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고지방식이 C57BL/6N 모델에서 降脂丸의 농도별 비알콜성 지방간질환 개선효과
안예지 ( Ye Ji Ahn ),윤기현 ( Ki Hyeon Yoon ),조주흠 ( Ju Heum Jo ),장두현 ( Du Hyon Jang ),정양삼 ( Yang Sam Jung ),김종훈 ( Jong Hoon Kim ),김병출 ( Byeong Chul Kim ),석화준 ( Hoa Jun Seok ),유재상 ( Jae Sang Yoo ),구자룡 ( Ja R 대한본초학회 2014 大韓本草學會誌 Vol.29 No.2
Objectives : This study was undertaken to verify the effect of Gangjihwan(Di-fatty, DF) composed with Pakistani Ephedra Herba on nonalcoholic fatty liver disease(NAFLD) using high fat diet-fed male mice. Method : Eight-week old C57BL/6N mice were used for all experiments. Standard chow diet-fed mice were used as normal group and high fat diet-fed NAFLD mice were randomly divided into 5 groups: control, atorvastatin, DF(1), DF(2) and DF(3). After 8 weeks, mice were treated with water, atorvastatin(10mg/kg) and DF(40, 80, 160mg/kg) for 8 weeks. And we investigated body weight gain, plasma lipid and glucose metabolism, histological analysis for liver on the mice. Results : Compared with controls, DF-treated mice had very significantly lower body weight gain and lower visceral adipose tissue weight, the magnitudes of which were prominent in DF(3). Consistent with their effects on body weight gain, DF-treated mice had lower blood total cholesterol and triglyceride level compared with controls. Consistent with their effects on body weight gain and blood plasma lipid level, DF-treated mice had lower liver weight and hepatic lipid accumulation of DF-treated groups was significantly decreased than control group. Also Blood plasma AST, ALT and γ-GT concentration were not changed by DF, and these results may indicate DF do not show any toxic effects. Conclusions : These results suggest that DF effectively improves NAFLD. DF reduces liver weight and prevents lipid accumulation of hepatocyte by reducing body weight gain and modulating blood plasma lipid metabolism levels.
안예지(Ye-Ji Ahn),양성모(Sung-Mo Yang) 건국대학교 부동산도시연구원 2023 부동산 도시연구 Vol.15 No.2
2017년 1월부터 시작된 ‘힐스테이트 범계역 모비우스’는 용도 컨버전의 대표 사례이다. 중심상업지역에 위치한구 평촌 NC백화점을 주거 용도로 변경하여 개발 사업을 진행하였다. 이를 통해 현재 부동산 트렌드 중 하나인 “턴투알(Turn to Residence)”에 대한 흐름을 확인할 수 있다. 또한, 해당 프로젝트에서 는 용도 변경에 따른 문제를 해결하는 과정을 자세히 다룸으로써 추후 발생할 컨버전 개발의 교본과 같은 역할을 하고 있다. 컨버전은 그 과정도 중요하지만 이를 통해 창출하는 효과 역시 중요하다. 본 연구는 컨버전이 지역에 미치는 영향에 주목하였고, 해당 프로젝트가 어떠한 도시문제 해결에 기여 할 수 있는지 자세히 다루었다. 이와 더불어 도시재생이라는 효과를 달성할 수 있는 다른 용도에 대한 추가적인 고찰을 통하여 연구의 폭을 넓혔다. ‘Hillstate Beomgye Station Mobius’, which started in January 2017, is a representative case of conversion. The former Pyeongchon NC Department Store, located in the central commercial district, was converted to residential use and the development project was carried out. ‘Turn-to-Residence’, a good example of current real estate trends, serves as a manual for conversion development that will occur in the future by carefully dealing with the process of resolving problems caused by change of use. This study specifically discussed what kind of urban problems the project can contribute to and additional considerations for other uses that can achieve the effect of urban regeneration.
GGEx16, GGEx18과 감비통성교낭(減肥通聖膠囊)의 항비만유전자 활성 비교
오재호 ( Jae Ho Oh ),안예지 ( Ye Ji Ahn ),이혜림 ( Hye Rim Lee ),임혜숙 ( Hye Sook Lim ),이형희 ( Hyung Hee Lee ),윤미정 ( Mi Chung Yoon ),신순식 ( Soon Shik Shin ) 대한본초학회 2013 大韓本草學會誌 Vol.28 No.2
Objectives: Gambigyeongsinhwan 16 (GGEx16), gambigyeongsinhwan 18 (GGEx18) and gambitongseong capsule are shown to be involved in the regulation of obesity. Therefore, the aim of this study was to compare the reporter activity of anti-obesity genes such as peroxisome proliferator-activated receptor a (PPARa) and PPARδ by GGEx16, GGEx18 and gambitongseong capsule. Methods: After NMu2Li liver cells, C2C12 skeletal muscle cells and 3T3-L1 preadipocytes were treated with GGEx16 (1 μg/ml), GGEx18 (1 μg/ml) and different concentrations of gambitongseong capsule, the transactivation of PPARa and PPARδ was measured by a luciferase reporter gene assay. Results: PPARa reporter gene activity in NMu2Li liver cells and 3T3-L1 preadipocytes was significantly increased by GGEx16, GGEx18 and gambitongseong capsule compared with control, whereas PPARa reporter gene activity in C2C12 skeletal muscle cells was significantly increased by GGEx18 only compared with control. Similarly, PPARδ reporter gene activity in 3T3-L1 preadipocytes was also significantly increased by GGEx18 compared with control. PPARδ reporter gene activity in C2C12 skeletal muscle cells was significantly increased by GGEx16 and GGEx18 compared with control although PPARδ reporter gene activity in NMu2Li liver cells was not changed by these three formulas. Conclusions: These results suggest that all three formulas have the ability to stimulate PPARa and PPARδ transactivation in animal cell lines with high metabolic rates. In particular, this effects were most prominent in GGEx18-treated cells. In addition, it is likely that GGEx18 may be used as an effective anti-obesity composition.
안진현,변소영,우서정,안예지,강정운,김민철,Ahn, Jinhyun,Byun, So-Young,Woo, Seo-Jung,An, Ye-Ji,Kang, Jungwoon,Kim, Mincheol 한국디지털정책학회 2021 디지털융복합연구 Vol.19 No.8
오름의 방문객 수가 증가하고 있고 관광의 트렌드는 빠른 속도로 변화하고 있다. 오름 방문의 동기도 과거의 휴식과 쾌락의 차원에서 경험과 체험을 중점으로 변화하고 있다. 이러한 변화에 맞춰 사람들은 오름에 오를 때 단순히 운동만이 아닌 결혼, 가족여행 등과 같은 동기를 선정하여 방문한다. 하지만 관광객의 오름 방문 동기에 맞는 오름을 찾는 것은 어렵다. 본 연구에서는 이러한 문제점들을 해결하기 위하여 웹문서 검색 엔진을 통해 오름과 콘셉트에 대한 연관 수치를 실시간으로 수집하여 오름의 콘셉트를 자동으로 분류하고 홈페이지에 제공하는 시스템을 제안한다. 원하는 날짜를 선정해서 과거 혹은 선택한 기간의 오름과 콘셉트에 대한 연관 수치 확인이 가능하다. 이러한 연구를 통해서 제주의 자연유산인 오름의 방문을 활성화하여 제주 관광의 발전에 이바지할 수 있다. 향후 제주 오름만이 아닌 해수욕장이나 바다 등으로 본 시스템을 확장할 수 있다. Currently, the number of visitors to Oreum is increasing and the trend of tourism is changing rapidly. The motivation for visiting Oreum is also changing from relaxation and pleasure to experiences. In line with this change, people visit the mountain by selecting motivation such as marriage and family photos, not just exercise. However, it is difficult to search for an Oreum that matches the tourists' motivation. In order to solve these problems, we proposed a system that provides the association between Oreum and concept based on the number of search results from web search engines in real time. User can select the desired date to check the associations for past or selected periods and concepts. Through this research, visitors to Oreum, Jeju's natural heritage, can contribute to the development of tourism in Jeju. In the future, the concept of visiting beaches or seas, not just Jeju Oreum, can be provided. In this work, search results from websites are collected, stored in a database, and search results of Oreum and concept are provided on the homepage to classify Oreum trends.
고지방식이 마우스 비만모델에서 인제청금단에 의한 체중감량과 혈중 지질대사의 개선효과
양승엽,이희영,이혜림,김병출,박순일,안예지,오재호,임혜숙,윤미정,신순식,Yang, Seung-Yeob,Lee, Hee-Young,Lee, Hye-Rim,Kim, Byoung-Chul,Park, Soon-Ill,Ahn, Ye-Ji,Oh, Jae-Ho,Lim, Hye-Sook,Yoon, Mi-Chung,Shin, Soon-Shik 대한한의학방제학회 2012 大韓韓醫學方劑學會誌 Vol.20 No.1
Objectives : We investigated the effects of Ingecheonggeumdan(ICD) on body weight and examined whether blood lipid levels and visceral fat are inhibited by it in high fat diet-fed obese male mice. Methods : 8 weeks old, high fat diet-fed obese male mice were divided into 6 groups: C57BL/6N normal, control, ICD-1(150mg/kg), ICD-2(300mg/kg), ICD-3(600mg/kg) and orlistat(10mg/kg). After mice were treated with ICD and orlistat for 8 weeks, we measured body weight gain, food intake, feeding efficiency ratio, fat weight, plasma leptin and lipid levels. We also performed histological analysis for liver and fat on the mice. Results : Compared with controls, ICD and orlistat-treated mice had lower body weight gain and adipose tissue weight, the magnitudes of which were prominent in ICD-3. Compared with controls, ICD and orlistat-treated mice had lower blood leptin levels, the magnitude of which was prominent in ICD-3. Compared with controls, ICD and orlistat-treated mice had higher blood HDL-cholesterol and lower blood plasma LDL-cholesterol, free fatty acid and triglyceride levels, the magnitudes of which were prominent in ICD-3. Blood plasma AST and ALT concentrations were not changed by ICD and orlistat, indicating ICD and orlistat do not show any toxic effects. Consistent with their effects on body weight gain, the size of adipocytes and hepatic lipid accumulation were significantly decreased by ICD and orlistat. Conclusions : These results demonstrate that ICD and orlistat effectively reduce body weight gain, blood plasma LDL-cholesterol, free fatty acid and triglyceride levels and improves abdominal fat, the magnitudes of which were prominent in ICD-3.
고지방식이 유도 비알콜성지방간 마우스 모델에서 육신국(六神?)의 지방간(脂肪肝) 개선효과
노종성 ( Jong Seong Roh ),이혜림 ( Hye Rim Lee ),안예지 ( Ye Ji Ahn ),윤미정 ( Mi Chung Yoon ),신순식 ( Soon Shik Shin ) 대한본초학회 2014 大韓本草學會誌 Vol.29 No.2
Objectives : This study was undertaken to verify the effects of Massa Medicata Fermentata (MMF) on nonalcoholic fatty liver disease (NAFLD) using high fat diet-fed male mice. Methods : Fifty four male C57BL/6N mice (age matched) were used for all experiments. Nine standard chow diet-fed mice were used as normal group and forty five high fat diet-fed obese mice were randomly divided into 5 groups: control, atorvastatin-10㎎/㎏, MMF(1)-62.5㎎/㎏, MMF(2)-125㎎/㎏ and MMF(3)-250㎎/㎏. After all groups were treated with several kinds of diets for 8 weeks, we measured body weight gain, adipose tissue weights, plasma lipid and glucose metabolism, visceral organ weights, histological analysis for liver on the mice. Results : MMF-treated mice had lower body weight gain compared with controls. Among MMF-treated mice, the effect was magnified in MMF(2). MMF(3)-treated mice had lower blood plasma total cholesterol (TC) and glucose level compared with controls. MMF decreased hepatic lipid accumulation, liver fibrosis and liver inflammation of mice compared with controls. The effects was maximized in MMF(2) and atorvastatin. Blood plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), γ-glutamyltransferase (γ-GT) concentrations tends to be decreased by MMF compared with controls. Blood plasma AST, ALT, γ GT concentrations and organ weights were not changed by MMF, indicating that all three kinds of MMF do not show any hepatotoxicity. Conclusions : These results suggest that MMF improves NAFLD by reducing body weight gain, hepatic lipid accumulation, liver fibrosis, liver inflammation.
고지방식이 비만마우스 모델에서 파키스탄산 및 중국산 마황으로 조성된 강지환(降脂丸)의 체중감량 효과 비교
김병출,석화준,유재상,구자룡,윤기현,조주흠,장두현,정양삼,김종훈,안예지,우상이,윤미소,신순식,Kim, Byeong Chul,Seok, Hoa Jun,Yoo, Jae Sang,Ku, Ja Ryong,Yoon, Ki Hyeon,Jo, Ju Heum,Jang, Du Hyon,Jung, Yang Sam,Kim, Jong Hoon,Ahn, Ye Ji,Woo, San 대한한의학방제학회 2014 大韓韓醫學方劑學會誌 Vol.22 No.2
Objectives : This study investigated the improvement effects of Pakistani (DF-a) and Chinese Ephedra herba-containing Gangjihwan (DF-b) on obesity in a high fat diet-fed obese mouse model. Methods : Eight-week-old C57BL/6N mice were divided into four groups: a normal lean group given a standard diet, an obese control group given a high fat diet, and DF-a and DF-b groups given a high fat diet with DF-a (80 mg/kg), and DF-b (80 mg/kg), respectively. After 8 weeks of treatment, body weight gain, feeding efficiency ratio, blood lipid markers, fat weight and histology were examined. Results : 1. Body weight gain and fat mass were significantly decreased in DF-a and DF-b groups compared with control. The extent of decreases was eminent in DF-a group. 2. Feeding efficiency ratio and circulating leptin concentration were significantly decreased in DF-a and DF-b groups compared with control, whereas circulating adiponectin concentration was increased in DF-a and DF-b groups compared with control. 3. Consistent with their effects on body weight gain and fat mass, circulating concentrations of triglyceride, glucose and insulin were decreased in DF-a and DF-b groups compared with control. 4. The size of adipocytes were decreased by DF-a and DF-b compared with control, whereas the adipocyte number per unit area was increased by them, suggesting that DF-a and DF-b decreased the number of large adipocytes. 5. Consistent with their effects on body weight gain, liver fibrosis was reduced in DF-a and DF-b groups compared with control. Conclusions : In conclusion, these results suggest that DF-a and DF-b not only decrease feeding efficiency ratio, plasma leptin concentration, and blood anti-obesity biomarkers, but also reduce fat mass, contributing to the improvement of obesity. DF-a and DF-b also inhibit liver fibrosis. In addition, these effects were similar between Pakistani Ephedra herba and Chinese Ephedra herba-containing Gangjihwan.