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대계와 실리비닌의 Mouse BV2 Microglial Cells에서 Lipopolysaccharide에 의해 유발된 염증반응에 대한 신경보호 효과
여현수,김동우,전찬용,최유경,박종형,Yeo, Hyun-Soo,Kim, Dong-Woo,Jun, Chan-Yong,Choi, You-Kyung,Park, Chong-Hyeong 대한한방내과학회 2007 大韓韓方內科學會誌 Vol.28 No.1
Objectives : This study was designed to evaluate the neuroprotective effect of Cirsium japonicum and Silibinin on lipopolysaccharide-induced inflammation in BV2 microglial cells. Methods : We studied on the neuroprotective effect of lipopolysaccharide-induced inflammation using MTS assay, western blot, and nitric oxide detection on mouse BV2 microglial cells. Results : Cirsium japonicum dose-dependently (50${\mu}g/ml$${\sim}$$250{\mu}g/ml$) inhibited nitrite production and iNOS expression in lipopolysaccharide-induced BV2 microglia and also significantly reduced lipopolysaccharide-induced COX-2 activation in western blot. Silibinin dose-dependently (10${\mu}M$${\sim}$$100{\mu}M$) inhibited nitrite production and iNOS expression in lipopolysaccharide-induced BV2 microglial cells. Silibinin also significantly reduced lipopolysaccharide-induced COX-2 activation in western blot. Conclusion : These effects of neuroprotection related to anti-inflammation suggest that Cirsium japonicum and Silibininmay be useful candidates for the development of a drug for related neurodegenerative diseases.
황기, 당귀, 칠피, 천화분의 역형성갑상선암세포 SNU-80에 대한 항암효과
여현수,이민혜,고성규,최유경,전찬용,박종형,Yeo, Hyun Soo,Lee, Min Hye,Ko, Seong Gyu,Choi, You Kyung,Jun, Chan Young,Park, Jong Hyeong 대한예방한의학회 2014 대한예방한의학회지 Vol.18 No.1
Objective : This study was performed to investigate the antineoplastic effect of Astragalus membranaceus, Angelica gigas, Rhus verniciflua Stokes and Trichosanthes kirilowii on SNU-80 anaplastic thyroid carcinoma cell line. Method : We examined whether our herbal medicines decreases cell growth rate of SNU-80 using MTT assay. We performed western blot analysis to verify that our herbal medicines induces apoptosis via caspase-dependent mechanism. We also performed wound healing assay and transwell invasion assay to investigate whether our herbal medicines affects the migration and invasion of anaplastic cancer cells, SNU-80. We also carried out ELISA assay to know our herbal medicines suppresses the expression of proinvasive molecules, such as VEGF and MMP-2 secreted from SNU-80. Results : MTT assay demonstrates that Angelica gigas, Rhus verniciflua Stokes, and Trichosanthes kirilowii suppressed strongly the growth of SNU-80. Western blot analysis demonstrates that Trichosanthes kirilowii induces apoptosis activating the cleavages of caspases (caspase-8, caspase-3) and PARP. Wound healing assay demonstrates that Rhus verniciflua Stokes, and Trichosanthes kirilowii inhibited the migration of SNU-80. Transwell invasion assay demonstrates that Rhus verniciflua Stokes, and Trichosanthes kirilowii inhibited the invasion of SNU-80. Elisa assay demonstrates that Astragalus membranaceus, Angelica gigas, Rhus verniciflua Stokes, and Trichosanthes kirilowii suppressed the expression of VEGF and MMP-2. Conclusion : We could conclude that several herbal medicines suppresses the growth and inhibits the migration and invasion of SNU-80 which is anaplastic thyroid cancer cells. Especially, Rhus verniciflua Stokes, Trichosanthes kirilowii had stronger anti-cancer effect suggesting that we can apply them to treat anaplastic thyroid cancer.
수종 한약 복합물의 역형성갑상선암세포 SNU-80에 대한 항암효과
여현수,이민혜,최유경,전찬용,박종형,Yeo, Hyun-Soo,Lee, Min-Hye,Choi, You-Kyung,Jun, Chan-Young,Park, Jong-Hyeong 대한한방내과학회 2014 大韓韓方內科學會誌 Vol.35 No.4
Objectives: The purpose of this study was to investigate the antineoplastic effect of several herbal medicine mixtures (compositions of Astragalus membranaceu, Angelica gigas, Trichosanthes kirilowii, Panax ginseng, Rhus verniciflua Stokes) on the SNU-80 anaplastic thyroid carcinoma cell line. Methods: MTT assay was used to examine whether our herbal medicine mixtures decreased cell growth rate of SNU-80. Wound healing assay and Transwell invasion assay was performed to investigate whether our herbal medicine mixtures affect the migration and invasion of anaplastic cancer cells, SNU-80. ELISA assay was performed to know if our herbal medicine mixtures suppressed the expression of pro-invasive molecules, such as vascular endothelial growth factor (VEGF) and matrix metalloproteinase-2 (MMP-2) secreted from SNU-80. Results: MTT assay demonstrated that A. membranaceus:A. gigas:T. kirilowii=1:1:1 or 3:1:1, A. membranaceus:A. gigas :T. kirilowii:P. ginseng=1:1:1:1 or 3:1:1:1, A. membranaceus:A. gigas:T. kirilowii:P. ginseng:R. verniciflua Stokes=1:1:1:1:1 or 3:1:1:1:1 strongly suppressed the growth of SNU-80. Wound healing assay demonstrated that A. membranaceus:A. gigas=3:1, A. membranaceus:A. gigas:T. kirilowii=1:1:1 or 3:1:1, A. membranaceus:A. gigas:T. kirilowii:P. ginseng=1:1:1:1 or 3:1:1:1, A. membranaceus:A. gigas:T. kirilowii:P. ginseng:R. verniciflua Stokes=1:1:1:1:1 or 3:1:1:1:1 inhibited the migration of SNU-80. Transwell invasion assay demonstrated that A. membranaceus:A. gigas=1:1, A. membranaceus:A. gigas:T. kirilowii =1:1:1 or 3:1:1, A. membranaceus:A. gigas:T. kirilowii:P. ginseng=1:1:1:1, A. membranaceus:A. gigas:T. kirilowii:P. ginseng :R. verniciflua Stokes=1:1:1:1:1 or 3:1:1:1:1 inhibited the invasion of SNU-80. ELISA assay demonstrated that A. membranaceus :A. gigas:T. kirilowii=1:1:1 or 3:1:1, A. membranaceus:A. gigas:T. kirilowii:P. ginseng:R. verniciflua Stokes=1:1:1:1:1 suppressed the expression of VEGF. Also, A. membranaceus:A. gigas=1:1, A. membranaceus:A. gigas:T. kirilowii=1:1:1 or 3:1:1, A. membranaceus :A. gigas:T. kirilowii:P. ginseng=1:1:1:1 or 3:1:1:1, A. membranaceus:A. gigas:T. kirilowii:P. ginseng:R. verniciflua Stokes =1:1:1:1:1 or 3:1:1:1:1 suppressed the expression of MMP-2. Conclusions: The results obtained in this study suggest that several herbal medicine mixtures suppresse the growth and inhibit the migration and invasion of SNU-80, which is anaplastic thyroid cancer cells. Especially, A. membranaceus:A. gigas: T. kirilowii=1:1:1 mixture had a stronger anti-cancer effect.
이시형,정기용,여현수,하유군,백종우,최유경,전찬용,김동우,박종형,Rhee, See-hyung,Jung, Ki-yong,Yeo, Hyun-soo,Hsia, Yu-chun,Baek, Jong-woo,Choi, You-kyung,Jun, Chan-yong,Kim, Dong-woo,Park, Chong-hyeong 대한중풍순환신경학회 2007 대한중풍.순환신경학회지 Vol.8 No.1
Objectives : This study was prepared for investigating the clinical features of stroke patients. Methods : We retrospectively reviewed the medical records of 75 patients who were admitted to Department of Internal Medicine, College of Oriental Medicine, Kyung-Won University with a diagnosis of stroke from Jan. 1, 2005 to Dec. 31, 2005. Results : Ischemic stroke(include TIA, 93.3%) was more common than hemorrhagic stroke(6.7%). The incidence in male was 36.0%, in female was 64.0% and the most prevalent age group is over-sixties. Cerebral infarction was most frequently noticed in MCA-infarction and hemorrhage in putamen & thalamus. Hypertention, the most preceding diseases, followed by diabetes mellitus and CVA. The rate of recurrence was 21.3%. Cerebral infarction and cerebral hemorrhage was much occurred after rising. The most patients visited the hospital within 24 Hours. The most common symptoms in admission time were motor weakness and speech disorder. The complication was mostly urinary tract inflamation. Conclusions : Our study on CVA patients was similar to previous studies from 1994 to 2004. In most cases, western and oriental treatment and medicine were given synthetically.
이시형,박정섭,여현수,최유경,전찬용,박종형,김동우,Rhee, See-Hyung,Park, Jung-Sup,Yeo, Hyun-Soo,Choi, You-Kyung,Jun, Chan-Yong,Park, Chong-Hyeong,Kim, Dong-Woo 대한한방내과학회 2006 大韓韓方內科學會誌 Vol.27 No.3
Objectives : This study investigated whether taking herbal medicine over the long-term had any side effects of liver damage. Methods : We checked LFT levels of the 58 admitted patients. Results : When we compared admission LFT levels with discharge LFT levels, we found the levels of AST, ALT and LDH had decreased. This test showed statistically significant decrease. When we compared admission LFT levels with discharge LFT levels, we found the increases of discharge LFT levels fell within the standard deviation. When we compared admission LFT levels with discharge LFT levels, we found the levels of LFT did not increase as much as two standard deviations. Conclusions : According to the above results, taking herbal medicine over a long-term did not have any side effects of drug-induced liver damage.
흰쥐의 간손상(肝損傷)에 대한 가미유간탕(加味愈肝湯)의 간(肝) 보호효과(保護效果)
정희,고호연,하유군,여현수,백종우,고성규,박종형,전찬용,강재춘,Jung, Hee,Go, Ho-Yeon,Hsia, Yu-Chun,Yeo, Hyun-Soo,Baik, Jong-Woo,Ko, Seung-Gyu,Park, Jong-Hyung,Jun, Chan-Yong,Kang, Jea-Chun 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.1
In order to investigate the protective effects of Gami Yugan-tang on liver damage in rats induced by $CCl_{4}$ and d-galactosamine, the serum transaminase(ALT & AST), alkaline phosphatase(ALP), lactic dehydrogenase(LDH), superoxide dismutase(SOD), catalase, glutathione S-transferase(GST), glutathione peroxidase(GPX) for enzyme activities, and lipid peroxidation were measured. All animals were divided into 4 groups: normal group (untreated), control group (treated with 0.9% saline solution), sample I group (treated with 740mg/kg Gami Yugan-tang), and sample II group (treated with 1,480mg/kg Gami Yugan-tang). The results were as follows : 1. The results of liver damage in rats induced by $CCl_4$ : The protective effects of ALT were displayed in sample I and sample II, and AST, ALP, LDH, SOD, catalase, GST, GPX, and lipid peroxidation were noted in sample II group. It showed slight necrosis of hepatic cell and pathologic changes, for example, inflammatory cells infiltration were improved in sample II group compared to the control group. 2. The results of liver damage in rats induced by d-galactosamine : The inhibitory effects of AST, ALT, LDH, and ALP activities were noted in both sample I and sample II groups. The findings from this experiment suggests that Gami Yugan-tang has protective effects against liver damage in rats induced by $CCl_{4}$ and d-galactosamine.
봉약침(蜂藥鍼)을 이용한 요추(腰椎) 추간판(椎間板) 탈출증(脫出症) 치료(治療)에 대한 증례보고
조태영,진성순,박정섭,여현수,임형호,이시형,Cho, Tae-Young,Jin, Sung-Soon,Park, Jung-Sup,Yeo, Hyun-Soo,Lim, Hyung-Ho,Rhee, See-Hyung 척추신경추나의학회 2006 척추신경추나의학회지 Vol.1 No.1
Objectives : This report was performed to evaluated the treatment of Bee venom acupuncture Therapy, acupuncture Therapy, Herbal medicaion and Moxibustion in herniation of inter-vertebral disc. Methods : We treated 1 case of herniation of inter-vertebral disc with Bee venom acupuncture Therapy, acupuncture Therapy, Herbal medicaion and Moxibustion. Results : After 12 days of Bee venom acupuncture Therapy, acupuncture Therapy, Herbal medicaion and Moxibustion, a remarkable improvement was made for herniation of inter-vertebral disc. The patient couldn't feel pain on walking. Conclusion : Bee venom acupuncture Therapy, acupuncture Therapy, Herbal medicaion and Moxibustion were effective in reducing the symptoms.
박정섭,정승민,이시형,정기용,여현수,하유군,최유경,전찬용,김동우,박종형,Park, Jung-sup,Jung, Seung-min,Lee, Si-hyung,Jung, Ki-yong,Yeo, Hyun-soo,Hsia, Yu-chun,Choi, You-kyung,Jun, Chan-yong,Kim, Dong-woo,Park, Chong-hyeong 대한중풍순환신경학회 2006 대한중풍.순환신경학회지 Vol.7 No.1
Objectives : This study was prepared for investigating the clinical features of stroke patients. Methods : We retrospectively reviewed the medical records of 102 patients who were admitted to Department of Internal Medicine, College of Oriental Medicine, Kyung-Won University with a diagnosis of stroke from Jan. 1, 2004 to Dec. 31, 2004. Results : Ischemic stroke(include TIA, 82.4%) was more common than hemorrhagic stroke(17.6%). The incidence in male was 41.2%, in female was 17.6% and the most prevalent age group is over-sixties. Cerebral infarction was most frequently noticed in lacunar-infarction and hemorrhage in putamen. Hypertention, the most preceding diseases, followed by diabetes mellitus and CVA. The rate of recurrence was 27.45%. Cerebral infarction and cerebral hemorrhage was much occurred after rising. The most patients visited the hospital within 24 Hours. The most common symptoms in admission time were motor weakness and speech disorder. The complication was mostly mental disorder. Conclusion : Our study on CVA patients was similar to previous studies from 1994 to 2003. In most cases, western and oriental treatment and medicine were given synthetically.
급성기 뇌중풍환자의 비만 및 복부비만과의 임상적 제특징 분석
하유군,정기용,고호연,정희,백종우,여현수,고미미,최유경,김동우,한창호,조기호,방옥선,박종형,고성규,전찬용,Hsia, Yu-Chun,Jung, Ki-Yong,Go, Ho-Yeon,Jung, Hee,Baik, Jong-Woo,Yeo, Hyun-Soo,Ko, Mi-Mi,Choi, You-Kyung,Kim, Dong-Woo,Han, Chang-Ho,Cho, Ki- 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.1
Background and Purpose : This study was to assess characteristics in acute stroke patients according to obesity and abdominal obesity. Methods : From1 Oct. 2005 to 31 Jul. 2007, 629 patients with a stroke were included. Patients were hospitalized within 30 days after the onset of stroke at Kyungwon University Incheon Oriental Hospital, DongGuk University International Hospital and Department of Cardiovascular and Neurologic Disease (Stroke Center), or Kyung Hee University Oriental Hospital. We investigated general characteristics preferences according to general obesity and abdominal obesity. Results : 629 acute stroke patients were included in the final analysis. Male, young age, hypertension, heart disease in the family history, hypertension in the past history, care of invalids or grandchildren and Taeumin in the Sasang constitution were higher among obese patients. Male, transient ischemic attack in the past history, smoker and Soyangin in the Sasangconstitution were higher among patients with abdominal obesity. The incidence of abdominal obesity corresponded to lower education level. Conclusions : In our study, we observed the general disposition of various characteristic distributions according to obesity and abdominal obesity in acute stroke patients.
이시형(See Hyung Rhee),조태영(Tae Young Cho),진성순(Sung Soon Jin),박정섭(Jung Sup Park),여현수(Hyun Soo Yeo),임형호(Hyung Ho Lim) 척추신경추나의학회 2006 척추신경추나의학회지 Vol.1 No.1
Objectives : This report was performed to evaluated the treatment of Bee venom acupuncture Therapy, acupuncture Therapy, Herbal medicaion and Moxibustion in herniation of inter-vertebral disc. Methods : We treated 1 case of herniation of inter-vertebral disc with Bee venom acupuncture Therapy, acupuncture Therapy, Herbal medicaion and Moxibustion Results : After 12 days of Bee venom acupuncture Therapy, acupuncture Therapy, Herbal medicaion and Moxibustion, a remarkable improvement was made for herniation of inter-vertebral disc. The patient couldn t feel pain on walking. Conclusion : Bee venom acupuncture Therapy, acupuncture Therapy, Herbal medicaion and Moxibustion were effective in reducing the symptoms.