증례(證例) : 추나치료를 이용한 특발성 척추측만증 치험 1례

안희덕 ( Hee Duk An ),우창훈 ( Chang Hoon Woo ),권오곤 ( O Gon Kwon ),정만진 ( Man Jin Jeong ) 대구한의대학교 제한동의학술원 2012 제한동의학술원논문집 Vol.10 No.1

Objectives: This study is designed to evaluate the effectiveness of chuna therapy on patients with idiopathic scoliosis. Methods: The patient had been treated with chuna therapy. We measured Cobb`s angle, Visual Analog Scale(VAS) before and after treatment. Results: After treatment, we confirmed these improvement: Cobb`s angle from 20 to 5; VAS from 10 to 2. Conclusions: The result suggest that chuna therapy was effective treatment on patients with idiopathic scoliosis.

긴장성 두통에 대한 추나요법 치험 3례

원제훈,김영준,안희덕,우창훈,Won, Je-Hoon,Kim, Young-Jun,An, Hee-Duk,Woo, Chang-Hoon 척추신경추나의학회 2015 척추신경추나의학회지 Vol.10 No.1

Objectives: The Purpose of this study is to report three cases on tension-type headache treated by Chuna manipulative therapy. Methods: Three patients diagnosed tension-type headache were treated with Chuna manipulative therapy only. To evaluate effect of treatment, visual analogue scale(VAS) and headache impact test(HIT) were used. We checked VAS and HIT score three times(pretreatment, post-treatment, follow-up). An interval among each evaluation time is 4 weeks. Results: At post-treatment evaluation, VAS and HIT score declined significantly compared with pre-treatment. At follow-up evaluation, the pain did not increased. Conclusions: These results suggests that Chuna manipulative therapy may be effective for tension-type headache.

說例: 가미분심기음(加味分心氣飮)으로 호전(好轉)된 심신증(心身症) 환자(患者) l례(例) 보고(報告)

최은실 ( Eun Sill Choi ),우창훈 ( Chang Hoon Woo ),안희덕 ( Hee Duk An ) 대구한의대학교 제한동의학술원 2012 東西醫學 Vol.37 No.2

Psychosomatic disorder is an physical disease or physical symtom caused by stress factor, That diseases are hypertension, respiratory ailments, digestive diseases, migraine, male impotence, skin diseases, gastric ulcer, The cause is that stress has an influence on neuroendocrine system, and it cause physical changes, For treatment, internal treatment for the improvement of symtoms is first, and consider psychiatric treatment, In this report, we introduce a case of psychothsomatic disorder caused by severe stress. The patient was a 43-year-old woman that admitted because of general paralysis for 2 weeks. For treatment, we put her on Chunwangbosin-dan, Gaegyulseogyung-tang, Gamibunsimgi-eum. And Gamibunsimgi-eum had a remarkable treatment effect.

요통환자에서 중성어혈 약침 사용 용량에 따른 효과

정만진,권오곤,우창훈,안희덕,Jeong, Man-Jin,Kwon, O-Gon,Woo, Chang-Hoon,An, Hee-Duk 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.2

Objectives : The object of this study is to analyse about Low Back Pain's intensity according to dosage of Jungsongouhyul pharmacopuncture. Method : Three groups were made with 15 patients in Po-Hang Oriental Hospital, which is affiliates to Daegu Haany University. They were observed August 1st, 2010 to September 30th. 2010. Each group was treated by based on acupuncture, herb and other therapy and differential dosage of Jungsongouhyul pharmacopuncture 0,4, 0.8, and 1.2cc. We had measured pain threshold and Visual Analog Scale during first week of their admission. The statistical analysis was performed by using the oneway ANOVA and Tukey's test. Result : Change of VAS was not statistically significant. Change of pain threshold was statistically significant. Multiple comparisons of pain threshold between the group1,2 was not statistically significant. Multiple comparisons of pain threshold between the group1,3 and group2,3 was statistically significant. Conclusions : Jungsongouhyul Pharmacopuncture 1.2cc was more effective than 0.4 and 0.8cc.

Therapeutic Effects of Binsosan(檳蘇散) on Adjuvant-induced Rheumatoid Rats

안건상,우창훈,권오곤,안희덕,An, Keun-Sang,Woo, Chang-Hoon,Kwon, O-Gon,An, Hee-Duk The Korean Medicine Society for the Herbal Formula 2008 大韓韓醫學方劑學會誌 Vol.16 No.2

실험목적 : 빈소산은 11가지 생약으로 구성된 복합 한약 처방으로 관절염을 포함한 다양한 염증성 질환의 치료제로 사용되어 왔으나, 관절염에 대한 직접적인 효력평가는 찾아 보기 힘들다. 따라서 본 실험에서는 빈소산 추출물이 Freund's complete adjuvant (FCA)로 유발된 rat 류마티스성 관절염에 미치는 치료 효과를 dexamethasone (15mg/kg, 복강 투여) 의 효과와 비교 평가하였다. 실험방법 : 류마티스성 관절염은 FCA (10mg in 1ml paraffin oil 0.1ml/rats)를 좌측 후지에 피내 투여하여 유발하였다. 실험동물은 Wistar 랫트를 사용하였고, FCA 투여 14일 후 유사한 무릎관절 둘레를 나타내는 류마티스성 관절염 유발 rat와 정상 rat 및 실험군을 그룹당 9마리씩 나누었다. 실험동물은 100 또는 200mg/kg의 빈소산 추출물을 FCA 투여 14일 후부터 14일간 경구 투여하였으며, dexamethasone은 15mg/kg 농도로 복강 투여한 다음, 희생하여, 체중, 연골내 collagen 함량 및 chondroitin sulphate, heparin sulphate 및 hyaluronic acid와 같은 뼈내 glycosaminoglycan 함량의 변화를 각각 관찰하였다. 실험결과는 항염 효과가 이미 입증되어 있는 dexamethasone 15mg/kg 복강 투여군과 비교하였다. 결과 : FCA 투여는 현저한 체중, 연골내 collagen 함량 및 chondroitin sulphate, heparin sulphate 및 hyaluronic acid와 같은 뼈내 glycosaminoglycan 함량의 감소와 함께 유발 관절 둘레 및 조직내 prostaglandin $E_2$의 증가와 같은 전형적인 류마티스성 염증을 초래하였으나, 이러한 류마티스성 관절염 소견은 dexamethasone 및 모든 용량의 빈소산 추출물 투여에 의해 현저히 억제되었으며, 특히 빈소산 투여군에서는 투여 용량 의존적인 감소가 인정되었다. 결론 : 이상에서 빈소산 추출물은 투여 용량 의존적인 prostaglandin $E_2$ 억제를 매개하여 FCA 유발 류마티스성 관절염에 대한 치료 효과를 나타내는 것으로 관찰되었다. 따라서 새로운 관절염에 대한 치료제로서 개발 가능성이 있을 것으로 판단된다. 한편 빈소산 추출물은 주로 prostaglandin $E_2$ 억제작용에 의해 항염 효과를 나타내는 것으로 관찰되었으나, 금후 다른 작용기전에 대한 연구와 빈소산의 구성성분 중 유효 성분 규명을 위한 실험이 수행되어야 할 것으로 판단된다.

종설(綜說) : 본초에서 분리된 유용 성분을 이용한 비만 연구의 경향

박지영 ( Ji Young Park ),안희덕 ( Hee Duk An ),김미려 ( Mi Ryeo Kim ) 대구한의대학교 제한동의학술원 2013 東西醫學 Vol.38 No.2

Objectives : The aim of this study was to contribute to the development of herbal extract active compound for obesity treatment by reviewing the studies of herbal extract active compounds and phytochemicals. Methods : We searched the papers with keywords of obesity and/or herbal compound, herbal component, active compound, natural compound, phytochemical in the search site, Pubmed. And then, abstract-opened, natural compound articles were separated as an object of research. Results : We reviewed 60 searched articles. ; 27 were studies animal experiment. 35 were cell study, 6 were about clinical trials. The herbs, used for obesity treatment, were Ginseng Radix Rubra, Rhei Rhizoma, Curcumae Longae Rhizoma et al. The phytochemicals for obesity treatment, were resveratrol. Betulinic acid, capsaicin et al. The mechanisms, of herbal active compounds and phytochemicals for obesity treatment, were lipogenesis, B-oxidation, differentiation, inflammation et al. Conclusion : Through animal and cell studies and clinical research, the treatment of obesity with herbal active compound therapy was effective. For clinical use, however in is considered that in vivo and vitro studies andclinical trial`s connection using studies about more herbal active compounds and associated side effects of decrease appetite drugs are needed.

강활도체탕(羌活導滯湯) 물 추출물의 Adjuvant 유발 류마티스 관절염 랫트에 대한 관절연골 보호효과

권오곤 ( O Gon Kwon ),안희덕 ( Hee Duk An ) 한방재활의학과학회 2013 한방재활의학과학회지 Vol.23 No.2

Objectives : This study was conducted to determine whether or not Kangwhaldoche-tang(Qianghuodaozhl-tang)(KDT)aqueous extracts can protect articular cartilage losses on the Freund’s complete adjuvant(FCA)-induced rat rheumatoid arthritis. Methods : 520, 260 or 130 mg/kg of KDT were orally administered once a day for 14 days from 14 days after FCA treatments, and 15 mg/kg of dexamethasonewas intraperitoneally administered as reference drug in this experiment. Changes on the body weight, knee circumferences, gross arthritis score,inflammatory tissue prostaglandin(PG) E2 levels were monitored with cartilage collagen components and glucosaminoglycans(GAGs) compositions .chondroitin sulphate, heparin sulphate and hyaluronic acid in the present study. Results : As results of FCA treatment, classic rheumatoid arthritis featuring dramatic decreases of the body weights, cartilage collagen and GAGs contents with increases of the knee circumferences, gross arthritis scores and inflammatory tissue PGE2 levels, were demonstrated in the present study. However, these changes from FCA - induced rheumatoid arthritis were clearly inhibited by treatment of dexamethasone and all three different dosages of KDT. Although overall anti-inflammatory effects of KDT 520 mg/kg were lowered than those of dexamethasone 15 mg/kg treated rats, KDT 520 mg/kg showed more favorable preserve effects on the cartilage GAGs and KDT 260 mg/kg treated rats showed similar preserve effects as compared with dexamethasone 15 mg/kg in this experiment. Conclusions : The present results supported that over 75 mg/kg of KDT showed favorable anti-arthritic effects on the FCA-induced arthritis mediated by suppression of PGE2, representative inflammatory mediator, and may help improve rheumatoid arthritis.

홍화자(紅花子) 약침요법(藥鍼療法)을 가미한 한방치료로 호전된 마미증후군(馬尾症候群) 환자(患者) 1례(例)

서보명,이윤경,김성웅,이세연,임성철,정태영,안희덕,한상원,서정철,Seo, Bo-Myung,Lee, Yoon-Kyoung,Kim, Sung-Woong,Lee, Sea-Youn,Lim, Seong-Chul,Jung, Tae-Young,An, Hee-Duk,Han, Sang-Won,Seo, Jung-Chul 경락경혈학회 2005 Korean Journal of Acupuncture Vol.22 No.1

갑작스러운 요통과 양측하지통, 하지의 근력 감소, 대소변 장애 및 운동, 감각장애로 양방병원에서 마미증후군으로 진단받고 추궁판 절제술과 감압술을 시행 후 임상적인 호전을 보이지 않은 환자 1례에 대해 홍화자(紅花子) 약침요법(藥鍼療法)을 중심으로 복합적인 한방치료를 시행한 결과 요통에 대한 VAS와 요통점수표, ODI 항목에서는 각 항목 모두에서 현저한 호전 양상을 나타내었다. 운동기능 및 보행에 있어서 입원 당시에 보행기에 의지하여 보행하였는데 치료 후에는 안독으로 보행이 가능하고 일상적인 가벼운 생활도 가능해지게 되었다. 배뇨기능에 있어서도 자발적인 배뇨가 가능할 정도로 완전회복 되었다. 하지만 배변의 상태는 입원 당시와 치료 후에는 변의가 느껴지는 것 이외에 자발적인 배변은 이루어지지 않았다. 감각 기능의 회복에 있어서도 온통각, 압촉각과 하지 냉감은 호전 양상을 보였으나 안장 감각과 괄약근의 기능은 거의 회복되지 않았다. 본 연구를 기초로 하여 향후 수술이나 양방적인 치료 후에 발생할 수 있는 후유증의 관리에 있어서 홍화자(紅花子) 약침(藥鍼)에 대한 더욱 심도있는 후속 연구가 이루어져야 할 것이다. Objectives : This study was to investigate the effect of the Carthami Semen Herbal acupuncture therapy on a Cauda equina syndrome patient who has a complex of low back pain, bilateral sciatica, saddle anesthesia and motor weakness in the lower extremity and paraplegia with bladder and bowel incontinence. Methods : Oriental Medical Therapy was performed on the Cauda equina syndrome patient from July 15th 2004 to July 29th 2004. The patient was treated with Carthami Semen Herbal acupuncture at BL22, BL23, BL25, BL28 and GV3 in combination with herbal medicine and conventional body acupuncture. We evaluated The Visual Analog Scale(VAS), Improvement index, The Oswestry Diability Index(ODI), gaiting, dyschezia, bladder incontinence, duration of urination and area of anesthesia, Digital Infrared Thermographic Imaging(DITI) before and after treatment. Results : 1. After treatment, VAS, Improvement index, ODI were improved each from 10 to 2, from 21 to 73, from 333 to 166. 2. After treatment, gaiting, bladder incontinence, duration of urination and area of anesthesia and DITI were improved well, but dyschezia was remained. Conclusions : From this case it is thought Carthami Semen herbal acupuncture therapy is very effective to Cauda Equina Syndrome and further study is needed for the confirmation of the effect of Carthami Semen Herbal acupuncture.

Collagen으로 유발된 마우스의 관절염에 대한 의이인탕(薏苡仁湯) 추출물의 억제 효과

조중현 ( Jung Hyun Cho ),권오곤 ( O Gon Kwon ),우창훈 ( Chang Hoon Woo ),안희덕 ( Hee Duk An,) 한방재활의학과학회 2010 한방재활의학과학회지 Vol.20 No.1

Objectives :The object of this study was to observe the favorable anti arthritic effects of Euiiin-tang(yiylnren-tang) aqueous extract(EIITe), has been traditionally used in Korean medicine for treating rheumatoid arthritis on collagen induced arthritic(CIA) DBA/1 mice. Methods :In the present study, effects of EIITe on the releases of human tumor necrosis factor(TNF)-α, interleukin(IL)-1β, matrix metalloproteinase(MMP)-13 and production of Nitric oxide(NO) were observed by in vitro. In addition, to observe the effects on the CIA mice, three different dosages of EIITe, 300, 150 and 150 mg/kg were orally administered once a day for 18 days from 24hrs after antigen challenges(type II collagen) on 21 days after immunization using Type II collagen Freund’s complete adjuvant. Six groups, each of 8 DBA/1 mice per group were used in the present study as follows. Changes on the body weights, macroscopic arthritis scores, splenic weights, splenic TNF-α and IL-6 contents, articular cartilage(femur and tibia) collagen and glycosaminoglycans -chondroitin sulphate, sulphate and hyaluronic acid contents, histopathological observations(microscopic arthritis scores, thicknesses of femur and tibia cartilage thicknesses were monitored, compared to that of dexamethasone, a potent anti inflammatory agents, 1 mg/kg treated mice. Results :As results of collagen challenges, marked decreases of body weights and gains, articular cartilage collagen and glycosaminoglycan - chondroitin sulphate, sulphate and hyaluronic acid contents were observed with increases of macroscopic arthritis scores, splenic weights, splenic TNF-α and IL-6 contents, articular cartilage(in the both femur and tibia) loss and damages. However, these CIA signs were significantly and dosages dependently inhibited by treatment of EIITe 300 and 150 mg/kg as compared with CIA control, respectively. In addition, the releases of TNF-α, IL-1β, NO and MMP-13 were markedly and dose dependently inhibited by treatment of EIITe, in vitro. Although CIA were more favorably inhibited by treatment of dexamethasone 1 mg/kg as compared with EIITe 300 mg/kg, marked decreases of body weights were detected in dexamethasone 1 mg/kg treated mice. Conclusions :The results obtained in this study suggest that over 150 mg/kg of EIITe showed favorable anti arthritic effects on the CIA mediated by immunomodulatory and/or anti oxidative effects. However, detail mechanism studies should be conduced in future with the screening of the biological active compounds in this herb. lthough CIA were more favorably inhibited by treatment of dexamethasone 1 mg/kg as compared with EIITe 300 mg/kg, marked decreases of body weights were detected in dexamethasone 1 mg/kg treated mice, in the present study.

단순성 비만에 대한 추나요법의 효과 : 체계적 문헌고찰과 메타분석

이윤진(Yun-Jin Lee),이은별(Eun-Byeol Lee),김현지(Hyeon-Ji Kim),안희덕(Hee-Duk An),양두화(Doo-Hwa Yang) 척추신경추나의학회 2021 척추신경추나의학회지 Vol.16 No.1

Objectives The purpose of this study was to investigate the effectiveness of Chuna manual therapy (CMT) in the treatment of simple obesity. Methods We used seven databases to perform a literature search using the keywords “Chuna OR Tuina” AND “Obesity.” We selected randomized clinical trials in which Chuna was used as the main method for treating simple obesity. The risk of bias was assessed by three independent researchers using the Cochrane risk of bias. Results A total of 14 RCTs were selected and analyzed. The results of the meta-analysis showed a significantly higher efficacy rate in the patient group treated with CMT as the main treatment than that in the control group. Conclusions The results of this systematic review suggest that CMT is effective in the treatment of simple obesity. However, given the limitations such as the small number of studies and the high risk of bias in the studies, additional research is needed to lend further support to this claim.