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결핵 환자에서 Rifampin에 의한 Henoch-Shonlein Purpura
김혜련 ( Hye Ryun Kim ),박병훈 ( Byung Hoon Park ),손지영 ( Ji Young Son ),정지예 ( Ji Ye Jung ),안정련 ( Jung Ryun Ahn ),정윤숙 ( Yoon Suk Jung ),임주은 ( Ju Eun Lim ),정주원 ( Ju Won Jung ),문지애 ( Ji Ae Moon ),변민광 ( Min Kwa 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.2
Rifampin is one of the first line drugs for treating tuberculosis, but it might be associated with serious adverse effects, including renal failure. We report here on a case of a 57-year-old patient who developed Henoch-Shonlein purpura during antituberculosis therapy that included rifampin. The patient converted to negative on the AFB smear for tuberculosis two weeks after the initial administration of antituberculosis medication. After treatment for 60 days, this patient was diagnosed with Henoch-Shonlein purpura by the purpura lesion on the lower legs, the leukocytoclastic vasculitis, the renal impairment and the pathological examination. After stopping rifampin, the skin lesions disappeared in about 10 days and his renal function gradually improved. This case study showed that Henoch-Schonlein purpura can be caused by rifampin during antituberculosis therapy and we recommend that the use of rifampin should be restrained when clinical symptoms of Henoch-Shonlein purpura are observed. (Tuberc Respir Dis 2008;65:116-120)
증례 : 혈액종양 ; 가돌리늄 기반 조영제 주입 후에 발생한 신성 전신 섬유화증 1예
홍민희 ( Min Hee Hong ),구향모 ( Hyang Mo Koo ),최준정 ( Jun Jeong Choi ),안정련 ( Jung Ryun Ahn ),전홍재 ( Hong Jae Chon ),김찬 ( Chan Kim ),이승태 ( Seung Tae Lee ) 대한내과학회 2010 대한내과학회지 Vol.78 No.1
신성 전신 섬유화증은 가돌리늄 제제에 노출된 신부전 환자에게서 나타날 수 있는 전신성 질환으로, 예후가 불량하며 특별한 치료방법이 없으므로 예방이 중요한 질환이다. 저자들은 국내에서 최초로 보고하는 바이다. Nephrogenic systemic fibrosis is a rare multisystemic disorder mainly affecting the skin and joints in patients with underlying renal insufficiency exposed to gadolinium-based contrast. We report a patient who had renal insufficiency caused by multiple myeloma and developed nephrogenic systemic fibrosis after exposure to gadolinium-based contrast for the first time in Korea. (Korean J Med 78:127-131, 2010)