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이형환,차성철,어홍선,조재경,이준근,장동준,김수영,Lee, Hyung-Hoan,Cha, Soung-Chul,Uh, Hong-Sun,Cho, Jae-Kyung,Lee, Jun-Keun,Chang, Dong-Jun,Kim, Soo-Young The Korean Society of Virology 1999 Journal of Bacteriology and Virology Vol.29 No.4
Zosteriform lesions, occurring after left flank and intravaginal inoculations of Balb/c mice with the Herpes simplex virus type 1 strain McKrae, developed in clinically normal skin via nerve endings. The developments of zosteriforms were standardized in 5 phases with the following references; formation of small vesicles (phase 1); occurrence of erosion and ulceration of local lesions (phase 2); occurrence of ulcerations (phase 3); occurrence of severe ulcerations (phase 4); and death (phase 5). These results provide two valuable zosteriform models to further investigate and analyze the pathological symptoms in susceptible animals infected with HSV-1 or HSV-2 and DNA vaccines.
강현(Hyun Kang),박종국(Jong Gook Park),어홍선(Hong Sun Uh),김수영(Soo Young Kim),이형헌(Hyung Hoan Lee) 대한바이러스학회 1999 Journal of Bacteriology and Virology Vol.29 No.2
BamHI restriction pattern and genomic library of Herpes simplex virus type 2 (HSV-2) strain G were constructed, and locations of the glycoproteins gB and gD, and tk genes on the fragments were detected by Southern blot analysis. HSV-2 genomic DNAs were cleaved into twenty-seven fragments by BamHI enzyme in the range of 0.72 to 15.08 (total 150.44 kb), which were cloned into the BamHI site of pBluescript SK(+) to construct genome library of the HSV-2. The library was named by the order of the fragment size from smallest one to largest one. HSV-2 glycoprotein gD gene was located in pHLA2-21 and pHLA2-22 recombinant plasmids, gB gene in pHLA2-24 plasmid, and tk gene in pHLA2-11 clone by Southern blot analysis.
이형환(Hyung Hwan Lee),차성철(Sung Chul Cha),어홍선(Hong Sun Uh),조재경(Jae Gyung Jo),이준근(Jun Geun Lee),장동준(Dong Joon Jang),김수영(Soo Young Kim) 대한바이러스학회 1999 Journal of Bacteriology and Virology Vol.29 No.4
Zosteriform lesions, occurring after left flank and intravaginal inoculations of Balb/c mice with the Herpes simplex virus type 1 strain McKrae, developed in clinically normal skin via nerve endings. The developments of zosteriforms were standardized in 5 phases with the following references; formation of small vesicles (phase 1); occurrence of erosion and ulceration of local lesions (phase 2); occurrence of ulcerations (phase 3); occurrence of severe ulcerations (phase 4); and death (phase 5). These results provide two valuable zosteriform models to further investigate and analyze the pathological symptoms in susceptible animals infected with HSV-1 or HSV-2 and DNA vaccines.