzene with Fe(CO)_5 afforded aniline up to over 90% yield at room temperature. The reaction rate of nitrobenzene was dependent on the chain length and number of binding sites of PEG, and it was increased with the concentration of NaOH and solvent polarity. But the yield of aniline was maximum with 2N NaOH solution and it was decreased at higher concentrations.
PEG/γ-Al<sub>2</sub>O<sub>3</sub> 상이동 촉매상에서 니트로벤젠과 Fe(CO)<sub>5</sub>로부터의 아닐린 합성
오소영,이화수,박대원,박상욱,신정호,Oh, So-Young,Lee, Hwa-Su,Park, Dae-Won,Park, Sang-Wook,Shin, Jung-Ho 한국공업화학회 1993 공업화학 Vol.4 No.1
${\gamma}-Al_2O_3$, ${\alpha}-Al_2O_3$, $SiO_2$, $TiO_2$등에 고정화된 폴리에틸렌글리콜을 $Fe(CO)_5$에 의한 니트로벤젠의 상온 환원반응에 상이동 촉매로 사용하였다. 고정화된 PEG의 몰수는 담체의 비표면적에 따라 증가하였고 PEG/${\gamma}-Al_2O_3$가 가장 좋은 활성을 나타내었다. PEG의 사슬길이가 길고 NaOH 농도가 높을수록 반응속도가 증가하였다. 적외선분광기를 이용하여 반응기구에 대한 고찰도 함께 실시하였으며 폴리에틸렌글리콜 상이동 촉매는 본 반응의 활성물질로 알려진 $HFe(CO)_4{^{-}}$이온의 생성과 이의 유기상으로의 이동을 촉진시키는 것으로 판단되었다. Immobilized polyethylene glycols onto metal oxides such as ${\gamma}-Al_2O_3$, ${\alpha}-Al_2O_3$, $SiO_2$ and $TiO_2$ were used as phase transfer catalysts for the room temperature synthesis of aniline from nitrobenzene and ironpentacarbonyl. The amount of attached PEG molecules increased with specific surface area of metal oxides. Among the immobilized catalysts tested PEG/${\gamma}-Al_2O_3$ showed the highest activity. The reaction rate increased with the chain length of PEG mole-cules and the aqueous NaOH concentration. Mechanistic study carried out using infrared spectrometer revealed that the role of PEG was to increase the formation of $HFe(CO)_4{^-}$ ion, which is known as active species, and its movement from aqueous to organic phase.
경부에 전이한 Sex Cord Tumor with Annular Tubules의 세침흡인 세포소견 - 1예 보고 -
오소영,강명재,정명자,문우성,이동근,Oh, So-Yeong,Kang, Myoung-Jae,Chung, Myoung-Ja,Moon, Woo-Sung,Lee, Dong-Geun 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.2
A sex cord tumor with annnular tubules is a relatively rare ovarian neoplasm. The cytologic findings from a fine needle aspiration biopsy of neck metastasis of a sex cord tumor with annnular tubules are described. The origin of the neck metastasis was the right ovary, and the tumor was diagnosed six years ago. The cytologic findings were characterized by tumor cells arranged in solid or follicular patterns. The tumor cells formed rosette-like or complex tubular structures with central rounded or coalesced hyaline materials. It was difficult to distinguish this tumor cytologically from granulosa cell tumor, thyroid follicular neoplasm, Sertoli-Leydig cell tumor, and Brenner tumor, but complex tubular structures were helpful in discriminating between these tumors.
오소영 ( Soh Young Oh ),남기웅 ( Ki Woong Nam ),윤덕훈 ( Deok Hoon Yoon ) 한국환경농학회 2014 한국환경농학회지 Vol.33 No.3
BACKGROUND: The aim of this study is to investigate theeffects of Lycium chinense Miller fruit and itsrepresentative constituent betaine on reduction ofimmobility time and blood parameters in balb/c mice. METHODS AND RESULTS: We investigated theimmobility time and the changes in aspects of bloodbiochemical parameters by the administration of L. chinense Miller fruit and its representative constituentbetaine, after the forced swimming test. The immobilitytime was significantly reduced about 41.3% and 53.6%,respectively, in the animal of L. chinense Miller fruit and itsrepresentative constituent betaine-administrated group for7 days, in comparison with that of the control group. Thelevel of blood urea nitrogen was significantly decreased inL. chinense Miller fruit and its representative constituentbetaine-treated group compared with the control group (P <0.05), respectively. In addition, the interlukin-2 levels ofmice in L. chinense Miller fruit and betaine treated groupwas increased compared with the control group. CONCLUSION: These results indicate that L. chinenseMiller fruit and betaine might be helpful in the immunefunction improvement, enhance physical stamina, andfatigue recovery.
1-Methylcyclopropene을 이용한 ‘대석조생’ 자두의 유통기간 연장
오소영(Soh-Young Oh),임병선(Byung-Seon Lim),이재욱(Jae Wook Lee),도경란(Kyung Ran Do) 한국원예학회 2007 원예과학기술지 Vol.25 No.4
본 연구는 1-MCP가 ‘대석조생’ 자두의 자장 중 품질 변화와 유통기간 연장에 미치는 영향을 구명하기 위하여 수행하였다. 수확한 ‘대석조생’ 자두를 균일한 숙기와 크기로 선별하여 품온을 10℃로 낮춘 후 1-MCP를 1μLㆍℓ⁻¹ 농도로 10℃에서 24시간 동안 처리하였다, 1-MCP를 처리한 후 바로 20℃에서 모의 유통한 처리구와 0℃에 10일간 저장 후 20℃에 옮겨 모의 유통한 처리구 과실을 대조구 과실과 비교하여 상품성과 유통기간 연장 효과를 조사하였다. 에틸렌 생성과 호흡량은 상온유통 및 저온저장 후 상온유통 모두 1-MCP 처리에 의해 유의성 있게 감소하였다. 또한 1-MCP는 자두의 연화와 색도 변화도 억제하였다. 그러나 가용성 고형물 함량 변화에는 아무런 영향을 미치지 않았으며, 부패 억제 효과를 나타내었다. 모든 처리구에서 내부갈변은 발생하지 않아 1-MCP에 의한 영향은 관찰 할 수 없었다. 1-MCP는 자두의 유통기간 중 과피의 색깔 변화, 과육의 연화 방지, 그리고 산도 유지에 매우 효과적이었다. This study was conducted to investigate the effect of 1-MCP on the postharvest life of ‘Ooishiwase’ plum. Plums were treated with 1 μLㆍℓ⁻¹ 1-MCP at 10℃ for 24 h. Treated plums were divided in groups according to purpose before storage. Group Ⅰ was used to examine the effect of 1-MCP on plum ripening at 20℃. Group Ⅱ was used to examine the effect of 1-MCP on plum ripening at 20℃ and 0℃ storage. Our results found out that 1-MCP reduced production of ethylene, CO₂ and softening of plum fruits. The change in the rind color was delayed. Moreover, soluble solids content was not affected and decay caused by Botrytis cinerea and Penicillium expansum was reduced during storage. 1-MCP can be utilized as an effective means of maintaining quality and extending shelf life of plums.