흰쥐에서 망간에 의한 뇌 영향에 관한 연구

이재명,김정일,정갑열,이현재,예병진,이영일,Lee, Jae-Myeong,Kim, Jeong-Il,Jeong, Gap-Yeol,Lee, Hyeon-Jae,Ye, Byeong-Jin,Lee, Yeong-Il 대한산업보건협회 2008 산업보건 Vol.244 No.-

우리나라 특수건강진단 대상물질에 대한 6개 기관의 직업적 노출 기준 비교

이상윤 ( Sang Yoon Lee ),서춘희 ( Chun Hui Suh ),김세영 ( Se Yeong Kim ),예병진 ( Byeong Jin Ye ),설진곤 ( Jin Gon Sul ),손준석 ( Jun Seok Son ),윤종완 ( Jong Wan Yoon ),홍석우 ( Suk Woo Hong ),류지영 ( Ji Young Ryu ),김대환 ( Dae 한국산업위생학회 2013 한국산업보건학회지 Vol.23 No.2

Objectives: This study was performed in order to compare the average levels and similarity of occupational exposure limits in South Korea, the U.S., the E.U., Germany, Japan and Finland. Methods: In this study, occupational exposure limits (OELs) for one hundred and seventy seven hazardous substances which are managed in the workplace by the Occupational Safety and Health Act in South Korea were matched with those of other countries. The units for the exposure limits of the same substance (identical CAS number) were unified and the exposure limits in each country were compared with threshold limit values (TLVs) of the American Conference of Governmental Industrial Hygienists (ACGIH) using a geometric mean method. Geometric similarity was calculated to assess the association by each country. Results: The exposure limits according to ACGIH TLVs in South Korea, the E.U., Germany, Japan, and Finland were 148, 37, 76, 90, and 110, respectively. When using TLVs of ACGIH as a standard, the geometric mean ratios of Germany, Finland, the E.U., South Korea, and Japan were 0.79, 0.80, 0.82, 1.19, and 1.27, respectively. Geometric similarity with TLVs of ACGIH was highest in South Korea (0.75) followed by Japan (0.56), the E.U. (0.52), Finland (0.50), and Germany (0.46). Conclusions: Through the comparison of levels of OELs and similarities among South Korea, the U.S., the E.U., Germany, Japan, and Finland, we could better understand the characteristics of occupational exposure limits by countr

조선소 근로자의 직종과 혈청 암배아성 항원 농도와의 관련성

정갑열 ( Kap Yeol Jung ),김정원 ( Jung Won Kim ),예병진 ( Byeong Jin Ye ) 한국산업위생학회 2013 한국산업보건학회지 Vol.23 No.2

Objectives: The purpose of this study was to clarify the association between serum carcinoembryonic antigen (CEA) and type of work in the shipbuilding industry. Methods: 1,072 final study subjects were admitted to a general hospital from April through July 2010 for the purpose of medical examination. Data on general characteristics such as age, smoking history, alcohol history and exercise habits was gathered through structured self-administered questionnaires. Information on job factors was collected from a medical examination, by interview and through company personnel data. Serum CEA levels were measured after eight hours`` fasting and were analyzed by a radioimmunoassay. Results: On univariate analysis, the mean serum CEA level was significantly higher among married (p=0.02), older age (p<0.01), longer work time (p<0.01), smokers (p<0.01), lower education (p<0.01), and indirect and direct exposure groups (p<0.01). On multiple regression analysis, serum CEA level was influenced by smoking (p=0.001), duration of work (p=0.019), and direct exposure group (p<0.001). However, among the direct exposure group, serum CEA level was not significantly different between welding, mounting, electro-device constructive work, grinding and cleaning, and painting. Conclusions: The goal of this research was to determine if there were differences between serum CEA levels according to occupational role among shipyard workers. The direct exposure group of shipyard workers had a relatively higher level of serum CEA than did the indirect exposure group and office workers, most likely due to occupational exposure.

Rat를 이용 산소 및 유해가스 노출에 따른 운동성 변화와 치사농도 연구

김현영(Hyeon-Yeong Kim),이성배(Sung-Bae Lee),한정희(Jeong-Hee Han),강민구(Min-Gu Kang),예병진(Byeong-Jin Ye) 환경독성보건학회 2009 환경독성보건학회지 Vol.24 No.3

As an effort to prevent serious accidents involving oxygen deficiency and suffocation in confined spaces and to identify the causes of such accidents, the present study investigated relevant accidents and systems in Korea and other countries. This study also conducted a number of experiments at lethal concentration levels of oxygen deficiency using SD rats and observed the changes of experimental animals with humidity, organic gas (toluene), hydrogen sulfide, carbon monoxide and so on at the oxygen deficient environment. The results of the study are as follows. 1. The results from the experiment conducted using SD rats at lethal concentration levels of oxygen showed that there were no casualties at the 7% oxygen concentration level, but the mortality increase to 20% at 6% oxygen. it was jumped to 90% at 5% oxygen, and it was also dramatically reached 100% at 4% oxygen concentration. Therefore, 5.5% was calculated as the LC?? (rat, 4hr) from these dose-response experiments with oxygen deficiency. 2. When we changed the level of toluene, H₂S, CO, humidity, and so on, in an oxygen deficient environment, it was observed that the small concentrations of H₂S and CO make the highest effect on animals. In case of 350 ppm H₂S, it resulted in 30% mortality, and the 100% mortality was shown in 1,200 ppm CO concentration. The mortality increased as an oxygen deficient condition. However in the case of toluene up to 1,000 ppm, it were not affected with oxygen deficiency, and it did not indicate any significant differences in mortality as 20%, 90% humidities.

수리조선업 근로자들의 단순흉부촬영에서 흉막 비후 유병률 : 석면 노출과 관련하여

예병진,김정일,이현재,김기남,이기남,정갑열,김준연,윤성호 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.1

목적: 본 연구는 수리조선업 사업장의 석면 노출 근로자와 비노출 근로자의 단순흉부촬영 검사에서 흉막 비후의 유병률 차이를 비교하고 석면 노출군의 특징을 확인하는 것을 목적으로 하였다. 방법: 한 수리조선소에 현재 근무하고 있거나 퇴직한 근로자 중 2005년부터 2007년까지 단순흉부촬영을 받았던 근로자 1,701명(79.4%)을 대상으로 석면 노출 여부와 노출기간에 따른 흉막 비후의 유병률을 분석하였다. 결과: 흉막 비후 유병률은 석면 노출군에서 5.2%,비 노출군에서 3.1%를 보였으며(p<O.05),특히 50대 이상에서 석면 노출군 17.6%,비노출군 8.7%로 큰 차이를 보였다(p<O.05). 결핵의 병력이 있거나 의심되는 근로자들을 제외한 경우에도 유병률의 유의한 차이가 있었다. 20∼29년간 석면에 노출된 경우 16.5%. 30년 이상인 경우 30.8%로 흉막 비후 유병률이 매우 높았다. 석면 노출 기간이 20∼29년, 30년 이상일 경우 흉막 비후의 교차비가 각각 2. 34(95%CI: 1.15∼4.77), 2.95(95%CI: 1.08∼8.07)이었다. 결론: 20년 이상 석면에 노출된 경우 흉막 비후 위험도가 높아지므로 적극적인 의학적 감시와 연구가 필요하다고 사료된다. Objectives: This study evaluated the prevalence of asbestos exposure-induced pleural thickening on chest radiograph in repairing shipyard workers. Methods: A total of 2,114 incumbent and retired workers in a shipyard underwent chest radiograph, questionnaire study, interview, and physical exam from 2005 to 2007. Finally, 1,702 workers were selected and classified into two groups according to asbestos exposure: exposure and non-exposure groups. The characteristics in the exposure group were investigated. Results: The prevalence of pleural thickening on chest radiograph was 5.2 % and 3.1 % in the exposure and non-exposure groups, respectively (P<0.05). In those aged 50 years or above, the prevalence was 17.6 % and 8.7 % in the exposure and non-exposure groups, respectively (P<0.05). The prevalence was 16.5 % and 30.2 % and the odds ratio was 2.34 (95% CI; 1.15-4.77) and 2.95 (95%CI; 1.08-8.07) in the workers with an exposure duration of 20-29 years and more than 30 years, respectively. The prevalence was higher when considering tuberculosis history. Conclusions: The prevalence was increased with increasing exposure duration was more than 20 years. The authors therefore suggest that this group should be followed up periodically by special program and that a longitudinal study with repairing shipyard workers as the cohort should be undertaken.

인간공학평가를 이용한 요추간판탈출중의 작업관련성 평가

김정원,예병진 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Herniated nucleus pulpous(HNP) on lumbar spine is one of work-related musuloskeletal disorders. We evaluated a worker diagnosed HNP with some ergonomics tools to identify work-related risk factors at his workplace. One tool is are mainly developed to evaluate lumbar disc pressure of 5th lumbar on 1st sacral spine. We used another tool to evaluate lumbar posture. The worker's main job is heavy material lifting and handlings. The results show us that his work can be a musculoskeletal body burden of his low back such as pressure over 3,400N. Finally, We suggested some recommendations to improve his working conditions and prevent his disorder

인간공학평가를 이용한 외상과염의 작업관련성 평가

김정원,예병진 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Lateral epicondylitis is one of work-related musculoskeletal disorders. We evaluated a worker who diagnosed lateral epicondylitis with some ergonomics tools to identify work-related risk factors at his workplace. The worker's main job is drawing up a design using a CAD(computer aided design) program. The CAD job shows us that investigation and changes are required soon as an action level. We suggested some recommendations to improve his working conditions and prevent his disorder.